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* Luis reveals that Ashley and Leon are infected with Las Plagas immediately after the cabin fight, rather than in the castle in the original. He also establishes communications with them via Leon's earpiece.

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* Luis reveals confirms that Ashley and Leon are infected with Las Plagas immediately after the cabin fight, rather than in the castle in the original. He also establishes communications with them via Leon's earpiece.



* Ashley's first separation from Leon in the original was running in fear of her Plagas infection, only to run into a rather obvious trap that captures her. In the remake, Ashley became possessed due to Saddler's influence with her Plagas infection, causing her to separate herself from Leon. Despite regaining her composure, she flees in fear of harming Leon, locking herself in a room, though not trapped by any of Salazar's machinations.

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* Ashley's first separation from Leon in the original was running in fear of her Plagas infection, only to run into a rather obvious trap that captures her. In the remake, Ashley became possessed due to Saddler's influence with her Plagas infection, causing her to separate pull herself away from Leon. Despite regaining her composure, she flees in shame and fear of harming Leon, locking herself in a room, though not trapped by any of Salazar's machinations.



* In the original, Ada barely even acknowledges Ashley's existence and the only time they interact is when she distracts Saddler to aid her escape. Here, Ada and Leon now have a conversation where Ada advises him to just ditch Ashley on account of her infection. Ashley herself now acknowledges Ada's presence and wonders if Leon knows more about her than he lets on.

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* In the original, Ada barely even acknowledges Ashley's existence and the only time they interact are even in the same room is near the end when she distracts Saddler to aid her escape.while Leon rescues her. Here, Ada and Leon now have a conversation where Ada advises him to just ditch Ashley on account of her infection. Ashley herself now acknowledges Ada's presence and wonders if will also talk to Ada briefly right before the latter tosses Leon knows more about her than he lets on.
the rocket launcher needed to defeat Saddler.
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* For the island's [[spoiler:self-destruction sequence, it was originally triggered by Ada after she takes the Plaga sample from Leon and boards her helicopter. In the remake, Ada does not trigger the self-destruction, and the island simply starts blowing up momentarily after Leon kills Saddler. ''Separate Ways'' reveals that Ada rigged the self destruct sequence to start before the fight with Salazar.]]

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* For the island's [[spoiler:self-destruction sequence, it was originally triggered by Ada after she takes the Plaga sample from Leon and boards her helicopter. In the remake, Ada does not trigger the self-destruction, and the island simply starts blowing up momentarily after Leon kills Saddler. ''Separate Ways'' Ways'', however, reveals that Ada rigged ''did'' trigger the self destruct sequence to start self-destruct sequence, albeit via hacking under Wesker's orders and right before the fight with Salazar.Saddler.]]

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* Leon was trapped in a cage shortly after entering the dining room, and fought a ZergRush of zealots and a Garrador. Here, the entire sequence is in a cut scene, with fewer zealots and no Garrador.



* Wesker no longer explicitly orders Ada to kill Leon if she encounters him, forcing her to avoid him as much as possible. Instead, Ada insists on letting Leon live so he can continue decimating Los Iluminados, which Wesker grudgingly agrees to.


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* Ada now starts her campaign in the castle, and doesn't enter the village until Leon has left it.


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* Wesker no longer explicitly orders Ada to kill Leon if she encounters him, forcing her to avoid him as much as possible. Instead, Ada insists on letting Leon live so he can continue decimating Los Iluminados, which Wesker grudgingly agrees to.
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* Ada does not get to fight Krauser in this one. In fact even in this DLC, they never interact either mainly because he doesn't work for Wesker this time.
* A new monster is introduced in Ada's campaign, [[spoiler:Martinico]] on the island. [[spoiler:Martinico helps serve two purpose for Ada's story, one is to show what exactly the "Amber" can do to enhance the Las Plagas power, and second to put additional context to the laser hallway on the island, which has been given an additional purpose as a security measure to prevent Martinico from breaking out.]]

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* Ada does not get to fight Krauser in this one. In fact even in this DLC, fact, they never interact either even interact, mainly because he doesn't work for Wesker this time.
* A new monster is introduced in Ada's campaign, [[spoiler:Martinico]] on the island. [[spoiler:Martinico helps serve two purpose purposes for Ada's story, one is to show what exactly the "Amber" can do to enhance the Las Plagas power, and second to put additional context to the laser hallway on the island, which has been given an additional purpose as a security measure to prevent Martinico from breaking out.]]

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* Leon's first interaction with Hunnigan in the original game is the first time they talked, introducing themselves cordially. In the remake, their first interaction suggests that Leon had already met Hunnigan prior to this mission.

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* Leon's first interaction call with Hunnigan in the original game is the first time they talked, introducing themselves cordially. In the remake, their first interaction call suggests that Leon had already met Hunnigan prior to this mission. It also happens in the lodge, as opposed to on the trail leading to the village.



* The first Ganado Leon runs into is seemingly killed then and there, but comes back later to attack Leon and Luis when they are tied up together. In the remake, he is killed in a cutscene, but reanimates offscreen and attacks Leon again, but this time with the Plagas operating his central nervous system (showing off the new ability they have) in the basement of the house you met him in.




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* The Commilos now are introduced much sooner, as a pack of them is released into the village on your second trek through it. This can actually even be prevented if you kill the Ganado before he releases them. Originally they first showed up after the battle with the Del Lago.
* Leon will now immediately check the church door as soon as he approaches it, whereas before he could try and walk by the building, only to get a scolding call from Hunnigan.


