History Main / LongevityTreatment

* In ''Literature/{{Turnabout}}'' by Creator/MargaretPetersonHaddix, the government is working on a top-secret experiment in 2000 to reverse the aging process. It works -- the main characters, who were extremely elderly and would have died before long, are given the chance to grow young again. Unfortunately, they haven't figured out a working way to ''stop'' the un-aging. Within a few years, the subjects start to notice a few memory-related side effects...

* In Wil [=McCarthy=]'s ''The Queendom of Sol'' series, you can "print" a new body for yourself, and then have your mind transferred into it. In the golden years of the queendom, everyone travels ''everywhere'' by fax, and so has their body reset to a healthy 25 on pretty much a daily basis.

* In ''Turnabout'' by Creator/MargaretPetersonHaddix, the government is working on a top-secret experiment in 2000 to reverse the aging process. It works -- the main characters, who were extremely elderly and would have died before long, are given the chance to grow young again. Unfortunately, they haven't figured out a working way to ''stop'' the un-aging. Within a few years, the subjects start to notice a few memory-related side effects...

* ''Series/TheTwilightZone1959'': In the episode "[[Recap/TheTwilightZoneS3E96TheTradeIns The Trade-Ins]]", an elderly couple go to a clinic that can give them new, younger bodies. But, they only have enough money for one of them.

* [[GreenRocks Magma Energy]] in ''Anime/DarlingInTheFranxx'' acts like this when injected into humans, halting the aging process but coming with a veritable laundry list of side effects: the extraction process not only [[GreenAesop destroys soil fertility and causes rapid desertification]], but also attracts [[{{Kaiju}} Klaxosaurs]] because [[spoiler:Magma Energy is essentially the liquefied EnergyBeing form of the {{Precursors}} who made them]], which forced humanity to relocate into moving cities. The treatment [[ImmortalProcreationClause also renders the subject sterile]] and prevents them from piloting a [[HumongousMecha Franxx]], forcing the latter job to be done by vat-grown ChildSoldiers who did not undergo the treatment.

[[folder:Comic Books ]]
* ''Franchise/{{Batman}}'': The Lazarus Pits used by [[Characters/BatmanRasAlGhul Ra's Al Ghul]] rejuvenate him, allowing him to live for centuries. Various adaptations depict the process as having diminishing returns, putting more pressure on him to find a "worthy heir" before it stops working and/or he goes totally feral.
* In one ''Comicbook/TheAdventuresOfBarryWeenBoyGenius'' story, Barry remarks off-hand that he's been secretly sneaking supplements into his parents' food that will ensure they at least make it to 100.

* One ''ComicBook/{{Wolverine}}'' story involves him helping out a [[ContemporaryCaveman caveman]] who was one of three abducted and experimented on by a [[{{Ultraterrestrials}} Deviant]] scientist attempting to discover a way to extend Deviant lifespans. The process worked, but he never gets to see it as he dies when their civilization is destroyed just after he finishes the procedure. That was thousands of years before recorded human history and the caveman is visibly aged but still perfectly well.
* The non-canon "The End" story for the ''ComicBook/FantasticFour'' takes place in a distant future where Reed Richards' genius has [[AlternateUniverseReedRichardsIsAwesome finally ushered in a utopia]]. One of his inventions was the "Methuselah Treatment", which has extended everyone's life expectancy into centuries.

[[folder:Film ]]
* In ''Film/InTime'', the aging gene has been "shut down", freezing aging at 25. But to [[PopulationControl prevent overpopulation]] and present an {{anvilicious}} message about income disparity, people are programmed to die at a certain time and use their remaining time as currency.
* In ''Film/JupiterAscending'', "Recode" rejuvenates people when they bathe in it. Kalique Abrasax is 14,004 years old and her mother was starting her 91st millennium when she was murdered. [[spoiler:And it's [[HumanResources made from human cells]], harvested a planet at a time.]]
* Played with in ''Film/{{Selfless}}'', where a procedure allows you [[BrainUploading upload your consciousness]] into another body extending your life in some way.

[[folder:Literature ]]

* The ''Literature/RedMarsTrilogy'' features a specialized gene therapy referred to as a "gerontological treatment". The books span over two hundred years and most the major characters, many of whom were ''already'' in their 40s and 50s at the start of the series, are alive and active that entire time due to repeated use of the treatment. However, the treatment cannot overcome TheFogOfAges. [[spoiler:In the final book, a separate treatment is created for this, giving them nigh-eidetic memory. The increasing age of the characters leads to many dying of old age in their 200s despite the gerontological treatments]].
* In Creator/RobertAHeinlein's future history series, particularly ''Literature/MethuselahsChildren'' and ''Literature/TimeEnoughForLove'', humanity develops a form of rejuvenation through blood replacement after a group of naturally LongLived people reveal themselves and then hijack a starship when the rest of the species demand they reveal their "secret". Later more advanced methods including complete body replacement are developed.

