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* ''Theatre/{{La Forza Del Destino}}'' features Carlo and Alvaro becoming friends and swearing eternal friendship, which ends once Carlo finds out that Alvaro is in fact the man responsible for his father's (accidental) death.
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* In the ''WesternAnimation/ThomasAndFriends'' web series ''WebAnimation/{{Sodor}}'', Diesel and Diesel 10 used to be good friends due to their shared views on steam engines. However, after Diesel stops his plans in “The Branch Line Incident,” Diesel 10 now wants him dead if “Last Chance” is any indication.
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* In ''{{Series/Cybervillage}}'', Nikolay and Konstantin used to work together, but then Konstantin threw his friend out. The series start when Konstantin wants to build a factory in place of Nikolay's farm.
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Contrast with HeelFaceTurn. Compare with AchillesInHisTent, DeusExitMachina, MyGreatestFailure, GreyAndGrayMorality and JumpingOffTheSlipperySlope, EvilFormerFriend, BreakingTheFellowship, EtTuBrute. See TragicBromance, when a close (male) friendship ends because one of them dies instead of them having a falling out. See also CainAndAbel, when the former friends in question were either siblings, or were childhood friends who grew up with each other prior to their falling out. See FormerlyFriendlyFamily for more than just siblings that grew to hate each other. For the inversion, see also FireForgedFriends: enemies-turned-allies.

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Contrast with HeelFaceTurn.HeelFaceTurn and BullyTurnedBuddy. Compare with AchillesInHisTent, DeusExitMachina, MyGreatestFailure, GreyAndGrayMorality and JumpingOffTheSlipperySlope, EvilFormerFriend, BreakingTheFellowship, EtTuBrute. See TragicBromance, when a close (male) friendship ends because one of them dies instead of them having a falling out. See also CainAndAbel, when the former friends in question were either siblings, or were childhood friends who grew up with each other prior to their falling out. See FormerlyFriendlyFamily for more than just siblings that grew to hate each other. For the inversion, see also FireForgedFriends: enemies-turned-allies.
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* ''Theatre/Wicked'' opens with Glinda explaining her former friendship with Elphaba.

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* ''Theatre/Wicked'' ''Theatre/{{Wicked}}'' opens with Glinda explaining her former friendship with Elphaba.
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* ''Theatre/InheritTheWind'' features a scene where Henry Drummond and Matthew Brady, opposing counsels in the trial over evolution, meet and muse over their past friendship. It's stated that their differing views on religion caused them to party ways.

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* ''Theatre/InheritTheWind'' features a scene where Henry Drummond and Matthew Brady, opposing counsels in the trial over evolution, meet and muse over their past friendship. It's stated that their differing views on religion caused them to party ways.part ways.
* ''Theatre/Wicked'' opens with Glinda explaining her former friendship with Elphaba.
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* ''Series/TheLastKingdom:'' ZigZagged. At the battle in the Season 1 finale, [[spoiler: Uthred]] and his [[spoiler: former lover Brida and her new partner and adoptive brother of Uhtred, Ragnar the Younger]] fight on opposing sides, with [[spoiler: Ragnar]] claiming that if it comes to that, he would kill [[spoiler: Uthred]]. At [[spoiler: Brida's]] and [[spoiler: Uthred's]] prior interaction, [[spoiler: Brida]] is not very warm either. They later become friends again, but their animosity towards each other renews in Season 3, but after [[spoiler: Ragnar's]] death, [[spoiler: Brida and Uhtred]] become friends again, but [[spoiler: Brida]] turns on [[spoiler: Uhtred]] again, when she is captured by the Welsh at the Battle of Tettenhall, due to [[spoiler: Uhtred's]] inaction. She is enslaved by the Welsh and endures total humilitation. Since he didn't help her, [[spoiler: Brida]] returns with a [[RoaringRampageOfRevenge vengeance]] specifically targetting [[spoiler: Uhtred]].
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[[caption-width-right:350:And we'll always be friends forever, won't we?]]


