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* ''Literature/TheStrangeCaseOfDrJekyllAndMrHyde'': An impurity of salt is what makes the transformation from Dr. Jekyll into Mr. Hyde possible.

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* ''Literature/TheStrangeCaseOfDrJekyllAndMrHyde'': An impurity The only reason that Jekyll's potion worked (sort of) was because the batch of salt is what makes he used had been contaminated with an unknown substance. The potion has a limited supply because when he ordered more salt, the transformation from Dr. Jekyll into Mr. Hyde possible.other batches were pure, and he couldn't re-create his potion with them.


* R.W.Wood in one experiment noticed that a heating circuit is broken, but a wire in a glass with atomic hydrogen not only doesn't cool, but in fact is white hot. This provoked some useful research on recombination and the invention of atomic-hydrogen welding.

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* R.W.W Wood in one experiment noticed that a heating circuit is broken, but a wire in a glass with atomic hydrogen not only doesn't cool, but in fact is white hot. This provoked some useful research on recombination and the invention of atomic-hydrogen welding.



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* While software developers joke "it's not a bug, it's a feature!", sometimes those bugs do become features in later releases as seen in AscendedGlitch. Note that for all intents and purposes, a bug is an unintentional error in the implementation of the software.


** In the Lije Bailey series, the psychic robot, Giskard, is created this way.

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** In the Lije Bailey series, the psychic robot, Giskard, [[spoiler: Giskard]], is created this way.


* The antibiotic Penicillin was discovered when a Alexander Fleming found his bacterial samples contaminated by Penicillium mould and studied the way the mould was able to create bacteria-free areas on his petri dish.

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* The antibiotic Penicillin was discovered when a Alexander Fleming found his bacterial samples contaminated by Penicillium mould and studied the way the mould was able to create bacteria-free areas on his petri dish.



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* The antibiotic Penicillin was discovered when a Alexander Fleming found his bacterial samples contaminated by Penicillium mould and studied the way the mould was able to create bacteria-free areas on his petri dish.


* In the Literature/{{Discworld}} books, this is the best case scenario of allowing Bloody Stupid Johnson to build ''anything''. Case in point: his "improved manicure device" is best used for peeling potatoes.

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* In the Literature/{{Discworld}} books, this is the best case scenario of allowing [[BunglingInventor Bloody Stupid Johnson Johnson]] to build ''anything''. Case in point: his "improved manicure device" is best used for peeling potatoes.


* In ''Anime/GhostInTheShellStandAloneComplex'' the tachikomas [[spoiler: become sapient due to an imperfection on one of their circuit boards caused by Bateau giving his "personal" takioma natural oil which corroded part of it. This tachikoma induced sapience in the others when their AI's were synchronized.]] They did try that with the fujikomas, yet that did not work. They never quite figured the reason out.

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* In ''Anime/GhostInTheShellStandAloneComplex'' the tachikomas [[spoiler: become sapient due to an imperfection on one of their circuit boards caused by Bateau giving his "personal" takioma tachikoma natural oil which corroded part of it. This tachikoma induced sapience in the others when their AI's were synchronized.]] They did try that with the fujikomas, yet that did not work. They never quite figured the reason out.


* As explained in the opening credits of ''WesternAnimation/ThePowerpuffGirls'', the eponymous heroines were born when [[DitzyGenius Professor Untonium]] accidentally spilled [[{{Unobtainium}} Chemical X]] into his mixture of Sugar, Spice, and Everything Nice. (Although, a later episode would reveal there was more to it than that.)


* Uhm, {{Spider Man}}s origin. For those who don't know about it, he was visiting a demonstration at his school of a strange type of radiation, when a spider got caught in it; it crawled on his arm, bit him, and the next thing he knew, he had the speed, strength, and agility, proportionately, of a spider.
* More like a "Cataclysmic Malfunction", but the monstrous villain Chemo was created this way. Originally it was a plastic vessel used by scientist Ramsey Norton to dispose of the chemical by-products from his failed experiments, built in the shape of a man to remind him of his failures. One day (ironically, the day he planned to empty it) he dumped the remnants of a failed growth formula in the vessel, accidentally causing it to double in size and coming to life. After killing Norton and destroying the lab, it lumbered forth with no purpose but to destroy, fighting numerous heroes, including the ComicBook/MetalMen and ComicBook/{{Superman}}.

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* Uhm, {{Spider Man}}s origin. For those who don't know about it, he was visiting a demonstration at his school of a strange type of radiation, when a spider got caught in it; it crawled on his arm, bit him, and the next thing he knew, he had the speed, strength, and agility, proportionately, of a spider.
* More like a "Cataclysmic Malfunction", but the monstrous villain Chemo was created this way. Originally it was a plastic vessel used by scientist Ramsey Norton to dispose of the chemical by-products from his failed experiments, built in the shape of a man to remind him of his failures. One day (ironically, the day he planned to empty it) he dumped the remnants of a failed growth formula in the vessel, accidentally causing it to double in size and coming to life. After killing Norton and destroying the lab, it lumbered forth with no purpose but to destroy, fighting numerous heroes, including the ComicBook/MetalMen and ComicBook/{{Superman}}.


* Invoked in an episode of ''WesternAnimation/TheAdventuresOfSonicTheHedgehog'', where Robotnik explicitly says that the creation of his "Super-Genius Program" was a million-to-one shot - and after the program is stolen and he orders his computer to make it again, the computer has to remind him of exactly this fact (which he said himself not five minutes before!).

