Naria and Eriya's Rapid Aging due to the side-effects of the fortune/luck intensifier is a very unpleasant sight. Its also tragic when they die in Folken's arms.
When Hitomi is placed under hypnosis by the fake-Plactu aka Zongi, her psychic abilities begin overwhelming the both of them and Hitomi gets caught in a horrible vision of witnessing fake-Plactu/Zongi's horrible murder, as he is crushed to death by a very angry Dilandau since he killed and then replaced one of his soldiers. The trauma is so intense for Hitomi that she goes into catatonic shock and her heart stops. Adding to the Nightmare Fuel of the scene is Millerna's frantic attempts to perform CPR and her resulting hysteria when she realizes she's not strong enough to keep it up. Though Van is more successful with the CPR, the lack of music and everyone's desperate pleas for Hitomi to snap out of it add to the tension of the scene.
And later... Hitomi's vision does come true. Exactly as she predicted, Zongi gets caught and crushed by Dilandau's Guymelef, in punishment for killing and replacing his subordinate Miguel.It's as unpleasant as it seems.
The idea of a single person finding him/herself face to face with an actual Dragon, and without mechas or effective weapons handy, is fucking horrifying. It happens to Van and the recently Heel–Face Turn-ed!Folken towards the end of the series, when neither was armed and Van wasn't riding Escaflowne. Understandably, Van (who had fought and defeated Dragons but had never been indefense against one) was about to have an Heroic B.S.O.D., and Folken (who had been mutilated by another Dragon and barely survived thanks to Zaibach) had to gather all of his wits to get himself and Van away to safety, managing to both net himself his biggest Crowning Moment of Awesome and recover Van's trust and affection.