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Ambiguous Disorder

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Wil Wheaton: Did he just say "revenge is a dish best served cold" in Klingon?
Stuart: Yeah.
Wil Wheaton: What is wrong with him?
Stuart: Everyone has a different theory...

This character's behaviour is bizarrely outside the norm — it's way beyond mere ordinary quirkiness. No reasons are given for the strange behaviour. No specific diagnosis is ever mentioned in the story. In fact, any resemblance to any real disorder is likely accidental; the character's symptoms are exactly those symptoms the writer wants them to have. It is a case of Ambiguous Disorder.


The disordered behaviour will often be Played for Laughs. This technique is generally used to avoid writing yet another Patient of the Week story about some specific disorder and to focus on the laugh-producing elements without having to deal with the serious issues. Or, less generously, to mock the kooky outer aspects of mental illness without the risk of getting angry letters.

In the instances where this trope is played seriously, the character usually overlaps with The Spock, Pinocchio Syndrome, or Tin Man and focus on this character's struggle to befriend people or otherwise fit into society.

A lot of mentally ill people in classical literature, especially from the 19th century and earlier, tend to be this; psychiatry was a very young field back then (and, until a certain point in history, didn't exist at all), and so there was no manual to turn to if you wanted to give your character odd quirks. Also, the lack of psychiatric expertise during these periods means that many historical figures might have had undiagnosed conditions (vast Wild Mass Guessing exists about this topic). Even today, due to difficulties in pinpointing an exact diagnosis, this is also often Truth in Television. That said, No Real Life Examples, Please! We don't want to start any sessions of "armchair diagnosis," since that kind of speculation about real people inevitably leads to controversy. Also please note that in Real Life, most mental health diagnoses require that the behaviors the diagnosis purport to explain contribute significantly to impacted functioning in one or more domains of daily living. Plenty of people behave oddly from time to time without meeting the criteria for any major mental health diagnosis, and Occam's Razor applies to the diagnostic process. Personality quirks and variations are perfectly normal, even if they may seem very strange or downright unrelatable to outsiders. Basically, as a rule of thumb: If your behavior doesn't significantly and negatively impact your quality of life, well-being and desired relationship with others, you don't have a mental disorder. Additionally, if the observed behaviors are best accounted for by an explanation that does not invoke a major mental health disorder, clinicians generally don't invoke a major mental health disorder.


Compare The Disease That Shall Not Be Named, Soap Opera Disease, Victorian Novel Disease, and G-Rated Mental Illness.

For when a character is explicitly confirmed (either in-story or by Word of God) to have a specific disorder but their portrayal isn't necessarily accurate, please check Hollywood Autism, Hollywood Tourette's, Super OCD, "L" Is for "Dyslexia", Attention Deficit... Ooh, Shiny!, Funny Schizophrenia, and The Schizophrenia Conspiracy.



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    Anime and Manga 
  • Miss Koizumi Loves Ramen Noodles: Koizumi prefers to eat and wear the same things every day, appears very expressionless, withdrawn and almost never speaks to anybody, and when she does speak, all she ever talks about is ramen.
  • Sound! Euphonium: Kumiko Oumae is unintentionally dismissive, far more empathetic than her actions imply, and rather poor at demonstrating appropriate emotional responses to situations. In the original book she also is so Oblivious to Love that she needed her friends outright telling her that she loved Shuichi to make her realize her feelings for him.
  • Persona 4: The Animation: At several points, Yu Narukami seems a tad... odd. Of course, most of his antics can simply be chalked up to Rule of Funny.
    • For example, during their first visit to the TV World, he sees nothing wrong with Yosuke, in the midst of a Potty Emergency, dropping his pants and relieving himself against a wall, and even asks Chie why he would want to stop him from doing so.
    • When he and Yosuke are knocked into the water for making perverted comments about the girls, he continues to have a complete lack of facial expressions, while Yosuke is simultaneously laughing and flailing about.
    • He has a rather odd habit of agreeing to random comments made by the other characters, regardless of their seriousness.
      Yukiko: The next time he creeps me out, he's ash!
      Yu: Sounds good.
    • He also has a tendency to not react at all to absurd situations, and to be way too into certain antics of the more... eccentric members of the investigation team. Case in point: While the other characters are freaking out about the implied size of Naoto's chest, he and Kanji hang back and have this gem of a conversation:
      Yu: Aren't you even the least bit curious, Kanji?
      Kanji: Huh? About what?
      Yu: Naoto, big melons or not.
      Kanji: Huh? Why are you asking me? I didn't look at her tits, I swear!
      Yu: Okay.
      Kanji: But that chick, she is pretty amazing.
      Yu: Which chick? Oh right, Funbags.
  • Aya from Shibariya Komachi is a Softspoken Sadist, admits he doesn't really have emotions, and feels no sympathy for others. He reveals he has started to feel some emotions due to magical bonding with the others in his group, but otherwise just does as he's told. He often will tell facts coldly in dangerous situations if he's safe instead of saving his friends, and sometimes even strangles them from behind for fun.
  • Yuuki Rieko of 14Juicy displays a limited emotional range and seems to have no interest in, or aptitude for, anything but soccer.
  • Area 88, the 2004 TV anime version:
    • Shin Kazama only speaks when absolutely necessary and has a blunted affect. He's socially awkward, as seen with how he interacts with Ryoko in flashbacks. He's aloof and detached from the other pilots at Area 88, and only slightly less so with friends such as Kim and Mickey. He demonstrated this behavior before his time at Area 88, so it can't be attributed to depression or war trauma.
    • Mickey has a somewhat bipolar temperament. He can be cheerful and gregarious in some situations, and extremely angry at other times. He's prone to violence, as demonstrated when he punches Makoto Shinjou in the first episode and beats him within an inch of his life in the last episode. It's not clear if this is Mickey's default personality or a result of his war trauma.
  • Assassination Classroom: Main POV character, Nagisa Shiota. There is definitely something... off about the kid, though it's not really clear what. From the start, he's acknowledged as having the most potential to become a real assassin, isn't at all intimidated wielding a deadly weapon, even though it's pointed out he should be, shows disturbingly little regard for his own well being in the very first episode, and has the uncanny ability to walk up to a person smiling, and try to kill them without any outward signs. That said, he shows no signs of being an outright sociopath, no attempts at cruelty or manipulation; heck, he's possibly the nicest character in the cast short of Koro-Sensei himself, yet he can make trained killers wet themselves with his casual attitude towards murder.
  • While a great number of the cast from Attack on Titan has several mental issues, special mention should be made of the main character, Eren Yeager, considering that even if in his early years he grew up in one of the most stable and loving environments for the setting: Even as a child he was prone to uncontrolled anger outbursts, had difficulty socializing with other children (his only friend was Armin, another awkward boy), constantly himself got into fights, and he stabbed to death two adult men as a child, granted, they were human trafficker kidnappers who had previously murdered Mikasa's parents in right front of her. His rationale for doing it? "I killed some dangerous animals. Animals who happened to look like humans". Later events through the series have not helped his sanity very much.
  • Generally Played for Laughs, but the extremely strange behavior of most of the cast of Axis Powers Hetalia coupled with how they've lived through countless years of wars, diseases, and other difficult times makes one wonder.
  • Osaka from Azumanga Daioh thinks in ways so completely different from other people that it's easy to think she might be mentally disabled in some way. She's dreamy and inattentive, prone to weird misunderstandings, has poor motor control, and occasionally seems to suffer from actual hallucinations. But although she seems mentally slow, she gets only slightly below average grades at a regular school and manages to socialize more-or-less normally. She even has some Genius Ditz tendencies: she's prone to penetrating insights that escape all the other characters, she's surprisingly well-versed in some obscure topics like marine biology, and her odd way of looking at the world makes her extremely good at certain kinds of riddles. The joke here — which can easily escape Western viewers — is that Osaka's spacey, laid-back personality makes her a humorous inversion of the stereotypical brash, loudmouthed, Hot-Blooded Idiot from Osaka.
  • Claire Stanfield from Baccano!. There's definitely something off about him, though it's hard to pinpoint exactly what. He's prone to violence but follows a set of rules so completely alien to the average person that he can't really be called "good" or "evil", and can be affable and calm, even while brutally murdering someone. He's even said that he believes the world to be an illusion and everyone to be a dream of his own making, which is often attributed to sociopaths, and thinks of himself as completely invincible (which might even be true, thanks to Achievements in Ignorance).
  • Bakuman。: Eiji Niizuma has extremely odd sitting patterns, demonstrates some trouble with social conventions and nonverbal clues, and has an obsessive interest and talent in a particular subject. Ice Queen Aiko Iwase also qualifies.
  • Bungo Stray Dogs:
    • Although incredibly intelligent, Edogawa Ranpo can't complete daily tasks like taking trains or going home alone without guidance, and at times has no common sense at all. He also doesn't really care one way or the other how things go, unless he has proper motivation. Before Fukuzawa took him in, he could neither understand social norms nor get along with other people, causing him to be kicked out of every job he got, and gradually became severely disconnected and isolated from humanity.
    • Not only Dazai Osamu is a suicide enthusiast, but he also cares very little for the conventional ideas of good and evil. He treats cruelty as nothing but a means to an end, and is not above manipulating his own coworkers if it means accomplishing his goal. His sociopathic tendencies were taken Up to Eleven during his mafia days, and despite have had became a better person, still has his moments now .
  • Edward from Cowboy Bebop is ludicrously intelligent but shows absolutely no ability (or inclination) to socialize in a remotely normal fashion for even brief periods. She almost always skips, cartwheels or dances instead of walking, and she sings improvised songs about whatever she's doing, often as a substitute for normal conversation. Her closest friend is a hyperintelligent, non-talking dog.
  • Death Note:
    • Super-detectives L and Near have several odd tics and habits and a near genius intellect that highly suggest some manner of disorder, though nothing's ever spelled out in the series.
    • Villain Protagonist Light Yagami is also undeniably insane, but it's never clarified where exactly it comes from. Between his monster god complex, inability to cope with any perceived evil, and constant manic laughter, there's something definitely wrong with him; that's all without even discussing the fact that he picks up mass-murder like a new, exciting hobby. For the record, Word of God states that the reason Light went off the deep end was because he was a perfectionist and couldn't reconcile that with the fact that he had unintentionally murdered someone except through Insane Troll Logic.
  • Detective Conan:
    • Hattori Heiji's really thick about other people's feelings, bad at picking up social cues, and extremely awkward a lot of the time. He can't lie without stuttering and giggling like an idiot, and he latches onto ideas or interests and does not let them go. For example, when he first became friends with Conan, he talked about Shinichi SO incessantly that his childhood friend believes him to have a girlfriend in Tokyo with the last name Kudo. He's also extremely adept at remembering little details and noticing anything out of the ordinary, no matter how minor.
    • The protagonist, Shinichi Kudo/Conan: In the first episode, he does not know when to stop rambling on about Holmes and Conan Doyle and talks to Ran about it the entire time they are at the roller coaster. Even whenever he dates her and starts off wanting to tell her his feelings, instead he ends up gabbing about Holmes again. He is not very social and it is implied that many of his teachers and classmates believed him to be arrogant and self-absorbed. Also, he seems to be quite blunt and unaware of social tact.
  • Maria, from A Devil and Her Love Song, is shown to be incredibly blunt, has great difficulty in expressing her feelings, and shows an immense lack of social tact, namely bringing up topics that make other people very uncomfortable or upset and not realizing it. In flashbacks, this is shown to have been normal for her since she was a small child, with her mother worrying that it would cause trouble for her later in life. She shows little restraint when it comes to lashing out at others (she was expelled from her first school for hitting a teacher who didn't take a friend's bullying seriously) but also goes to great lengths for and clearly cares about people close to her. Personal attacks and harassment on her, meanwhile, are generally met with emotionless responses.
  • Considering how quirky most of the characters in Eyeshield 21 are, the fact that both Shin and Tetsuma are both considered a little "off" by both the other characters and standards of the series says something:
    • Shin speaks in monotone with textbook level formality, has an encyclopedic knowledge of everything related to physical fitness (he maintains a VERY strict nutrition plan and seems to be very well-read on human anatomy), and absolute devotion to improving himself as a football player. At the same time, he speaks his mind in the most direct way possible (both positively and negatively), has no interpersonal skills or awareness of social norms (he doesn't see anything wrong with walking around shirtless), and is completely oblivious about anything that's not football or school-related (when his teammate Sakuraba grows a beard, gets a crew-cut, and starts training harder, the only thing Shin notices is that Sakuraba's muscle tone has improved). Nonetheless, he's very respectful and always means well, so the few friends he has seem to take his many idiosyncrasies in stride.
    • Tetsuma is very literal-minded, even more oblivious to social norms then Shin (as well as being an expert on his position), and can't seem to function normally without his best friend to tell him what to do. When he does speak (which he'll only do if someone specifically tells him to speak), it's very robotic and formal. Most likely because of his difficulty in interacting with people, he dearly treasures his friendship with Kid, who accepts him regardless.
  • Erza Scarlet from Fairy Tail is extremely socially awkward and serious, and holds other people to such high standards that she tends to drive them away. Much of this can be explained by her traumatic childhood and the fact that she hasn't been very well socialized with other people.
  • In Free!, if it weren't Played for Laughs Haruka's obsession with water and swimming, to the point that he once attempts to dive into a fish tank after stripping down to his swimsuit in a pet store, would almost certainly result in someone trying to diagnose him with a disorder. He's also extremely socially awkward, rarely emotes at a normal level, and is very blunt when interacting with others, which isolates him from most of his peers. While he gradually improves his social skills over time at the beginning of the series he's almost entirely dependent on his friend Makoto, who makes sure he actually goes to school and communicates for him.
  • Fruits Basket:
    • Ren has some sort of intense codependency focused on her husband Akira — so much so that years after his death, she remains intensely hostile to the point of extreme emotional abusiveness toward any female character she saw as a rival for his affection, including her own daughter. This seems reflect insecurity over class issues in their relationship — Ren was a lowly maid before the head of the household fell in love with her — but her behavior is so extreme that it's hard to believe she wasn't a bit unhinged even before; at one point, her response to feeling as if her "mind is very clear" is to take a knife and threaten her own child with it, to get back an empty box. The most we're told is that she's "a little sick, mentally and physically", but no specifics are given.
    • Akito shows similar behavior. Intense co-dependency towards the other Zodiacs (to the point of having a complete breakdown at the thought of any of them leaving) is just the tip of the iceberg. Akito has also been known to physically and mentally assault anyone who threatens what she considers to be the happy little world the Zodiac all live in. She has no friends outside of the Zodiac, and those relationships are awkward and strained. While more than a little of this is likely the result of Akito's abuse at the hands of Ren, it's also hinted that Akito inherited some sort of mental instability from Ren and/or Akira.
    • Machi seems to have some sort of disorder, too, although it's considerably more subdued than Akito's or Ren's. She has no friends (except her half-brother), dangerously low self-esteem, and trouble communicating with people in general. And then she feels compelled to ruin things when they're too "perfect", either methodically or in fits of violence. Presumably this is because of all the stress and anxiety that she built up trying to be a "perfect child", all compounded when her parents essentially declared her a failure and shifted their affections to her little brother.
  • Shu Ouma from Guilty Crown is an Extreme Doormat with No Social Skills who admits to himself that his mind might be out of step with everyone else's, and has only made "friends" by going along with what other people say. When he makes a carelessly cold remark about someone else and is reprimanded for it, he can only think about his own feelings that were hurt, rather than feeling bad about what he said. He also has trouble with making eye contact with other people.
  • Erio from Ground Control to Psychoelectric Girl is a delusional teenage girl who believes she's an alien who can fly. For the entirety of the first episode she's rolled up in her futon and even walks around in it. She also has shown dangerous behavior trying to "prove" that she's an alien. Erio starts the series as an Emotionless Girl and a hikikomori until Makoto coaxes her out of her shell. Her behavior is due to having gone missing a year prior and having no memory of the six months she was gone. Erio has since become convinced she's an alien.
  • Gugure! Kokkuri-san: Kohina is very intelligent and level-headed for her age, but has a very peculiar way of speaking, shows severe emotional detachment and is convinced she's a doll rather than a real person.
  • Several protagonists in the Gundam franchise have traits like this. Seems to have something to do with being a Newtype.
    • Amuro Ray of the original Mobile Suit Gundam is capable of social interaction, but absolutely hates it. He's paranoid, prone to focusing on himself, and in his Establishing Character Moment, is shown sitting in his room in his underwear, not having eaten in a day, looking at a computer chip through a microscope and studiously ignoring the evacuation siren blaring outside. His friend Frau specifically states that this isn't uncommon behavior, and that his neighbor was supposed to come in and tell him if the siren was going off.
    • Kamille Bidan of Mobile Suit Zeta Gundam has similar Newtype traits to Amuro in addition to a volatile temper and a near-genius intellect, but is also capable of compassion. Big Bad and sort of Shadow Archetype to Kamille Paptimus Scirocco is similar but has incredible disdain for people and an extreme Lack of Empathy, which he compensates for with his Psychic Powers.
    • Kira Yamato of Mobile Suit Gundam SEED shares many of Amuro's personality traits; the main difference is that he tries to be social (despite sucking at it) while Amuro deliberately avoids other people at all times.
    • Tiffa Adill from After War Gundam X is a Mysterious Waif who in the beginning largely keeps to herself and fixates on creepy drawings she makes to express her emotions, wears loose-fitting clothing that looks like something a girl with sensory integration issues would wear and demonstrates a form of Spider-Sense in additional to more explicitly supernatural Seers abilities. The fact that she herself questions whether she's really a Newtype makes it even more ambiguous.
    • Mikazuki Augus from Mobile Suit Gundam: Iron-Blooded Orphans is extremely quiet and rarely shows any kind of emotion on his face or in his voice. Whether happy, angry, or sad, his voice and expression are always perfectly level. He also kills with zero hesitation, and seems to outsource all of his agency to his friend Orga Itsuka: no matter what Orga orders, Mikazuki will do it, and it is rare for Mikazuki to decide to do something on his own. What's scary is that flashbacks show that Mikazuki was like this even before he became a Child Soldier; the very first scene shows a young Mikazuki with a gun in his hand over a bleeding corpse, asking Orga what it is he should do next.
  • Hime Shirayuki/Cure Princess from Happiness Charge Pretty Cure seems to suffer from sensory overload issues when more than one person tries to speak to her or when she hears loud music. A Running Gag in early episodes is that she usually becomes overwhelmed to the point that she physically flees the room when in these types of situations. She also displays a general lack of knowledge of how to behave in most social situations.
  • Eru Chitanda of Hyouka gets easily distracted and has an outright obsession with mysteries, and isn't able to stop thinking about them until she solves them. It's also implied she may have some sensory integration issues and seems to have much sharper senses than other people.
  • Shinji Inui of Initial D lacks basic social skills and understanding societal norms, such as failing to know why people would find his actions, like giving the opponent the lead in a race or ramming his car against theirs, deplorable. However, Shinji can memorize the most minute details of the Tsubaki Line, making him one of the most formidable drivers on the course, yet his meticulous behavior or interest in the subject is deemed unusual by most people.
  • Inside Mari implies this with the original Mari (as opposed to the protagonist-Isao-in-Mari's-body); when Isao tries repeatedly to tell Mari's mother who he really is her reaction is a strained smile and trying to get Isao to take medication. As the manga goes on there are heavy implications that no body swap occurred and Mari has a Split Personality. This is later confirmed.
  • Sawako from Kimi ni Todoke. At the age of fifteen she's never made a single friend, and frequently misinterprets social cues with hilarious results. She doesn't seem to find this at all weird. Though this is mostly explained by her frightening appearance causing people to avoid her and her resulting social inexperience.
  • Marginal #4's Atom Kirihara tends to obsess over things and get attached to rituals, schedules, and lucky charms; plus he's very loud and hyper, with little observance of social norms, leading others to call him the unit's "Wild Shooting Star". Played a bit differently as he is still an attractive, successful Idol Singer, and he and his unit make these traits into a positive, rather than a problem.
  • Buchi from Mekko Rarekko is quite the example: He knew as a kid that he's not as smart as the other kids, claiming that he's hopeless and hapless while being aware that his parents wanted him to be a normal child. Because of that he hated going to school, but he felt that if he didn't continue going to school that he couldn't become normal and that his parents would hate him for it. Because of all that, he never told his parents about how he was bullied and he just stayed quiet about it, leading him to developing a very small number of social skills. Later on, he takes up photography because he realized that his parents would see him as a good-for-nothing son and he wanted to be noticed. In the end, it didn't work and he believed that no one would ever notice or like him, which in turn lead to him tearing up one of the pictures he took and breaking down crying. He only got much better when Taishou noticed him and helped him out. Buchi then focused on making sure that Taishou wouldn't hate him, doing anything for him. Buchi goes to extreme lengths to make sure that his friends stay his friends and when it doesn't work, he wonders if he did something wrong or if there is something wrong with him.
  • Monster:
  • Most of the main Neon Genesis Evangelion cast would probably count — it comes with the Dysfunction Junction nature of the show. Whether they have anything diagnosable, though, is anyone's guess. Their highly traumatic backstories certainly don't help, at any rate.
  • One of the first things the audience learns of Shiro of No Game No Life is that she has a communication disorder. In Japanese parlance, that is a catch-all phrase that covers not only what is strictly the medical definition of the term, such as Speech Impediment, but also such things as social anxiety or autism.
  • The protagonist Tomoko from No Matter How I Look at It, It's You Guys' Fault I'm Not Popular! seems to live this trope. She's extremely socially awkward, to the point of being incapable of talking to anyone who isn't her relative or best friend without stuttering and stumbling over the simplest of words several times. She also seems to view herself as superior to other people for no good reason, often taking anime and manga clichés as her stepping stones to becoming popular but they generally end up failing. While the series is playing it for comedy at times, it gets Played for Drama just as often.
  • In The Pet Girl of Sakurasou, despite Mashiro's behavior, it's never outright stated that she has a mental disorder. The closest thing her dormmates did to name her a disorder was for Sorata to call her "special", having been fed up with her antics earlier that day.
  • Jirarudan/Lawrence III from Pokémon 2000. He's an art collector of a ridiculously high magnitude who seems to have learned social skills by rote, has a narrow and fixed attention span, wears a long coat with an undershirt to tropical islands in the middle of summer, has almost no change in facial expression or vocal intonation despite living by his passions, seems to have difficulty recognizing cues from others, and takes everything, including the legend and Misty screaming at him, only by the words presented without considering tone or alternate meaning.
  • Pokémon Adventures:
    • Black is so focused on his goals that he needs his Munna to eat his dreams in order to focus on the task at hand. Attempts to do so without clearing his mind causes him to overload his brain and faint. He does eventually get a little better whenever White is concerned, but it still takes a lot of considerable effort. Black also has No Social Skills as a result of being so focused; he isn't inherently a Jerkass, but often he honestly just doesn't notice how his actions can inconvenience or hurt others.
    • Despite having high intellect and physical skill, Blake lacks emotions and has to memorize various manuals that tell him how to interact with other humans and Pokémon. He is willing to push a very damaged Genesect in order to unfreeze the Musketeers, and states that he doesn't understand how that is cruel — if Genesect gets hurt he will just heal it. He admits that concepts like "fear" and "pity" are unknown to him, shocking Whitley and Kelden.
    • Lillie's abusive mother has clearly taken a toll on her. She freaks out at being called "pretty like a flower" by Sun and is otherwise triggered by childhood memories.
  • The Nuns of Princess Jellyfish clearly have something, what with their singular obsessions, various tics, and near-total inability to interact with anyone outside of each other, but this isn't focused on and usually only pops up as a source of comedy.
  • Ami Mizuno/Sailor Mercury from Sailor Moon is incredibly intelligent, but has a hard time making friends or fitting in with kids her own age, and often comes off as cold and unemotional to her peers. This is even more pronounced in the live-action version, where she also displays a complete inability to understand sarcasm, hyperbole, or social cues (which is Played for Drama a few times). Ami also on occasion displays low self-esteem, and seems to have some form of social anxiety. A notable but ambiguous disorder attached to this would be her "allergy to love letters", where she actually breaks out in hives when she is presented with a love letter.
  • Nozomu "Mr. Despair" Itoshiki of Sayonara, Zetsubou-Sensei. Focuses on one topic for an incredible amount of time; depressive and paranoid to a nearly delusional degree (although it's Played for Laughs); is a self-proclaimed master of not looking people in the eye due to a family custom that would force him to marry the first person he makes eye contact with. The rest of his family have their own quirks and likely played a large role in making him the dysfunctional mess he is.
  • Yuki from School-Live! is an eccentric Cloudcuckoolander who acts much younger than her actual age. She is delusional and is oblivious of the Zombie Apocalypse due to Repressed Memories, until being forced to kill a zombie snaps her out of her hallucinations. Miki thinks she has Multiple Personality Disorder, however her symptoms don't fit. Even prior to the zombie outbreak, Yuki was shown to have been bullied by some other girls due to her personality and looks (she wears a cat-eared Nice Hat and has a kiddie looking backpack) and as a result she had few peers besides her teacher.
  • Lain in her initial appearances within Serial Experiments Lain. She shows impairment in the use of nonverbal behaviors, has developed few peer relationships and the ties with two of her friends are very weak, does not show enthusiasm to seek enjoyment or socialization with others, and lacks social or emotional reciprocity. She also rarely speaks, and cannot converse well or start/hold a prolonged conversation. Finally, she becomes unusually enthralled by computer/technological objects and their construction as the series goes on. Never mind the loss of sense of time and space, vivid hallucinations(?), moments of amnesia, hearing voices... All possibly justified from being an Artificial Human. Or the Anthropomorphic Personification of the Internet. Or something. In the video game adaptation, Lain sees a therapist who diagnoses her with several disorders. Her Creepy Child aspects are also far more pronounced than in the anime.
  • Shounen Note:
    • Yutaka is a highly emotional and sensitive boy who is prone to Tender Tears. He also has sensory issues, but he's very skilled at singing soprano.
    • Vladmir is a prodigious boy soprano who has a sensitivity to sounds.
  • Saori from Wandering Son is asocial and moody beyond the normal pubescent awkwardness. She's shown to have not have any friends most of her life and goes near hikikomori once. She Cannot Tell a Joke, has terrible social skills, and is awkwardly blunt. When confronted with a friendship issue Saori decides to ruin her 2-year friendships and avoid them.
  • The character Satsuki Yatouji from X/1999 is a computer genius and one of the world's most dangerous hackers. In her personal life she mostly avoids contacts with other people (and is frequently annoyed by it) and spends most of her time connected to the supercomputer Beast. She is also extremely rational and seems to have problems with understanding human emotions.
  • Medaka and most of the other Abnormals in Medaka Box, by virtue of being a form of Super Soldier. Medaka herself, for instance, has no real personality outside of what she thinks people think she is. She never shows any kind of worry or unease, makes snap decisions about people that go against her friends' suggestions and tends to ape the poses of people around her when they show emotion. The show is mostly a parody of the God-Mode Sue, so it's usually Played for Laughs, though her odd behavior is a point of contention to Straight Man Zenkichi.
  • Bleach: Something is not right with Giselle's mind. She seems to have some disconnection with reality, as she genuinely doesn't seem to realize that performing Cold-Blooded Torture and receiving an orgasm while hearing the screams of someone she kills, makes her a sadist, as she denies being one. She likewise seems to have no problems with abusing Bambietta, even though she loves her, despite being much nicer to people she doesn't have the same affection for. It seems Giselle treats Bambietta that way precisely because she loves her. She can go from bashing Bambietta's head in a fit of rage to gushing and hugging her in extreme joy and proclaiming how much she loves her within mere seconds. And when Giselle looked at what she had done, she had a look of confusion in her face, as if she didn't realize what she actually just did. She also displays several control and abandonment issues throughout the series and that is without going into her necrophilic tendencies.
  • In When Marnie Was There, Anna is frequently noted to act oddly for a child or focus on strange things. The book starts with her acting incredibly detached from other people, enjoying spending time alone, limiting interactions with the family she lives with, and sending postcards to her guardian that are only a few sentences long. She views the world as being a circle with people on the "inside" and on the "outside", believing herself to be on the outside and separate from everyone else. At one point, she goes into a fury over an insult which everyone, even the narrator, considers to be silly. She also doesn't seem to have many friends, but the people she does meet and bond with (Marnie and, later, the family that moves into her house) she's able to form very close ties to. Some of her behavior can be attributed to her fearing that her foster mother is only keeping her for the money, but her reaction to that still comes across as unusual for an upset child.
  • White from Tekkonkinkreet: there's definitely something mentally different about him, but it's impossible to distinctly tell what. He's exceedingly childish for his age, refusing to bathe unless prompted and unable to tie his own shoes at age ten. Yet at the same time White has a... ''vivid'' imagination and occasionally a strange, almost cosmic insight.
  • No one in the cast of Osomatsu-kun / Osomatsu-san is very normal, but a few characters seem to have something a little more specific going on than general cartoony weirdness:
    • Ichimatsu is almost always monosyllabic, speaks in a deadpan tone, is seemingly depressed and has sadistic tendencies, which makes his family worry if he'll ever become a functional member of society. The only thing he seems to care about are cats. In an episode where the sextuplets' parents decide to get divorced, Ichimatsu blackmails his mom to get her to choose him to stay under her custody by saying he could easily become a murderer if left unsupervised.
    • Jyushimatsu is the polar opposite of his brother Ichimatsu: he's childlike, nonsensical, extremely hyperactive, has a goofy smile permanently plastered to his face and is obsessed with baseball, speaking almost exclusively using baseball terms. His brothers constantly wonder what "happened to him" to make him this way. Unrelated (or maybe not?) to that, he also has reality-bending powers that no one can quite explain, even in a surreal universe such as the show's.
    • At first glance, Iyami's obsession with France and insistence on saying he came from there seems like a harmless quirk, but the original manga reveals he's actually quite delusional. He's convinced he's French, to the point he eats using chopsticks as if they were Western cutlery and writes Japanese characters in cursive. It's even implied on a few occasions he wishes he could be... well, white. In one story where his assumptions about France are challenged by someone who has actually been there, Iyami has a severe nervous breakdown and speaks without his "accent" for the first and only time in the series.
  • Yuri Katsuki from Yuri!!! on Ice is a very anxious person, which doesn't help his low self-esteem, struggles with Performance Anxiety, and introverted personality that contributes to him having very few social skills.
  • Dragon Ball Super: Even before he falls off the deep end and becomes an Ax-Crazy Knight Templar, there's something clearly wrong with Zamasu. He fits many of the characteristics of a high-functioning sociopath, but he also has an inability to cope with any perceived evil, is extremely sadistic despite his "noble" intentions, and is incapable of even considering the possibility that he might be wrong. What makes him stand out compared to other villains in the series is that Zamasu wasn't born or created evil like King Piccolo, Frieza, Cell, and Majin Buu. He's supposed to be a god who overlooks the living world and give it guidance. So it's all the more jarring that he's so twisted, which is probably why Gowasu doesn't know how to deal with him.
  • Yu-Gi-Oh! VRAINS has two notable examples. The protagonist Yusaku lacks social skills is very blunt and direct and doesn't seem to realize that he comes off as rude this way; his emotions don't show on his face or body language even when he verbally states he is enjoying himself; and he has a tendency to list things in carefully ordered categories (of three), going so far as to stretch two ideas to fit three bullet points, while Aoi Zaizen, also known as Blue Angel, shows a lot of suspicion towards everyone outside of her online avatar and rarely shows emotions.
  • Fate/strange fake regularly suggests that both Saber and Flat Escardos have some sort of serious, untreated mental illness, and even the characters themselves readily acknowledge the likelihood. However, none of the characters have any sort of psychiatric background, and both Richard and Flat come from cultures where the field of psychiatry is all but nonexistent (Medieval Europe and a society of sociopathic luddite mages, respectively), so nobody is able to articulate just what they might have other than to say that Saber is "touched in the head" and that Flat is "a flat expanse with unintelligible scribbles on it."
  • Ryoko Satou from Aura: Koga Maryuin's Last War lacks social skills, shows weird speech mannerisms and often, an extremely monotone voice.
  • Goblin Slayer:
    • The titular Goblin Slayer has very few people skills and an incredibly single-minded obsession with killing goblins. He doesn't seem to pick up on social cues and spent most of his time alone before the story starts.
    • The Witch, a member of the guild, has an odd cadence and seems to take a long time to speak, as evidenced by all the ellipses during her dialogues.
  • The titular Violet from Violet Evergarden is extremely Literal-Minded, incredibly blunt, nearly incapable of making any decisions for herself, incredibly attached to one person, and fairly emotionless. How much of this is her real personality and how much of this is due to how she was brought up is up to interpretation.
  • Tanaka of Tanaka-kun is Always Listless is known to be a very lethargic sleepyhead to the point that he's being carried over the shoulder by Ohta at least Once an Episode. It is unclear which of the many conditions that could cause lethargy and/or fatigue he may have.
  • My Roommate is a Cat: Subaru is very uncomfortable around crowds and exhausted by basic social interaction, to the point of actively avoiding people as much as he can. He can also get hyperfocused on his work and reading to the point that he Forgets to Eat when deadlines come close.
  • My Next Life as a Villainess: All Routes Lead to Doom!: Katarina's family and friends pretty much all agree she's not normal by any stretch of the imagination, and they find it charming and frustrating in equal measure. She acts on impulse, is oblivious to subtext, can be spacey and absent-minded, is easily distracted, has difficulty with paying attention unless she's interested, has only a few things she's interested in trying to learn, frequently forgets or puts off her homework, isn't good at long-term planning, takes time to absorb information, seems immune to lectures, etc.
  • Besides the obvious social anxiety, Hitori Bocchi of Hitori Bocchi No OO Seikatsu displays a number of other quirks, such as trying to adhere to a literal script when hanging out with a friend, not being able to tell whether people are joking, and going into way too much detail about something off-topic. These traits are mostly used for comedy, though, so the possibility of her having actual psychiatric issues never comes up.
  • Lily of Wasteful Days of High School Girls has a pathological androphobia that manifests with hives whenever she comes in direct contact with men... and Tanaka. Her classmates speculate that the hives manifest out of her hatred of men, but a blind trial proves that Tanaka may be an exception to the rule and that the hives is not psychosomatic.