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* Invoked in an episode of ''WesternAnimation/TheAdventuresOfSonicTheHedgehog'', ''WesternAnimation/AdventuresOfSonicTheHedgehog'', where Robotnik explicitly says that the creation of his "Super-Genius Program" was a million-to-one shot - and after the program is stolen and he orders his computer to make it again, the computer has to remind him of exactly this fact (which he said himself not five minutes before!).


* ''Literature/DirkGentlysHolisticDetectiveAgency'' - Professor Chronotis' time machine seems to be in a strange relationship with the telephone system. After he has his phone repaired, the time machine is inoperable too.

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* ''Literature/DirkGentlysHolisticDetectiveAgency'' - Professor ''Literature/DirkGentlysHolisticDetectiveAgency''--Professor Chronotis' time machine seems to be in a strange relationship with the telephone system. After he has his phone repaired, the time machine is inoperable too.




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* In ''Literature/StarWarsKenobi'', Annileen Calwell's husband Dannar fiddled with a vaporator at their store once, and it began producing water so incredibly sweet and delicious that the farmers are afraid to ever touch the settings again, but that means they have trouble replicating the results. Their friend and business partner Orrin Gault has come close and is attempting to ramp up production (he considers it an exquisite irony that the desert planet might ''export'' water), but nothing can match Old Number One. [[spoiler:And then the Tuskens smash the control panel to bits during their raid on the Claim, [[NoPlansNoPrototypeNoBackup destroying the formula forever]]. Orrin's copycat vaporators somehow stop producing the sweetwater themselves after that, worsening his cashflow problem.]]


* A darker example occurs in one of the vignettes in [[Creator/ArthurMachen Arthur Machen's]] ''The Three Impostors'' (specifically, ''The Novel of the White Powder'', where a character's antidepressant prescription is accidentally filled from an expired batch of the drug that (thanks to unknown environmental conditions) has degraded to the point of being chemically identical to ''Vinum Sabbati'', the wine of the witch's sabbath (which isn't wine so much as a sort of horrifying [[FantasticDrug eldritch version of ecstasy]] that temporarily converts the taker into a HumanoidAbomination). Since [[PhlebotinumOverdose the prescribed dosage of antidepressant is several orders of magnitude larger (and much more frequent) than the amount of ''Vinum Sabbati'' offered at a Witch's Sabbath]], BodyHorror ensues, and the unfortunate victim is eventually [[ImMelting reduced to a permanent mucous stain]] [[AndIMustScream (but not actually killed)]].

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* A darker example occurs in one of the vignettes in [[Creator/ArthurMachen Arthur Machen's]] ''The Three Impostors'' (specifically, ''The Novel of the White Powder'', Powder''), where a character's antidepressant prescription is accidentally filled from an expired batch of the drug that (thanks to unknown environmental conditions) has randomly degraded to the point of being chemically identical to ''Vinum Sabbati'', the wine of the witch's sabbath (which isn't wine so much as a sort of horrifying [[FantasticDrug eldritch version of ecstasy]] that temporarily converts the taker into a HumanoidAbomination). Since [[PhlebotinumOverdose the prescribed dosage of antidepressant is several orders of magnitude larger (and much more frequent) than the amount of ''Vinum Sabbati'' offered at a Witch's Sabbath]], BodyHorror ensues, and the unfortunate victim is eventually [[ImMelting reduced to a permanent mucous stain]] [[AndIMustScream (but not actually killed)]].



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* A darker example occurs in one of the vignettes in [[Creator/ArthurMachen Arthur Machen's]] ''The Three Impostors'' (specifically, ''The Novel of the White Powder'', where a character's antidepressant prescription is accidentally filled from an expired batch of the drug that (thanks to unknown environmental conditions) has degraded to the point of being chemically identical to ''Vinum Sabbati'', the wine of the witch's sabbath (which isn't wine so much as a sort of horrifying [[FantasticDrug eldritch version of ecstasy]] that temporarily converts the taker into a HumanoidAbomination). Since [[PhlebotinumOverdose the prescribed dosage of antidepressant is several orders of magnitude larger (and much more frequent) than the amount of ''Vinum Sabbati'' offered at a Witch's Sabbath]], BodyHorror ensues, and the unfortunate victim is eventually [[ImMelting reduced to a permanent mucous stain]] [[AndIMustScream (but not actually killed)]].
** However, the miraculousness can be explained by the fact that the vignettes in story [[UnreliableNarrator are all lies]] (which doesn't necessarily mean ''Vinum Sabbati'' doesn't actually work that way, and [[SecretCircleOfSecrets the liar in question]] would definitely know if it did).


[[folder: Film ]]

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[[folder: Film Films -- Animated ]]

* In ''WesternAnimation/CloudyWithAChanceOfMeatballs'', Flint hooks up his machine to the town's power station to give it enough electricity to create food from water. Instead, the extra power makes the machine take off like a rocket and start orbiting in the lower stratosphere, creating food that comes down in showers using moisture from the clouds. Later, being [[PhlebotinumBreakdown overworked]] makes the machine start overmutating the food and it eventually [[InstantAIJustAddWater gains sentience]].

[[/folder]]

[[folder: Films -- Live-Action
]]



* In ''WesternAnimation/CloudyWithAChanceOfMeatballs'', Flint hooks up his machine to the town's power station to give it enough electricity to create food from water. Instead, the extra power makes the machine take off like a rocket and start orbiting in the lower stratosphere, creating food that comes down in showers using moisture from the clouds. Later, being [[PhlebotinumBreakdown overworked]] makes the machine start overmutating the food and it eventually [[InstantAIJustAddWater gains sentience]].

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