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1* AbilityOverAppearance: Crazy Jane in the comics is very tall, has pale white skin and was designed as not being the typical conventionally attractive comic heroine. Creator/DianeGuerrero is the polar opposite, being 5'2, Latina and undeniably beautiful, even when dressed down. Her performance has been widely acclaimed all the same.
2* AllStarCast: Creator/TimothyDalton, Creator/BrendanFraser, Creator/MattBomer and Creator/AlanTudyk are all fairly well-known as is Creator/DianeGuerrero due to ''Series/OrangeIsTheNewBlack''.
3* AndStarring: With Matt Bomer and Brendan Frasier. Special Appearance by Creator/TimothyDalton.
4** In season 3, Creator/MichelleGomez receives the "Special Appearance" credit. The one episode that has her and Dalton gives Dalton a second "And" credit.
5* AwesomeDearBoy: Creator/DianeGuerrero had been vocal about wanting to be in a superhero adaptation for some time prior to being cast as Crazy Jane.
6* BillingDisplacement:
7** Creator/AlanTudyk (Mr. Nobody) is billed above Creator/MattBomer (Larry Trainor) and Creator/BrendanFraser (Cliff Steele) in the first season, but Bomer and Fraser actually play members of the eponymous Doom Patrol who appear in every episode, while Tudyk portrays the antagonist and is absent from a fair number of episodes. Fraser's character is also arguably the main protagonist of the series, despite being billed sixth. This primarily stems from Bomer and Fraser receiving AndStarring credits, with their lower billing intended to draw additional prominence to their names.
8** Abi Monterey is credited as a guest star in the second season, despite appearing in all but one episode and being a focal point of the season's story.
9* TheCastShowoff:
10** Matt Bomer kills it during Negative Man's karaoke ImagineSpot.
11** Likewise Alan Mingo Jr. who plays Maura Lee Karupt has a background in musical theater, and has played a drag queen on stage previously.
12** Abi Monterey gets a chance to demonstrate her musical chops in season 2 with Dorothy's performance of [[Film/WillyWonkaAndThechocolateFactory "Pure Imagination"]] at Danny's party. "Immortimas Patrol" sees her not only sing the opening song, but also perform a bit of ballet; Monterey is a trained ballet dancer.
13* CelebrityParadox: Jane calls Laura, played by Creator/MichelleGomez, Doctor Who at one point. Michelle played Missy on ''Series/DoctorWho''.
14** Funnily enough, Missy also briefly pretends to be the titular Doctor at one point.
15* DawsonCasting:
16** Creator/DianeGuerrero was 32 at the time the series started. Crazy Jane is stated to have been born in 1950 and got her powers and presumably stopped aging in 1976, meaning Guerrero is playing someone who is physically supposed to be a 26 year-old. May also be FridgeBrilliance as she's also meant to be able to play the adult Doctor Harrison.
17** Dorothy Spinner, who is physically 11 years old when she is chronologically older than a century (at least prior to puberty catching up with her after she gets her first period in "Dad Patrol"), and the Chief as a child are played by the 19-year-old Abi Monterey.
18** Charles Rowland, Edwin Paine and Crystal Palace are teenagers as they were in the comics, but are respectively played by 19-year-old Sebastian Croft, 18-year-old Ty Tennant and 26-year-old Madalyn Horcher.
19* DuelingWorks: Somewhat. Both this and Creator/{{Netflix}}'s ''Series/TheUmbrellaAcademy2019'' premiered on the same day, were based on comics and were about a RagtagBunchOfMisfits and BigScrewedUpFamily becoming a superhero team.
20** It doesn't help that both have, at least at one point, been written by Gerard Way.
21* FakeAmerican: Cyborg is played by the British Joivan Wade.
22* FakeGuestStar: Credited as [[AndStarring Special Appearance by...]] in the opening credits, Creator/TimothyDalton appears in almost every episode. While mostly limited to {{Flashback}}s and {{Meanwhile Scene}}s in the first season, this continues into Season 2, where he's part of the main cast.
23* FlipFlopOfGod: The series was originally conceived and announced as a ''Titans'' spin-off. However, some comments from actress Creator/AprilBowlby and showrunner Jeremy Carver suggest that in fact the series is not set in the same continuity as ''Titans''. This would explain why some of the information and actions of the characters do not fit with what we saw from them in ''Titans''.
24** ''[[Series/CrisisOnInfiniteEarths2019 Crisis on Infinite Earths]]'' officially designates ''Doom Patrol'' as taking place on Earth-21, separate from ''Titans''' Earth-9.