* In Norman Spinrad's ''Literature/BugJackBarron'', an investigative reporter and consumer advocate begins investigating an organization that provides rejuvenation treatments to the rich and powerful, and finds far more than he bargained for.
* Creator/RogerZelazny:
** In ''Literature/LordOfLight'', the so-called "Gods" (actually mutant humans) have mind-transfer technology that they use to reward or punish people. Be good, and you may end up with a bright, shiny new young body. Be bad, and you may end up with the old, worn-out body left by someone who was good.
** In ''Literature/CreaturesOfLightAndDarkness'', the technologically advanced world of Blis has more-or-less eliminated death by old age. Death is so rare that the few who volunteer for suicide can leave their heirs a legacy by selling tickets to watch the death.
* In Creator/JohnScalzi's ''Literature/OldMansWar'', rejuvenation treatment via consciousness transfer to a genetically enhanced body is only available to military personnel -- and the minimum age for joining the military is 75.
* In Wil [=McCarthy=]'s ''The Queendom of Sol'' series, you can "print" a new body for yourself, and then have your mind transferred into it. In the golden years of the queendom, everyone travels ''everywhere'' by fax, and so has their body reset to a healthy 25 on pretty much a daily basis.
* Creator/LarryNiven's stories:
** In the ''Literature/KnownSpace'' setting, Boosterspice (a drug derived from genetically engineered ragweed) can tremendously extend the human lifespan.
** ''Literature/{{Ringworld}}''. There is an equivalent to boosterspice available on the title space construct.
** ''Literature/AWorldOutOfTime'' has an immortality treatment for adults that involves removing impurities from the body.
* The ''Literature/HonorHarrington'' universe includes a set of treatments called "prolong," which are ExactlyWhatItSaysOnTheTin. Once you're past a certain age prolong doesn't work, so most people who get it, get it young. How long it extends the human lifespan isn't clear, but with advanced prolong, it seems that humans adopted by treecats can live as long as their furry partners do, which is around 200 years. Honor's mother, Allison, is 90 years old at the time of the main series, and she's still very attractive and capable of bearing children. And since Honor received a more advanced version of the treatment, she's likely to live even longer. Also, people not only look very young for decades, they also have the hormonal levels corresponding with the apparent age ''for decades''. [[note]]Not always a positive thing -- it also means the physical disruptions of puberty are also extended, and a person old enough to be a midshipman looks like a pre-teen.[[/note]] In the later books, prolong becomes a key indicator of how socially and economically evolved a planet is: if you look old, it likely means you're poor. When the [[spoiler:Star Empire of Manticore]] is created, receiving prolong is made a fundamental, inalienable right of every citizen.
* Citizens of ''Literature/TheCulture'' are genetically engineered to live for centuries, longer if they feel like it.
* In John Norman's ''Literature/{{Gor}}'' novels, the Caste of Physicians developed a treatment called the Stabilization Serums, which allowed the recipient to live for hundreds of years.[[note]]In 'Marauders of Gor', Tarl meets someone who is almost certainly the legendary founder of Torvaldsland, which would make him about 1000 years old.[[/note]] The Priest-Kings, the {{Physical God}}s of the setting, have a similar treatment, the oldest being about 5,000,000 years old.
* In the final part of ''Literature/TheManWhoAwoke'' scientists have perfected the treatment to restore a person to youth, with the result that humanity effectively becomes immortal.
* In ''Turnabout'' by Creator/MargaretPetersonHaddix, the government is working on a top-secret experiment in 2000 to reverse the aging process. And it works -- the main characters, who were extremely elderly and would have died before long, are given the chance to grow young again. Unfortunately, they haven't figured out a working way to ''stop'' the un-aging. Within a few years, the subjects start to notice a few memory-related side effects...
* In Creator/VernorVinge's ''Literature/RainbowsEnd'': the Venn-Kurasawa treatments. They only work for one in a thousand, but for those they do work for, they can restore the appearance of youth, and add many years of actual lifespan. Robert Gu is one of the lucky few who respond to the treatments.
* Poulsen treatments in the ''Literature/HyperionCantos'' series. It will extend one's life to a few centuries -- one person lived to close to a thousand years, although it also included a lot of time as a HumanPopsicle. However, after a few times, the skin starts literally glowing blue, and it is of limited use on old people. [[ArtificialHuman Androids]] are built with the process being constant in their bodies, and can live for six or more centuries without visible signs of aging.
* The same name was later used in Creator/RobertReed's novel, ''Literature/TheRemarkables''. It can greatly expand one's life (beyond the already genetically enhanced ~150 year lifespan), though the treatment leaves visible marks -- one of the characters who has had extensive treatments has an almost young face, but wrinkled hands and oddly colored skin.
* In the ''Literature/ChildrenOfSteel'' series it's mentioned that humans can take life extension treatments that make the age of some of the executives hard to discern. There's no indication whether it's possible to use those on [[ArtificialAnimalPeople animorphs]].
* In Creator/MikhailAkhmanov and Christopher Nicholas Gilmore's ''Literature/CaptainFrenchOrTheQuestForParadise'', the Cellular Regeneration treatment available on most worlds has, effectively, [[WeWillHavePerfectHealthInTheFuture turned humanity into]] TheAgeless. People choose when to "freeze" their age with most picking [[ImmortalityBeginsAtTwenty sometime in their 20s]], although some wait until 30 in order to look "more mature". The only people who die of old age are either criminals on worlds where capital crime is punished by aging (reversing the treatment) and on recently-settled worlds where CR machines have not yet been set up. It's mentioned by the titular protagonist that, even before CR, various treatments (including [[CloningBodyParts cloned organs]] and blood vessel cleansing) have extended expected lifespans to centuries.

