These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Squick: Possibly the greatest concentration of squick in the history of cinema.
Tear Jerker: Yes, of all films! Admittedly, Divine's reaction to seeing her trailer, her home, burning, was quite the whiplash. She dropped to her knees, crying uncontrollably. Even in a World of Ham movie like this, the way she acted was still pretty damn convincing. Worse, after they vowed that the criminals will not make it out alive and leave, the scene ends with the shot of the trailer collapsing, literally burning down to the ground.
Values Dissonance: The Marbles are guilty of much evil, but many modern viewers probably aren't bothered that they adopt out babies to lesbian couples.
Seeing that the adoptive lesbians parents seem to be the most decent and grounded characters in the film, Waters may have been making a point about how ridiculous it would be to consider them inappropriate parents.
The lesbian aspect of the adoption ring ties into the overall nightmare fuel aspect of it: imagine being kidnapped, raped until you get pregnant, held in a pit for nine months and fed a diet of tranquilizers to keep you quiet, then to have the delivery of said baby purposely blotched to cause you die after the kid is born. And that said kid doesn't go to some wealthy couple, but to a homosexual couple. The only thing keeping it from going full tilt towards unfortunate implications is that A. The lesbian couple are probably the only decent folks in the film and B. The fact that the gay clients of the Marbles are purposely kept in the dark about exactly HOW the Marbles procure the infants they adopt.