    Comic Books 
  • Marv from Sin City is often considered stupid and insane, an opinion that he shares. He did poorly in school, has No Social Skills, gets "confused" a lot, and often has violent blackouts, although he has mentioned fighting in a war and suffering from traumatic symptoms. In his first story, he mentions that he has always been good at puzzles, implying that he's capable of solving complex mysteries. He was certainly intelligent enough to go up against a powerful crime family. He also cares a lot about his friends and family, is friendly towards complete strangers, and is something of an awkward gentleman with women. On the other hand, he often displays bizarre emotional responses, most prominently a near-sociopathic Lack of Empathy — there have been multiple instances of him remaining genuinely perfectly calm during moments of intense chaotic violence, and he's capable of cool, calculated cruelty and a complete lack of queasiness or discomfort while casually torturing people to death (not that his victims didn't deserve it).
  • Every Batman villain, as well as Batman himself in some interpretations. If anything The Joker could probably be diagnosed with "Being the Joker".
  • Cammi from Annihilation and Avengers Arena seems incapable of feeling empathy and has absolutely no verbal filter. Numerous characters remark how incredibly bizarre this behavior is for an 11-year-old girl.
    Nova: Oh, this is Cammi. She says out loud stuff most people just think.
  • Brian of Knights of the Dinner Table. He has a job that involves running an online service from his home (which he is said to not clean) and painting model figurines. He has a savant-like memory of obscure roleplaying game rules, yet sometimes forgets his own phone number. He is stated to become very uncomfortable when any social group exceeds four to six people, especially when it happens away from the context of a shared interest. He rarely speaks unless dealing with gaming, and has a face and body language that is usually unreadable. And finally, some things that would annoy other people seem to have no effect on him at all, while something that others would take in stride can send him into a sudden and brutal fury, typically involving flipping over the gaming table in rage.
  • Runaways:
    • Nico is shown to have issues dealing with stress, loss, and rejection. In the first story arc, she mentions having "this thing with stress and eating". Later, after Karolina leaves to marry Xavin, Nico sits in her bedroom, with a pile of her clothes scattered around her. She later notes that she has a tendency to throw herself at "the nearest warm body" when she's upset or confused (kissing Chase after a near-death experience, even though he's dating Gert, reacting to Gert's death by sleeping with Victor, etc.) All of the characters act in different ways to cope with the stress of growing up as the children of supervillains, but Nico is the only one who feels her behavior is unacceptable.
    • Later member Klara talks to plants, is prone to weird moods, and occasionally blurts out appallingly rude things. Whether her behavior is due to her traumatic background, her Fish out of Temporal Water nature, some sort of neurological issue, or just a consequence of the inconsistent writing that plagued the series in its later arcs has never been explicitly stated.
  • It was implied for years that Hank Pym from The Avengers likely had some sort of mental illness, as he displays obsessive behavior, sometimes goes through violent mood swings, and is prone to frequent identity crises. After years of this, Marvel finally dropped the "ambiguous" part and made it canon that Hank suffers from bipolar disorder.
  • Rufus Whedon from Locke & Key. He's definitely "special" in some way, but he seems too articulate to be handicapped or have Downs. His first appearances made him appear to have some sort of disassociative identity disorder (he only talked through his action figures) but later ones had him talk on his own and say that was just pretend.
  • Spinister from The Transformers: More Than Meets the Eye. Some describe him as "autistic child meets violent psychopath". Despite this, he's also an ace surgeon who can defuse bombs. He's not a complete fail at socializing either; he just seems to get distracted easily.
    Spinister: The fire's giving me funny looks, Krok. I think I'm gonna shoot it.
  • Sonic from Sonic the Comic. He cannot express his feelings well, which results in him bullying and acting cruel even towards his loved ones. Back when he was younger, he was asocial enough to rely on the Token Human of their world (instead of other animals) for companionship. Sonic also seemed to only care for running when younger.
  • Herbie Popnecker from the Herbie comic is extremely uncommunicative, has no interest in social interaction of any kind, usually shows absolutely no visible emotions, and seems utterly indifferent to what other people think of him.
  • Cyclops is introverted to an unhealthy extent: the people he interacts with outside of work can be counted on one hand. This trait is compounded by his difficulty with expressing emotion and extreme dependency on his few close friends - all of whom, not coincidentally, are telepathic. Everyone else perceives Cyclops as colder than he actually is. Growing up with a deadly superpower that could kill anybody you look at unless you wear special glasses will do that to a man.
  • In Twilight Guardian, the titular heroine is obsessive about her patrols, goes to absurd lengths to protect her secret identity, and is convinced that her comic books are sending her messages. It's frequently mentioned that she used to be on medication (which she has long since stopped taking) but it's never mentioned what specifically the medication was supposed to treat.
  • Batgirl (2000): Cassandra Cain has been claimed as neurodivergent by some writers and certainly seems like it, but it's ambiguous as to how much is credited to the canonically confirmed parts (dyslexia and a bad upbringing) and how much is something more. Among other things, she's extremely socially awkward, frequently obsessive, acts on impulse, taciturn even in terms of the little language she does know, and seems highly sensitive to attention. James Tynion IV, her writer in Detective Comics, has refused to nail down anything on the basis of not wanting to make her a stereotype.
  • Harvey Comics: Little Dot, whose entire personality revolves around the fact that she is obsessed with polka-dot patterns (and by extension, virtually anything circular), to the point that she paints dots on everything, even other people's property. Her only rationale for her impulsiveness is "dots are beautiful". She gets upset to the point of distress if her handiwork is removed or ridiculed, as in one story where Little Lotta pointed out numerous things that were troublesome despite being dot-shaped.

    Comic Strips 

    Fan Works 
  • Nutty for Wonka:
    • The protagonist, Matilda Prescott, is mentioned by another character to have a disorder, highlighting her intense fixations with her candy notebook. Matilda is also very blunt at times and can be slightly short-tempered.
  • Rosario Vampire: Brightest Darkness:
  • The My Little Pony: Friendship Is Magic fanfic Jericho has a case of this which is not played for laughs, but rather for drama. The narrator Jericho has one of these. While his behavior is often kooky and generally silly (like monologing his life aloud), at times he gets downright evil (being mentally unable to comprehend how beating a girl into unconsciousness was wrong). Word of God states Jericho has a real condition, but the author refuses to admit what it is. As such, there's a lot of guessing by the fans as to what condition he really has.
  • John Egbert in Homestuck fanfic Brainbent is the only person in St. Lobaf whose disorder is unclear, though fans speculate that he has schizophrenia.
  • Sai in Second Bloom is not very social, very good at art, loves bright colors, has a lisp and is a little slow, but since this is the shinobi world, they don't identify it.
  • Otacon's portrayal in Stray maintains the Ambiguously Disordered traits he has in canon but adds a few new symptoms — he's not great with metaphors and figurative language and it's mentioned at one point that he can find facial expressions hard to read.
  • In the Sherlock fanfic Baker School Blitz, while everyone at Baker Boarding House has some sort of mental disorder or disability since it's a special school for the disabled, no one explicitly comments on the nature of Sherlock's disorder, nor that of his brother, Mycroft.
  • A recurring theme in Gender Confusion, during one arc, is the author attempting to find a credible diagnosis for some of the characters using Zetsu as the resident psychologist. Subverted after a believable conclusion actually is drawn, rather than left ambiguous for the whole story.
  • Caim from Mass Effect Human Revolution is clearly heavily traumatized by his past, but there's no DSM-recognised anxiety disorder that can be staved off by harming others.
  • Ada Linus from The Bombshell is shy, has an adverse reaction to touch and noise, has certain habits she strictly adheres to such as wearing the same clothes for days at a time, and has a difficult time reading emotions and body language as well as idioms, among other things. She also exhibits an extreme fascination with all things technical.
  • Gensokyo 20XX:
    • When Yukari had gone insane, remaining like that for about two stories, she was prone to wandering around, which occasionally involves searching for Ran like a lost pet, screaming at random periods (whether or not that is part of it is left up in the air), going ballistic at a moment's notice (according to Amoridere), rambling, and generally incoherent most of the time. By the time of Gensokyo 20XXV, she seems to have regained her sanity, aside from the bouts of Attention Deficit... Ooh, Shiny!!
    • Reimu has mood swings during the events of 20XXIV and, later in 20XXV, chapter 54, it is revealed she periodically stares into nothing, muttering nonsensically or in what she used to communicate in, along with catatonia. It was also noted that she seemed to have some sort of psychosis, which is made more apparent in chapter 115, where she starts clawing at mirrors, claiming to see messages in them.
  • In the Kill la Kill fanfic titled Second Story Window, its inherently clear Ragyo has some sort of psychosis, said psychosis causing her to lash out violently against her children, but we don't know what it is and neither does Satsuki who is narrating. Amoridere did state in the end note that whatever is wrong with Ragyo or Satsuki (who is suffering from a kind of psychosis in the former's POV) when the perspectives are flipped, is anyone's guess.
  • History's Strongest Shinobi: While very competent and of decent intellect, Naruto is hyperactive, has a short attention span, misses obvious social cues at times unless it involves fighting or him getting maimed and/or killed and has an interest in fighting. At one point the narration lampshades this by explaining how his friends honestly think Naruto has an undiagnosed attention disorder.
  • From Kiryuuin Chronicles, we have Ragyou, as a result of her husband's abuse, and it is clear she is suffering from some form of psychosis or delusional disorder, yet she does have moments of clarity, which is clear when she holds Satsuki in her arms for the first time in a long time.
  • Tom Riddle's Schooldays:
    • Marca. It is generally believed that what she's afflicted with hasn't even been codified yet at the time of the story.
    • Tom himself is obviously an undiagnosed psychopath, although that is supposed to be hard to tell when it comes to children.
  • The Pandora Hearts fanfic Beyond The Winding Road plays with this a bit in-universe. Lewis' parents took him to many, many psychologists and psychiatrists as a child, trying to figure out exactly what was going on with him. Word of God says they eventually concluded he had Dissociative Identity Disorder, but his mother Beatrix eventually realized that there was more to it. His 'episodes' turn out to be a symptom of his reemerging past memories.
  • Luna from Friendship is Witchcraft is an exaggerated stereotype of awkward fangirls. She also has little care for personal space and has No Social Skills.
  • In Death Note Abridged Parody Charleston VO, it's implied that Light is The Ditz because he has some kind of learning disorder, but it's never specified exactly what it is.
  • Satsuki in The Mysterious Lady Kiryuuin is implied to have some kind of a disorder, likely one relating to social anxiety, considering that she is so painfully shy and seems to have some agoraphobic traits, considering that going outside scares or, to a lesser degree, upset her. There's also the fact that she doesn't interact with her new house-guests directly and her mother's ghost described her as "fragile in mind", along with having been like that since she was a child. However, while her condition is, to some extent, debilitating, it doesn't keep her from being a caregiver to her younger sister, Ryuuko, and a child she adopted, Nui.
  • This was used early in The Loud House's fanfic My Sister Leni. Leni often doesn't understand other's thoughts or behavior, is Literal-Minded, seems to have minor sensory issues, and goes to speech therapy.
  • Pokémon Reset Bloodlines:
    • Belladonna Tyrian demonstrates mood swings that can rapidly lead her to a desire to kill people, or away from it with little care for those around her except for those she really cares for. She seems to be aware of her changing emotions, however, and she appears to be able to at least control it to the point she doesn't go from loving to murderous around those few she really cares about. This may have originated from having grown in an abusive home in a heavily polluted part of a polluted city, though given the mood swings of her possible uncle Capriccio, genetics may also play a part (though none of her other possible relatives have shown these behaviors.)
    • The aforementioned Black of Pokemon Adventures, in this case, Black Gaiman, shares his canon selves odd behavior pattern and need of a psychic type chewing on his memories to focus on them. Without the focus, he talks fast and needs prompting from White to stay on task. However, when his mind is focused he is highly observant and clear.
  • Child Born of Love: Noah has had an obsession with his weapon partner Maria that is so string that a part of her was relieved when she thought he died. This obsession led him to hate Death the Kid, seeing him as a symbol of what he could not have. Inversely, when Gopher dresses him up as Maria, Noah seems to genuinely think that he is Maria. He is also prone to mood-swings, going from loving and possessive to Chronanote  to physically abusive.
  • Agent South Dakota is noted to have genuine mental problems in the fic Stress Relief. She has a lot of issues with controlling her anger and her brother North says it isn't new. She has had the problem for a while. In addition, there is her blatant disregard for the thoughts and opinions of others. She also tends to view everyone else as out to get her when people try to address these problems, showing an utter refusal (or even inability) to see herself as the issue. After being exposed for raping C.T., The Counselor says that her symptoms seem to line up with Cluster B personality disorders, but a diagnosis is not specified beyond that.
  • Cinder Fall shows some very severe mental issues in the series The Makings of Team CRME. She is called a sociopath a couple of times In-Universe and by the author, but her issues are much deeper than just that. Her egomania is implied to be the result of childhood abuse that she suffered and an attack on Melanie Black shows that her childhood haunts her since she attacked this person because they reminded her of her abusive mother. Watts also implies that she's emotionally stunted because of her abuse. She later has more prominent childish traits. Along with her random bouts of anger and intolerance for criticism on top of her sociopathic symptoms, the Cinder Fall of this series is a psychological mess.
  • Roanapur Connection: Nathan Andre is heavily implied in Eye Of the storm to be the anxious type from the way he taps his leg throughout the meeting, needing the toilet often. He also reacts to being touched by his boss, his reaction to a door slamming shut being similar to sensory overstimulation. Along with his often social miscuses noted by Ganabati. To further complicate it, he's been noted to scream out at night from Noodle Incident of Romania that Ganabati describes as having been...horrific.
  • The assassin Sho in the Avatar fan comic How I Became Yours in many ways resembles an expy of Major Solf Kimblee of Fullmetal Alchemist. His perfectionism, macabre philosophical speculations, formal and somewhat idiosyncratic speech patterns, and Lack of Empathy combine to give him an unsettling air. He is obviously high-functioning, competent, intelligent and even intellectual, but something is definitely not right about him.
  • Vale's Underground: Officer Penny Polendina is a rather strange individual. She has trouble picking up on social cues and tends to blurt out inappropriate things at times that might not be the best without thinking. She's incredibly friendly and wants to make friends with everyone, but she's not very great at conversing with others. She also has a fascination with macabre things and is way too willing to share it. The writer says they didn't have a specific disorder in mind when writing her and encouraged any readers to try to diagnose her.
  • Warriors Redux: Ravenpaw has been a Nervous Wreck since kittenhood. He's also terribly shy and speaks with a stutter.
  • Cellar Secrets: As we find out from chapter 21, Ragyo seemed to have some sort of mental illness the which is characterized by her erratic behavior, bitterness, feeling of emptiness, and fits of anger. However, said mental illness being the concern of her husband, who opted on leaving her and taking the children with him.
  • Control takes Yukari's normal high-strung personality and turns it into this. She's been destructive and antisocial since childhood, which leads to her peers rejecting her. Her Only Friend is Nyamo and even then she doesn't completely trust her. Yukari turns to drug usage, which soon spirals into addiction. It's also mentioned that Yukari gets much of her personality from her mother (who is so bombastic that even her husband prefers to avoid her).
  • The writer of Sunset's Recovery Arc has stated their intended diagnosis for Sunset Shimmer in the comments but also says it's up to interpretation. Sunset goes through periods of depression as well as periods of mania. In her depressed state, she displays lethargy, suicidal ideation, Self-Harm, and a lack of self-care. She's had these symptoms for years, maybe even dating back to her time in Equestria, but can't afford therapy.