* In Creator/StephenBaxter's ''Literature/XeeleeSequence'' novels, humanity invents Anti-Senescence technology which repairs genetic damage due to age via nanobots. The treatment has a 99% success rate, though treatment failures typically end with a terminal illness. Lifespan with AS treatments theoretically has no upper limit, though in practice the treatments begin to break down at 400-500 years; in the novella ''Mayflower II'', after 40,000 years of flight the captain of a GenerationShip is little more than a BrainInAJar, with his desiccated body permanently wired into a life support chair.
* In ''Literature/ThisImmortal'', there is the so-called S-S treatment that's never specified but is said to be able to prolong a human's lifespan to 150 years and above.
* The setting of ''Literature/ThePrincesOfTheAir'' has a longevity treatment which is only available to the rich and powerful. When we first meet the protagonist, he's running a con where the bait is illicit access to the longevity treatment.
* In ''Literature/{{Neogicia}}'', this is one of the applications of the Empire's BioAugmentation technology. The ruling family keeps it mostly for itself. A character suspects they do this because too many people with access to this treatment may cause the ImmortalProcreationClause to kick in and it may not make everyone happy.
* In Creator/DavidDrake's ''Literature/RanksOfBronze'' the alien trade guild that purchases [[LostRomanLegion Crassus' legions]] as slave-warriors give them longevity treatments to keep them fighting for roughly two thousand years.
* The {{Dystopia}}n setting for ''Literature/TheDeclaration'' by Gemma Malley has the "Longevity" treatment, which starts at 16 years old when the user signs the titular Declaration in exchange for a regular supply of pills and renouncing to ever have children (to avoid overpopulation). Not only the second volume reveals it needs [[PoweredByAForsakenChild fetal cells]], the formula is ''incomplete'', as shown in the third volume when people go senile and suddenly die because their treatment doesn't work anymore.

* ''Literature/LilithsBrood'': The Oankali alien species can extend human lifetimes to several centuries through their powers of {{Biomanipulation}}. It's less effective the older the human is when they receive the treatment, but, as of the second book, the [[OurHumansAreDifferent entire human species]] has it.
* ''Literature/TheSpeedOfDark'' has [=LifeTime=], an expensive new brain therapy. Some of the autistics demand it if they go through with the [[ThrowingOffTheDisability cure]], but they don't get it.
* ''Literature/AfterTheRevolution'' has the [=JuvEn=] treatment, a relatively cheap treatment available in most of the world, which suppresses most visible signs of ageing. As a result of [=JuvEn=]'s ubiquity, the POV characters always expresses surprise whenever they encounter a person who actually looks old.
* The ''Literature/WellWorld'' series by Creator/JackChalker includes "rejuvenation," usually called "rejuve", which seems to take about fifty or sixty years off the recipient's physical age. Not everyone can tolerate the rejuve treatment, and no one can take an infinite number of rejuves.