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[[quoteright:310:[[Franchise/StarWars https://static.tvtropes.org/pmwiki/pub/images/friends3_3180.jpg]]]]
[[caption-width-right:310:"You were my ''brother'', Anakin... [[PlatonicDeclarationOfLove I loved you...]]"]]

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[[quoteright:310:[[Franchise/StarWars [[quoteright:350:[[WesternAnimation/TheFoxAndTheHound https://static.tvtropes.org/pmwiki/pub/images/friends3_3180.jpg]]]]
[[caption-width-right:310:"You were my ''brother'', Anakin... [[PlatonicDeclarationOfLove I loved you...]]"]]
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* ''Literature/HowISurvivedMiddleSchool'' has Jenny [=McAfee=] and her former childhood friend Addie Wilson, who became an AlphaBitch while the former was away at summer camp and consequently ditched her on the first day of middle school for the popular crowd. They run against each other in the school's presidential election in the second book, which Jenny wins, and they're forced to work together as the respective class president and vice president for school events from then on.
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Contrast with HeelFaceTurn. Compare with AchillesInHisTent, DeusExitMachina, MyGreatestFailure, GreyAndGrayMorality and JumpingOffTheSlipperySlope, EvilFormerFriend, BreakingTheFellowship, EtTuBrute. See also CainAndAbel, when the former friends in question were either siblings, or were childhood friends who grew up with each other prior to their falling out. See FormerlyFriendlyFamily for more than just siblings that grew to hate each other. For the inversion, see also FireForgedFriends: enemies-turned-allies.

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Contrast with HeelFaceTurn. Compare with AchillesInHisTent, DeusExitMachina, MyGreatestFailure, GreyAndGrayMorality and JumpingOffTheSlipperySlope, EvilFormerFriend, BreakingTheFellowship, EtTuBrute. See TragicBromance, when a close (male) friendship ends because one of them dies instead of them having a falling out. See also CainAndAbel, when the former friends in question were either siblings, or were childhood friends who grew up with each other prior to their falling out. See FormerlyFriendlyFamily for more than just siblings that grew to hate each other. For the inversion, see also FireForgedFriends: enemies-turned-allies.
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* In ''Series/HatfieldsAndMcCoys'' the series starts off with Anderson "Devil Anse" Hatfield and Randall McCoy being close friends who were fighting for the Confederacy in the Civil War, complete with both men saving each other's lives during several occasions. Howver Hatfield [[ScrewThisImOuttaHere decides]] the Confederacy cannot win and decides to head home. When confronted by McCoy Hatfield tries to get him to come home as well. McCoy refuses but allows Hatfield to go home, ending their friendship. Not too long afterwards McCoy is captured and spends the remainder of the war in a prison camp. Meanwhile Hatfield has returned home and prospered in the intervening time. Over the next three decades the relations between the two families degenerate into armed conflict, with Hatfield wondering where he and Randall had gone wrong after so much death and destruction.

