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The Powerpuff Girls
In episode "The Dad Who Knew Too Little", Homer and Lisa are framed for a crime and go on the run. They use a black hair gel to disguise themselves and Lisa comments she looks like a Powerpuff Girl.
The Simpsons The sketch "2 Broke Powerpuff Girls" is a mix of this show and MAD . 2 Broke Girls Tara Strong and Tom Kane reprise their roles of Bubbles and HIM.
The show has been referenced twice in
Robot Chicken A three-second sketch has Professor Utonium say "All thanks to stem cell research", with the girls concurring with him.
Another sketch shows what happens if cocaine was added into the ingredients to create the girls.