    Films — Animation 
  • Lilo in Lilo & Stitch has a bad case of All of the Other Reindeer, but unlike many examples of that trope, she really is a genuinely strange little person who weirds out her "friends" with a strange mix of eccentricities, behavioral issues, social inappropriateness, and unusual interests. She may have the behavioral and social issues though because of her parents' sudden death in a car accident, as well as the stress of possibly being split up from her older sister by social services.
  • Frozen: Princess Anna is a very hyperactive young lady who is very friendly, impulsive, outgoing, and very eager to find romance. This same girl was locked away in her parents' castle with little to no interaction with anyone for over a decade.

    Films — Live-Action 
  • In Anchorman: The Legend of Ron Burgundy Brick Tamland is a seriously odd guy, especially in the second film where his Bunny-Ears Lawyer qualities get taken Up to Eleven and it's clear he can barely function in society. He's also identified as having an I.Q. of 48, but a lot of his behavior suggests other disorders on top of that. He puts mayonnaise in a toaster, tries to eat a lava lamp, and when his friends believe he's died and hold a funeral for him, he starts thinking he's dead and has to be convinced that he's still alive. In the second film, he meets an equally strange woman and they end up getting married.
  • In Assassination Games, Brazil has no emotional affect, is obsessed with maintaining his house in perfect order, doesn't seem to get sexual gestures, and has a fascination with using bizarre and archaic weapons in his kills.
  • The Big Lebowski has the two eccentric and dysfunctional leads, Jeffrey "The Dude" Lebowski (not to be confused with Jeffrey Lebowski the millionaire) and Walter Sobchak. The Dude is an unemployed and unmarried Lazy Bum who refers to himself in the third person and centres his life around bowling (though in the movie's insane setting, he may actually be the Only Sane Man). Meanwhile, Walter is The Vietnam Vet, which explains a lot (and the original screenplay revealed him as a Phony Veteran, raising even more questions about his sanity). He also remains obsessed with his ex-wife, continuing to perform random favors for her and practice her religion (namely Judaism, even though Walter was Raised Catholic) five years after she left him. And whatever you do, do not disrespect Walter's Judaism, car, or the rules of bowling, lest you discover the true meaning of Serious Business.
  • Miss G from Cracks certainly has some form of disorder. Possibly agoraphobia as she seems nervous during her trip to town whenever villagers so much as look at her. She's also a Control Freak, a fantasist and a pathological liar who becomes obsessed with an attractive teenage girl in her class to the point of eventually raping her.
  • Adolf Hitler in Downfall can be surprisingly courteous at times but is still prone to explosive fits of rage and violent mood swings, he repeatedly blames other people for mistakes he himself makes, shows a pronounced intolerance of views that differ from his own and engages in magical thinking; he's convinced that Germany will win the war despite the Allied Forces having the upper hand, when he sends his men to look for a subordinate who has defected and fled the bunker, he refuses to believe that he's fled and just thinks his men aren't searching the bunker hard enough, is prone to infantile behaviour and has a pronounced sense of entitlement. Even his own henchmen agree that he's odd, pointing out that he doesn't drink, smoke or eat meat, suggesting that this may exacerbate his frustrations. At the end of the film when he can shut reality out no more, he decides to order all of Germany destroyed for having failed him.
  • Damsels in Distress. When Violet was a girl, she would perform various actions in an obsessive-compulsive manner, starting all over again if she couldn't do them right ten times in a row.
  • Mark, in Death Grip, generally doesn't make eye contact, obsessively replaces the hors d'ouevres on a tray he's serving from as people take them, and automatically locks any door he enters.
  • Pollux Troy in Face/Off is said to have a high IQ which is evidenced by his ability to create highly complex, sophisticated and deadly weapons but he also has an unspecified mental disorder and screws up simple tasks. He's said to take Mylax, which in real life is the name of a few different medications, none of which are for the mentally ill.
  • Jenny from Famine. She's clumsy and twitchy, yells at random during conversations, goes on profanity-laced rants, her people skills are sketchy at best, and her demeanor (horrified to nonchalant, or hateful to loving in the blink of an eye) jumps all over the place, to the point that a teacher wonders if she is a junkie or suffering from some kind of premature PMS. Oh, and there are bits like this:
    Ms. Vickers: Yeah, Nick just isn't man enough, is he?
    Jenny: Nick is a man! He came on my face!
  • Ghostbusters
    • Ghostbusters (1984): Egon is very socially awkward, has quirky and specific interests ("I collect spores, molds, and fungus"), speaks largely in a monotone voice, once tried to drill his own head, and almost never smiles.
    • In the same vein, Ray's speech patterns can be a bit awkward, he can apparently repair a massively ruined car in less than 24 hours, his behavior is very childish and immature, he also fixates strongly on specific interests (the paranormal), and he frequently speaks with his hands while talking- though this one might just plain be an unspoken case of autism, as Dan Aykroyd is himself autistic in real life and based Ray's enthusiasm for the paranormal on his own, as well as playing him with his own mannerisms.
    • In the 2016 reboot, Jillian Holtzmann also falls into this category. While she's very charming and friendly, she's also very socially inept and doesn't really seem to have much interest in or an ability to understand typical social norms or appropriateness. Her savant-like genius for engineering is balanced by a bucketload of quirks and eccentricities, and she generally comes off as rather manic and hyper. She also tends to wear yellow-tinted glasses and goggles which, while they could also be merely an unconventional stylistic choice or a tool to help with her work, could also be indicative some kind of tendency towards sensory overload, perception or visual disorders/issues.
  • Benjamin Braddock from The Graduate and Harold Chasen from Harold and Maude are both young misfits with little social ability and little motivation to take part in society, largely due to the overbearing presences of the adults in their lives. Benjamin is somewhat well-adjusted - he was an outstanding student and athletenote , and his parents and their friends all adore him. He still has no friends and no idea what he wants to do with his life - after all, he prefers lying in his parents' swimming pool to going out into the Real World™. Harold, unlike Benjamin, actively resists interaction with other people. For example, he enjoys horrifying girls with fake suicide attempts whenever his mother sets him up on a date. (He torments his mother with fake suicide attempts too, but she's used to it.)
  • Ashburn from The Heat probably has something, given how Literal-Minded and obsessive she is. Might be because she was a foster kid and by implication wasn't well socialized growing up.
  • Gang-du from The Host is very open and loving, but completely clueless about social conduct. He unselfconsciously falls asleep in public places (which is implied to just be narcolepsy), gives his thirteen-year-old daughter beer and eats his customers' food. His father tries to tell Gang-du's two younger siblings that it may have stemmed from a miserable childhood and a protein deficiency, but it's never really confirmed. He was a very early reader as a child, and in a deleted scene Hee-bong recalls Gang-du reading from a calendar when he was never taught the Korean alphabet. He also has a specific interest, but that interest is in his daughter and being a good father to her, even though he's hapless at it. He has no medical history of a mental disorder, but it's likely that his family hadn't been able to afford a diagnosis for his behaviour.
  • Ingrid from Ingrid Goes West has some sort of mental illness that compels her to act the way she does. She's being treated for it in the second scene of the film and seems to have been prescribed medication, but besides a few requests later on for her to seek professional help and her own admission that something isn't right with herself, the movie doesn't explicitly deal with it further.
  • Sarah in Labyrinth is naïve, awkward, and emotionally unstable (though some of that can be chalked up to teenage Jennifer Connelly's lack of acting chops at the time). She thinks like a fairy tale and prefers LARPing alone in the park and collecting stuffed animals to interacting with actual friends. It doesn't help that she kicks off the plot by entreating the Goblin King to carry off her baby brother, despite not yet knowing that the Goblin King even exists.
    The Nostalgia Critic: Man, there are so many medications she would be on today. You know what you need, honey? "Magic and mystery?" No, Zoloft and Ritalin. Just mix it in with the liquid tranquilizer.
  • Martian Child: The titular character is a young boy who doesn't understand facial expressions (he takes pictures of other people's facial expressions to try and puzzle them out at his leisure) and has multiple sensory issues (he wears a weight belt all the time to keep from "floating away", is overly fond of seat belts, and can't stand sunlight). He also displays signs of having Synesthesia.
  • Napoleon Dynamite: Napoleon, Kip, Pedro and Deb all display really, really severe social awkwardness and fixations on various unusual subjects (e.g. ligers).
  • The Omen (2006): Damien's supposed to be the son of the devil but if you take the "It was all a coincidence and not supernatural forces at work..." he's just a really weird kid.
  • One Flew Over the Cuckoo's Nest never has a diagnosis for any of the individuals in the asylum any more than the book does. Partly for this reason, at least one Psychology teacher has used the film as a classroom exercise in both learning to pick out symptoms that would "ping" for various disorders (for example, the impulsive behavior of the film version's POV character could easily be chalked up to what we now call Attention Deficit/Hyperactivity Disorder) and to show how complex and nuanced mental health diagnosis can actually be, including the evolving understanding of the human mind and brain since the time of the film's setting and how one cannot always judge another person's "sanity" very easily; he made a point of mentioning that not only was the protagonist's gambit itself a backfire since he really did have serious psychological issues, in the book version, the POV character is actually the "mute" Native American character...who is completely lucid despite choosing not to speak for the majority of the story, and was likely in the institution in the first place due to racism. When he kills his freshly-lobotomized friend at the end of the film, it's even clear that he believes it's a Mercy Kill to set his spirit free, rather than any kind of actual psychotic break
  • π: Max Cohen is never diagnosed, but he suffers from intensive social withdrawal, obsessive compulsiveness, chronic migraines, psychotic episodes, and possesses savant-like abilities in regards to mathematics (performing division on par with a pocket calculator).
  • Séance: A character is antisocial and awkward, and takes an unnamed medication that he claims is supposed to make him "normal".
  • Robert Downey Jr.'s portrayal in the 2009 Sherlock Holmes film and its 2011 sequel A Game of Shadows was more socially-challenged than usual, had some weird eye contact moments, and was implied to have issues with sensory integration. This is actually more accurate to the original stories by Conan Doyle than most portrayals of the character (see below under "Literature").
  • Denny in The Room seems completely ignorant of social norms and generally acts much younger than his apparent age, at one point leaping into bed with Johnny and Lisa as they are about to have sex. In an interview, director Tommy Wiseau admitted that Denny is "retarded, a little bit," but he failed to tell the actor that or spell it out in the script, so the performance is confused.
  • The Social Network: Zuckerberg. He cannot hold down a single topic in a conversation. He shows very little tact as well, as an offhand comment he makes to his girlfriend causes her to break up with him. In short, he is much more at home with his computers and code than he is with other human beings.
  • In Spiral, Mason avoids eye contact, goes on manic bouts of obsession with painting a particular set of poses, frequently hallucinates a dead blond girl, and is either killing his models, imagining them and their deaths, or a little of both.
  • There have been numerous articles speculating about Anakin Skywalker and trying to form a diagnosis based on the symptoms he shows in the Star Wars prequels. Likewise, in The Force Awakens, his successor and grandson Kylo Ren shows a similar collection of huge mood swings, extreme outbursts of anger, lack of empathy, difficulties with interpersonal relationships, emotional disturbances, and odd obsessions and anxieties.
  • It stands to reason that most of the cast of Sucker Punch isn't All There upstairs, seeing as they're in a mental institution, but no actual diagnostics are given on their conditions (possibly justified in that it's the 1950s). There's also Blue, who seems to have something wrong with him. He acts like he's just as powerful in the real world as he is in the brothel fantasy, even though he's clearly just an orderly. He continuously declares himself to be the one in charge, completely loses his mind when he realizes that he can't make Babydoll return to consciousness, after her lobotomy, and tries to order the police into letting him go, even though they're there on the orders of Dr. Gorski (Blue's superior) and they clearly saw him trying to molest Babydoll.
  • Garth from Wayne's World. His speech is stilted, he doesn't eat anything that isn't brightly coloured and fruity (to the point of eating a jelly donut with a straw), goes off on some extremely bizarre tangents in conversations, and spends hours obsessing over strange mechanical gadgets.
  • The Wizard: Jimmy, by way of The Rain Man with the way he plays video games. Seems to be trauma related, as it began when his sister died.

