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* ''Manga/OnePiece'': Doctor Vegapunk is considered the smartest man in the world and is responsible for futuristic inventions. His head is normal-sized in the present, but in the past, he had a brain that was four times bigger than the rest of his body, and a giant cranium to match. He states that this is due to him eating the Brain-Brain Fruit, which causes his brain to constantly grow to the point that his true brain is housed in a massive dome.
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* ''Manga/OnePiece'': Doctor Vegapunk is considered the smartest man in the world and is responsible for futuristic inventions. His head is normal-sized in the present, but in the past, he had a brain that was four times bigger than the rest of his body, and a giant cranium to match. He states that this is due to him eating the Brain-Brain Fruit, which lets him memorize knowledge perfectly, but it causes his brain to constantly physically grow larger. Eventually it had to the point that his true brain is be removed and housed in a massive dome.dome, and Vegapunk converted the rest of himself into a RemoteBody that's connected to it wirelessly.
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*** Natalie X is a psychic mutant member of a team from a BadFuture that confronted the Fantastic Four in an attempt to save refugees from that future. After resolving it with a move to an artificial Earth, she took a serum to increase her telepathic powers that had the side effect of increasing the size of her brain. It's very grotesque; she eventually becomes the HiveQueen of the colony they established and her head becomes big enough to fill out ''[[Characters/MarvelComicsGalactus Galactus]]' helmet''.
*** Reed Richards did this to himself once in ''Fantastic Four: 1234'' by Creator/GrantMorrison. In order to defeat [[Characters/MarvelComicsDoctorDoom Doctor Doom]] in a [[SmartPeoplePlayChess 4-dimensional chess game]] that was threatening to destroy the Fantastic Four, Reed used his [[RubberMan stretching powers]] to literally grow new structures in his brain in order to out-think Doom.
*** Reed Richards did this to himself once in ''Fantastic Four: 1234'' by Creator/GrantMorrison. In order to defeat [[Characters/MarvelComicsDoctorDoom Doctor Doom]] in a [[SmartPeoplePlayChess 4-dimensional chess game]] that was threatening to destroy the Fantastic Four, Reed used his [[RubberMan stretching powers]] to literally grow new structures in his brain in order to out-think Doom.
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*** In ''ComicBook/FantasticFour1998'', Natalie X is a psychic mutant member of a team from a BadFuture that confronted the Fantastic Four in an attempt to save refugees from that future. After resolving it with a move to an artificial Earth, she took a serum to increase her telepathic powers that had the side effect of increasing the size of her brain. It's very grotesque; she eventually becomes the HiveQueen of the colony they established and her head becomes big enough to fill out ''[[Characters/MarvelComicsGalactus Galactus]]' helmet''.
*** Reed Richards did this to himself once in''Fantastic Four: 1234'' ''ComicBook/FantasticFour1234'' by Creator/GrantMorrison. In order to defeat [[Characters/MarvelComicsDoctorDoom Doctor Doom]] in a [[SmartPeoplePlayChess 4-dimensional chess game]] that was threatening to destroy the Fantastic Four, Reed used his [[RubberMan stretching powers]] to literally grow new structures in his brain in order to out-think Doom.
*** Reed Richards did this to himself once in
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*** And Batman actually. In ''World's Finest #151'', when an ancient Kryptonian device landed on Earth, it evolved Batman into a big-brained human from 800,000 years in the future.
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*** Muto, a villain of one of Superman's descendants, and who later appeared in the 2499 segment of ''ComicBook/TheDominusEffect''.
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*** Muto, a villain of one of Superman's descendants, and who later appeared in the 2499 segment of ''ComicBook/TheDominusEffect''.some few stories like ''ComicBook/ActionComics'' #338-339 and ''ComicBook/WorldsFinest1941'' #166, is a mutant with a giant, hairless yellow head and huge psychic powers as telekinesis and matter-transmutation.
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* ''VideoGame/TheLegendOfZeldaTheWindWaker'': The younger of the two retired swordfighting brothers, Sturgeon, has become a MiniatureSeniorCitizen a gigantic swollen head that's nearly 70% of his body's total mass. While he doesn't have any psychic powers, he's the more intelligent and well-learned of the two brothers, although Orca is actually a fair bit more calm than Sturgeon.
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* ''VideoGame/StarFox'': "Only I have the [[{{Pun}} brains]] to rule Lylat!" says Andross after assuming his giant brain form.
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* ''VideoGame/StarFox'': ''VideoGame/StarFox64'': "Only I have the [[{{Pun}} brains]] to rule Lylat!" says Andross after assuming his giant brain form.
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* Mad Rocket Slave "Grosshirn der Krankheit" from ''VideoGame/NineteenSeventeenTheAlienInvasionDX'', an alien giant whose forehead takes up most of his body. Fittingly he can use PsychicPowers to spam projectiles as a boss.
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* ''Anime/DoraemonNobitaAndTheTinLabyrinth'': The main villain, Professor Napogistra, have a huge brain that takes up around one-third of his entire body. Justified since his brain is a neural link to his entire robot army.
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* ''Anime/DoraemonNobitaAndTheTinLabyrinth'': The main villain, Professor Napogistra, have has a huge brain that takes up around one-third of his entire body. Justified since his brain is a neural link to his entire robot army.
