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Tear Jerker: Metal Gear Rising: Revengeance
The Jetstream DLC ending. The content itself doesn't hurt, but when you listen to "The Only Thing I Know For Real" again... everything starts to make sense about Sam's character. Fridge Brilliance and Fridge Horror kicks in a lot when you look over "Collective Consciousness" and Armstrong's cutscenes.
There's something about the way Bladewolf pleads for you to stop attacking him just before you finish him off in his battle. He barely has his own life, but he doesn't want Raiden to take it away. Thankfully, Raiden has Doktor fix him up later on.