  • In Dragon Bones, Ward's mother is drugged with some fantasy drug almost all the time, but never acts sober, anyway. She sometimes hums, sometimes babbles nonsense, sometimes says something correctly, that could tip off others about facts she knows about but they don't. As it is a medieval fantasy setting, no diagnosis is ever mentioned, but her children seem to think it is self-induced, and are bitter about it.
  • Ignatius J. Reilly from A Confederacy of Dunces. He's a hoarder, a massive conspiracy theorist, and an extreme luddite and creature of habit.
  • Lisbeth Salander of The Millennium Trilogy. She exhibits several oddities, including Photographic Memory, extremely selective interests (mathematics and computer hacking), and very few changes in expression or vocal tone. The author said he envisioned her as somebody who has turned into "somewhat of a sociopath" from incredibly traumatic experiences, or how a modern-day Pippi Longstocking might turn out after growing up as a mentally-odd orphan handled by the somewhat infamous Swedish bureaucratic system.
  • No clear diagnosis for Matt is ever given in Peter Pays Tribute. He carries a bottle of Febreeze with him to public restaurants for fun, apparently.
  • In the book Changeling by Delia Sherman, it's strongly implied that Changeling has been diagnosed with something, but it's never stated what.
  • Colin from An Abundance of Katherines — his social skills are a mess. His only real friend in high school actually needs to tell him when his conversation topics are boring. They become friends after he thinks it is funny to refer to his eye as a "pupillary sphincter." His friend, who was home-schooled up until that point, remarks something along the lines of, "I've only been in public school for two days, and I know that your sphincter is not something you talk about."
  • In Peter F. Hamilton's The Dreaming Void, implants giving people their own built-in "heads-up display" are ubiquitous, but only Troblum is described as having or needing a "protocol behaviour program" to prompt him through ordinary social situations. He's got an obsessive interest in a thousand-years-past war (that just so happens to be the subject of the two previous books set in that universe) and is explicitly stated to have no real ties to anyone in the Commonwealth.
  • Sherlock Holmes, arguably. Modern adaptations tend to play this up a lot, but even in the original stories, he's described as... eccentric, to say the least. He's very anti-social, has a number of weird and inappropriate habits like indoor revolver practice, and is prone to bouts of lethargy and depression when he has no case to keep him occupied. And that's not even getting into the cocaine addiction...
  • The Curious Incident Of The Dog In The Nighttime: the main character is clearly neuro-atypical and reads like an autistic stereotype, but no diagnosis is stated in the book — and in fact, the author has said he didn't intentionally base the character's behaviour on any specific disorder.
  • Daymar the wizard from the Dragaera books is truly brilliant, but also extremely Literal-Minded, and oblivious to social cues unless they're explicitly spelled out — and after they are explicitly spelled out, he never shows even a trace of embarrassment about how awkward his own behavior was.
  • Charlie in The Perks of Being a Wallflower is a more serious example of this. He was held back for being "emotionally damaged", but the disorder is never named. He seems to have trouble in social situations and seems to be very sheltered from normal life. Around the halfway point of the book, it's revealed that his issues stem from a childhood trauma involving his favorite aunt being killed in a horrific car wreck on Christmas Eve, which was also his birthday.
  • Jay in the Spaceforce series is clearly not quite normal by the standards of his own species, the Taysans, and perhaps even by human standards. His commander Salthar describes him as a 'sociopath', but this seems to be because, unlike most Taysans, he's adept at lying and has no shame when it comes to pursuing sexual liaisons. However, despite his ruthlessness and tendency to be a Manipulative Bastard, he is capable of feeling love and loyalty.
  • Bella from Twilight. By her own admission, she has trouble connecting with people in general. Apparently, her only friend in Phoenix was her mother, who she still forgets to write to when in Forks. She becomes extremely obsessed with things like becoming a vampire while making no plans for things like college or a career. She becomes so unhealthily obsessed with Edward that when he leaves her, she first is catatonic and then makes no effort to move on with her life, instead choosing to spend her college money on motorcycles and nearly killing herself cliff diving. She gives very little thought to the consequences of her actions and tends to not understand why people react the way they do. Edward's theory on why he can't read her thoughts is that her mind works differently than others. Bella also mentions that she's so clumsy it almost counts as a disability, but that was likely a joke.
  • There are several examples in The Night's Blade, notably Angharad and Kestrel. Angharad is easily distracted, has a terrible memory, cannot sleep for the thoughts in her head and has an alarming reaction when confronted with a figure from her past. Kestrel is a mood-swinger who jumps between extremes of emotion at the slightest provocation, is downright possessive of those she cares about, and generally blows things out of proportion. She's more than aware that something isn't right, but she can't control it.
  • The narrator of Oh, the Humanity!: A Gentle Guide to Social Interaction for the Feeble Young Introvert has a pretty spectacular one, mixed with generous doses of denial and Know-Nothing Know-It-All. Traits include an obsession with germs, total disinterest in other people's lives ("I meant to call you to tell you you have so much to live for...I'm sorry, I've just been doing so much gardening lately"), a grasp on human interaction that can at best be called fumble-fingered, an inability to focus or prioritize (at one point delaying a pub crawl for two hours because he forgot to give his parakeet its ear medication, and didn't like to wake it up), and massive, hubristic pride in the social skills he does not in fact possess. It's unclear how much of this emerged from his Hilariously Abusive Childhood.
  • A side story in The Dresden Files, told from Murphy's point of view, makes Harry Dresden an in-universe example of this: From most Muggles' viewpoint, Dresden, a self-declared wizard, has a tendency to poke around crime scenes, looking or asking for things like toenail clippings or hair straws, mumbling to himself and never looking people in the eyes. In addition to this is his at-times-dubious personal hygiene, Manchild personality, near-pathological need to snark at and gainsay authority figures and Nerves of Steel that makes it unnerving when he seldom shows outwards reactions to things normal people would lose their wits over. The end result is that it makes him seem, at best, very eccentric. By reading most of the books (which are from Harry's point of view), most of these behavior patterns are explained logically, but that doesn't make him seem any less weird to the muggles he must uphold The Masquerade to.
  • Gracie Milne, a minor character in Tipping the Velvet, is a bit like this. She doesn't really have any identifiable symptoms, but she's definitely more than a little odd, acts rather young for her age, and she may have sensory processing differences considering her fixation with colors.
  • Diary of a Wimpy Kid: Fregley has no friends and is blissfully unaware that his bizarre behavior disgusts others. He's a more negative portrayal, with his social deviations shown as weird and repulsive. This could be a case of Unreliable Narrator since Greg Heffley (the narrator) is just a kid and probably doesn't know much about any disorders that Fregley might have. His repulsiveness in Greg's eyes could just be due to a lack of understanding.
  • Ada Byron (aka Ada Lovelace) in The Wollstonecraft Detective Agency shows signs of being on the autism spectrum. She is a brilliant engineer at age eleven, but will say the bare minimum about any other subject. She had no friends before meeting Mary Godwin (aka Mary Shelley), barely has any sense of tact, does not understand the point of many social cues, is upset by change, (even wearing clothes besides her favourite dress,) and experiences what is clearly a panic attack while in a crowd in the first book.
  • Harry Potter:
    • Luna Lovegood could have some kind of personality disorder, probably because of her upbringing under her eccentric father Xenophilius (who himself is an odd duck) combined with witnessing her mother's death and being socially isolated for her outlandish ideas. However, she's a very wise girl with a strong sense of empathy and understanding of people, especially Harry.
    • The books heavily imply that Voldemort (both as Tom Riddle and after the name change) was a sociopath, but it's never directly stated what precisely is wrong with him. He sees absolutely no value in forming relationships with others unless there is some benefit in it for him, he is completely incapable of feeling love in any capacity, he enjoys working alone and refuses to confide in any of his "friends", he is disturbingly good at understanding how to manipulate people into doing what he wants, and can kill anyone, from babies to his own remaining family, without any hint of remorse.
    • Severus Snape is a genius when it comes to magic; he exhibits a narrow, intense interest in magical studies and, as a preteen during his first year at Hogwarts, knew more about dark magic than most seventh-years did. But on the flip side, he's twitchy, reclusive, lacking in social graces, and generally creepy and off-putting.
  • Discworld:
    • Jeremy Clockson in Thief of Time, who has No Social Skills and becomes agitated to the point of violence when confronted with inaccurate timekeeping. He also has medicine, so presumably he has been diagnosed with something, but we never learn what (and this being Discworld, where No Sense of Humor is Nichtlachen-Keinwortz Syndrome, it's unlikely the diagnosis was anything a Roundworld psychologist would recognize).
    • Stanley Howler from Going Postal is profoundly awkward, slightly neurotic, and obsessed with two things, pins (and later stamps) and the Rules and Regulations of the Post Office: "The world of pins was simple, but everything else was very complicated and only worked if you followed the rules." He's also prone to occasionally violent meltdowns (which Mr. Groat refers to as Stanley's "Little Moments").
  • Fifty Shades of Grey:
    • Anastasia Steele is extremely thin, has poor self-esteem and body-image and never wants to eat.
    • Christian Grey, who by his own admission is "fifty shades of fucked up". He dislikes interacting with others, save for a small circle of people he's close to. He seems to have difficulty with communications, often getting angry with Ana for not knowing something she couldn't know unless he told her. He has extreme issues with impulsive behavior, immediately responding to a joke e-mail Ana sent by driving to her house, tying her to the bed, and forcing himself on her, without giving her a chance to explain the situation. He also seems unable to rationally think about previous situations (for example, he continues to hate blondes because a blonde police officer took him away from his dead mother's body, even though sixteen or so years have passed and he should be able to think about it differently). Oh, and he enjoys taking submissives who look like his "crack whore" mother (his own nickname for her) because he enjoys pretending he's beating her. He blames this behavior all on childhood trauma even though said trauma ended when he was four and, by his own admittance, he doesn't remember much of it.
  • Handled fairly realistically in the works of H. P. Lovecraft. Several of his stories involve characters going insane but never clearly diagnosing them. Part of this can be attributed to the fact that psychological terminology was not as mainstream when he was writing. It can also be justified by the fact that some of his characters may be suffering from mental conditions that even modern psychology wouldn't be able to clearly place (any "official" diagnosis being an approximation), especially given that most of his "insane" characters became such as a result of seeing horrors beyond their comprehension.
  • Bradley Chalkers from There's a Boy in the Girls' Bathroom clearly has some kind of behavioral/conduct disorder—he bullies people, performs poorly in class, has almost no friends, displays odd behaviors like cutting paper into tiny pieces—but it's never specified.
  • In Hush, Hush, Nora generally can not/will not remember traumatic events that happened to her (such as Jules trying to kill her, or someone drugging and chasing her). She is obsessed with her boyfriend and whether or not he's cheating on her, and is incredibly concerned about him leaving her even before he shows any indication that he'd do so.
  • Brandon from The Leonard Regime acts very strangely. Some of his thoughts and acts are outright ridiculous, and nobody knows why he does it.
  • The title character's sister from Raptor Red, though not human, is clearly stated to not think or act like a normal raptor. She has terrible fits of temper, doesn't think logically, and is so highly aggressive that she can't stand the company of other raptors (they're normally a social species). It's possible she has some form of dinosaurian psychosis.
  • Willy Wonka in Charlie and the Chocolate Factory is undoubtedly brilliant: a Supreme Chef on a grand scale, a Gadgeteer Genius, a Fiction 500 businessman, etc. At the same time, he is a Mad Scientist with a wildly whimsical way of thinking, his factory is a CloudCuckooland of his own design, he can be Literal-Minded (he believes whipped cream needs to be prepared with actual whips), and he has severely Skewed Priorities — namely, his sweets/inventions over people — and No Sympathy for those who get into trouble despite his warnings. Summed up quite nicely in the 1971 film adaptation:
    Veruca: He's absolutely bonkers!
    Charlie: And that's not bad.
  • The titular character from The Body Of Christopher Creed, from his description, is terrible at picking up on social cues, seems to have a slight Self-Serving Memory, speaks in Antiquated Linguistics, and obsesses over random subjects like Eastern religions and lead poisoning.
  • Bigend Books: Main character Cayce has a panic reaction to brand logos that's downright pathological, needs verbal stimming, and considers herself someone who doesn't have hobbies — she has "obsessions", worlds to retreat into.
  • In One Flew Over the Cuckoo's Nest, of all the main characters in the institution, no one has an explicitly given mental illness that puts them there, putting it all up to speculation. And while some of the characters (including the Unreliable Narrator) show clear symptoms that something's wrong, others appear to be garden-variety misfits who wound up there because they didn't conform to The Man's expectations (hey, it was The ’50s).
  • The Mahabharata character Mayaa is an unparalleled architect who unconsciously vocalizes his thoughts, obsesses about work to insomniac degrees, and rarely speaks to even his coworkers. When one of Mayaa's creations is destroyed, he falls into the sort of deep depression most people reserve for human deaths.
  • Joe Pickett: Wyatt, the youngest of the Scarlett brothers in In Plain Sight, is generally regarded as 'odd' and 'not quite right' without any specific diagnosis being offered. There's also recurring character Nate, whose strange behavior and almost pathological need to live outside society is generally not commented on by people who know him but is definitely out of the ordinary.
  • Barnaby Gold, the eponymous central character of The Undertaker series, is generally regarded as 'not right up top'; being cold and emotionally detached and not having normal emotional responses to events like his father's death.
  • A Song of Ice and Fire: Stannis Baratheon's defining traits are social awkwardness, limited emotional display, blunt honesty, and also displays lack of flexibility, by-the-book behavior, tendency to ruminate, and stubbornness.
  • The Stormlight Archive:
    • Due to the requirements for becoming a Surgebinder (essentially, when someone is broken emotionally or mentally, an Elemental Embodiment might come along to fill in the cracks where the person was broken), nearly every single one of them has some serious mental problems that go undiagnosed. Kaladin clearly has severe depression in addition to the trauma of losing his brother, and his moods tend to be linked to the weather. Shallan is not only violently repressing specific memories, but sometimes she goes into "stone cold killer" mode and has difficulty believing that she is the one who did those things. And then there's Szeth, who is obviously traumatized by the things he is forced to do, to the point that he is starting to hear voices, and can probably be labeled with about a dozen other disorders besides.
    • The ambiguity is played for laughs with Renarin. He says he has a "blood weakness," which Kaladin (who actually has medical training) notes is a mostly meaningless folk description. He quizzes him for a few minutes and diagnoses him as a symptomatic epileptic, though he later mentions that there's something off, and Renarin's explanation doesn't quite fit. This is because Renarin is secretly a Surgebinder as well, and the Healing Factor Stormlight provides has ameliorated some of his symptoms.
  • In Goodbye To Berlin, Bernhard Landauer's various "peculiarities" - his professed difficulty with socialization and obsessive attention to Christopher's expressions - suggest some form of undiagnosed high-functioning autism.
  • In Fer-de-lance Mrs. Barstow has an ambiguous disorder. She, her daughter, and her doctor are all quite open that there's something wrong with her, but the audience is never told what it is, beyond that it negatively affects her attitude toward her husband. The family doctor indicates that he believes it will cease being an issue after her husband is killed. The closest thing to an identification the audience gets is "neurosis".
  • Zhang Xinjie of The King's Avatar never deviates from his sleeping schedule, going to bed at exactly midnight on the dot; when the Animated Adaptation was released, Xinjie is showcased eating a meal meticulously one bite at a time. All signs seem to point towards a form of obsessive-compulsive disorder, but neither the animation or web novel confirms this.
  • The unnamed Queen in Fairest of All: A Tale of the Wicked Queen, a Perspective Flip backstory of Grimhilde from Disney's Snow White and the Seven Dwarfs, thinks she's ugly no matter what others say, refuses to be seen without makeup, and cannot tell her Strong Family Resemblance to her Missing Mom. She also shows doubt in other people and their views towards her. The reason for her self-worth issues is her father used to blame her for her mother's death and he constantly told her how ugly she was.
  • The vampires in The Shadowspawn are all various degrees of mentally unhealthy by human standards. This stems from the psychological traits of the original vampire species, which was an essentially solitary predator, as opposed to a social animal like modern humans. Modern (i.e., mixed-blood) vampires tend, in varying degrees, toward symptoms and characteristics vaguely reminiscent of sociopathy, sadism, autism, abnormal sexualities and a whole slew of other diagnoses, with behaviors, quirks, and tics often described as cat- or birdlike. For some examples, they are usually either socially awkward or extravagant, nearly always lacking in empathy, intelligent but prone to impatience and non-directed thinking, fastidious about food, drink, and dress, and may sometimes hiss or growl like animals at each other.
  • The original Dracula presents its titular villain as intelligent but strangely mentally impaired. He is charismatic, good with languages and capable of planning — but also rigid in his thoughts, overly habitual, incapable of higher abstract thinking, selfish, and emotionally unbalanced, ranging from shallow affect to violent fits of rage. Professor Van Helsing speculatively characterizes him as a "criminal personality" in the novel, a now-obsolete diagnosis which is in some ways similar (but not equivalent) to the modern idea of sociopathy.
  • In the novel The Rules of Survival, Matthew's deranged mother Nikki is extremely abusive in multiple ways.
    • First and most importantly, she suffers from a severe Lack of Empathy, ultimately cares only for herself, and does not care who she has to hurt in order to get what she wants. When she does good things for her kids, it's only to further her own image as a good mother and give herself something to hold over their heads, so when they complain about something, she can accuse them of being ungrateful later. Even when she was a child, her sister Bobbie remembers her being manipulative, a chronic liar, and a Big Sister Bully who always got her in trouble by framing her for things she didn't do. In short, Nikki seemingly has no Freudian Excuse for why she's the way she is...she just is.
    • She is violently Ax-Crazy and suffers from severe mood swings. On several occasions, she acts loving and doting toward her children, only to flip on a dime and get enraged at them for a perceived slight, usually because she thinks they don't love or appreciate her enough. Matthew remembers that on one occasion when he was a child, she giggled and called him a "cookie thief" for stealing cookies, then held a knife to his neck until he apologized.
    • She shows blatant favoritism in the way she treats her three children. Her youngest daughter Emmy is the favorite (when she's not being "difficult"), her oldest son Matthew is The Unfavorite because he's the only one who dares to rebel against her, and her middle child Callie is simply ignored most of the time.
    • Despite being a grown woman, she has very little impulse control (if any at all), giving Callie a Traumatic Haircut to show her "how important hair is to a woman", deliberately driving her car into traffic to scare her kids, and dangling Emmy over sharp rocks.
    • She never takes responsibility for any of her mistakes or wrongdoings, and always finds a way to blame someone else for them. When she loses custody of her children because of her mental instability and irresponsibility, she blames Matthew, her sister Bobbie (who tried to help her and received no thanks for it), and her ex-boyfriend Murdoch (who was a better parent to her children than she ever was).
    • She is highly paranoid and perceives nearly everyone in her life as an enemy, even when they have done nothing to her or are trying to help her—this includes her own children when she loses custody of them, for reasons that are entirely her fault. Near the end, she nearly kills Emmy by forcing her to drink several bottles of alcohol to "shut her up" while Nikki was having it off with her new boyfriend. It's not clear if she was intentionally trying to kill her, but it is made clear that if Emmy really had overdosed and died, she would not have cared one bit.
  • Roofshadow from Tailchaser's Song is the Sole Survivor of her entire clan and came home to find everyone torn to pieces. It's implied this hasn't been great on her psyche, as she's quieter than other cats, but this isn't thoroughly explored.
  • Survivor Dogs: Bella's temper and mood-swings are so apparent that one of the writers has discussed it (with note that he doesn't think it's bipolar disorder).
  • As a young child, Elphaba from Wicked was considered odd by almost everyone that came across her (and not just for her green skin). Even at a few weeks old her nanny could swear Elphaba understood her, Elphaba (who was born with sharp teeth) had a habit of biting herself to the point where she was in a sling for her first several months, and she had slightly delayed speech as a toddler. It's unknown whether this is all due to Elphaba's neglected upbringing (with her mom barely touching her until she was a toddler), her young age, some form of disorder or Elphaba being born evil.
  • Leaving Poppy: There's definitely something wrong with the titular Poppy but whatever it is isn't quite said, however, we do know that she's emotionally unstable.
  • Given that Of Mice and Men is set in the 30s, this might be justified in Lennie's case. It's not said the exact nature/diagnosis of what Lennie's condition is but he's got the mental functioning of a child and he likes to hold (and pet) soft things. This actually adds some drama to the story, as, due to this (and him not knowing any better), Lennie doesn't understand he can do damage with his strength and has to be watched.

