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Tear Jerker: From Fake Dreams
Chapter 23, where the letter Kiritsugu left behind for Saber was revealed, you can clearly see the grief and desperation that has gripped the man, to the point where he was actually putting his faith in a Heroic Spirit, an entity which he had despised for the better portion of his life due to them (from his point of view) being no better than common murderers.
Save them Saber. Please save my children. I have bet everything on you and Shirou to make things right where I have failed, where I have gambled everything on a lie and gained nothing but destruction. Every other attempt I have had at trying to make someone close to me happy and live has ended only in death, violence, and sending them on the path of ruin.
Please give me a reason to believe that there is worth in heroes one last time.