YMMV: Dr. Mario
- Ear Worm: "Fever" and "Chill" by Hirokazu Tanaka. And from one of the commercials, "Call the doctor, Mario, ohh-oh."
- Nightmare Fuel: As usual, here we have the Game Over music. It starts off in a chilling way and then it doesn't get better, either. It's chilling. "Chill," too.
- Nintendo Hard: Once you reach the later levels, it can be hell trying to organize pills with over half the screen being filled with viruses. Good luck trying to beat the last two levels, where you have exactly three height spaces to work with.
- Suspiciously Similar Song: "Fever" for "Lady Madonna" by The Beatles. And the main title theme for "Sherry" by Frankie Valli And The Four Seasons.
- Ugly Cute: The viruses.
- Uncanny Valley: Many fans are creeped out by Dr. Mario and Dr. Luigi's Thousand-Yard Stare in Miracle Cure