These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
It gets worse: throughout the ordeal, she's desperately trying to send messages to him explaining what's happening, but he's so single-mindedly fixated on destroying the Dolem that he fails to notice, all the time believing that he's protecting her.
Hilarious in Hindsight: Ayato's claim in the first episode that he's "not interested in older women" is much more amusing on the second viewing.
There's much, much more, actually. This anime thrives on making small conversations much more interesting with a second viewing. For example, when Ayato first visits Itsuki's place, Itsuki mentions that he should be like visiting a relatives house. Ayato replies that he's never done that. The irony in this is that unknown to Ayato Itsuki is Ayato's clone and Quon is their biological mother.