Please don't list this on a work's page as a trope. Examples can go on the work's YMMV tab.
Tear Jerker: Questionable Content
The strip's first major one starts in strip #500, when Faye point-blank asks Marten if he's attracted to her, and ends at #509, with the culmination being right in the middle when Faye reveals that she watched her father commit suicide.
Dora and Marten's breakup, both in-universe and out.
Comic #2082, as Faye angsts over her feelings for Angus.
Recently Angus has asked Marigold if the recent loud and enthusiastic sex with Faye has disturbed her and she says no. She then angrily asks whether her regular masturbation sessions keep him awake. While funny at first her angry response makes sense given that this a man she's had a crush on for god knows how long and even if she's over it, she's constantly being reminded of how much fun he's having with someone else.