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* In ''Series/HatfieldsAndMcCoys'' the series starts off with Anderson "Devil Anse" Hatfield and Randall McCoy [=McCoy=] being close friends who were fighting for the Confederacy in the Civil War, complete with both men saving each other's others lives during several occasions. Howver Hatfield [[ScrewThisImOuttaHere decides]] the Confederacy cannot win and decides to head home. When confronted by McCoy [=McCoy=] Hatfield tries to get him to come home as well. McCoy [=McCoy=] refuses to desert but allows Hatfield to go home, ending their friendship. Not too long afterwards McCoy [=McCoy=] is captured and spends the remainder of the war in a prison camp. Meanwhile Hatfield has returned home and prospered in the intervening time. Over the next three decades the relations between the two families degenerate into armed conflict, with Hatfield wondering where he and Randall had gone wrong after so much death and destruction.
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* In ''Series/HatfieldsAndMcCoys'' the series starts off with Anderson "Devil Anse" Hatfield and Randall McCoy being close friends who were fighting for the Confederacy in the Civil War, complete with both men saving each other's lives during several occasions. Howver Hatfield [[ScrewThisImOuttaHere decides]] the Confederacy cannot win and decides to head home. When confronted by McCoy Hatfield tries to get him to come home as well. McCoy refuses but allows Hatfield to go home, ending their friendship. Not too long afterwards McCoy is captured and spends the remainder of the war in a prison camp. Meanwhile Hatfield has returned home and prospered in the intervening time. Over the next three decades the relations between the two families degenerate into armed conflict, with Hatfield wondering where he and Randall had gone wrong after so much death and destruction.
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* ''Webcomic/ScarletLady'': Over the course of the comic, Chloé's {{Alpha|Bitch}} EntitledBitch attitude, amplified by her behavior as the titular {{Nominal Hero}}ine, causes Sabrina and Adrien to break off their friendship with her. In the former case, she was only angry that she'd be unable to hoist her homework on Sabrina; in the latter, after throwing a party to prove she could be "nice" (and failing), she decided to [[IRejectYourReality reject reality]] and tell herself that Adrien was just being melodramatic.

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* This is what happens to Anna and Elsa in ''WesternAnimation/{{Frozen|2013}}.'' Elsa shuts Anna out of her life and refuses to play with her. Anna is convinced that Elsa doesn't love her anymore. However, Elsa did this because she wanted to protect Anna from [[IAmAMonster herself]]. This is because Elsa accidentally almost killed Anna with her powers when they were playing, and Anna doesn’t know this because Grand Pabbie altered her memories so that she doesn’t remember Elsa’s powers so he could heal her. During an argument between the two at Elsa's coronation, Elsa loses control of her powers again, forcing her to flee and causing Anna to realize what Elsa had kept hidden all these years. However, Anna [[TheDeterminator refuses to give up on Elsa]] and continues to [[ThePowerOfLove love her]], believing that they can once again become friends. [[spoiler:Anna even goes as far as making a HeroicSacrifice for Elsa, and saving herself from her DisneyDeath since this was an ActOfTrueLove. After Elsa realizes that love fixes everything, [[HeterosexualLifePartners they reconcile and eventually becomes best friends with Anna]].]]

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* This is what happens to Anna and Elsa in ''WesternAnimation/{{Frozen|2013}}.'' ''WesternAnimation/Frozen2013''. Elsa shuts Anna out of her life and refuses to play with her. Anna is convinced that Elsa doesn't love her anymore. However, Elsa did this because she wanted to protect Anna from [[IAmAMonster herself]]. This is because Elsa accidentally almost killed Anna with her powers when they were playing, and Anna doesn’t know this because Grand Pabbie altered her memories so that she doesn’t remember Elsa’s powers so he could heal her. During an argument between the two at Elsa's coronation, Elsa loses control of her powers again, forcing her to flee and causing Anna to realize what Elsa had kept hidden all these years. However, Anna [[TheDeterminator refuses to give up on Elsa]] and continues to [[ThePowerOfLove love her]], believing that they can once again become friends. [[spoiler:Anna even goes as far as making a HeroicSacrifice for Elsa, and saving herself from her DisneyDeath since this was an ActOfTrueLove. After Elsa realizes that love fixes everything, [[HeterosexualLifePartners they reconcile and eventually becomes best friends with Anna]].]]



