Spoilers are unmarked.
General
- Take a drink when the word "hope" or "despair" is said.
- Two drinks if said by Monokuma, Junko, or Nagito.
- Reduce it to a small sip in the final Argument Armament of Danganronpa V3.
- Take a drink when Monokuma laughs.
- Take a drink when anytime a character under suspicion of murder is proven to be innocent, even if they were only suspected for a brief time.
- Take a drink when somebody falsely suspects someone else of being the killer.
- Take two drinks if the person that was falsely suspected was Himiko.
- Take a drink whenever someone says "In other words".
- Or “In the end.”
- Take a drink whenever a body is discovered.
- Take a drink if you screw up the Final Strike for the Panic Talk Action/Bullet Time Battle/Argument Armament.
- Take a drink whenever Monokuma uses Insane Troll Logic in Monokuma Theater. Take another one if he's judging someone's business sense.
- Take a drink whenever Junko switches between personalities, or Tsumugi switches between cosplays. note
- Two drinks if Tsumugi switches between Junko's personalities.
- Take a small sip whenever Monokuma makes a completely overblown threat.
- Finish your drink if your most hated character dies.
- By contrast, drown your sorrows if your favorite character dies.
- Take a drink when Toko (or Genocide Jack) calls Byakuya "master".
- Take a drink when Hiro talks about the occult.
- Take a drink when Hina talks about donuts.
- When she briefly takes control of Monokuma to demand donuts, chug for however long you laughed at the line.
- Take a sip whenever Byakuya says something that would get him arrested in present time.
- Take a drink whenever he claims to have information and then makes Makoto figure it out instead of just telling the class himself.
- In the first trial, take a sip whenever somebody accuses Makoto of being the culprit after he was already proven innocent.
- During the first trial, take a drink when Leon says "stupid"
- During the 3rd trial, take a drink every time Celeste says "because"
- Take a drink whenever Hiro is accused of either murder or idiocy. Take two if he responds in a Comically Missing the Point or I Take Offense to That Last One fashion that casts more doubt into him.
- Take a drink whenever Kyoko has to help Makoto with the trial.
- Take a drink whenever Hifumi mentions he's only into "2-D."
- Take a shot whenever Kyoko does something that brings vital or previously unknown evidence into light.
- Take a shot every time Celeste drops her accent/loses her cool (excluding the third trial).
- During the 4th trial, take a drink whenever someone makes a confession.
- Take a drink for every unnecessary flashback.
- Take a drink for every time Hiyoko bullies someone.
- Take two if she's bullying Mikan.
- Take a drink when Chiaki becomes sleepy.
- During the first two chapters, drink a full box if Fuyuhiko says a text box that doesn't contain any insult or profanity.
- Take a drink every time Kazuichi flirts with Sonia.
- Take a drink every time a character ends up Breaking the Fourth Wall.
- Take a drink every time Nekomaru says the word "shit".
- Take a drink every time Akane threatens to abuse another character and has her threats halted.
- Take a drink every time Teruteru makes a lewd comment.
- Take a drink every time Mikan apologizes or asks for forgiveness.
- Take two if it happens during her Villainous Breakdown in Chapter Three.
- During Chapter 3, take a drink everyday time Mikan says "Not fair"
- Take two drinks when Sonia does or says something that makes you question her innocence.
- Take a drink to calm your nerves if things are going awry with the Improved Hangman's Gambit.
- Take a drink everytime Kazuichi is wrong about something.
- Take a drink every time Peko mentions justice during the second trial.
- Add another one if the sentence is accompanied by an emoticon.
- Take a drink every time you see Nagito's excited sweaty sprite when he talks about hope.
- Drink a couple drops every time someone's eyes have spirals in them. (Between the Despair Disease and Nagito, any more would be a pretty serious health hazard. The author of this rule would rather not be pursued by Mikan's vengeful ghost.)
- Raise a toast to Gundham's Devas whenever they do something cool.
- Take a drink when Monaca refers to herself in the first person.
- Take a drink every time Komaru cries.
- Take a drink every time the game asks you if you want to press the button in the end or not.
- Take a drink every time the Warriors of Hope treat Nagito like a Butt-Monkey.
- Take a drink every time Komaru talks about manga.
- Take a drink whenever Toko has a fantasy about Byakuya.
- Take a drink whenever you want to remind Komaru that she has a Hacking Gun.
- Take a sip each time you switch to Genocide Jack in order to preserve Komaru's health.
- Take a drink when somebody's forbidden action is revealed.
- Take a drink every time Ruruka Ando talks about candy.
- If watching the English dub, take a drink every time you find a line that was said funny.
- Take a drink every time somebody talks about brainwashing.
- Take a drink every time Mukuro gets happily embarrassed when Junko says something degrading.
- Take two drinks whenever Kyosuke makes an insane speech about crusading against despair.
- Take a drink every time Nekomaru causes impossible amounts of damage to the surroundings.
- Take a drink every time Teruteru says something lewd.
- Take a drink every time someone's terrible life choices ultimately lead to the end of the world.
- Finish the drink in sadness after Chiaki is killed.
- Take a drink whenever someone interrupts someone else.
- Take a drink every time the word "truth" or "lie" (or any equivalent) is said.
- Two drinks if Kokichi is the one saying it.
- Take a drink every time Monodam talks about becoming friends with everyone.
- Take a drink every time Monophanie throws up.
- Two drinks if the vomit is a color other than white.
- Finish your drink if Monotaro throws up.
- Take a drink whenever you hear Kokichi, Korekiyo, Miu, or Angie doing their distinct laugh.
- Take a drink every time Miu swears, makes a lewd comment, or calls someone a virgin.
- Take a drink every time Keebo says "logical", "illogical", or "100%".
- Take a shot whenever he mentions robophobia.
- Take a drink every time Kaito swears.
- Take a drink every time Tenko expresses her obsession over Himiko.
- Take two drinks every time Gonta says "unpossible".
- Take a drink every time Gonta talks about being a gentleman.
- Take a drink every time Gonta says his own name.
- Take a long sip whenever "Clair De Lune" plays.
- Drink until you've drowned your sorrows over Kaede.
- Take a drink every time Ryoma says "I've still got a ways to go" or something along those lines.
- Take a drink every time Keebo is bullied.
- Take two if Kokichi is the one harassing him.
- Take a drink every time Maki asks if you want to die.
- Take a drink every time Tenko says "Degenerate male"
- Take a drink every time Himiko says "it's magic"
- Take a drink every time Kaede says "Jeez"
- Take a drink every time Kokichi trolls somebody.
- Finish your drink at his fake death troll in Chapter 3.
- Take a drink every time Himiko insists that she is a mage or she calls something tiresome.
- Take a drink every time someone calls Maki "Maki Roll".
- Take two if someone other than Kaito says it.
- Take a drink every time Angie talks about religion or her god.
- Take a drink every time Korekiyo gets dramatic.
- Take a drink every time Korekiyo changes into the tulpa of his sister.
- Take a sip every time Korekiyo says "apologize".
- Take a drink every time Tsumugi says "plain".
- Take a drink every time someone says "Danganronpa" in the Chapter 6 trial.
- Take a shot if you are watching someone else play the game and they voice the opinion that Tsumugi is a suspicious person.
- Try out a fancy cocktail that you've never had before if you are watching someone else play the game and they pinpoint her as the mastermind before Chapter 6.
