in tales of the abyss, when the game kept trying to get laughs out of guys gynophobia, even after its been revealed to the party and the player that it originated from a serious trauma
that...really shouldnt be trivialized for the sake of cheap laughs. also i think once or twice the group rubs luke's ignorance in his face long after his pointing out he's spent the 7 years he's effectively had to live trying to learn the faces of the people he was supposed to know.
not a personal experience, since i havent finished legendia yet, but a friend of mine once told me she found maurits being so easily forgiven kind of sickening. she didnt tell me what he did though...
oh and during arkham city, batman's..less than patient interactions with mr freeze.
Pro Tip: Spiders are not technically insects, but actually skeletons made of congealed hate.