A brief moment in "Mack Becomes a Jew" where Mack stares into a star of David that has appeared on the ceiling.
The climax of "Mack Fixes Life" is quite unsettling as well as tear-jerking, as Mack calls himself a useless piece of shit and suffers a massive emotional breakdown.
If you freeze-frame, you'll see Mack's search for "suicidal ideation".