    Live-Action TV 
  • The Sopranos:
    • Tony Soprano himself. Between his Lack of Empathy, Hair-Trigger Temper, uncontrolled outburst of frustration, and grandiose sense of entitlement, there's definitely something wrong with him. While the psychiatrists in the show clearly diagnose Tony as an incurable criminal psychopath, there are several moments throughout the series when he is seen expressing true remorse for his actions as well as acting on genuine feelings of altruism, so yeah, he has a vague mental disorder left to viewers interpretation.
    • Christopher Moltisanti, who has emotional outbursts, fits of alternating aggression and depression, and serious attention deficit difficulties. He self-medicates through drug abuse. His various undiagnosed mental problems are brought up by other characters on multiple occasions.
    • While Ralph Cifaretto has several signs of anti-social personality disorder, he seems to really care about his son Justy, so his highly impulsive, borderline-sociopathic personality is probably due to his drug addiction.
  • Breaking Bad: There is something really wrong with Todd. While the creators of the series have called him a sociopath, the issue is that he is too emotionally crippled, quiet, calm, easygoing, relaxed, friendly and self-controlled to even qualify as one. On the other hand, having a sociopathic monster as an uncle and father figure (Jack), it is almost inevitable that he was going to develop a ruthless side anyway.
  • Coronation Street has Roy Cropper, who is simply seen as odd by his neighbours with his bizarre lectures on really trivial subjects, fascination with details, and that little bag he carries everywhere.
  • CSI: Gil Grissom. His level of social understanding fluctuates between episodes, along with his attention to trivial details and love of bugs.
  • Law & Order: Criminal Intent: Detective Robert Goren; it's suggested he simply never learned proper social skills growing up because his family suffered from one mental illness or another. Goren is what happens when the genetic dice are loaded to roll Snake-Eyes and come up Lucky 7 anyway.
  • The Big Bang Theory:
    • Sheldon is socially challenged, has fairly monotonous speech, and exhibits heavily ritualized behavior.note  He even has hypersensitive hearing; the others refer to it as "Vulcan hearing" and are usually cursing it due to his overhearing things they wish he didn't. He has Eidetic Memory, which means he remembers every little detail about everything. He also shows a disturbing lack of empathy, obsessive behavior, and an unusual number of phobias. Sheldon also displays some form of synesthesia- certain sequences of numbers glow red to him, and he claims to be able to taste the speed of light. Additionally, Sheldon is a huge fan of incredibly strict schedules and rules, and has even made a timetable containing his and Leonard's allowed time in the bathroom, much to Leonard's dismay, since he's ONLY allowed to go to the bathroom during those three timeslots. Aside from that, he feels a constant need to control everything, to the point where Leonard had to sign a several dozen pages long Roommate-agreement and later a just as long Neighbour-agreement and Amy had to sign first a friendship-agreement and later a relationship-agreement. He also consistently displays narcissistic behaviour, having convinced himself he is the smartest in the group, and completely dismissing any other member's achievements in lieu of his own. Even when one of them becomes an astronaut he still maintains he is the most esteemed member of the squad. Oh, and we also learn that he's kept literally everything he's ever owned, locked up in a storage facility.
    • Leonard rather noticeably struggles with keeping eye contact in a conversation and fidgets with his fingers constantly. Besides Raj (who is unable to speak in front of a girl) he is the one with the most trouble actually trying to communicate in an unfamiliar social environment. Unusual for this trope, these things are downplayed as the series progressed, factoring a lot of his issues into his low self-esteem at the beginning and showing a great deal of personal growth.
    • Raj was shown to be almost biologically unable to to speak in front of a woman without some sort of anti-anxiety medication or alcohol to calm his nerves. This ended up actually being, well, diagnosed in the second season by Leonard's mother as selective mutism.
    • Sheldon's Distaff Counterpart Amy Farrah Fowler shows many of the same symptoms, but later given a twist that makes her further removed from being a female Sheldon. Some of her oddity stems from the show playing her demisexuality for laughs.
    • Before Amy was introduced, fans saw Leonard's mom as a "female Sheldon". She's cold, detached (to the point she's only ever had sex to procreate and Leonard was forced to build a hugging machine that his dad borrowed) has no problem with treating her son as a test subject and embarrassing him (despite, ironically, studying and understanding human behavior is her job, which also makes this a case of The Cobbler's Children Have No Shoes), and several weird Sheldon-esque traits such as demanding her coffee be made a certain impossibly specific way and announcing "I have to urinate" every time she gets up to go to the bathroom. From dialogue, it's possible her own mother deliberately held her back from socializing with other children when she was growing up or else, Beverly was born the same horrible person she is in the show and was never once in her life interested in socializing because of Avoidant personality disorder and instead dedicated her life to science and studying.
  • Community: Abed is incredibly fascinated with films and television and is a bit obsessed with projecting their tropes onto real life. He has a strange, somewhat sterile demeanor, doesn't seem to know (or even when corrected, care about) how to go about certain social situations, and is face-blind. He also becomes highly distressed whenever anyone tries to tamper with his life as he's familiar with it (such as messing with the engine of his Dreamatorium or moving clocks an hour back). Whenever he's about to have a meltdown he lets out a high-pitched whine. Lampshaded on numerous occasions, either by the story (in "Advanced Dungeons and Dragons" he is referred to as "Abed The Undiagnosable"), other characters and himself (in the pilot he rattles off everything he knows about Britta from their one conversation including that she has a brother who "works with children with a disorder I might want to look up"). During the Musical Episode, in one of the songs he sings, "On the spectrum? None of your business.", apparently to the audience.
  • Taxi: While not being exactly there at all, Jim Ignatowski often forgets about people, he lived for five years in a condemned building and he once pestered Alex to the point of harassment for not watching E.T. the Extra-Terrestrial. He's also an Hero-Worshipper of Louie, who ostensibly treats him like crap.
  • It's Always Sunny in Philadelphia:
    • The episode "Sweet Dee Is Dating A Retarded Person" revolves around this trope, with Dee dating a rapper named Lil' Kevin, who acts much younger than his age, displays odd hand tics, and is incredibly strong, all of which Dee to believe that he is mentally disabled. However, at the very end of the episode, it turns out that he isn't, he's simply very eccentric.
    • A whole book could be written on Charlie. He displays dyslexic tendencies and can't read, is a musical savant (he is able to masterfully play a keyboard despite having absolutely no formal training, and claims "Keyboards just make sense"), displays almost superhuman strength at times, displays unhealthy fixations on his love interests, and seems to have an impossibly high threshold for pain.
  • Spinelli, on General Hospital, nicknames everyone and uses unnecessarily long words... but when Dr. Matt Hunter suggests undergoing tests for autism, he refuses, saying "I am me".
  • Reginald Barclay from Star Trek: The Next Generation shows severe social anxiety, along with an obsessive streak and a compulsive tendency to retreat into fantasy.
  • The reason behind Dr. Julian Bashir's genetic enhancement on Star Trek: Deep Space Nine. Based on his descriptions after the fact, he obviously had some kind of learning disability, but it's never specified beyond that.
  • Buffy the Vampire Slayer:
    • Anya — at first viewers are led to believe her complete lack of social skills is a result of having been a demon for centuries, but eventually it's revealed that she acted exactly the same before she became a demon.
    • Andrew also shows a fair degree of social ineptness, sometimes flat affect, and a fascination with certain topics that leads him to recite in detail at times.
    • Spike managed to improve his social skills over the course of a century, but he has a mixed bag of vaguely bipolar, obsessive, borderline and schizoid tendencies which come and go with the story. Whenever he's bored, he'll do something ridiculously suicidal just for the hell of it, he stalked Buffy for over a year, and once had a full-blown psychotic episode.
  • Michael Scott of The OfficeNo Social Skills, near-total inability to understand metaphors, sarcasm or hyperbole, savant-like skills in regards to sales, very strong indications that he has never had any friends, and overall behavior that no normal person would believe was acceptable. This pops up in a lot of Steve Carell's roles.
    • Dwight Schrute—easily distracted on random topics and turns minor issues into Serious Business.
  • Cal Lightman of Lie to Me. Quite socially uncomfortable, with a very fixated interest on lies and facial expressions as well as psychology. He destroyed his own marriage because he couldn't switch off, and deliberately pretends he can't read his daughter, so they can still have a relationship.
  • Fringe:
    • Dr. Walter Bishop started like this, but this is jossed in a Cerebus Retcon where Walter got William Bell to perform brain surgery on him to stop him becoming evil like Walternate. All indications are he was already an emotionally distant genius before, though.
    • Over There's Astrid is a computer and maths genius with severe socialisation difficulties.
  • Bernard Black of Black Books. Very socially awkward and uncomfortable with changes in an extremely repetitive routine. Also has an extreme Lack of Empathy, enjoys the suffering of others, and honestly doesn't seem to understand that having his book shop sell books and make money is a good thing (he's infuriated when Manny sells his stock, because it would mean a minute long phone call to his supplier). Also The Alcoholic, which probably exacerbates things. When Manny leaves, he is so unable to take care of himself that it nearly kills him.
  • NCIS: Lab Rat Abby Sciuto. She is very good at what she does and shows a childlike sense of joy while working, she will often give long-winded and highly technical speeches when explaining something, she is extremely attached to and protective of those she cares about, and she becomes almost unable to function both professionally and personally if she has to dress in anything other than her typical goth style or can't listen to her music while working.
  • Chloe O'Brien of 24. It's not mentioned as any sort of possible mental illness in the show; other characters just vaguely refer to her as having an odd personality. She is often blunt to the point of rudeness, easily irritated, especially when she is in the middle of something, and is generally dismissive of other people. She is, however, not without empathy. She usually isn't aware she's engaging in behavior most would find odd or annoying until she notices the way people are looking at her. It's just that most of the time, she doesn't care. Unfortunately, the writers clearly felt that Chloe could only accommodate one character trait at a time, as in Season 9 her Disorder is replaced by being an emo. Most of her behavioral issues magically disappear, however it could be argued that this is a result of the death of her husband and child.
  • RO from Sea Patrol has a very black and white view of the world, and when asked if this was true he responded "I'm not racist." Then there's his believing Bomber fancied him after she gave him a peck on the cheek, and him not wanting to take credit for saving her life because she told him not to go near her.
  • Renfield Turnbull from Due South is just odd, even compared with Bunny Ears Mountie extraordinaire Benton Fraser. Some fans have wondered how someone with his apparent emotional volatility and clumsiness ever made it into law enforcement.
  • In Raw, Philip displays poor social skills, is incredibly awkward at making small talk, likes to keep orderly lists and cooking is his big obsession.
  • Leon from Tucker is obsessed with Mexican wrestling and sea creatures (even sponsoring an octopus) and has a strange collection of human hair.
  • Brick Heck on The Middle. He has the Verbal Tic of, at least once each episode, repeating what he just said in a whisper while looking downward. He's in a special social skills class at his school. He is obsessive about reading almost continually, to the point that he's delighted to get a toy robot for his birthday... because the instructions are in different languages, and he hopes to learn Japanese that way.
  • Saga Norén of Bron|Broen has No Social Skills to an extreme degree, is shockingly lacking in apparent empathy and compassion (despite having a very strong sense of morality and plenty of actual/felt compassion), and has an extremely rule-bound attitude to life. The actor and creators have said that she probably is somewhere on the autistic spectrum, but that they deliberately didn't state it explicitly or work from a list of recognized symptoms because they wanted to write her as they wished without misleading or offending people. Her French equivalent in The Tunnel, Elise Wasserman, is the same.
  • Jerry, Elaine and George of Seinfeld. Complete Lack of Empathy, constant selfishness, unthinking cruelty, continual rejection of any maturity or adult responsibility, and meticulous adherence to a (often fabricated) social code not because they care about others but because it is expected of them. Surprisingly, Kramer is rarely presented as anything other than a regular person who just has a lot of quirks and a wild imagination, while the other three are sociopaths Played for Laughs.
  • Father Ted:
    • Ted is supposed to be the most levelheaded, but is a chronic liar, willing to break laws to achieve his means, and dreams of completely unrealistic things. Bishop Brennan is the only character who can see Ted for what he really is, which is why they mutually hate each other. The creators have noted they were inspired by Seinfeld and it really shows with him.
    • Dougal is so dim that one wonders how he managed to become a priest in the first place as he needs a diagram to differentiate between dreams and reality. He also has a hard time understanding that toy cows are small but the real ones are far away.
    • Mrs Doyle has some very odd quirks that suggest she is hiding something about her life (not even the main characters know her first name, for example). The most glaring of these is the fact she wants people to forget she was ever married.
    • Tom, who likes to boast of being a psychopathic killer, but is always friendly to people.
  • In a flash forward on Roseanne we see Jackie take an adult DJ to a psychologist. He expresses little emotion, has a monotone speech pattern, and is fixated on how Becky has changed.
  • Person of Interest:
    • In "Masquerade," Finch seems to have a panic attack while taking the dog out for a walk, but it's not confirmed what exactly caused this. Seeing how this happened after Root kidnapped him, it's possible that the trauma of the ordeal may have affected Finch substantially.
    • Root herself. She was initially believed to be a sociopath, but she denied it, and has shown that she is far too capable of regret, love, and fear to be one. A psychologist once thought she was a paranoid schizophrenic, but that's because he didn't know that she wasn't imagining the hitman coming to kill her or the Machine that was talking to her. The basic consensus from everyone seems to be that she's just plain crazy, but there's no exact indication as to why.
      Finch: [When he realizes Root plans to steal a cop car] Are you out of your mind?
      Root: Since when is that relevant?
    • Shaw has an undisclosed Axis II personality disorder that is mentioned several times throughout the show. It is described as not lack of emotion, but as if the emotions are there, but just turned way down like on an old radio machine. The symptoms most closely match Schizoid Personality Disorder but she still shows attachment to co-workers and through a simulation that takes place inside her head the viewers are shown the depth of her emotions for her love interest, Root.
  • Occurs in-universe in an episode of 30 Rock, when Pete and the writers become concerned that Jenna might be a sociopath, when she passes this supposed test. At the end of the episode, she shows that she's capable of empathy and it's concluded that she's not a sociopath, just highly narcissistic.
  • Timothy Spall, who plays Lord Emsworth in Blandings, said of the character, "Nowadays he'd be diagnosed with some kind of condition."
  • Power Rangers RPM: Dr. K has absolutely No Social Skills, while Gem and Gemma have the mentality of five-year-olds and an inordinate fondness for explosives, yet all three are technical geniuses. Fans tend to blame their issues on the fact that they were denied normal childhoods: a government think tank abducted them and nurtured their scientific gifts at the expense of everything else.
  • Power Rangers S.P.D.: Bridge is a Cloudcuckoolander who has a tendency to ramble and make odd, if usually accurate, statements.
  • Supernatural: The angel Castiel has a lot of vaguely related traits: literal-mindedness, limited interpersonal skills, No Sense of Humor, and schizoid tendencies which he attributes to not having spent much time on Earth, even though none of the other angels (including a number who have spent less time on Earth) have any of his problems. Before the civil war, he seems to have been fairly well-liked and to have had a good relationship with his angelic siblings, so his quirkiness probably hasn't caused him any real problems.
  • Cat Valentine, the red-haired Genki Girl from Victorious goes a little beyond normal Cloudcuckoolander-ness and sometimes acts strangely eccentric. Sometimes she even knows what she is saying and is a bit ditzy.
  • Game of Thrones: Being a pseudo-medieval setting predating psychiatry, characters' mental health issues are left entirely undiagnosed in-universe.
    • Viserys: First, there's all his mood swings which range from intense calmness to manic twitchiness. There's also his uncontrollable rages, bouts of depression, and extreme self-delusion. His sister Daenerys says that the worst of it only started after they were forced to sell their deceased mother's crown to survive, but considering he's the son of "Mad King" Aerys Targaryen and there's an in-universe saying that the Gods flip a coin when a Targaryen is born as to whether they'll be destined for "insanity or greatness" this makes sense, and centuries of incest probably haven't helped.
    • Daenerys shows no emotion while watching her brother be killed via molten gold to the head, and later unflinchingly ties the woman who killed her son to Khal Drogo's funeral pyre. From there on, she's shown as being extremely focused on her goals, occasionally to the point of foolishness (for example, badgering merchants for ships, without considering that she has no way to pay for them). While she certainly shows more empathy for those in her care than Viserys did, including putting her own goals in jeopardy for the sake of freeing slaves on several occasions, she also is shown to be capable of violently dealing with anyone who tries to hinder her without showing any signs of being bothered. A major source of dramatic tension with her character is what side of the coin for the Targaryens she'll end up being.
    • Joffrey, a product of incest himself, displays a disturbing fondness for violence. At times he even seems to be sexually aroused by it. He shows no signs of empathy whatsoever, is extremely impulsive (ordering a crowd of peasants slaughtered because someone threw a cow pie at him), derives joy from inflicting random cruelty on others, and is convinced that everyone loves him. It's difficult to pinpoint exactly what's wrong with him, but it doesn't help in the long run.
    • Cersei has black and white concept of friends and enemies (with nearly everyone falling under the latter), penchant for risky indulgences like adultery and alcoholism, poor control of her emotions, and difficulty empathizing with anyone who's not her kids.
  • Merlin:
    • Merlin would appear to have this. He has to make up increasingly bizarre explanations that are maybe just plausible to deflect suspicion, but earn him many a weird look. Arthur alone thinks he is a cross-dressing woodworm-obsessed pathological snarker who can barely function as a keeper of cleanliness. Justified when nobody points this out often since this is nearly a thousand years before anyone began seriously diagnosing mental disorders.
    • By the end of the series, Merlin has ceased caring about anything that's not Arthur, to the point of wild mood swings, irrational and irritable behavior, and selling out his people. Many have called his behavior obsessive.
    • Morgana and Uther seem to share some deeply rooted tendency towards madness. Even Arthur shows some signs of it sometimes. In one deleted scene, Arthur mentions that his grandfather went mad as well, and Merlin points out that these things tend to run in families.
  • The Home and Away villain Angie Russell seemed to become increasingly obviously manic as her tenure went on. Despite having a relatively successful career as a teacher, she had an odd habit of seducing her son's friends if they were mean to him and her method of getting a promotion was to lock the other candidate up to try and bring on a Super OCD attack. And that's before you get on to the hiring hitmen and arson. Despite this, no-one really seemed to consider her mad and no diagnosis was made, possibly because no-one could think of a mental illness that would turn you into an Angie.
  • The chubby-yet-implacable-assassin Arby in Utopia suffers from a multitude of ills. His speech and mannerisms are stilted and he appears to suffer from a complete Lack of Empathy or even meaningful interaction with other people and kills at the behest of his handlers without question. It turns out he had been tortured and experimented on by his father as a child and Arby isn't even his real name, and after suffering regret from murdering a bunch of schoolchildren he proves he has Hidden Depths and performs a Heel–Face Turn.
  • Randy from My Name Is Earl, despite multiple characters claiming he isn't handicapped or disabled, just "slow" and "simple". It was eventually implied that his behavior is the result of brain damage incurred when he once inexplicably stopped breathing long enough for his parents to assume he had actually died. At one point, Earl tells Randy "The doctor did say that you were borderline artistic" (Earl isn't very bright either).
  • Doctor Who originally played off the Doctor's eccentricities as them being an alien, until later seasons established that other Time Lords viewed them as weird and unpredictable, their mountains of trauma (which in canon they just ignore) certainly not helping. The exact nature and severity of their quirks varies wildly between actor, writer, and individual episode, but it's evident that they're largely unique in the universe and would defy diagnosis anyway.
    • The final Fourth Doctor story, "Logopolis", ups this to extreme levels when he starts being paranoid, unfeeling, scary, and rude towards his (granted, mostly new) friends and thinking peculiarly even by his own standards. It seems like depression, but could also be a Deconstruction of the Fourth Doctor's more famous comical generic-'madness', or Time Lord old age instability.
    • The Twelfth Doctor is prone to being Innocently Insensitive and using Brutal Honesty, is less comfortable than his predecessors with lying even when it's necessary to achieve his goals, has next to No Social Skills, Hates Being Touched or touching others unless it's by someone he is really close to, a dreadful memory (he can't even recall how old his companion Clara is supposed to be!) and severe prosopagnosia, extremely expressive body language, and often lets impatience and impertinence get the better of him — all of which hides how compassionate and sensitive he actually is Beneath the Mask. Clara is effectively (and by his own admission) his "carer" in that she helps bridge the empathy gap between him and others, and in Series 9 she tutors him in better social interactions. Also, if most Doctors manage to hide/ignore their PTSD, this one (coming right off of 900 or so years spent just defending one little town in his previous life) certainly doesn't — he has a marked dislike for soldiers with only a few exceptions, doesn't want to be seen as an officer either (preferring that anyone who does anything to help him exercises their free will rather than just following orders), and questions his own actions, especially his mistakes past and present, surprisingly often.
  • Miss Fisher's Murder Mysteries: Beatrice Mason, one of the suspects in "The Blood of Juana the Mad", is generally agreed by most characters to be suffering from some kind of 'mental affliction'.
  • Artie from Warehouse 13 has poor social skills, a Hair-Trigger Temper, Super OCD tendencies, has trust issues, and rants and snaps whenever his status quo gets challenged. This is strongly suggested to have been caused by the fact that he's spent a large part of his life working alone in the Warehouse. Having his once best friend betray him and become a Manipulative Bastard borderline supervillain probably didn't help.
  • The Good Wife: Elsbeth Tascioni, who's easily distracted by things surrounding her and led to flights of fancy by them. It's implied that this is partly responsible for the end of her marriage.
  • Gotham:
    • Obviously, young Bruce Wayne is not in the best headspace after watching his parents get killed right in front of him, but there's something else going on with him that's distinct from the trauma. He demonstrates hyper-awareness and has some obsessive-compulsive tendencies, he has difficulty relating to and socializing with children his own age, and his speech patterns are overly formal and precise, bordering on unnatural-sounding. And we viewers know that these tendencies are only going to deepen as he gets older and resolves to put them to use.
    • Nobody knows what's up with Ed Nygma (the future Riddler), but even by Gotham City standards this young man is extremely eccentric. He's perfectionistic (to the point of rearranging someone else's filing system to "improve" it), obsessed with science and riddles, has No Social Skills, and he doesn't seem to notice when he's making other people uncomfortable.
  • Ed Chigliak on Northern Exposure has an odd clipped way of speaking, seems to avoid eye contact, and only seems comfortable addressing a few topics, like movies.
  • Sherlock in Elementary has many of the quirks that various Sherlock Holmes adaptations give to the character, along with an array of symptoms such as constant fidgeting, an obsession with order and routine, and an addictive personality (that sometimes manifests in plain addiction) that's a response to attempt to make sense of a constant overwhelming influx of sensory input. He eventually dates a woman who is explicitly on the autism spectrum. She lampshades this by mentioning she can't tell if he's autistic or not.
  • Murdoch Mysteries:
    • Murdoch's interests tend toward a specific type of scientific bookishness, coupled with a mechanical aptitude, as opposed to literature or sport (though he has recognized quotations from Shakespeare and played sports well enough on occasion). At times, he is an adult version of the "little professor" explaining things to his boss Brackenreid and the various constables, among others. He often fails to understand the popularity of things like fads, fictional movies and spectator sports, and certain forms of humour leave him cold (making him an excellent straight man). Later in the series, he speaks positively of the anonymity of living in a hotel, since it allows him to avoid "useless" conversations with his neighbours. Some of his personal conversations (even those with his beloved Julia) end abruptly when he sees something that brings his mind back to his current case, and he hastily takes his leave to follow up an idea, with the others reacting to his sudden departure. All that said, his colleagues and friends seem to regard him as merely a bit unusual. Even Julia tells him, "You're not the only one who lives inside your head." It must also be said that Murdoch's continual studies (and the deep concentration to pursue them) have provided him with a highly useful expertise, though when asked about this in court, he merely replied, "I am an expert, yes."
    • Detective Watts never maintains eye contact for long, is constantly fidgeting with things, has an unusual method of solving crimes, doesn't have many friends and got forced out of Station House One because he wasn't liked enough, is very smart and accomplished for his age (he was already a detective at age 26), and seems to have underdeveloped motor skills (he can't really hold a fork properly and his handwriting is very messy).
  • Daredevil (2015):
    • Wilson Fisk is a brilliant Chessmaster, but surprisingly shy and awkward in face-to-face interactions. He also has unusual body language and speech inflections and trouble with eye contact, he's very routine-bound, and he can be explosively angry when he's particularly embarrassed or frustrated.
    • Melvin Potter clearly has some kind of mental disability, which is acknowledged in the show, but his diagnosis is never mentioned. He's a talented designer and tinkerer and you wouldn't want to have to take him on in a fight. He also has somewhat childlike mannerisms, he's rather emotionally volatile, and by his own admission, he gets confused sometimes.
  • Barry in Best Friends Whenever lacks social skills and has trouble matching facial expressions with emotions; despite this he has a circle of understanding friends as well as being a full-on Teen Genius.
  • SCTV: Almost the entire cast is a psychologist's field day, but a short list:
    • Floyd Robertson has a Hair-Trigger Temper, is rather impulsive, struggles with alcoholism, has unstable relationships, and is prone to wild and violent mood swings.
    • Sammy Maudlin has a repetitive Character Tic (slapping his knee), frequently repeats words and phrases, appears to laugh and/or applaud when he isn't sure how to react to something, and fails to realize when he's said something rude.
    • Bobby Bittman is confirmed to be a compulsive liar, but aside from that, he's preening, egomaniacal, cocky, and grandiose with a huge helping of It's All About Me.
    • Earl Camembert, among other things, tried to eat his dinner at the news desk, went on-air stoned out of his mind, tried to have his son sit in for Floyd while the latter was out getting coffee, locked himself in a cell with violent prisoners to do an interview, and attempted to connect with the youth by roller-skating onto the set to disco music. Something is obviously wrong with him.
  • Second Chance (2016): Until Otto was nine years old, he never spoke to anyone except his sister, and only in a language he invented called Twinspeak. While he has improved significantly since then, he still avoids speaking to anyone but Mary and Arthur, and part of the reason Mary is willing to go so far to fight her cancer is because she knows he'll shut down completely without her.
  • River Tam on Firefly is introduced with vague Ophelia-style "insanity" that developed during the experiments and other tortures she endured at the Academy. Later in the series, the characters find out that much of her trauma stems from the destruction of her amygdalae and the revelation of the Miranda experiment. This still leaves some questions open, though. For example, is her madness connected to her Psychic Powers in any way? And why did the removal of her amygdalae reduce her emotional inhibition, instead of eliminating her fear response like it would in a typical brain?
  • The Flash (2014):
    • The various versions of Harrison Wells all exhibit poor social skills, trouble understanding or reading the emotions of others, a very task-oriented mindset, and a tendency to babble at length without realising that they're doing it, which are all traits that are often exhibited by people with autistic spectrum disorders.
    • Eobard Thawne also has a lot of similar traits. He struggles to understand or relate to the emotions of others, has a very particular way of speaking and tends to repeat certain phrases, has very rigid internal rules and plans things far in advance, and fidgets a lot while stressed or thinking. The intensity of his obsession with the Flash is also very similar to the special interests that autistic people often have. He seems to be over that particular obsession by Legends of Tomorrow, though, although that's probably because he's literally running for his life from the Black Flash.
  • In Emerald City, the Wizard may be intelligent, but he also exhibits a number of psychological problems that, given the setting, go undiagnosed. Strangely, he was also not diagnosed on Earth before ending up in Oz in 1992. He has a hair-trigger temper, doesn't trust anyone, can't stand anyone being better than him (which fuels his hatred of magic), and has an inflated sense of his own importance. He has no trouble claiming credit for things he didn't do and tends to act (rather violently) on his suspicions, even if they're unfounded (like shooting his potential Love Interest when he suspects she might be working against him, even though she was the only person on his side).
  • Travelers: Original Marcy's disability is described as a "congenital underdevelopment of her brain" which, despite being a meaningful diagnosis, could refer to any of dozens of disorders. Even after this, the Traveler who takes over possibly has something as well, since she's very surprised at David's reaction upon finding her performing minor surgery on herself, acting like this is perfectly normal.
  • Scrubs: As the series went on and Flanderization set in, JD's fantasy segments went from a minor quirk to an apparent full-on compulsion. When JD is shown having a fantasy from another character's viewpoint, he abruptly stops talking, stares off vacantly into space for up to a minute and then spouts off a non-sequitur unrelated to the preceding conversation, which is bizarre behaviour by any measure. He is also shown to have no conscious control over his fantasies, sometimes seeing imagery that legitimately frightens or disturbs him, and on one occasion, when a sexual fantasy is interrupted, he complains that he "missed it" as if he couldn't simply imagine it at any time. Also, while most follow from JD's train of thought, some are involuntary and are triggered by something he sees, hears or experiences, to the point that his friends have learned to set them off on cue. At least one episode has taken place almost entirely inside JD's head without him realising until the last second, meaning he can potentially hallucinate a full day of his life. It's all Played for Laughs, but neurotypical people do not experience random, frequent and vivid waking visions.
  • Little Lunch: Rory's behavioural issues are quite impulsive, Batty has a tendency toward Attention Deficit... Ooh, Shiny!, and Debra Jo has some Super OCD traits.
  • Million Yen Women: Yuki has a formal way of speaking, is socially awkward and can be blunt. She turns out to be nothing like that once she turns out to be the person behind several major events of the story, which means that she handpicked every single one of those behaviours.
  • Ode to Joy: An Di Hates Being Touched, is somewhat reserved and socially awkward, and is The Spock. It's later revealed that she has a hereditary mental illness passed on from her mother.
  • Dirk Gently's Holistic Detective Agency:
    • The titular character, Dirk Gently has trouble reading emotions and social situations, doesn't understand common sayings/metaphors, infodumps/rambles constantly, is incredibly impulsive and is constantly moving (stimming), especially when he's excited about something.
    • Farah Black. It's not entirely clear what psychological issues she's dealing with, but there are some there. She tends to immediately put all the blame on herself regardless of circumstances and is pretty paranoid, although considering the fact a body-swapping cult is involved, the paranoia is appropriate. Some of her mannerisms and insecurities also suggest she may have an autistic spectrum disorder or some kind of social anxiety disorder.
  • Naturally, Crazy Ex-Girlfriend has this in spades with its main character Rebecca Bunch, a deconstruction of the Psycho Ex-Girlfriend trope and of romcoms in general. She's prone to wild mood swings and deep depression, is obsessive about the people she fixates on and often totally ignores anyone else, and has a tendency towards very extreme impulsive actions - the plot of the series itself kicks off when she totally abandons her successful career in New York to move across the country just because she encountered her ex-boyfriend and found he was living there. Her erratic behaviour is commented on by a number of characters throughout the show, and she's explicitly linked to depression, but in season three this trope is done away with as she is formally diagnosed with Borderline Personality Disorder.
    • Also deconstructed in the first episode of Season 4, where Josh is certain that he must have one condition or another that explains his obliviousness and immaturity. It turns out that no, he really is just oblivious and immature - not every character flaw is an undiagnosed disorder.
  • In the Turkish miniseries Innocent, Tarık suffers from auditory and visual hallucinations. He lapses into believing he is still in the military, salutes an imaginary officer, and follows imaginary orders. After Emel's death, he sometimes hallucinates she is alive and even has conversations with her. He is prone to manic episodes and physical outbursts. He is described by another character at being unable to stand the pressure of responsibility and crumbles under the stress, though he excels at tasks he pursues at his own volition. He is acknowledged as mentally ill, but the narrative never assigns him a specific diagnosis.
  • The description of the many eccentricities of Frasier's Maris Crane — terror of gaining weight, obsessive dietary habits, a plastic surgery addiction — strongly imply that for all her Jerkass ways, she's genuinely suffering from eating disorders and body dysmorphic disorder.
  • Euphoria:
    • When Rue was little, she kept compulsively counting things, and her parents took her to a doctor, who suggested that she might have OCD. Later on, she started suffering severe panic attacks.
    • Jules was committed to a juvenile ward showing signs of severe anxiety and dysphoria, while the diagnosis is not mentioned. It's also implied that her mother had some sort of mental illness of her own.

