- Doing It for the Art: The graphics in the 2009 game. Every movement of the Boy, the Blob, and the enemies is lovingly hand-drawn. The backgrounds exquisitely painted. The developers said they wanted a deliberately nostalgic, warm feel, and knew only traditional animation would get them that. And it looks awesome.
- WayForward has had a history of this, with their previous game Shantae.
- Dummied Out:
- In the 1989 game tricking Blob into eating a ketchup jellybean will turn him into a brick wall. The brick wall is essentially just a stepping stone.
- In the 2009 game, the enemy concept art shows a Spider Blob enemy. It is seen standing among the other enemies in the finalized art. You never encounter it, however.
- Also in the 2009 game, there's a test movie in the game's data. Its the intro to the Sam & Max: Freelance Police cartoon, oddly.
- What Could Have Been: This remake was originally going to be in 3D with a different art style, and for the DS. 
- Some of the concept art for the remake includes a Water Skipper enemy that never made it into the game.
Trivia / A Boy and His Blob