[[folder:Live-Action TV ]]

* ''Series/StargateSG1'', several examples, all with severe side effects:
** The sarcophagus can extend the life of a human without a [[PuppeteerParasite Goa'uld]] for 700 years or so, and a human that is a host to Goa'uld for millennia. Unfortunately it makes the user megalomaniacal. [[ImmortalityImmorality Because reasons]].
*** A later episode eventually reveals that even a sarcophagus has its limits for a Goa'uld symbiote. Lord Yu is, apparently, one of the oldest symbiotes in existence. He spends most of his time in a sarcophagus, but still has fits of senility (such as ordering his fleet to a system half a galaxy away in order to fight a battle that was already fought years ago). His First Prime knows all this and covers it up, loyally following his master's orders even if they are the result of his senility.
** In the episode "[[Recap/StargateSG1S4E162010 2010]]", the Aschen give earth a life-extension drug that serves to explain why SG-1 hadn't aged at all in ten years. It also turned out to cause sterility, as part of an Aschen plot to depopulate earth so they could turn it into an agricultural colony, necessitating TimeTravel to prevent the earth-Aschen alliance.
* A less sci-fi example in ''Series/{{Torchwood}}'' with Angelo Colasanto. After witnessing Jack's immortality in 1927, he starts researching ways of prolonging his life, which appear to be grounded in RealLife techniques (e.g. going vegetarian, slowing down one's metabolism), and manages to live until 2011.
* ''Series/StarTrekDeepSpaceNine'': {{Parodied|Trope}} in the episode "[[Recap/StarTrekDeepSpaceNineS05E25InTheCards In The Cards]]". Dr. Giger believes that people die because their cells get bored of doing the same thing day in and day out, literally boring them to death. His invention intends to provide stimulating entertainment to the user's cells to entice them into immortality. After listening to this spiel, the protagonists decide that -- even given the miraculous science of the ''Franchise/StarTrek'' universe -- this guy's a loon.
* In the ''Series/RedDwarf'' episode "[[Recap/RedDwarfSeasonXLemons Lemons]]", the guys find a Rejuvenation Shower that's supposed to turn old people young again and was common enough to be sold in [=IKEA=]. But the Dwarfers end up putting it together wrong and it becomes a time machine.

[[folder:Tabletop Games ]]

* ''TabletopGame/BluePlanet'': One of the more famous applications of Xenosilicates is reversing the aging process, hence the common nickname Longevity Ore or "Long John."
* Anagathic drugs in ''TabletopGame/{{Traveller}}'' allow characters to extend their lifespan but are frequently banned or controlled, and extremely expensive. Require monthly doses or the character is forced to make an aging roll. Worse, GoingColdTurkey can cause serious RapidAging issues as well.
* A couple of nanosymbionts in ''TabletopGame/{{GURPS}} -- TabletopGame/TranshumanSpace'' extend life expectancy by 10 years and expensive "rejuvenation" treatments can actually reverse the aging process.
* The {{Space Marine}}s' biological enhancements in ''TabletopGame/Warhammer40000'' setting allow them to live a millennium or more. Unenhanced human nobles and dignitaries have "rejuvenat" or simply "juveant" treatments, enabling them to live several centuries longer than ordinary humans. Some sources imply that certain variants of these procedures use raw materials [[PoweredByAForsakenChild from living children]].
* The CCG ''TabletopGame/{{Illuminati}}'' has the [[http://media.adamdodson.org/index.php/Illuminati-Card-Game/immortality-serum "immortality serum" card]] that makes a personality indestructible and can also cause an opponent's personality to defect.

* ''TabletopGame/{{Shadowrun}}'' features a number of age rejuvenation treatments. Leonization, the most expensive, restores physical age to approximately 21, a life span extension is a one-time procedure that adds 10 years to your life, while physical vigor simply counters the physical side effects of aging.
* Longevity treatments exist in the ''TabletopGame/MutantChronicles'' setting, but between the astronomic expense, the invasive surgery and the extremely strict regimen of diet and exercise required for the treatment to be effective, very few people bother.