[[folder:Films — Live-Action]]

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[[folder:Films -- Live-Action]]



* ''Series/{{The Defenders|2017}}'':
** ''Series/{{Jessica Jones|2015}}'':
*** In the season 1 finale, Jeri Hogarth is implied to be a friend with district attorney Samantha Reyes, or at least, on good enough terms to [[FirstNameBasis address her by her first name]]. However, midway through season 2 of ''Series/{{Daredevil|2015}}'', Foggy has a conversation with Marci Stahl, who has joined Jeri's firm since Wilson Fisk's arrest, and she mentions that Jeri and the partners are worried about Frank Castle's trial because if Reyes convicts him, she sets precedence for vigilantes like Daredevil and Jessica to persecuted as well. Marci implies that Jeri may have also had a falling out with Reyes as a result of the latter's attempts to persecute Jessica.
*** Jessica and Malcolm have a falling out in season 2 after a season of Malcolm getting shit upon and him [[DudeWheresMyRespect not feeling like he's getting the respect he deserves]].
*** Jessica also has a falling out with Trish in Season 2 as the latter relapses into drug problems and develops a reckless hero complex. In the final episode of the season, Trish [[spoiler:kills Jessica's mother basically unprovoked despite claiming it was Jess's defense, resulting in Jessica disowning Trish as her sister]].
** ''Series/{{Daredevil|2015}}'': Elektra was Matt's college flame, and later his crimefighting partner for a bit in season 2. But then she is killed in the season 2 finale of ''Daredevil'', and when she's resurrected by the Hand, she's also now working for them, and even fighting against Matt, who she doesn't recognize. And even once she gets her memories back, she decides to still carry out the Hand's agenda.
** ''Series/{{Iron Fist|2017}}'': Danny and Davos have a falling out at the end of Season 1, when Davos's jealousy over Danny becoming the Iron Fist finally boils over, and KnightTemplar views grow far too extreme for Danny. Davos is Danny's main enemy for Season 2, and [[spoiler:kidnaps him, bleeds him, and steals the power of the Iron Fist from him]].



-->'''Jim:''' I was your friend.
-->'''Ed:''' Were you, Jim? Were you my friend? Or did you just pity me?

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-->'''Jim:''' --->'''Jim:''' I was your friend.
-->'''Ed:'''
friend.\\
'''Ed:'''
Were you, Jim? Were you my friend? Or did you just pity me?



-->'''Ivy:''' You always did think you were better than me.
-->'''Selina:''' That's not true. I was your friend.

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-->'''Ivy:''' --->'''Ivy:''' You always did think you were better than me.
-->'''Selina:'''
me.\\
'''Selina:'''
That's not true. I was your friend.



* ''Series/{{Merlin|2008}}'': Morgana discovers that Arthur is her half-brother in the third series and spends the remainder of that series and all of the next trying to kill him so that she can consolidate her claim on the throne. When they finally come face-to-face at the end of series four, Arthur sadly asks her: "What happened to you, Morgana? I thought we were friends." When Merlin asked her a similar question in series 3, she replied that she hasn't forgiven him for poisoning her. This trope is the only reason Merlin hasn't killed Morgana.

