This is based on opinion. Please don't list it on a work's trope example list.
Tear Jerker / Drake & Josh
"Josh is Done".
Drake's breakdown when his life falls apart without Josh leading to an embarrassing incident in the science room.
Drake: I need you more than you need me! I need you WAY more than you need me! I'm sorry I made you late for your exam! I'm sorry I ran over your bike! I'm sorry I'm probably the worst brother in the world, and you're way better off without me! I just need you to understand...(stammers) Sorry, Josh. I'm sorry.(leaves)
On a meta-level, this episode becomes a lot Harsher in Hindsight, following the drama that ensued after Drake didn't receive an invitation to Josh's wedding, essentially inverting the episode's premise.note Don't worry; they made up.
Josh's reaction when he thinks Walter is cheating.