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!!! Chapter 4
* El Gigante was first brought out by a group of Ganados who quickly lose control of it and are promptly massacred before Leon's fight with the creature. Here, it is summoned by a red robed Zealot, making their first appearance much earlier in the game. Also, this time instead of the dog just disappearing as soon as the fight ends, it can be found relaxing off to the side of the entrance of the area.
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* The boulder running quick time event portion of the area is replaced by Ganado blowing up a trap and causing a rock slide. Leon can avoid it with a button prompt or simply walk away from it when it detonates.

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* The boulder running quick time event portion of the area is replaced by Ganado Ganados blowing up a trap and causing a rock slide. Leon can avoid it with a button prompt or simply walk away from it when it detonates.



** In ''Separate Ways'', it turns out that Ada fights the El Gigante that would have been encountered in the two route.

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** In ''Separate Ways'', it turns out that Ada fights the El Gigante that would have been encountered in the two second route.



* Salazar, while still short, now has a more appropriate appearance in the remake of a severely-aged man despite being noted to still be young, compared to the original where he looked like a child.

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* Salazar, while still short, now has a more appropriate appearance in the remake of a severely-aged man despite being noted to still be young, compared to the original where he looked like a child. He is also dressed more like he's from the late 17th century, rather than the late 18th century.



* The section between Ashley and Leon's first separation and their first reunion (consisting of Novistador waterway, dozens of castle rooms, fights with the red "Leader" Zealots, hedge maze, a meeting with Ada, Ashley's rescue and Ashley's NoGearLevel) is reworked into a detour through the Wine Cellar and Castle Battlements. Ada's meeting and a fight with a red Zealot are retained, while the hedge maze now occurs right after Ashley reunites with Leon.

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* The section between Ashley and Leon's first separation and their first reunion (consisting of the Novistador waterway, filled sewers, dozens of castle rooms, fights with the red "Leader" Zealots, the hedge maze, a meeting with Ada, Ashley's rescue and Ashley's NoGearLevel) is reworked into a detour through the Wine Cellar and Castle Battlements. Ada's meeting and a fight with a red Zealot are retained, while the hedge maze now occurs right after Ashley reunites with Leon.



* In the original, Ada barely even acknowledges Ashley's existence and the only time they interact is when she distracts Saddler to aid her escape. Here, Ada and Leon now have a conversation where Ada advises him to just ditch Ashley on account of her infestation. Ashley herself now acknowledges Ada's presence and wonders if Leon knows more about her than he lets on.

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* In the original, Ada barely even acknowledges Ashley's existence and the only time they interact is when she distracts Saddler to aid her escape. Here, Ada and Leon now have a conversation where Ada advises him to just ditch Ashley on account of her infestation.infection. Ashley herself now acknowledges Ada's presence and wonders if Leon knows more about her than he lets on.



* Novistadors now are not met until just before the ballroom (roughly equivalent to the Novistador hive from the original). Their first encounter in the original, the Novistador waterway, is transplanted to the ''Separate Ways'' campaign. The Novistador hive itself is also not seen in the Castle proper, and instead becomes a part of the mines.

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* Novistadors now are not met until just before the ballroom (roughly equivalent to the Novistador hive from the original). Their first encounter in the original, the Novistador waterway, castle sewers, is transplanted to the ''Separate Ways'' campaign. The Novistador hive itself is also not seen in the Castle proper, and instead becomes a part of the mines.
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* Rather than being abducted by a Novistador in the Novistador hive, Ashley is abducted by a zealot in the Grand Hall after her NoGearLevel.

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* Rather than being abducted by a Novistador in the Novistador hive, Ashley is abducted by a zealot the Verdego in the Grand Hall after her NoGearLevel.

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** Instead of the two of them, it is Ada who rides the gondola in ''Separate Ways'' but this section is at the Island, not the Village area.



* Prior to getting trapped, Leon and Ashley had to get heads of a snake, lion and goat and fit them on the Chimera statue which said trap was then triggered by a Zealot, trapping Leon. These 3 heads are nods to the lion, snake and goat ornaments which were brought earlier from the fight against Krauser in the original on the island to the castle here in the Remake.

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* Prior to getting trapped, Leon and Ashley had to get the heads of a snake, lion and goat and fit them on the Chimera statue which said trap was then triggered by a Zealot, trapping Leon. These 3 heads are nods to the lion, snake and goat ornaments which were brought earlier which, after setting the ornaments, Ashley gets trapped not long after running away from the fight against Krauser Leon in the original on the island to the castle here in the Remake.
[=RE4=].
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to:

* Prior to getting trapped, Leon and Ashley had to get heads of a snake, lion and goat and fit them on the Chimera statue which said trap was then triggered by a Zealot, trapping Leon. These 3 heads are nods to the lion, snake and goat ornaments which were brought earlier from the fight against Krauser in the original on the island to the castle here in the Remake.
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* Leon loses his weapons and gear when he is first captured, along with his jacket. He is able to recover his weapons fairly quickly, but the jacket is still lost for the duration of the first playthrough. (It is later unlocked for use throughout the entire game after the first playthrough is completed.) Originally, they left him with all his weapons and only took his jacket.

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* Leon loses his weapons and gear when he is first captured, along with his jacket. He is able to recover his weapons fairly quickly, but the jacket is still lost for the duration of the first playthrough. (It is later unlocked for use throughout the entire game after the first playthrough is completed.) Originally, they left him with all his weapons and only took his jacket. \n Hilariously, ''Separate Ways'' reveals that the jacket was taken by a random Ganado in the abandoned factory, and retrieving it is a merchant request.

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