    Pro Wrestling 
  • Something is clearly wrong with Jon Moxley (a.k.a. Dean Ambrose, former WWE World Champion and WWE US Champion and former member of The Shield), but precisely what that something might be is unknowable. Aside from being violent and angry, which could be attributed to his traumatic childhood, Moxley also exhibits paranoia, hears "voices" occasionally, and swings wildly between despair and begging his opponents to "put him out of his misery" to being a ranting near-psychotic with a God complex. As Ambrose, he showed some of these traits early on, but they were downplayed after his Heel–Face Turn.
  • Kane has similar issues, probably even worse than Dean. The character has said and done some truly outlandish things over the years, including committing murder on-screen when he rescued his In-Universe father Paul Bearer, only to then say "to hell with it" and chuck him back into the freezer he saved him from in the first place. Apparently just because he felt like doing it. His anger management session is pretty much a cavalcade of insanity and hilarity combined as he rattles off some of the things he's done. He even lampshades the trope on screen by claiming that "for reasons never quite explained, I have an unhealthy obsession with torturing Pete Rose." The looks on the rest of the people in the anger management group that Kane was in when he was describing this says it all.
  • Subverted in SHINE, where Leva Bates dives into several texts books and makes a case for what exactly is afflicting Kimberly based on her behavior. Unfortunately, Bates wasn't qualified to treat her and in fact may have made things worse.

  • In The Pajama Party Murders, Eddie Cosmo has difficulty with metaphors, is obsessed with numbers, acts inappropriately, and is easy to enrage over small things.
  • George Banks from Mary Poppins demands precision and order, is often insensitive when he doesn't mean to be, has difficulty with emotional intimacy and romance, and recoils from physical contact (at least to begin with). We eventually learn that he was abused by his childhood nanny.
  • Abigail Williams from The Crucible has a single-minded obsessed with John Proctor, is willing to get people killed with zero remorse, and seems to care little about anyone but herself. How much of this was the result of seeing her parents killed in an Indian raid was unknown.
  • Laura Wingfield from The Glass Menagerie is stated as being "painfully shy" by her brother, who also mentions that a lot of people see her as peculiar, but her behavior seems to indicate something much more. She has intense anxiety, even a speed test at business school is enough to make her sick at the stomach and make her not want to return. She seems to like to keep a routine with few variations. Laura also has a lot of trouble making eye contact with her high school crush when he comes over to the apartment. Laura is also intensely fixated and knowledgable on her glass figurine collection and plays her father's old records, usually to keep herself calm. She also has a fairly good memory, recalling that she and Jim "sat across the aisle from each other in the aud...Mondays, Wednesdays, and Fridays," and also recalling the news article that claimed he was engaged.
  • Dawn in Waitress, seems to have a lack of social skills, and is obsessed with Lifetime movies, and Revolutionary War reenactments. She also seems to have severe anxiety, as explained in "When He Sees Me". She also explains that she likes how the days are almost exactly the same in "Opening Up", showing she likes to follow a strict routine and doesn't like change.

    Video Games 
  • Grand Theft Auto IV: Niko had tough experiences in the Bosnian and Yugoslav Wars that caused ambiguous sign of mental illness. However, Niko cares about his family, and part of him wants to live a normal life. But he kidnaps, robs, murders, sells drugs, and in general, does not seem to have anything close to a conscience. Interestingly, he realizes this about himself and readily recognizes that the things he does are awful. An Alternative Character Interpretation may be Niko desperately wants to believe this. Given that his protectiveness of Roman and Kate, this interpretation is very likely.
  • Grand Theft Auto V:
    • There's clearly something off about Michael. He frequently uses extreme force when dealing with mundane tasks, (especially in matters involving his family) is anti-social, and appears to suffer from a Lack of Empathy. (If the player kills a couple NPCs, and then goes to Michael's therapist, he'll acknowledge the killings, saying that he "Doesn't even care." His tone of voice even indicates that he feels guilty, about NOT feeling any guilt.) His therapist diagnosises him differently depending on how you play. Including, but not limited to: A Nice Guy with a terrible home life, a sociopath, a psychopath, both a sociopath AND a psychopath, and a sexual devaint.
    • Franklin. He might be on to something here. Despite his status as the decidedly most "sane" protagonist (or should we say less villainous?), he frequently shows signs of being unable to form real attachments to people; Lamar is his only friend at the start of the game and he shows open contempt for him most of the time (he seems to stick with him only out of fear of being alone) and his love for Tanisha comes off as very self-serving. Of course, he has a massive Lack of Empathy, but unlike true sociopaths, he is much more self-controlled and civil, so we may be talking about some mental disorder left to the interpretation of the players themselves.
    • Trevor is undeniably demented, but it's never specified where his signs of mental illness come from:
      • Given his hallucinations and weird behavior, Trevor has clear signs of psychosis, a severe mental disorder characterized by an impaired relationship with reality.
      • Trevor's instability, impulsive behavior, mood swings, drug abuse and his emotional dependency on others (most notably Michael) coupled with his massive fear of abandonment seem to indicate that he also suffers from borderline personality disorder AND intermittent explosive disorder.
      • Interestingly, Trevor has signs reminiscent of psychopathy and antisocial personality disorder, but the issue is that he's too insane, so he lacks moral agency.
  • Handsome Jack from Borderlands 2 is shown to be very emotionally unstable and impulsive to the point of buying a horse made of diamonds because he's rich, he's suffered physical abuse at the hands of his grandmother, he seems to genuinely believe he is the Lawful Good hero of the story, and nearly everyone he's worked with has either died or betrayed him. It was shown that in Borderlands: The Pre-Sequel! that while Jack was never the most moral person, he was a considerably better person before being betrayed by the Vault Hunters, experiencing visions of the Warrior reawakening and being horrifically scarred by Lilith's attack. Prior to these events, Jack was actually concerned about his subordinates and the innocent people of Elpis and generally much more stable and humble than the monster of Borderlands 2.
  • Oracle of Tao: Ambrosia has a Sugar-and-Ice Personality, coupled with dramatic Tsundere moments, and occasionally has rather dramatic depressive episodes. You'd probably say she's bipolar, except her down periods are more flat, like a schizoid. She also has serious fears that she doesn't exist, and that she's hallucinating the game events. Add a few Axe-Crazy episodes, and you get a very strange picture. It's clear what the cause is though, her real parents had to give her away because she was note , her adoptive parents died, and people she hired to help with her inheritance used her money and left her on the street. She has no trust in people until Nevras comes along.
  • Tales Series:
    • Tales of Symphonia has Raine Sage: a cold and calculating but incredibly intelligent young woman who normally acts like an aloof mentor who always has to be right... and who devolves into a child-like state the moment she discovers a temple ruin, an ancient weapon or anything to do with the civilisations of past eras. She's shown to have difficulty relating to the other party members, especially in the anime where her Ice Queen elements are really played up. It's mostly treated as comedic, as her similarly-bright sibling Genis is just plain embarrassed by her enthusiasm (at one point, she even descends into maniacal laughter over the insides of an old temple). Her mother left her and Genis at a ruin that transported them to the world of Sylvarant when they were very young, terrified at the possibility that they would grow up as lab rats or labourers like most half-elves. Raine's obsession with ruins developed from a wish to be reunited with her family.
      • In a sidequest, you can learn that her mother fits the bill. It's not clear what's the matter with her but she has very clearly gone insane from the pain of being forced to abandon her children, as she spends all of her time talking to a doll that she believes is Raine.
    • In Tales of the Abyss, most of the characters show some kind of dysfunction, but only one of them has the dysfunction as the cause of their backstory, instead of the result: Jade Curtiss. He's bizarre when you first meet him - highly intelligent and mixing traits of Stepford Smiler and Stepford Snarker into one darkly humorous mask of unreadability. You later learn that as a child, he never showed any outward emotion besides confidence in his skill and intelligence that extended into arrogance, that he liked to kill even weak and harmless monsters, and that he's 'never understood what it means to die'. This attitude led to him killing his teacher with a spell he couldn't control when he was twelve, and spending the next decade or so trying to bring her back, creating clone after clone, until he nearly died as a result and his best friend had to convince him to stop. He also shows some social awkwardness (in one skit, he joins Anise in tickling Guy as if he either doesn't understand or doesn't care that what's cute from a fourteen-year-old girl is weird from a thirty-five-year-old man) and obliviousness to his own emotions (in the Disc-One Final Dungeon, Anise points out to him that he must like and respect the other party members, and Jade seems genuinely surprised to realize that she's right).
    • Guy Cecil freaks out every time a woman makes physical contact with him as a result of post-traumatic stress from having his sister and all of the maids in his household sacrifice themselves to protect him, causing him to be buried under a mountain of female corpses for days.
    • Pascal in Tales of Graces seems to have rather strange obsessions and does not understand exactly how socially awkward she can be at times. Her immature behavior makes many players surprised to discover she's 22 years old (although the visual design for her character doesn't help).
    • It seems possible in Tales of Vesperia that Raven could have some type of Split Personality. His alter ego Schwann is drastically different from his Raven persona - the first upstanding, militaristic, well-mannered and honorable, and the second friendly, goofy, flirtatious and casual. They also refer to each other as different people when they talk about each other, as in Schwann's boss fight when Schwann says Raven isn't here. However, unlike most classic examples, he's completely aware of what happens when he's in either persona, hence the ambiguity.
  • Metal Gear:
    • Otacon is socially awkward and bad at reading other people's motivations, rather Literal-Minded, alternates between losing himself in his work and retreating into fantasy worlds, and has tenuous control over his emotions. His stepmother sexually abused him, his estranged father committed suicide after learning of the affair, and his stepsister was nearly drowned in the process.
    • Big Boss in Metal Gear Solid 3: Snake Eater and Metal Gear Solid: Peace Walker. Despite his charisma, he's not very sociable and tends to not handle emotions well, has a tendency for repeating other people's phrases, has unusually dedicated obsessions with guns and cardboard boxes, is surprisingly naive and trusting towards people who end up deceiving him in some major way (Miller, Paz, Huey), and has some rather unusual beliefs (such as being afraid of vampires and believing in Santa Claus well into his 30s). His sons also exhibit a few of these traits.
    • While it has been Lost in Translation and somewhat buried by the English voice performance in which he is significantly cooler, Ocelot was intended at first to be a caricature of a Japanese-style "gun maniac", with rude, blunt, poorly-socialised speech patterns, snort-breathing over his Cool Guns, and the apparent motivation to turn America into something like the Spaghetti Westerns he Cosplays. He's almost unimaginably intelligent, but his plans are often bizarre and obsessive.
  • There's explicitly something wrong with the title character of American McGee's Alice, but the traumatic suffering from her family's deaths doesn't explain the hallucinations, delusions, or episodes of mania and catatonia so severe she was institutionalized. When asked later on, American McGee confirmed that this game was a "natural extension" of the Alice series going under the assumption that the previous stories weren't either fantasies or real events, but hallucinations she honestly thought were real.
  • Touhou:
    • Marisa Kirisame actively shuns human interaction (to the point of willingly living in a youkai infested forest), has multiple obsessions that she seems to abandon as often as she acquires them, has no sense of personal property, is a severe hoarder, and is belligerent and trigger-happy even by Gensoukyou standards. It is repeatedly noted that she is much more like a youkai than a human, which would put her into Blue and Orange Morality if she weren't determined to retain her humanity.
    • Flandre Scarlet clearly has something wrong with her, though how much of that is the result of being a youkai, how much an inborn condition, and how much due to being locked in the mansion basement for nearly 500 years with little to no social interactions is a good question. Either way, she has the mentality of a child, no real concept of restraint, and has No Social Skills to the max.
    • Alice Margatroid suffers from nightmares for unknown reasons, holds conversations with her dolls, and manages to creep out everyone even in a society composed largely of monsters and supernatural beasties.
    • Yukari Yakumo is just plain weird even compared with everyone else in Gensoukyou, with only her friend Yuyuko (who gets a pass for weirdness by being dead) having any idea how to deal with her. There are hints that she was originally a human, namely Maribel Hearn, who herself is an example.
    • Koishi Komeiji has a hard to follow speech pattern, bizarre thought processes, a severe case of Attention Deficit... Ooh, Shiny!, a fascination with obscure or difficult topics while struggling to understand relatively simple concepts, and generally acts far younger than even other immature characters. In her case she sealed off her Psychic Powers, gaining control over her subconscious and having no emotions or thoughts beyond the surface, which obviously defies human classification.
    • Kosuzu Motoori, the star of Forbidden Scrollery, is lovingly obsessed with her books and nothing else, brushing off concerns of the dangers of youma books because of how interesting they are, and while she doesn't actively shun other humans she's rather awkward and avoidant around them most of the time. Her only real friend is a Wise Beyond Her Years Reincarnation, and they get along swimmingly.
  • The incarnation of Sweet Tooth in Twisted Metal: Black is noted as having insomnia and an "unidentified mental illness" in his psych profile. Whether he is a psychopath or just an incredibly twisted individual, he's a professional serial killer, and he loves his job.
  • Dragon Age:
    • Alistair from Origins is used to people belittling his intelligence and found the silence in the monastery where he grew up absolutely unbearable; he eventually resorted to screaming just to bring people running. This discomfort with regards to his upbringing in the Chantry is referenced again in The Silent Grove, when he notes that screaming prisoners remind him of being forced to listen to the chant during his studies with the Templars, and how claustrophobic it made him feel.
    • Merrill has trouble understanding figurative language, has No Social Skills, gets easily distracted, and borderline Hikikomori behaviour.
    • Despite being a spirit that can read the hearts of people to immediately know their memories, feelings, and thoughts, Cole exhibits curious and slightly unsettling behaviors that allude to a damaged psyche. In Asunder, he exhibits signs of disassociation and amnesia. In Inquisition, on one of the occasions when you approach him in Skyhold, he becomes extremely unnerved and overwhelmed when surrounded by many suffering people. If you speak with him after Wicked Eyes, Wicked Hearts, he expresses confusion as to the purpose for the facades that the Orlesian nobility put on for one another, and party banter from then on may further touch upon this sentiment; and difficulty in recognizing the subtleties underlying certain questions that other companions ask him. His default outfit includes a wide-brimmed floppy hat, which he uses to shield his gaze from others when speaking; it is rare for him to make eye contact with others. He also displays childish behaviors that seem out-of-place due to his form's supposed age being 20 years old, which could be chalked up to his being a spirit unused to the physical world, the original Cole having possessed a mind predisposed to such behaviors, or a mixture of both. Examples of this include speaking with a child-like wonder about the hats worn at the ball in Halamshiral and, in the initial cutscene where the player character decides if Cole should stay or leave Skyhold, being found sitting on the ground catching what may be insects. Above all, Cole is extremely adamant about his way of viewing others: Those who help are good and those who hurt (even if they had good intentions, like the Grey Wardens) are bad. After his personal quest, in which he resolves his biggest trauma and fully embraces either his human side or spirit nature, he settles down considerably.
  • Pokémon:
    • In Pokémon Black and White, N was raised by Pokémon without human contact to be groomed into a tool for world conquest. The result of this is an inability to empathize with humans, speaking very fast and in a lot of scientific terms, having a black and white morality viewpoint, and a slight tendency to stalk people.
    • Courtney in Pokémon Omega Ruby and Alpha Sapphire. Her official character profile describes her as highly intelligent, she is disinterested in most people and things (except for a few special interests), and she rarely speaks. Courtney also has an odd way of speaking where she uses few words and constantly pauses in-between words.
  • Royce Bracket from Transistor is undoubtedly a genius, able to master the Process. But he speaks with a stilted cadence, often repeating phrases or mumbling to himself, or pausing to find words. This is reflected in his subtitles, so his awkward speaking style is completely intentional.
  • Fire Emblem games, due to having Loads and Loads of Characters, tend to have a number of characters exhibit odd mannerisms and quirks:
    • Miriel in Fire Emblem Awakening, for instance, lacks social skills, sacrifices any sense of empathy for a tireless ambition to learn and discover things, and often is detached from reality. She also doesn't seem to feel fear, as shown in her support conversations with Lon'qu where she continually puts herself in life-threatening situations just to test if he will save her or not.
    • Lindhardt from Fire Emblem: Three Houses is Brilliant, but Lazy to the extreme, and only applies himself to things that fit his narrow interests. He's seen as a Lazy Bum by most other students, but some of his comments imply he might suffer from some form of Chronic Fatigue.
    • Also from Three Houses is Bernadetta. She's a Nervous Wreck with poor social skills and is incredibly shy, and she only indulges in special interests when people aren't looking.
    • Again from '' Three Houses is Felix, who has difficulty in expressing emotions, a near-singleminded focus on swordfighting, and a self-admitted dislike of making eye contact when talking.
  • Monkey Island:
    • Guybrush Threepwood is shown as a Manchild who nobody respects or believes when he says he's a mighty pirate. Yet, he's very resourceful and is perfectly willing to do sociopathic things to achieve his ends. He has no problem talking to complete strangers, but is hopeless around Elaine, to the point where even after he's married her, he does whatever she says and she handles his business whilst he furthers his interests in being a pirate. Guybrush manages to alienate almost any friend he makes.
    • Otis, the prisoner, is just a little strange - he says he was jailed for stealing a flower, fails to notice the fact that a cake is hiding a file despite it weighing more, says he would do anything for his freedom before proceeding to do absolutely nothing when Guybrush invites him onto his ship.
    • Stan is extremely self-serving - his response to his businesses getting a bad reputation is to simply change the nature of his business, and his attempts to be friends with Guybrush are always a flimsy excuse to sell something.
    • Wally is good at cartography and hopeless in every other situation. He's admittedly based on nerd stereotypes.
    • In "Curse Of Monkey Island", the Shakespearean actor Slappy Cromwell seems to have no issue playing to an audience entirely of monkeys.
  • To some extents this trope is averted with River in To the Moon. The name of her "condition" is never outright stated, but she gets a Pervasive Developmental Disorder diagnosis by a psychologist in the game who also gives her and her boyfriend a book by Tony Attwood, a prominent real-life psychologist who has written several books about Asperger's Syndrome, so that they can better understand her condition.
  • The Lutece twins in BioShock Infinite are Insufferable Geniuses with a very narrow range of interests, have a hard time understanding the thought processes of other people, speak in a near constant monotone with little to no visible emotion, act very rigidly and appear to enjoy constant repetition... Some of this could be chalked up to their status as Physical Gods, but the game's voxophones show they acted more or less the same when mortal.
  • Kapura from the Mata Nui Online Game is a weird, eccentric Ta-Matoran whose manner of speech sounds like deliberately awkwardly worded philosophizing, often repeats himself, and sounds as if he's unable to articulate his thoughts in a way that doesn't make them come off as random. While other Ta-Matoran do their work, he's out practicing the art of "walking quick by moving slow" (and farting) in a creepy, dead forest. He doesn't stop practicing even when conversing with the player, and casually asks if you're the Makuta or not. He's slow (except when performing his technique), deliberate and unnervingly calm among all the hot-headed, fiery Ta-Matoran. Kopeke from the same game also shows signs of this trope, being coldly antisocial, quiet and emotionless in his rare moments of talking, doing his work with robotic precision.
  • Kenny Jr AKA Duck from The Walking Dead video game, goes from talking his head off to suddenly becoming quiet after a brush in danger. He also seems to lack any social cues from not noticing a distressed Clementine after the end of the episode "A New Day" to ignoring Lee's warnings that they're eating Mark's legs in "Starved For Help"
  • The eponymous Non-Ironic Clown from Dropsy. He's a trusting, grotesque clown who seems to be mute and has no desires beyond helping people, but doesn't immediately understand why they wouldn't want to be hugged by a looming, mute, bald clown with only a handful of yellowing teeth left. Despite all this, he demonstrates a certain amount of brilliance in how he solves the town's problems..
  • Persona 5:
    • Many of Goro Akechi's personality traits, such as his extreme black-and-white thinking, need for praise, and general Lack of Empathy could be chalked up to this, caused by Parental Abandonment and abuse from his father.
    • There's also Futaba Sakura, who displays several traits suggestive of this. These include having a narrow range of interests, a tendency to hyperfocus on things, finding social interaction physically draining, and a habit of trying break down everyday life in video game terminology; and her Confidant involves her trying to adjust to life after rejoining society and not viewing the protag as a Living Emotional Crutch anymore.This further supported by her English voice actress stating she that had approached the role as if she were autistic. Prior to joining the party, she was hit by a potentially unmanagable situation of her mother getting assassinated for crucial research that might expose Shido and Akechi and being manipulated by a forged suicide note, which obviously attributes to her PTSD-esque symptoms such as visual and auditory hallucinations, memory loss, suicidal ideation and paranoid delusions at that point.
    • In a Like Mother, Like Daughter manner, her mother, Wakaba Isshiki is a professor who hyperfixates on researching the Metaverse and is said to also have No Social Skills.
    • Yusuke Kitagawa also displays symptoms of this: overwhelming focus on a single subject (art), overly formal speaking style, and constant misunderstanding of social cues. At one point Ann claims that he is "on a different wavelength than other people".
  • On a similar note, Hikari in Persona Q2: New Cinema Labyrinth suffers from similar issues as Futaba or Yusuke, as she simply shuts down as soon as she sees people, appears to be extremely withdrawn and depressed and actively represses her memories, which turns out to be attributed to being led to believe that she was hated by everybody, including her beloved father by a Trauma Conga Line of emotional abuse. Even after her rehabilitation, she more often than not overwhelmingly focuses on only one subject when it is bought out (Movies).
  • Alexa from Xenoblade Chronicles X is obsessed with Skells to the point that she has a hard time focusing on or caring about anything else. She also seems to have a hard time reading people, at one point needing a colleague's feelings spelled out to her when the situation is obvious to everyone else involved. An optional conversation reveals that she's speculated In-Universe to have some kind of disorder, but that's all that's said on the matter.
  • Night in the Woods:
    • As the game goes on it becomes more and more apparent something has happened that has messed with Mae's mental state. Bea suggests she possibly has depression or anxiety after a traumatic event in her childhood; said event matches up with a textbook description of dissociation. The near-end of the game seems to imply Mae has psychosis.
    • Gregg mentions having "really up up days and really down down days" and exhibits some poor impulse control and self-destructive habits when particularly "up". Bea explicitly says he is probably bipolar.
  • The Elder Scrolls series backstory has Emperor Pelagius the Mad. Infamous for his eccentricities, he certainly lived up to his nickname, though exactly what caused his madness is unknown. He suffered from extreme weight fluctuations and tried to hang himself at the end of a royal ball. He insisted on his palace always being kept clean and (perhaps apocryphally) was said to defecate on the floors to keep his servants busy. He would only communicate with the Argonian ambassador in grunts and squeaks, believing it to be the Argonian language. He'd frequently strip naked in public and, toward the end of his life, would attack and bite visitors. His madness is theorized to have even been something supernatural left behind in Castle Solitude by his mad aunt, the Wolf Queen Potema, but it remains a mystery. Sheogorath's quest in Skyrim has the Dragonborn posthumously cure Pelagius of whatever madness ailed him by ridding him of his night terrors, combating his fear of his mother and strengthening his self-confidence.
  • Ayano Aishi, the titular Villain Protagonist of Yandere Simulator, is described as being emotionless her entire life. She can get frustrated and feel pity, but otherwise, she's unable to make friends, experience joy, or even develop a hobby. The reason why she becomes a Yandere to begin with is because being around her beloved Senpai was the first time she ever felt happiness. Throughout the game, she exhibits extreme obsession, Lack of Empathy, and stalking behavior. We also find out that it's genetic; her mother was much the same way to the point of kidnapping Ayano's father in their teens, and it's confirmed that all Aishi women have similar issues. Word of God confirms that she wasn't designed with any particular diagnosis in mind.
  • Tryggvi of The Banner Saga has random mood swings, frequently misplaces things important to him, talks in jumbled up sentences that don't make much sense, and is generally very forgetful and perpetually confused. In the third game, he has a conversation with Alette in which he is uncharacteristically lucid and straightforward for a moment before reverting to his usual self. During this conversation, he confides in Alette that he knows there's something wrong with him and that he attempts to treat his condition by focusing on objects of personal importance.
  • While much of the cause of Dutch Van Der Linde's descent into madness through the events of Red Dead Redemption II is left open to interpretation (including receiving a nasty knock on the head), what stays consistent (even in Red Dead Redemption which takes place twelve years later) is his paranoia, impulsiveness, narcissism, and delusions of grandeur. He’s also a major Control Freak.
    • In 1 Bill Williamson is an Ax-Crazy bandit who commits Rape, Pillage, and Burn. However in 2, he's given a more sympathetic portrayal/ backstory although he’s still violent and kooky. His time in the army seems to have permanently scarred him mentally. He can be found waking up in a cold sweat thinking the “Injuns” are coming to get him. He worries he will end up with the same dementia that his dad had that caused him to lose his mind. He is implied to be gay living in the not accepting of being gay 1890s, meaning he’s likely dealing with a lot of shame and self-loathing. It’s not clear what exactly is wrong with him but it’s no wonder he’s so troubled.
  • Life Is Strange: Max Caulfield is shown as extremely introverted, preferring to stay in her room, has to isolate herself with music and excuse herself to the loo to to have a "meltdown" after being called on in class, is reluctant to submit her photo (despite strong encouragement from her favourite teacher), and has trouble getting to know people (even her dorm-mates), until her powers allow her to "cheat". She also comes across as aloof to her peers (a common experience for people on the autistic spectrum or with anxiety disorders) and apparently fluctuates between being too quiet or too chatty. She is in an IEP (Individualized Education Program, a program usually reserved for students with some form of disorder which means they need help) according to her student file, but otherwise nothing is confirmed.
  • Lucas Baker from Resident Evil 7 mentions in a childhood diary that he was brought into the hospital for a brain scan when he was very young, followed by an account of him locking a schoolmate in an attic and leaving him to waste away to death in revenge for picking on him for being "crazy". He exhibits a Lack of Empathy that enables him to torture and murder others habitually at least as much for shameless personal entertainment as for trespassing or failing to "behave," he doesn't seem motivated by anything other than a need for stimulation or immediate gain, and he's prone to childish irritability and tantrums or sulking when things don't go his way. In addition, he's highly talkative and vocal when "in the zone" despite not being especially interested in interacting with others unless he wants something from them; his way of speaking, body language, and facial expressions are all (somewhat clumsily) performative even if no one's necessarily paying attention; he's got a rarely-blinking, near-constant Thousand-Yard Stare that wanders frequently and seldom focuses on eye contact; and he's very intelligent in the sciences, but has something of a Complexity Addiction, going out of his way to turn anything he can into a "game" or "toy".
  • Mio Aiba of Omega Labyrinth Life has near-crippling social anxiety, leaving her unable to talk to people, and for them to mistake her as a cool, aloof loner. She does not have this problem with flowers, of which she is obsessed with; she speaks with them freely, takes long, detailed journals about their growth and daily activities, and even personifies them, giving them names, personalities, and as evidenced by one in-game event, the ability to be jealous.

