Take a drink every time the phrase 'Harry, Ron and Hermione' is used.
Take a drink every time Harry CAPSLOCKs.
Take two if it's during or near a conversation in which Dumbledore praises his power of love.
Take a shot for every time a Meaningful Name crops up (Sirius and Lupin, for instance).
Take a shot for every time a MacGuffin is mentioned in passing. This includes people such as Sirius.
Take a shot every time 'green' is mentioned. Two shots if it's 'emerald' or 'bright'. Take three if it's to do with Harry's eyes.
Take a shot for every time 'sock' or 'socks' turn up. Take two if it's related to Dobby.
Take a sip every time Harry's scar is mentioned. Take another if it's hurting. Finish your drink if Harry's history is summed up within the next three sentences.
Are you trying to kill us all?
Take a drink every time Harry is compared to his parents. Take two sips if Harry says something about hearing that all the time.
Every time Snape's appearance is referenced in a negative way. Double it if the words "sallow", "slimy" and/or "greasy" are used. Triple if he's compared to a bat.
Heck, every time that any unsympathetic character's appearance is referenced negatively (Dudley being 'fat and piggy', Pansy Parkinson being 'ugly and pug like', Petunia being 'long-necked and horsey' . . . Am I noticing an unfortunate trend here?)
For the 'Harry Potter' films:
Take a drink every time the name of a spell is said
Take a drink if someone uses a spell in combat that does something other than knock the enemy back in a blast of light
Take a drink every time Harry's scar is mentioned. Take another if it's hurting. Take three if Harry's connection to Voldemort is mentioned
Take a drink every time Harry is compared to his parents. Take two sips if Harry says something about hearing that all the time.
Down your drink when Voldemort does an awkward hug
Take a sip every time you notice Emma Watson moves her eyebrows a lot every time she speaks
Take a drink every time someone uses Polyjuice potion, and another when they change back this could be a nasty one with Barty Crouch jr.
Take a drink everytime someone scores in a Quidditch match
Take a drink whenever there's a reference to Ron being poor or Hermione being clever
Take a drink whenever "Voldemort", "Horcrux" or "Deathly Hallows" are said
Take a drink whenever house points are awarded
Take two when someone takes points away from a house.
Take a drink whenever Draco sneers
We'd all be down and out in a minute.
Take a drink whenever magical creatures appear on screen (for example dementors, hippogriffs, doxies, Nagini)
Our livers give up before the 4th movie, if marathoning.
For the simplest film drinking game:
Drink whenever magic is used or appears- a spell, brooms flying, portraits moving, a ghost appears on screen, whatever
Drink whenever the words "magic", "wizard" or "witch" are said
Congratulations, you now know what alcohol poisoning feels like!