[[folder:Video Games ]]
* ''VideoGame/{{Cyberpunk 2077}}'': Used to explain how a number of characters from the original 2013/2020-timeframe are still around. It's also very well done in that characters' respective wealth, and accompanying access to treatment, is shown in their appearance; Saburo Arasaka, owner of most of the Pacific Rim and most powerful man in the world, is 156, but looks like an active and healthy 70 (and somehow managed to recover from a crippling stroke). In contrast, Nancy (a successful music journalist), is in her early 90s but looks like a worn 55-year-old.
** Averted in the case of Santiago Aldecaldo; the devs couldn't find a reasonable excuse for a mercenary and smuggler to be able to afford longevity treatment, so he was replaced with an expy and quietly mentioned to have died of old age during the TimeSkip.
* In the ''VideoGame/{{Fallout}}'' series, radiation under very specific conditions[[note]]by and large this seems to be long-term exposure to high levels of background radiation[[/note]] can render a person effectively immortal, turning them into a '[[OurGhoulsAreCreepier ghoul]]'. Ghouls [[TheAgeless do not age]] and even [[RadiationImmuneMutants heal from radiation]], but [[BodyHorror lose most of their skin and hair as it flakes off in big chunks]], suffer the long term effects of age leading to severe cataracts and arthritis, and become infertile. However, those exposed to too much radiation during ghoulification -- but not enough to outright kill them -- lose their mind and become 'feral', essentially mindless zombies. Ghouls who receive even more radiation can become Glowing Ones, ghouls that have a SicklyGreenGlow and can erupt in a burst of radiation to harm and heal. While most Glowing One ghouls are feral, one Jason [[MeaningfulName Bright]] is a Glowing One who hasn't become feral and leads a cult in a rocket facility in [[VideoGame/FalloutNewVegas Henderson]]. In ''VideoGame/Fallout4'', Eddie Winters, a Pre-War crime lord, underwent an experimental radiation regime months before the Great War. He's still kicking 220 years later. Other people got ghoulified the hard way -- gamma radiation from nuclear bombs.
** The [[SuperSoldier Super Mutants]] altered by the Forced Evolution Virus in ''VideoGame/Fallout1'' are still around and at full fighting strength over a century later. Super Mutant bodies have increased healing, durability, and strength, but are infertile due to said healing[[note]]as Marcus says, it takes a few years to "get the juices flowing", so it doesn't mean they are castrated[[/note]] and lack secondary sexual characteristics. Of course, becoming a Super Mutant isn't easy, painless, or safe. It involves being dipped in a massive vat of FEV or having direct injections to force the change and only humans from Vaults have the minimum damage to their DNA to allow themselves to keep their intelligence afterwards before long-term Stealth Boy usage rots their minds. The East Coast Mutants in the [[VideoGame/Fallout3 Capital]] and [[VideoGame/Fallout4 Boston]] Wastelands are the result of leftover FEV found in Vault 87 in the former and used by the Institute in the latter.

* In ''VideoGame/MoonChronicles'' an alien installation is discovered on the moon. Further investigation shows that the aliens have been [[HumanResources harvesting humans]] for centuries in order to make a substance that restores health and prolongs life.
* The ''Ideology'' [=DLC=] from ''VideoGame/RimWorld'' has the biosculpter pod, which does wonderful things such as healing injuries and diseases, granting pleasure buffs, and the most significant feature: reversing the age of colonists. It requires a few amount of nutrients to have it work and once a colonist is inside a pod, the cycle process can range from a few days to a whole week depending on the treatment. The pod is especially important for those whose ideoligion is centered towards transhumanism as [[ImmortalitySeeker they seek to stay young and essentially become biologically immortal]], though it can be built by anyone without transhumanist beliefs. Unfortunately, the pod cannot treat certain diseases such as dementia/Alzheimer's or restore missing body parts, so unless you have access to the [[TooAwesomeToUse extraordinarily rare healer mech serum]], you're out of luck.
* In ''VideoGame/ScarletNexus'' all members of the [[CreatureHunterOrganization Other Suppression Force]] (OSF) receive a special drug that slows their aging. Precise extent of the drug's efficiency seems to vary from person to person, and may leave the recipient looking anywhere from ten to thirty years old. However, after about 40 years of usage the drug stops being effective, and the person starts to age again, at which point they usually [[RetiredBadass retire]].

* ''VideoGame/TheSims 2'' features a carnivorous plant (the cowplant) that produces a substance that, when drunk, gives a Sim an extra day of life.
** ''VideoGame/TheSims3'' has a plant called '''life fruit''', which expand at least one day of a sim's life. Said fruit is a critical ingredient in the Ambrosia recipe that resets a Sim to the start of their current life stage.