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* ''Series/{{Merlin|2008}}'': ''Franchise/MarvelCinematicUniverse'':
** ''Series/JessicaJones2015'':
*** In the season 1 finale, Jeri Hogarth is implied to be a friend with district attorney Samantha Reyes, or at least, on good enough terms to [[FirstNameBasis address her by her first name]]. However, midway through season 2 of ''Series/Daredevil2015'', Foggy has a conversation with Marci Stahl, who has joined Jeri's firm since Wilson Fisk's arrest, and she mentions that Jeri and the partners are worried about Frank Castle's trial because if Reyes convicts him, she sets precedence for vigilantes like Daredevil and Jessica to persecuted as well. Marci implies that Jeri may have also had a falling out with Reyes as a result of the latter's attempts to persecute Jessica.
*** Jessica and Malcolm have a falling out in season 2 after a season of Malcolm getting shit upon and him [[DudeWheresMyRespect not feeling like he's getting the respect he deserves]].
*** Jessica also has a falling out with Trish in Season 2 as the latter relapses into drug problems and develops a reckless hero complex. In the final episode of the season, Trish [[spoiler:kills Jessica's mother basically unprovoked despite claiming it was Jess's defense, resulting in Jessica disowning Trish as her sister]].
** ''Series/Daredevil2015'': Elektra was Matt's college flame, and later his crimefighting partner for a bit in season 2. But then she is killed in the season 2 finale of ''Daredevil'', and when she's resurrected by the Hand, she's also now working for them, and even fighting against Matt, who she doesn't recognize. And even once she gets her memories back, she decides to still carry out the Hand's agenda.
** ''Series/IronFist2017'': Danny and Davos have a falling out at the end of Season 1, when Davos's jealousy over Danny becoming the Iron Fist finally boils over, and KnightTemplar views grow far too extreme for Danny. Davos is Danny's main enemy for Season 2, and [[spoiler:kidnaps him, bleeds him, and steals the power of the Iron Fist from him]].
* ''Series/Merlin2008'':
Morgana discovers that Arthur is her half-brother in the third series and spends the remainder of that series and all of the next trying to kill him so that she can consolidate her claim on the throne. When they finally come face-to-face at the end of series four, Arthur sadly asks her: "What happened to you, Morgana? I thought we were friends." When Merlin asked her a similar question in series 3, she replied that she hasn't forgiven him for poisoning her. This trope is the only reason Merlin hasn't killed Morgana.



* ''Series/TheOuterLimits1995'': In "Nest", Robby Archer and Jack Burrell were best friends as children but they drifted apart after the death of Robby's brother Matt. The three boys were playing hockey on the ice when it gave way and Robby and Matt fell through. Jack tried to rescue both of them but he was not strong enough. Matt insisted that he save Robby instead of him. Jack complied and Matt was sucked under the ice and died.

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* ''Series/TheOuterLimits1995'': In "Nest", "[[Recap/TheOuterLimits1995S6E20Nest Nest]]", Robby Archer and Jack Burrell were best friends as children children, but they drifted apart after the death of Robby's brother Matt. The three boys were playing hockey on the ice when it gave way and Robby and Matt fell through. Jack tried to rescue both of them them, but he was not strong enough. Matt insisted that he save Robby instead of him. Jack complied and Matt was sucked under the ice and died.



* ''Series/TheShield'': With the end of Season 3 and [[spoiler: the disbandment of the Strike Team]], the relations between its former members are heavily tensed. Especially [[spoiler: Shane, who seems to have crossed the line, thinks very differently about his former best friends:]]
-->'''Army''': Jesus Christ. [[spoiler: Lem]]'s one crazy-ass white boy. You really used to be tight?\\
'''Shane''': Yeah. A lifetime ago.
* ''Series/{{Smallville}}'': [[Franchise/{{Superman}} Clark Kent]] and ComicBook/LexLuthor, who go from close friends to [[ArchEnemy Arch Enemies]] over the course of the show, while the breakup of their friendship is an obvious ForegoneConclusion throughout the earlier seasons.

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* ''Series/TheShield'': With the end of Season 3 and [[spoiler: the [[spoiler:the disbandment of the Strike Team]], the relations between its former members are heavily tensed. tense. Especially [[spoiler: Shane, [[spoiler:Shane, who seems to have crossed the line, thinks very differently about his former best friends:]]
-->'''Army''':
friends]]:
-->'''Army:'''
Jesus Christ. [[spoiler: Lem]]'s [[spoiler:Lem]]'s one crazy-ass white boy. You really used to be tight?\\
'''Shane''': '''Shane:''' Yeah. A lifetime ago.
* ''Series/{{Smallville}}'': [[Franchise/{{Superman}} Clark Kent]] Kent and ComicBook/LexLuthor, Lex Luthor, who go from close friends to [[ArchEnemy Arch Enemies]] Arch-Enemies]] over the course of the show, while the breakup of their friendship is an obvious ForegoneConclusion throughout the earlier seasons.



