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* Most characters in ''Manga/SoulEater'' who go through a FaceHeelTurn starts to suffer from quick deterioration of their mental faculties soon after, which is not at all surprising, considering that a FaceHeelTurn in this series usually means giving in to [[TheCorruption insanity]]. Examples include [[spoiler: Franken Stein]] in the anime; [[spoiler: Justin Law and Crona]] in the manga; and, obviously, [[BigBad Kishin Asura]] in both.
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* Most characters in ''Manga/SoulEater'' who go through a FaceHeelTurn starts to suffer from quick deterioration of their mental faculties soon after, which is not at all surprising, considering that a FaceHeelTurn in this series usually means giving in to [[TheCorruption insanity]].madness]]. Examples include [[spoiler: Franken Stein]] in the anime; [[spoiler: Justin Law and Crona]] in the manga; and, obviously, [[BigBad Kishin Asura]] in both.
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* During the Alien Costume StoryArc, Franchise/SpiderMan becomes addicted to the power and freedom the ComicBook/{{Venom}} symbiote gave him... until he learned that it exacerbated his aggressive tendencies and would've absorbed him into itself in the long run. Peter Parker managed to "quit" the symbiote, but his successor, Eddie Brock, wasn't so lucky. Note that this wasn't actually a part of the original comic book version, [[LostInImitation but has appeared in all the adaptations]]. Brock '''seems''' to be better, now. At the moment. Sort of. Meanwhile, under the symbiote's influence, Mac Gargan has crawled up the food chain of evil, in more ways than one. A few hosts later, Eddie is currently reunited with Venom, although over the years the symbiote stopped being a bad influence and became much more benevolent.
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* ''ComicBook/SpiderMan'': During the Alien Costume StoryArc, Franchise/SpiderMan Spider-Man becomes addicted to the power and freedom the ComicBook/{{Venom}} symbiote gave him... until he learned that it exacerbated his aggressive tendencies and would've absorbed him into itself in the long run. Peter Parker managed to "quit" the symbiote, but his successor, Eddie Brock, wasn't so lucky. Note that this wasn't actually a part of the original comic book version, [[LostInImitation but has appeared in all the adaptations]]. Brock '''seems''' to be better, now. At the moment. Sort of. Meanwhile, under the symbiote's influence, Mac Gargan has crawled up the food chain of evil, in more ways than one. A few hosts later, Eddie is currently reunited with Venom, although over the years the symbiote stopped being a bad influence and became much more benevolent.
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* The Apple of Discord has this effect in ''Series/TheLibrarians''. Anyone who touches it becomes the worst version of themself, with Cassandra Cillian in particular becoming rather murderous. Ezekiel Jones is the only person immune to its effects, as he is already the worst possible version of himself.
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* The Apple of Discord has this effect in ''Series/TheLibrarians''.''Series/TheLibrarians2014''. Anyone who touches it becomes the worst version of themself, with Cassandra Cillian in particular becoming rather murderous. Ezekiel Jones is the only person immune to its effects, as he is already the worst possible version of himself.
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* ''Series/Highlander'' had Duncan suffer from a Dark Quickening, which turned him evil ("Something Wicked" S413). He got better ("Deliverance" S414).
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* ''Series/Highlander'' ''Series/{{Highlander}}'' had Duncan suffer from a Dark Quickening, which turned him evil ("Something Wicked" S413). He got better ("Deliverance" S414).
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* In ''Film/SpiderMan3'', the Venom symbiote has this effect on its hosts. Peter is eventually able to [[FightingFromTheInside fight off its influence]] after he has an [[MyGodWhatHaveIDone epiphany]] on what it's turning him into, while Eddie Brock eventually decides that he ''[[EvilFeelsGood likes]]'' being evil.
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* In ''Film/SpiderMan3'', the Venom symbiote has this effect on its hosts. hosts, enhancing their physical abilities and increasing their aggression to the point that they stop restraining their darker impulses. Peter is eventually able to [[FightingFromTheInside fight off its influence]] after he has an [[MyGodWhatHaveIDone epiphany]] on what it's turning him into, while Eddie Brock eventually decides that he ''[[EvilFeelsGood likes]]'' being evil.evil. He becomes so addicted to the power the symbiote granted him, in fact, that he dies while trying to save it from being destroyed by Peter.
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* ''Series/Highlander'' had Duncan suffer from a Dark Quickening, which turned him evil ("Something Wicked" S413). He got better ("Deliverance" S414).