* ''VideoGame/{{Stellaris}}'' has a variety of technologies that add extra years to your Leaders' life expectancies, it's also possible to use [[LegoGenetics gene tailoring]] to add the [[LongLived Enduring (+20 years) or Venerable (+80)]] traits to one or more of your species.
** There's also an event where [[ShoutOut you find a]] [[Film/TheFountain tree floating in space]] with sap that can extend your leaders' lifespans, or be distributed to the whole population for a boost in morale.
** It's also possible for certain leaders to become {{immortal|ity}} through events or other special conditions.

[[folder:Webcomics ]]

** A plot point in ''Webcomic/SchlockMercenary'' is "Project Laz'r'us," which was intended to circumvent humanity's [[WeAreAsMayflies short lifespans]] in comparison to many other sophonts using hyper-advanced {{nano|machines}}technology. The nannies are also capable of repairing a clinically dead host and even making internal backups of the brain.

* In the future of ''Webcomic/{{SSDD}}'', the wealthy are able to afford implants that extend lifespans until an accident kills them. At least two of [[MegaCorp Maytec's]] board of directors are in their fifties and appear to be twenty.
* In ''Webcomic/{{Freefall}}'', life extension drugs are apparently available over the counter. At one point, Florence (an [[UpliftedAnimal uplifted]] red wolf) states that her projected lifespan of 160 years is slightly shorter than that of a human.
* In ''Webcomic/EscapeFromTerra'', rejuvenation treatments are one of many examples of bio- and nanotechnology that are officially banned on Earth. Reggie King and Babbette the elder undergo the treatment on Mars, and the first man on Mars is a great-great-great-grandfather who looks no older than 30.
* In ''Webcomic/QuantumVibe'', rejuvenation treatments are even more readily available. One of the main characters is reportedly in his third century, but there's evidence that he's ''[[ReallySevenHundredYearsOld over 500 years old]]''.
* ''Webcomic/TheDragonDoctors'': The effects of a FountainOfYouth were reverse-engineered about a century earlier. The Fountain itself is a deadly lake that regresses everything to nothing within its radius, but learning its magic has allowed other characters to get regular rejuvenation treatments. In Mori's backstory it is shown that she helped discover it and was rather old before someone tried to kill her by dunking her head in the lake, whereupon she went from about 60 to 20. She also adopted the sole survivor of the previous team to the area who had been regressed to a baby.
* In ''Webcomic/GenocideMan'', the titular Genocide Men had a variety of procedures done that allowed them to continue operating well into their 90s or 100s -- artificial glands to stabilize hormones, nanotube-laced skeletons to prevent broken bones, and telomerase to prevent cancer. The former two sets of augmentations have [[SuperSoldier other bonuses]] as well. Jacob is 98, but thanks to his mods he is still one of the deadliest men in the world.

[[folder:Web Original ]]
* In ''Website/OrionsArm'' most [[HumanSubspecies nearbaselines]] are genetically engineered to live about 500 years. But due to medical {{nano|machines}}technology and BrainUploading, most in the Sephirotic Empires live to 3,000 before succumbing to ennui or [[AscendToAHigherPlaneOfExistence transcending]].

* One of the very rare dungeon lot drops in ''Literature/TheDailyGrind'' can add months to your total lifespan.

[[folder:Western Animation ]]

* ''Franchise/{{Batman}}'': The Lazarus Pits used by [[Characters/BatmanRasAlGhul Ra's Al Ghul]] rejuvenate him every century or so. Various adaptations depict the process as having diminishing returns, putting more pressure on him to find a "worthy heir" before it stops working and/or he goes totally feral.

* ''VideoGame/{{Cyberpunk 2077}}'': Used to explain how a number of characters from the original 2013/2020-timeframe are still around. It's also very well done in that characters' respective wealth, and accompanying access to treatment, is shown in their appearance; Saburo Arasaka, owner of most of the Pacific Rim and most powerful man in the world, is 156, but looks like an active and healthy 70 (and somehow managed to recover from a crippling stroke). In contrast, Nancy (a successful music journalist), is in her early 90s but looks like a worn 55-year-old.
** Averted in the case of Santiago Aldecaldo; the devs couldn't find a reasonable excuse for a mercenary and smuggler to be able to afford longevity treatment, so he was replaced with an expy and quietly mentioned to have died of old age during the TimeSkip.

* In ''WebOriginal/OrionsArm'' most [[HumanSubspecies nearbaselines]] are genetically engineered to live about 500 years. But due to medical {{nano|machines}}technology and BrainUploading, most in the Sephirotic Empires live to 3,000 before succumbing to ennui or [[AscendToAHigherPlaneOfExistence transcending]].