Anvilicious: There is nothing in the world more anvilicious than this special, except possibly flashing "DRUGS ARE BAD FOR YOU" for half an hour (which might be just as entertaining in a weird way, if not more so). It actually tries to drop multiple anvils at once: the anti-drug one, the one about talking to others if you know someone's on drugs and/or committing crimes because of drugs, and one for the parents about watching your children like hawks for any sign of deviance. While the third is pretty groan-inducing as well, the Corey subplot actually makes the good point that confronting problems like this directly is the best way to keep a family unit healthy, so this one usually gets the fewest complaints.
Ear Worm: "Wonderful Ways to Say No", oddly enough.
Michelangelo of the Teenage Mutant Ninja Turtles chastises Mikey for trying to get his wallet after it's stolen. Bear in mind that not 5 minutes ago, Mikey was chastised for stealing a piggy bank. Stealing is bad, getting your stolen things back is also bad? It could be Hand Waved as Michelangelo getting Mikey to focus on one thing at a time, because as we all know, drugs are more important than money.
John Oliver played a portion of Cartoon All-Stars to the Rescue (as a depiction of how much of an Anti-Drug fervor we were in the 80s and 90s) before mentioning this Family-Unfriendly Aesop:
John Oliver: [Cartoon All-Stars to the Rescue] had a clear message to kids: "If you do drugs, all your favorite cartoon characters will show up and talk to you. Is that what you want? Is that what you want?"
Mark Gordon Legan: As our movie starts, a pot crazed brother is stealing from his cute, Aryan-looking sister.
What Do You Mean, It Wasn't Made on Drugs?: Considering the intent of the special, that's a stupid question to ask. Then again, if you look at it with a cynical eye, then it does feel like someone had to have been on drugs to come up with something this batshit insane. Simon from Alvin and the Chipmunks explaining what marijuana on its own is a little mind-bending.