Executive Meddling: Valerie owes her entire existence to this. As the comic was about to be retooled into one about a traveling band, Pepper was dropped from the comic at the request of higher-ups due to being too similar to student protesters and activists at the time. Valerie was then introduced, and the rest is history.
Archie Comics knew a good setup when they had one. A story about a redheaded hero being fought over by a blonde and a brunette, while having a brunette rival and a quirky, dark-haired best friend.
The comic itself underwent many retools in response to pop-culture trends. In 1968, due to the popularity of Laugh In, the comic became a Laugh-In clone, even using catchphrases directly borrowed from the show.
Cowboy BeBop at His Computer: Some references have "The Nemo's A No-No Affair" as the first episode. This was probably the first produced episode; "A Greenthumb Is Not A Goldfinger" was the first to air on CBS September 12, 1970.
Box Office Bomb: Budget: $39 million. Final box office gross: $14.8 million. Its self-referential tone alienated family audiences, and as mentioned below, the film's flopping led to Scooby-Doo (which began as a college-oriented semi-parody along the lines of Josie) toning down its adult humor so it wouldn't make the same mistake.
Creator Killer: Pulled a triple on directors/writers Harry Elfont and Deborah Kaplan and executive producer Kenneth "Babyface" Edmonds. Elfont/Kaplan never directed another movie and would not write another film until 2004, while "Babyface" Edmonds never produced another film.