    Visual Novels 
  • Ace Attorney:
    • Vera Misham from Apollo Justice: Ace Attorney dislikes being outside or in crowds, doesn't show much emotion on her face, does not understand "rules" of social behaviour (like when she stares at Klavier in court for a very long time), and communicates either in short, broken sentences or through sketches. She also shows signs of being a savant, as demonstrated by her ability to create perfect forgeries of artwork and evidence.
    • The Big Bad of the second Ace Attorney Investigations is heavily implied to be a sociopath, despite the term never being explicitly used. The idea of trusting others is utterly incomprehensible to them, they're a master manipulator and they only see other people as tools, not caring who they hurt as long as it furthers their goals.
  • CLANNAD: Fuko Ibuki is amazingly immature for her age. Yes, she's technically younger than the rest of the cast and still has the mentality of a freshman even when she's in her twenties due to her being comatose for years, but she still acts far less mature than the average teenager, to the point where she gets mistaken for a grade schooler.
  • Katawa Shoujo:
    • Kenji is obsessed with delusional conspiracy theories to a degree that would probably have psychologists scrutinizing him for schizophrenic tendencies in Real Life, although unlike all the other disabilities in the game this is almost purely Played for Laughs. That's before mentioning his extreme dislike of being around other people or open spaces, frequently locking himself in his room for days at a time.
    • Rin definitely does not think like most people, forming connections and inferences that seemingly make no sense, switching rapidly between topics, is clearly artistically gifted even without considering she paints with her feet, and her behavior and comments can be socially inappropriate, not in the manner of someone who doesn't understand normal social interaction but more as if she simply doesn't care. Later in her route, it's shown that Rin is aware to some extent of how odd she comes across to people, and the difficulties she has with expressing her thoughts, whether through words or through her art, are quite frustrating to her.
    • Misha is an inverted variant. She has no obvious disabilities, so many players are left wondering why exactly she's at Yamaku. She's a bit quirky (energetic, laughs a lot, has some volume control issues), but not to the point that she'd be considered seriously mentally unstable, and Yamaku is not supposed to cater to mental disabilities in any case. It turns out that she came to Yamaku for other reasons: namely, she wants to be a sign language instructor and Yamaku is one of the only schools that has sign language courses. It's later revealed that Misha's bubbly, hyperactive self is a facade to hide her crippling and near-suicidal depression as a result of unrequited love towards Shizune, and in the unused beta arc due to the unrequited love and previous homophobic bullying at her old school.
    • Hanako has severe social anxiety that goes beyond that of the typical Shrinking Violet. She also suffers from panic attacks.
  • Almost every mage in the Nasuverse who isn't a psychopath could qualify for this at some level. They're socially distant, obsessed with their own singular interests (their magic fields, their Origins and the Akashic Records in this case), and frequently have special repeated tics or actions associated with activating magecraft.
  • Steins;Gate:
    • Shiina Mayuri is a very sweet, if slow young woman. She often misunderstands or misphrases information she overhears, often has innuendo or subtlety fly over her head, and acts much younger than her age, but the most explanation we ever get is her childhood friend Okabe saying she's a little "off" and that she's always been like this.
    • Moeka Kiryu is shy to the point of preferring to communicate via text message even when face to face with the person she's talking to and responds with extreme distress if anyone attempts to take her cell phone from her, and is almost always emotionally repressed and expressionless. She's also completely dependent on her contact FB, to the point that she commits suicide once FB's messages stop in one timeline.
  • When They Cry:
    • Rena from Higurashi: When They Cry is suggested to have a mental illness even ignoring the Hinamizawa Syndrome everyone in her town has. She can be violent and has mood swings, though some of them are related to the aforementioned problem, some of her violence is understandable, and others times it's the case of another character being an Unreliable Narrator. Rena is shown taking medicine for whatever illness she has, but it's never shown just what it is.
    • Umineko: When They Cry:
      • The Ushiromiya family patriarch Kinzo's behavior explains a lot about his children, with one flashback to WWII showing he was so depressed that he joined the army hoping to be killed in battle, and only snapped out of it when he met his lover, Beatrice Castiglioni and once she suffered Death by Childbirth went completely off the rails to the point of raping his own illegitimate daughter with said mistress because he believed she was her mother's reincarnation, an act which produced Yasu, below. Nearly every scene he's present in features him screaming at the sky.
      • Maria is nine years old but behaves far younger, has bizarre reactions (or lack of same) to events around her, and she never seems to be able to avoid hitting her mother's Berserk Button when she really should know better. There's also her Verbal Tic (which unlike most examples tends to annoy other people) and lack of focus towards anything except for her hobby of studying black magic.
      • Maria's mother, Rosa, definitely seems to have a few screws loose. Besides the aforementioned Berserk Button there's her abuse towards Maria, including rapidly alternating between screaming at her, hitting her and apologizing for her behavior, and her angry reactions to hearing about Beatrice since the young Rosa saw "Beatrice" fall off a cliff to her death and blames herself for it.
      • Erika Furudo, introduced later in the series, definitely comes off like this because of her obsessive behavior and egomania. It says something when the Ushiromiyas, who themselves are a major case of Dysfunction Junction, immediately notice something's off about her and she quickly wears out her welcome.
      • The spoilerific example of Sayo Yasuda, and by extension Shannon, Kanon, and Beatrice, whose issues seem to include pretending to be multiple people to the point of almost becoming them and probable gender dysphoria in addition to body dysmorphia caused by a horrific injury to their sexual organs that causes them to refer to themselves as "furniture" after finding out the truth about their origins mainly, the aforementioned rape of his own daughter by Kinzo.
  • Starship Promise:
    • The player character's rapid-fire, disorganized, and easily-distracted thought processes, combined with her extreme self-consciousness and social awkwardness, point to some disorder.
    • Captain Antares Fairchild's need for control over himself and the people and things around him goes far beyond the authoritative behavior one might expect from someone in a position of command to the point of an obsession. Even his explanation for why he keeps fish as pets includes the remark that he can completely control their environment in order to keep them safe.
  • Missing Stars is an in-development game that takes place in a boarding school for teenagers with mental health issues. All of the main characters obviously have some sort of mental disorder or issue, however, none are clarified at first. The demo, however, hints at certain things:
    • The protagonist, Erik, was in an accident while out mountain climbing. It left him with no physical scars but instead he has mental scars. Erik has psychosomatic pain and stiffness in one of his legs. He also suffers from insomnia, nightmares, and lethargy.
    • Katja has gauze on her wrists and wears an eye-patch. It's unknown if the two are related, however the former implies that she Self Harms.
    • Isolda is not in the demo but Word of God is that she's a worrywart who misattributes people's words as something more than they are,
    • Lena is a blunt girl who wears a mask akin to Hannibal Lecter which is more than likely not for show, suggesting she can be a danger to herself and/or others.
    • Annaliese is painfully shy, avoids interacting with anyone, and spends her classes staring out the window listening to music. When Erik tries to get to know her, she has a panic attack and runs off. Her teacher doesn't mention when she leaves class early, so apparently, it's common for her to do so.
    • One of the first thing Natalya's does is try to force Erik to eat her food so that her sister doesn't find out she won't eat. Sofiya then makes references that imply that Natalya has difficulties eating. Natalya is also shown to eat in small bites.
    • Natalya's twin sister Sofiya is apparently a Hard-Drinking Party Girl, however, she doesn't go to the school (unlike she was early in development) and thus it's most likely she doesn't have any major mental health issues.
    • Irene is an eccentric and energetic Cloudcuckoolander that seems at least somewhat paranoid.
  • Ikemen Sengoku: Mitsunari is a Ditzy Genius who, while capable of being perfectly polite and charming in social interactions, is said to forget the name of the person he's talking to halfway through a conversation if he's not interested in that person and doesn't recognize any form of flirting or sarcasm directed at him or other people. He also Forgets to Eat or sleep whenever he's absorbed in reading or some other activity that he's passionate about, causing his friends Hideyoshi and Masamune to have to constantly look after him to make sure he gets proper meals and rest.

    Web Animation 
  • In Red vs. Blue, Locus's lack of free will, the fact he uses his armor as his name, his denial towards his murderous actions as anything but evil and his obsession/insistence to prove to Washington that he is a soldier just like Washington all indicate that something is wrong with him (Santa mentions Locus was "broken by war").

    Web Comics 
  • Homestuck:
    • Mituna has an ambiguous brain injury from over using his psionics that leaves him with strange tics, a tendency to become incomprehensible and have dramatic and sudden mood swings. He also lacks coordination and has to wear a helmet to avoid injuring himself.
    • Jake was raised in almost complete isolation on a deserted island by his grandmother and shows poor social skills that make him nearly oblivious to the feelings of others to the point it comes off as this, especially his tendency to ramble on about his issues without regard for the feelings of the person he's talking to, which actually causes Jane to destroy her computer out of frustration after he yet again fails to realize she has feelings for him and causes his boyfriend to break up with him. It's also implied that his Alternate Universe self Grandpa Harley (who seems to have had a normal enough upbringing, even though his stepmother was actually an alien empress) was similarly odd.
    • Clubs Deuce/Courtyard Droll is very childish (despite being a grown man who's part of a gang), gets easily excited at the smallest victory, and has difficulty paying attention to people or focusing on a given task. He also seems convinced that his fellow gangsters are just his eccentric and lovable family.
    • Caliborn/Lord English is undeniably a sociopath, but also admits finding it very hard to think clearly, often overlooks obvious solutions to his problems in favor of unnecessarily complex workarounds, has very poor social skills, lacks impulse control and self-awareness, and admits to "thinking in colours", suggesting he views the world in a fundamentally different way. At one point he does mention that he has a learning disorder.
  • Lalli of Stand Still, Stay Silent acts a lot like he's a cat. He sits on his haunches, sleeps in strange places and for extremely long periods of time, scratches doors rather than knocking when he wants someone to open them and has engaged his teammates in social grooming. However, in spite of all his strangeness, Lalli is a pretty well-adjusted human being (apart from having No Social Skills and being somewhat of a Cloudcuckoolander) and has found a way to turn his quirks into a useful career as a night scout.
  • Played for Drama with Dina of Dumbing of Age. She is obsessed with paleontology but doesn't really seem to understand other humans, by her own admission; at one point she gets depressed because some other girls mistook her for a handicapped child (aside from her behavior, she looks about twelve). Her roommate Amber has tried to help her read social cues with mixed results. The creator has gone on record saying she's never been diagnosed with anything, later acknowledging that she probably has Asperger's. For what it's worth, her parents behave similarly (at least, they're very laconic).
  • In Ha from Cheese in the Trap seems for the most part just selfish, shallow and lazy, but then someone says something to set her off and she shows just how insane she is. This often involves physically attacking the people around her, though sometimes it is just shown in her sudden personality change, and her inability to be reasoned with. It's never played for laughs. Also Professor Baek hinted that Jung had some kind of disorder, but never specified what that was. He certainly has difficulty forming relationships with others or understanding how other people process the world.
  • Afkinz from Zoophobia does come across as rather odd. He has super-long hair that he lets his cat live in and sometimes hisses at random people.
  • Donovan from Silver Bullet Nights is highly intelligent and a bit socially clueless. His lack of tact and directness definitely falls outside social norms. Might be a reflection of the author's experiences as someone diagnosed on the spectrum.
  • Ethan from Ctrl+Alt+Del just doesn't seem to be capable of functioning as a normal human being. He's so obsessed with gaming that he suffers actual withdrawal symptoms if deprived of any means of gaming for more than an hour or so, his behaviour to his friends is often deeply insensitive, and his behaviour towards people he doesn't like can be downright sociopathic, to the point where he inflicts potentially murderous levels of violence against his co-worker Rob for the heinous crime of liking Counter-Strike and saying "bro" rather a lot.
  • Brun the bartender in Questionable Content. At first, she just comes across as taciturn and undemonstrative, then when the bar burns down she continues to be taciturn and undemonstrative, eventually explaining when Clinton congratulates her for being calm "I'm not ... great. With emotions", and the stress is actually making it hard for her to talk at all. Later, her friend Renee says she's "not great at working out people's intentions", and she says needs a new routine now that the bar is gone. She also says she has trouble interpreting facial expressions at one point.
  • At the beginning of The Stupiders, we are told that everyone has at least one problem or quirk, but what exactly those problems are is left up to the reader to discern.
  • Lil Char and the Gang: Bulbasaur is excessively childlike even compared to the other children, can only speak in Pokémon Speak (while everyone else speaks normally), and tends to eat game pieces.
  • Oswald Blivius Bystander in The Inexplicable Adventures of Bob! has an iron-clad Weirdness Censor and is so out of touch he believes that Sputnik is still up there and that hippies and punk rockers are the same thing. Ironically for someone so utterly clueless, he reads his newspaper obsessively.
  • Rocky in Lackadaisy is impulsive to the point of recklessness, has a slightly worrying fixation with fire, is talkative to the point of logorrhea, and regularly sports a Slasher Smile and Evil Laugh. Then he gets hit by a car and gets worse.

    Web Original 
  • Amoridere:
    • Toki is a rather odd case, as she has had a few conditions diagnosed and they are known (along with her being medicated for them), however, she has also the symptoms of several others undiagnosed, the symptoms being some obsessive-compulsive tendencies (as implied in the poem Lipstick), mood swings, fears of being abandoned, impulse control problems, and fits of rage and violence.
    • According to her description (from 2012), Madgie has issues but it's not said what they so happen to be, besides her being "psychologically backwards", leaning toward destructive impulses, and having alternate personalities. Bunny thinks she should be institutionalized.
    • Killerbunnies:
      • Razelle has some sort of psychosis if her backstory is to go by. Unfortunately, in her fits of delirium, she is prone to committing violent acts if left unrestrained, although that could be part of some underlying impulse problem, worsened by said psychosis. Despite either of the two, be she coherent or not, she can be described as pleasant.
      • Coriander, according to her deviantArt description, is a rather eccentric sort with bizarre obsessions of counting to nonsensical numbers, plants, beaches, and nature in general, along with suffering a short attention span and is generally unaware of where she is, even in familiar territory, in which case, she may remember or she may forget.
      • Gas is described as being "not right in the head". However, considering what she does normally, which is playing with chemicals and making gases from them, this can be seen as a result of brain-damaging side-effects.
      • Frankie, as per her profile, is described as being "ambiguous and erratic", along with the fact that she is friendly, yet tends to disregard others, and that she seems to lack some understanding of her actions.
      • "Nuclear Blast" Nova's page describes her as "not being right in the head" and states that she doesn't have a comprehension of her actions and is "painfully reckless" with a small burst of rationality. It's not said if she was born that way or her mental state was a caused by a brain tumor.
      • Greastain has obsessive tendencies.