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* ''Series/Highlander'' had Duncan suffer from a Dark Quickening, which turned him evil ("Something Wicked" S413). He got better ("Deliverance" S414).
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* ''Series/Highlander'' had Duncan suffer from a Dark Quickening, which turned him evil ("Something Wicked" S413). He got better ("Deliverance" S414).
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* The boy who would become Wrath in the 2003 anime version of ''Anime/FullmetalAlchemist'' was a sweet, shy, and innocent young child who was suffering from a nasty case of amnesia when he was first introduced to the audience. [[AxCrazy Then Envy has him eat unfinished Philosopher's Stones...]]
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* The boy who would become Wrath in the 2003 anime version of ''Anime/FullmetalAlchemist'' ''Anime/FullmetalAlchemist2003'' was a sweet, shy, and innocent young child who was suffering from a nasty case of amnesia when he was first introduced to the audience. [[AxCrazy Then Envy has him eat unfinished Philosopher's Stones...]]
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-->'''Pumpkin''' Forget it, it's too risky. I'm through doing that shit.\\
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->'''Pumpkin''' Forget it, it's too risky. I'm through doing that shit.\\
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* ''Film/PulpFiction'' opens with this discussion of armed robbery between Ringo "Pumpkin" (Creator/TimRoth) and Yolanda "Honey Bunny" (Creator/AmandaPlummer):
->'''Pumpkin''' Forget it, it's too risky. I'm through doing that shit.\\
'''Honey Bunny:''' You always say that, the same thing every time. "I'm through, never again, too dangerous."\\
'''Pumpkin:''' I know that's what I always say. I'm always right too.\\
'''Honey Bunny:''' But you forget about it in a day or two.\\
'''Pumpkin:''' Yeah, well the days of me forgetting are over, and the days of me remembering have just begun.
->'''Pumpkin''' Forget it, it's too risky. I'm through doing that shit.\\
'''Honey Bunny:''' You always say that, the same thing every time. "I'm through, never again, too dangerous."\\
'''Pumpkin:''' I know that's what I always say. I'm always right too.\\
'''Honey Bunny:''' But you forget about it in a day or two.\\
'''Pumpkin:''' Yeah, well the days of me forgetting are over, and the days of me remembering have just begun.
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* In ''Film/SpiderMan2'', Otto Octavius has an epiphany after getting knocked around by Peter, realizing that his arms have been manipulating ''him'', and urging him to evil. Sadly, he was surgically fused with them and [[NotQuiteDead may have "died"]] because RedemptionEqualsDeath. Also the Venom suit in ''Film/SpiderMan3''.
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* In ''Film/SpiderMan2'', Otto Octavius has an epiphany after getting knocked around by Peter, realizing that his arms have been manipulating ''him'', and urging him to evil. Sadly, he was surgically fused with them and [[NotQuiteDead may have "died"]] because RedemptionEqualsDeath. Also RedemptionEqualsDeath.
* In ''Film/SpiderMan3'', the Venomsuit in ''Film/SpiderMan3''.symbiote has this effect on its hosts. Peter is eventually able to [[FightingFromTheInside fight off its influence]] after he has an [[MyGodWhatHaveIDone epiphany]] on what it's turning him into, while Eddie Brock eventually decides that he ''[[EvilFeelsGood likes]]'' being evil.
* In ''Film/SpiderMan3'', the Venom
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* In ''VideoGame/AITheSomniumFiles'', [[spoiler:BigBad Saito Sejima was born with a brain defect that made him unable to produce oxytocin (the hormone associated with love and pleasure) except when killing. This is what made him become a SerialKiller, as it was the only way he could feel any positive emotions. Due to BodySurfing shenanigans, Saito ends up in a body that does secrete healthy amounts of oxytocin, but at this point he's addicted to the stronger rush his original brain gave him from killing, and only wants to return to his own body so he can continue killing for fun. Meanwhile, the one who ended up in Saito's body is prevented from becoming AxCrazy thanks to synthetic oxycotin (which tragically proves that Saito's condition could have been treated if he had received proper care).]]
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* ''Fanfic/YourAlicornIsInAnotherCastle'' gives Bowser an extra-nasty version of this, in that he didn't even have to make the choice in the first place. He simply was given (or acquired, or something) the destined role of Princess Kidnapper, and when he quite naturally refused to kidnap Princesses he was plagued with intrusive thoughts and other withdrawal-esque symptoms.