25* TheOtherDarrin: For some reason, several members were recast from ''[[Series/Titans2018 Titans]]'' to this.
26** Creator/BrunoBichir doesn't reprise the Chief and, instead, Creator/TimothyDalton takes over.
27** Matthew Zuk replaces Dwain Murphy as Negative Man.
28** Jake Michaels portrays Robotman in ''Titans'' but, in this show, the role is split between Creator/BrendanFraser (who provides his voice and portrays him in his previous human form) and Riley Shanahan (who portrays him in the present).
29* PlayingAgainstType: A mild example, with the casting of Creator/BrendanFraser as Cliff Steele. Whilst Fraser is well-known for playing goofy, shouty, socially-awkward characters (which puts Cliff in his general wheelhouse), it can be a little jarring for his fans to find out that he's also easily the most ''foul-mouthed'' character in the show (apart from Jane, that is). Likewise, the flashbacks revealing Cliff's spiral of sex, drugs and alcohol can be a little surprising for those used to Fraser's usual "nice guy" image.
30* ProductionPosse: Creator and showrunner Jeremy Carver has brought on several former ''Series/{{Supernatural}}'' cast members - Creator/JulieMcNiven, Creator/MarkSheppard, and Creator/RuthConnell among them.
31* QueerCharacterQueerActor: In a minor case of FirstEpisodeTwist, Creator/MattBomer's character Larry is revealed to be cheating on his wife with a man.
32** Jane's actress Diane Guerrero has been open about how she is not straight, and in season 4, Jane is also shown to be queer.
33* SerendipityWritesThePlot: In the comics, Kay Challis’ original personality remains as a child within the Underground, but her actress has aged since her first appearance. Rather than recasting her the production team chose to make Kay’s growing up a major point, exploring both her learning to move on from her abuse and the implications and impact of the change on her many personas.
34* TorchTheFranchiseAndRun: The show concludes with [[spoiler:Rita Farr and Cliff Steele dying as the rest of the Doom Patrol move on with their lives]], preventing any chance of a continuation happening.
35* TroubledProduction: Like all TV shows being produced in 2020, Season 2 was cut short due to the COVID-19 pandemic shutting down various DC productions. [[WordOfSaintPaul According to Abi Monterey]], who plays Dorothy Spinner, there were only a few scenes left to film for Episode 10. It would have served as the finale for Season 2, but production was halted and the show was released anyway, leaving "Wax Patrol" as the season finale.
36* WhatCouldHaveBeen:
37** Creator/KelseyGrammer had discussions for the role of Niles Caulder before the casting of Creator/TimothyDalton.
38** Creator/AlexandraDaddario screen-tested for the part of Crazy Jane before Creator/DianeGuerrero was cast. [[HilariousInHindsight Ironically]], she later starred in ''Series/MayfairWitches'' alongside Hannah Aline, who plays one of Jane's alternate personalities.
39** Creator/WarnerBros had wanted a ''Doom Patrol'' movie back in 2006, and yet nothing ever came of it. After many years, ''Doom Patrol'' will now be refit for web television.
40** There were plans for the cast to appear in the first season finale for ''Series/Titans2018''. It would have been established that the team here is not the one that first appeared on ''Titans'', arriving from a different universe and helping in the battle against Trigon. The writers also wanted the finale to be Cyborg's debut but no actor had been cast in time so a mere mention was planned instead.
41** Originally, Abi Monterey was only contracted for a few episodes of Season 2, before her role was expanded.
42** Season 2 was supposed to have 10 episodes, but the Covid pandemic forced them to stop production while they still had a few scenes left. The producers were forced to, as a result, re-edit episode 9 to act as a season finale in case the actual finale was never completed. Thankfully, the original Season 2 finale was repurposed as the Season 3 opener without compromising the intended resolution of the storyline.
43** "Dead Patrol" was intended as a [[PoorlyDisguisedPilot backdoor pilot]] for a spinoff series starring ComicBook/TheDeadBoyDetectives. While the series would eventually be greenlit, it was later announced that it would no longer have any ties with the live-action ''Doom Patrol'' show and that it would instead be connected to the [[Series/TheSandman2022 Netflix adaptation]] of ''ComicBook/TheSandman1989'' (which is still a fitting decision, as the ''Sandman'' comic was where the Dead Boy Detectives made their debut in the first place).
44* WordOfSaintPaul: Jane is a lesbian, according to Creator/DianeGuerrero. The show begins depicting this in “Dada Patrol” through her relationship with Shelley Byron.

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