Codename: Kids Next Door: The main characters all seem to live in the same American neighborhood, but if you listen to their parents, you realize they're basically this trope one generation removed—-both of Numbuh 1's parents are British, Numbuh 3's are Japanese (though only her father has an accent, so either his wife has done away with the accent or he's a direct immigrant), Numbuh 4's are Australian, and Numbuh 5's mother is French African. Numbuh 2 seems to be the only one who (as far as we know) has a "normal" American family.
Captain Planet and the Planeteers: Led by the racially ambiguous Gaia, voiced by Whoopi Goldberg, features an American, an African (at one point revealed to be Ghanaian), a Soviet (tagline later changed from "From the Soviet Union" to "From Eastern Europe"), an Asian (at one point revealed to be Thai), and a South American (revealed to be a grandson of a Kayapo shaman, which makes him Brazilian).
Xiaolin Showdown: Led by a Chinese boy, teammates are Brazilian, Japanese, and American.
The J-Team — Jackie, Uncle, and Jade (Chinese); Tohru (Japanese); Captain Black (white American); El Toro and Paco (Mexican); and Viper (American and Ambiguously Brown / Jewish - the Christmas Episode shows her at a Hannukah party).
Also the Dark Hand — Valmont (English), Finn (Irish-American), Chow (Chinese-American), Hak Foo (Chinese guy with red hair), and Ratso (American of unclear ethnicity; he has green skin).
An in-universe example; Aang (Air Nomads), Katara and Sokka (Water Tribe), Toph and Suki (Earth Kingdom), Zuko (Fire Nation).
The prominent members of the Order of the White Lotus: Iroh, Piandao, and Jeong-Jeong are all Fire Nation; Pakku is from the Water Tribe; and Bumi is of the Earth Kingdom; (by extension there would have once been Air Nomad members, and fanon holds Gyatso was included). In fact, multinational cooperation is the basis for the Order.
Code Lyoko: Set in France. Yumi is Japanese; most other characters are French, but for some their names suggest their families have various origins: Ulrich Stern (possibly German), William Dunbar (possibly Scottish), Odd Della Robbia (possibly Scandinavian, Italian, or both).
About Odd: Della Robbia is a last name of clear Italian origins, and Odd works as shorts for a couple of very embarassing Italian first names (at least, Odorico and Oddo are embarassing for an Italian). He's probably an Italian who moved in France for his parents' works, and goes by Odd due an embarassing first name...
The 11 racecars from Cars 2 comprise two Americans (one of them being Lightning McQueen), one Italian, one Japanese, one Spanish, one French, one Brazilian (and the only female), one German, one pure-British, one half-British, half Grenadian; and one New Rearendian.
In James and the Giant Peach, Grasshopper, Earthworm, Ladybug, Glowworm and James are from different parts of Britain. Spider is French and Centipede is from Brooklyn.
Batman: The Brave and the Bold features the Batmen of All Nations mentioned in the Comics page in one episode's Cold Open. They include the Legionary from Italy, the Gaucho from Argentina, the Knight from the United Kingdom, etc. They also added Impala, a black South African hero not associated with Batman in comics, for the sake of greater racial diversity. Their meeting is crashed by the Joker, who brought his own Multinational Team, featuring a Scottish Joker, an Inuit Joker, a Japanese Joker, etc.