    Western Animation 
  • Adventure Time has quite a bit of it due to being set in a Dysfunction Junction.
    • Jake has a very short attention span and often blurts things out without thinking as well as a tendency to do things without thinking about consequences or the impact on others, both physical and emotional. (Though he can probably be excused by the fact that, anthropomorphic or not, he's still a dog)
    • Marceline is overly flirtatious with others, displays mild sociopathic tendencies, and seems to have trouble understanding other people's emotions. At the same time though, she is also a vampiric cambion (heck, her dad is the ruler of Ooo's version of Hell, the Nightosphere) and it's later revealed that beneath her cheerful and easygoing exterior, she has suffered a lot of personal losses and fears getting too close to people as a result, despite desperately wanting to.
    • Lemongrab, in particular, could keep a team of psychologists busy for weeks, with his wildly exaggerated emotions, total incomprehension of other peoples' emotions and thought-processes, extreme arrogance, constant suspicion of others, and ability to switch from pathetic to frighteningly vicious on a dime. Interestingly, his clone Lemongrab II still has issues but is much gentler and more moral.
  • American Dad!:
    • Stan. His thought process runs on Aesop Amnesia, Insane Troll Logic, and Too Dumb to Live, and other characters often consider him insane.
    • Steve Smith. Several episodes prove that he's capable of extreme violence, self-abuse, and just plain undiagnosable problems for laughs. Roger even lampshades this with his response to Steve's plan to exact revenge on a bully by dressing up as a girl and seducing him: "Yes, let's keep that plan between you, me, and the string of therapists who won't be able to help you."
    • The Ditz Barry, though it was revealed in one episode that he is, in fact, a complete sociopath whose criminal inhibitions are "retarded" (their words) by powerful anti-psychotics that cause his odd behavior. Though the real Barry still shines through sometimes ("Let's kill his parents next! Let's kill them all!").
    • Roger often displays signs of mental disability himself. One episode reveals there's an imaginary little boy in the attic who he talks to, he developed a Split Personality in "The One That Got Away" and in "Oedipal Panties" he freely admits to Francine, "I don't know what's real."
  • The titular protagonists of Apple & Onion are immature for their ages, are Literal-Minded, and have No Social Skills. They both have Friendless Backgrounds as well. Apple has issues with concentration and Onion is a Motor Mouth.
  • Aqua Teen Hunger Force:
    • It's often implied that Meatwad has some kind of mental disability. In "Super Bowl" and "Ezekial," he outright calls himself "messed up in the head" and "retarded" in those respective episodes, and in "Rabbot Redux," when Shake complains to Frylock about Meatwad upsetting him, Frylock responds, "He doesn't know any better, and he's never gonna know any better. And you know that."
    • Master Shake himself sometimes acts so sociopathic that it ends up being lethal.
  • Archer:
    • The titular character is a Psychopathic Man Child that can instinctively count bullets fired, instantly recognizes the model of every gun he sees, gets easily distracted and despite all that is an ace when killing/torturing enemies. Several characters have wondered if he is, in fact, autistic or if he has any other number of mental/psychological problems up to including brain damage.
      Lana: My theory, and I'm serious, is that he's got some rare kind of pervasive developmental disorder or even undiagnosed atypical autism.
      Archer: Umm... your mic's hot.
      Lana: I know.
    • Cheryl gets aroused by emotional and physical violence, is extremely aggressive, constantly tries to call attention to herself, and, according to her brother, her pyromania has been a problem since she was a little girl.
  • Avatar: The Last Airbender:
    • Avatar: The Last Airbender: Azula is manipulative as all get out and such a Consummate Liar that Toph, the Living Lie Detector, can't tell when she's lying. Yet despite this, in "The Beach", she proves to be cringe-inducingly inept when it comes to actually interacting with people as opposed to manipulating them. She also demonstrates one instance of rather inappropriate nigh-sexualized behavior towards her brother, though this seems mainly designed to creep him out (and quite possibly unintentional on the writers/director's part). Even as a child, her mother wondered just what was wrong with her because she already demonstrated what amounts to Ambiguous Innocence at best and Troubling Unchildlike Behavior at worst. As of Book 3 and Avatar: The Last Airbender – The Search, she begins to exhibit some pretty unambiguous raging paranoia though, to the point of delusions and hallucinations. It's complicated by Bryke's word in Sozin's Comet: The Final Battle that she turned crazy because she felt her mother didn't love her as much as Zuko and that while she could turn out better, her nation's Take Over the World policy only worsened her problems.
    • In The Legend of Korra, Eska and her twin brother, Desna, are almost emotionless and speak in a creepy monotone. Eska has occasional emotional outbursts and abusive treatment of Bolin and violent reaction to him running out on the wedding. She isn't exactly rational, either, as she blames Korra for the ruined wedding, even though it's rather clear in the show that she and Bolin are Just Friends and Korra is way more interested in Bolin's brother, Mako. Like Azula, the twins didn't have the best upbringing; their daddy is the season's Big Bad. Unlike Azula, they were not shown to have been just the same when little, so maybe when you've lived their lives the world really is just that dull.
  • Big Hero 6: The Series: Wasabi is absolutely obsessed with order and cleanliness, to the point where he almost has a breakdown because he thought he misplaced Honey Lemon's invention.
  • Bob's Burgers:
    • All three Belcher kids to some extent:
      • Tina speaks in a Creepy Monotone, expresses distress through long groans, has No Social Skills and awkward body language. Louise even says she's probably autistic in the first episode, and when Bob tries to deny it, Louise dumps a bunch of straws onto the floor and tells Tina to count them to which she replies "three".
        Louise: She's the worst kind of autistic. She can't even count.
      • Gene is a Cloudcuckoolander with limited reasoning abilities and his Attention Deficit... Ooh, Shiny! so severe that his name is synonymous with getting distracted and screwing up in the Belcher family. "The Laser-inth" shows Gene has some kind of sensory processing issues, as he gets overwhelmed by the lights and noise at the laser show.
      • Louise is the most normal but she is manipulative, has a strong sense of schadenfreude, quick to anger, frequently advocates violence and often tries to escalate situations for her amusement to the point where she tried to convince a biker gang to cut a kid's ear off after he took her bunny ear hat.
    • The Pesto kids are if anything even weirder. Jimmy Junior's only apparent mechanism for dealing with his emotions is random Footloose-style dance numbers in public, and listing every weird thing Andy and Ollie do would require its own page.
    • Mr. Fischoder, the perpetually cheerful wealthy eccentric who owns most of the town is certifiably insane, most notably he seems to place no value on human life, including his own.
    • Aunt Gayle is a Crazy Cat Lady, severely emotionally fragile, displays obsessive tendencies, very neurotic, and, at one point mentions being medicated. She has eaten her own lipstick, worn a dress made out of shrimp to church and shaved her cat.
  • Pretty much every character from BoJack Horseman:
    • The titular character shows signs of chronic depression and is a confirmed alcoholic. He's also a bit of an Attention Whore and prone to impulsive and self-destructive behavior.
    BoJack, inner thoughts as he wakes up: Stupid piece of shit. You're a stupid piece of shit... but at least I know I'm a stupid piece of shit which makes me better than all the other stupid pieces of shit who don't know they're stupid pieces of shit.
    • Diane can be a bit of a nervous wreck in certain situations and obsesses over gaining approval and finishing her next big projects. She's also referred to herself as 'miserable' and BoJack attempted to say that they weren't so different, to which she gave a You Keep Telling Yourself That response.
    • Sarah Lynn is basically BoJack if he were a (more successful) human female about two decades younger. She's an Addled Addict, Attention Whore, and her mood shifts rapidly. In addition, the first time we meet her, she's shown to not exactly care for her own well-being... as she'd just stabbed herself with a rusty bayonet in the middle of a hardware store over a breakup... then sealed the wound with duct tape...
    BoJack (in response to Sarah Lynn telling him she'll just find somewhere else to party): Well, you should... not... do that.
    Sarah Lynn: Oh, I know. I know, but I can, so I will. I'm at a place in my life right now where I don't have to "grow as a person" or "rise to any occasion," so I can just keep surrounding myself with sycophants and enablers until I die tragically young.
    • BoJack's mother, Beatrice has symptoms of three personality disorders, mixing equals parts entitlement and desire for attention.
  • Ed the otter from Brandy & Mr. Whiskers has something. He has awkward speech patterns, uses big words, he's also a bit on the stoic side for the most part and is also physically clumsy when it comes to sports.
  • Nonny from Bubble Guppies is a smaller example. He rarely ever smiles, has a bored, monotone voice, and is quite awkward compared with the other guppies.
  • On Caillou, Andy is referred to as a "different child," and he has a tendency to isolate himself and dislikes loud noises, among other things.
  • Gadget Hackwrench of Chip 'n Dale Rescue Rangers. She has to stop and remind herself about normal social conventions when she first meets Chip and Dale, frequently just plain forgets them anyway, is possibly Oblivious to Love and the fact that she's actually quite attractive, (especially to Chip and Dale) and is prone to bouts of poor self-esteem as both an inventor and pilot. She can be quite scatter-brained and forgetful even of important things that aren't related to her current task, is easily distracted, and has a tendency to fall into rambling Motor Mouth tangents, leading Monty to snark in an aside that her "elevator doesn't go to the top floor." She's also a ridiculously intelligent and brilliant Gadgeteer Genius, capable of building almost anything the team needs at any given moment in that moment, including building a fully-functional airship out of the wreckage of her father's plane and whatever trash she found lying around.
  • Cleveland, Jr. from The Cleveland Show. He's a teenager with the mentality of a child, and has a number of disturbing quirks, such as an obsession with cleanliness and order, and random bursts of violence (such as strangling a mannequin head for being "so pretty"). He also believes one of his stuffed animals is alive, to the point of hiring a nanny for it.
  • Numbuh One from Codename: Kids Next Door is often paranoid and can become obsessive to the point where it has visible impact on him.
  • On Daniel Tiger's Neighborhood, O the Owl shows several signs of mental problems. For example, when Elaina wants him to play backwards in the Backwards Day episode, he becomes more and more upset, almost to the point of becoming panicky. Also, he is very insistent about a box that Teacher Harriet wants everyone to play pretend with being just a box, at least at first, and mostly just ignores the whole situation in favor of his reading, at least until he finally decides to play race car. He also sometimes is particularly upset by loud noises that don't really bother others.
  • DC Super Hero Girls: Pam Isley, AKA Poison Ivy, has a Green Thumb and can control plants, but even then she's a bit unusual. She has a Friendless Background but it's from her own free-will. She prefers to avoid people, Eating Lunch Alone and even going as far as to ask the teacher for no lab partners. Pam has a disheveled appearance with Messy Hair and Creepy Shadowed Undereyes. She has an obsession with plants and talks to them, but she thinks Humans Are Bastards and puts plant safety over human safety.
  • Dexter's Laboratory has Dexter's family, who are not the most stable people;
    • Dexter himself. He's a genius, but has No Social Skills and has trouble understanding basic concepts; for example, in different episodes, he has no idea what flour and chicken pox are.
    • Dee Dee also has hints of this. She lacks a lot of social intuition, can't take a hint, seems to be very temperamental, and even her own friends get frustrated by her odd behavior at times.
    • Dexter's mother may be one of the more obvious examples; her obsession with cleanliness goes beyond what is healthy. A couple of episodes confirm that she has a crippling fear of germs and dirt, to the extent that she actually sought out psychological treatment when she was younger.
  • From Family Guy, we have Chris and Meg. Meg has displayed some attachment problems, prone to Self-Harm, suicidal tendencies, and reckless behavior, has anger issues, and has been noted to hear voices in her head. Chris, on the other hand, has displayed violent tendencies (i.e drowning a mouse in a puddle) and, like Meg, anger issues, at the same time, he displays some lack of comprehension and basic understanding, along with occasionally showing savant traits such as artistic ability and vast knowledge of film.
  • With Cheese from Foster's Home for Imaginary Friends, you can't really pin down what's wrong with him. He clearly was imagined by a special needs child (this is made painfully obvious when he's introduced), but what exactly that special need was is left ambiguous. Most likely it's just an amalgam of general "mentally challenged" stereotypes.
    • Meanwhile, Mac's cruel 13-year-old brother Terrence often torments Mac in ways that goes beyond sociopathy, and considering how much of a "doofus" he is, it's highly possible that he's mentally ill, which makes his cruel treatment towards Mac all the more horrifying.
  • The Grim Adventures of Billy & Mandy:
    • It's fairly obvious that Billy has genuine mental problems in addition to being extremely stupid, as shown by his bouts of psychotic, murderous rage. He can barely focus and is often hyperactive.
    • Billy's Mother as well. She's implied to be the source of Billy's psychopathic outbursts, as she goes nuts when things are out of order or untidy.
      Harold: Did someone forget to take their medicine today?
  • Hey Arnold! has the title character's cousin Arnie, who the other characters think is "dull" and "slow". His hobbies include counting things, reading ingredient labels (along with seemingly knowing what they are and how to pronounce them) and collections (specifically balls of lint and "plain flavored" gum), displays muted outward signs of emotion, and seems to have difficulty in social interaction (he constantly snorts and winks one eye at a time instead of blinking together).
  • Techrat from Jem Hates Being Touched by everyone except for very specific people (namely Minx), is obsessed with engineering, and has a tendency to freak out if things don't go his way.
  • Everybody on Kaeloo is implied to have something wrong with them. For example, Kaeloo is unable to draw the line between a "game" and a dangerous situation.
    Kaeloo: [to Mr. Cat, who is trying to pull her out of the path of a meteorite] Mr. Cat, it's just a game!
  • King of the Hill: Dale is an awkward, paranoid Cloudcuckoolander whose conspiracy theories border on outright delusional — and yet despite his constant suspicion of everyone and everything, he's completely oblivious to actual conspiracies that are obvious to absolutely everyone else, such as his wife's affair with John Redcorn.
  • Daffy Duck in The Looney Tunes Show (carried over somewhat from older cartoons in which he was clearly insane, but not debilitatingly so). Bugs Bunny guesses that he's "a sociopath, "a narcissist" and "probably a psychopath". (He also sometimes seems to be unable to tell fantasy apart from reality — just see the music video for "The Wizard.")
  • The Loud House: Leni tends to lean into this. She's a Cloudcuckoolander ditz, however she also has a tendency to misname her own brother, get distracted easily, be Literal-Minded, and is Super Gullible. Leni can't even chew bubblegum and walk at the same time.
  • Metalocalypse: All five members of Dethklok are rather... off, but in the cases of Skwisgaar, Murderface, and Pickles, this can be attributed to a combination of their terrible childhoods, the isolating effects of ultra-celebrity, heavy substance abuse (especially in Pickles' case), and just not being all that bright. Nathan and Toki seem to have something more going on.
  • Draggle from the original My Little Pony 'n Friends series shows signs of many disorders, and by default of her family life, Stockholm Syndrome. Also, her voice in "The End of Flutter Valley" indicates, erm, slowness due to Flanderization messing with her intelligence.
  • My Little Pony: Friendship Is Magic also has this, for a kids show, due to Dysfunction Junction:
    • Pinkie Pie is a really eccentric Cloudcuckoolander who seems to inhabit normal reality only part-time and is almost pathologically cheerful and silly, with an obsession with parties... except that when a misunderstanding makes her believe her friends are excluding her, she immediately snaps into a state of paranoia and depression so severe that she becomes delusional and starts hallucinating. Pinkie has shown that she is aware of how annoying she can be, but is either unwilling or incapable of altering her behavior. She is also implied to create the machines that she uses and has displayed incredible memory and eye for detail.
    • It seems to run in the family because Pinkie's sister, Maud Pie also displays eccentric behavior of her own. She shares her sister's literal-mindedness, but unlike Pinkie, she displays practically no emotion whatsoever. She also talks in monotone and has a narrow-minded obsession with rocks. This general behavior makes her so un-relatable to Pinkie's friends that they don't really know what to make of her and don't seem to "click" socially speaking. Maud is cognizant of this, though.
    • The official portrayal of Derpy Hooves shows her as ignorant to the scale of dangers and also simple in how she treats things, giving the impression that she's a bit... off.
    • Twilight Sparkle has Super OCD to the point that disruption to her routine can induce a panic attack, and while fiercely good at management and organisation she approaches everything in her life as a rigid task; Celestia had to largely trick her into making friends through her "friendship reports". She's seen using breathing exercises to keep herself in check by the later episodes of season three and has learned to interact with other ponies less clinically, but it's clear that even in-universe this is a real problem for her that she's working on getting better at dealing with.
    • Fluttershy is almost never seen with other ponies besides the other members of the Mane Six, preferring the company of her many animal friends. She has severe anxiety if she has to socialize beyond basic business transactions and small talk, with full-blown panic attacks (complete with hyperventilation and hallucinations) if ponies laugh at her.
    • "Testing Testing 1, 2, 3" shows that Rainbow Dash has a serious problem buckling down and studying, and is constantly being distracted, in addition to her established Brilliant, but Lazy tendencies and some other traits of hers (impulsive, stubborn, energetic).
    • Starlight Glimmer, the Arc Villain of the fifth season premier, displays symptoms for several disorders. She's absolutely obsessed with keeping the town under her control as harmonic, orderly, and equal as possible, to the point of making sure everypony's mane is identical, even if she has to rearrange it herself. She also shows extreme paranoia and distrust of those different from herself, to the point of not even trying to get to know the rest of her town until she'd convinced them to give up their Cutie Mark or outright stolen it (as Sugar Belle's plead with her attests to). And when something enrages her, she goes from calm and composed to explosions of anger and psychotic rage to the point of nearly attacking, and then actually attacking others who were supposedly friends. Unlike the mane six, these traits aren't Played for Laughs and combined with the power she has at her disposal, she's an extremely dangerous threat, especially since she isn't captured or reformed by the end of the two-parter. This gets to the point where she has three cameos stalking the Mane Six for the express purpose of revenge against them.
  • Phineas and Ferb:
    • Baljeet is dependent on routines and clear direction, unsocial, observant but somewhat oblivious and emotionally stunted, and is able to focus for long periods on repetitive behaviors.
    • Phineas is unaware of Isabella's advancement towards him, while Ferb rarely speaks (not at all in some episodes), and both are incredibly savvy in machines. It's shown that Phineas apparently has a pathological need to invent, as in one episode he suffered Heroic BSoD when he couldn't invent anything for hours, and the same may apply to Ferb; he did say he felt like he was going to scream if he didn't invent anything, though nothing came out of it.
    • Candace is extremely obsessive over busting her brothers and will do crazy things to do so – she also loses her sense of self when they're doing nothing 'bust-worthy'. "Monster from the ID" also proves that her head is quite messed up and is lampshaded by plenty of the characters.
  • From The Powerpuff Girls, we have the Mayor who is neither bright nor mature and relies heavily on his secretary and personal assistant, Ms. Sara Bellum, to do the real work around the place. He also seems to be very childish, causing him to act as if he needs to be taken care of. This is especially noticeable in the later seasons.
  • The Powerpuff Girls (2016):
    • Bubbles has a lot of mood swings, going from innocent one minute to insane the next.
    • Blossom hates the tiniest bit of dirt, melts down whenever things aren't as organized as she wants them to be, and feels like she must overachieve or she "is meaningless".
    • Packrat seems to be able to hear inanimate objects talk to him. He even appears to believe that they are alive.
  • Ready Jet Go!: Sean is afraid of going to space and becomes paranoid whenever someone touches his birthday telescope.
  • Ralph Wiggum from The Simpsons. He acts much younger than his age, has weird mood swings, is quite the Cloudcuckoolander, doesn't seem able to tell fantasy apart from reality, and one episode shows he hallucinates. It's stated numerous times that he's on meds and Chief Wiggum, his father, mentions that Ralph goes to a "special school" as well as Springfield Elementary. A later episode depicted a flashback with Chief Wiggum holding a baby Ralph, who is drinking out of his bottle. Wiggum accidentally drops Ralph, and after he picks him back up, Ralph can no longer find his mouth with the bottle, suggesting Childhood Brain Damage.
  • Butters from South Park can be Literal-Minded, laugh during inappropriate situations, has anger issues (more-so in the newer seasons), has repetitive Character Tics like fidgeting his knuckles together and singing to himself, and overall lacks a basic understanding about the world around him. Granted, these tropes start to phase out as the series progresses, and it can be argued that his behavior is a result of the abuse he receives at the hands of his parents and relatives alike.
  • SpongeBob SquarePants:
    • The title character is a Manchild who is utterly obsessed with working at the Krusty Krab (an episode has him going crazy when he's forced to take a vacation) and, despite having the knowledge necessary to drive, can't do it because he gets too nervous when he's behind the wheel.
    • There's also his best friend Patrick, who has been shown at times to be mentally unstable (e.g. "Valentine's Day", "Nature Pants") and Too Dumb to Live.
  • Star vs. the Forces of Evil:
    • Star Butterfly is prone to "stimming" behaviors like bouncing up and down or chewing on her wand, tends to be easily distracted, is frequently Literal-Minded, and has poor social skills (like having No Sense of Personal Space). She gets a bit better on all these points along with Character Development, though the behaviors don't entirely go away.
    • Mina Loveberry, Star's idol. A flashback shows her being an oddball, but still very sane, when she appears in the current time, her behavior is erratic, nearly violent at times, and even has Wide Eyes and Shrunken Irises, which the flashback shows she didn't have before.
  • Steven Universe:
    • Pearl gets obsessed with certain subjects like swords or gem history, tends to get annoyed by asymmetrical things, clenches her fists and makes various other gestures when she gets excited, takes hyperbole, sarcasm, and humour literally, is unable to pick up on social cues, has difficulties empathizing with those she doesn't have a close connection with (i.e. most humans), is ultra-logical most of the time but highly anxious and emotional in stressful situations, and has trouble understanding other people's perspectives. Given that the other Gems can seem to glean a basic understanding of earth and its inhabitants, Pearl's behavior may not be explainable by reference to her outsider status alone. This is on top of the rampant symptoms she displays in relation to the Great Offscreen War and the loss of her love interest, Rose Quartz.
    • Peridot gets obsessed over things (such as watching the same episode of the TV show "Camp Pining Hearts" over and over for more than three days straight), is VERY Literal-Minded, frequently records herself talking about what's happening to and around her until her tape recorder is broken, can be extremely rude without meaning to, and gets very annoyed by the Crystal Gems' "incorrect behavior". Aside from that, Peridot also shows signs of halted emotional development. She has the tendency to throw temper tantrums when things don't go the way she wants them to, seems to be unable to understand how she might have made others feel bad, and doesn't know how to put her emotions into words (she describes feeling good or bad as feeling "big" or "smaller", and the only way she shows gratitude is by saying "wow, thanks" - something she learned from Steven).
    • Ronaldo's I Just Want to Be Special and I Reject Your Reality tendencies, combined with what a Conspiracy Theorist he is, could be suggestive of some form of psychosis or personality disorder. He is at the very least slightly off.
    • Onion is almost completely non-verbal. When he speaks, it isn't coherent English, though his family can understand him anyway. He's prone to odd behaviors such as dumping food on the ground instead of eating it and is generally a Creepy Child. This is especially seen when he tries to bond with Steven in "Onion Friend" and does things like feed a mouse to a snake and show Steven a video of the day Onion was born. His friends introduced in "Onion Gang" are also generally this trope.
    • Amethyst's high confidence, low self-esteem, incredibly unstable relationships, fear of abandonment, hoarding, and other traits have led many fans to diagnose her with a few disorders.
  • Superjail!: Where to begin with the Warden? He is shown to be very intelligent and yet has the mentality of a child. He also interacts better with animals and machines than with people and has sociopathic tendencies, especially when he's murdering his own inmates. (Although these are usually Played for Laughs.) Oh, and when he does befriend/fall in love with someone, he tends to be clingy and almost a bit of a creep around them.
  • We Bare Bears:
  • Voltron: Legendary Defender introduces Leifsdottir in season seven. Alongside being intelligent with a focus on numbers and awareness of spatial directions, Leifsdottir is shown to misinterpret others' intentions, such as giving a description of the weather when asked for a status report during battle.


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