These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Harsher in Hindsight: The novel as a whole, given the recent #Yes All Women tag on Twitter, and the discussion about how women have to put in a lot of effort to avoid rape.
Laurie Halse Anderson has blogged about real-life teen rape incidences that have ample Karma Houdini and make you lament humanity.
Implied Love Interest: Very, very vaguely implied with David, Melinda's lab partner and one of her only true friends. It's more prominent in the book, with a few cute moments on Valentine's Day and mention that David watches her when he thinks she doesn't notice. For rather understandable reasons, though, it never really goes anywhere.
She Really Can Act: Kristen Stewart, since this was her first film role before Twilight. Stewart in an interview mentioned that she had trouble finding roles as a child actor because she's serious, and kids have to be funny on television.
They Just Dont Get It: Most of the male readers of Speak. Laurie Halse Anderson in the Tenth Anniversary edition remarks on how a shocking amount of these readers didn't see why Melinda was so upset, or what Andy had done wrong. These letters inspired her to write a later book Twisted, from a teenage boy's point of view when he is accused of rape, though in that case he was innocent.