* ''Series/TalesFromTheCrypt'': Roger and Alex in the episode "Half Way Horrible" were best friends in the past. This changed when Roger secretly sold Alex out by "volunteering" him as a HumanSacrifice to a tribe they were visiting in exchange for a tribal medicinal formula Roger sought to process into a preservative to enrich himself. This ensured that Alex harbored nothing but vengeful hatred against Roger since then, especially after Alex returned as a RevenantZombie.

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* ''Series/TalesFromTheCrypt'': Roger and Alex in the episode "Half Way Horrible" "[[Recap/TalesFromTheCryptS5E12HalfWayHorrible Half-Way Horrible]]" were best friends in the past. This changed when Roger secretly sold Alex out by "volunteering" him as a HumanSacrifice to a tribe they were visiting in exchange for a tribal medicinal formula Roger sought to process into a preservative to enrich himself. This ensured that Alex harbored nothing but vengeful hatred against Roger since then, especially after Alex returned as a RevenantZombie.



* ''Series/TheWalkingDead'': Rick and Shane -- former best buds -- share a tensed friendship since the outbreak, partly because [[spoiler:Shane, who erroneously believed that Rick was dead, slept with and is in love with Rick's wife]].

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* ''Series/TheWalkingDead'': ''Series/TheWalkingDead2010'': Rick and Shane -- former best buds -- share a tensed friendship since the outbreak, partly because [[spoiler:Shane, who erroneously believed that Rick was dead, slept with and is in love with Rick's wife]].
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* In ''In the Last Days'' by Lev Tikhomirov, most of the main characters — Lydia, Valentin, Edward, Jani, Antioch and Apollonius — attended Sorbonne together and were great friends (the men were also all crushing on Lydia, but due to her tact and kindness it never soured their friendship). Only a few years later, Antioch became TheAntichrist, Apollonius the sorcerer in his service, and Jani one of the policemen of their regime; while Lydia and Valentin, as Christians, became their enemies and formerly rationalist Edward joins them too. In the course of the novel, they occasionally reminisce about the old days and marvel at how different things used to be. [[spoiler:By the end, Jani, having gone through LoveRedeems with his still-enduring feelings for Lydia, deserts Antioch's side, so he, Valentin, Lydia and Edward are all reunited at the Second Coming of Christ. Antioch and Apollonius… [[KarmicDeath not so much]]]].
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* ''Series/HowToRock'': Kacie Simon and Molly Garfunkel were best friends and the most important members of the Perfs, until Kacie's unexpected braces and glasses got her kicked out and she soon realized Molly only liked her because she was perfect.
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** [[spoiler:Peter Pettigrew]] in The other surviving Marauders view him with extreme disgust for siding with Voldemort.

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** [[spoiler:Peter Pettigrew]] in The as the other surviving Marauders view him with extreme disgust for siding with Voldemort.
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* In ''LightNovel/TheUnexploredSummonBloodSign'', [[ThouShaltNotKill Kyousuke]] and [[spoiler:Mary Ann]] were lovers three years ago until she killed someone. Since she had promised him she wouldn't, he couldn't trust her after that, and things escalated from there into a massive conflict that defines their lives right up to the present day.

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* In ''LightNovel/TheUnexploredSummonBloodSign'', ''Literature/TheUnexploredSummonBloodSign'', [[ThouShaltNotKill Kyousuke]] and [[spoiler:Mary Ann]] were lovers three years ago until she killed someone. Since she had promised him she wouldn't, he couldn't trust her after that, and things escalated from there into a massive conflict that defines their lives right up to the present day.
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* ''Series/MakoMermaidsAnH2OAdventure'': Rita and Veridia were best friends as teenagers, until it was revealed that Rita had been leaving the ocean to visit her human boyfriend and was banished by the Mako Pod's elders as a result. Veridia spent years trying to get Rita to dump him and return to the pod, even becoming the pod's leader with the promise of letting Rita back in no strings attached. Rita refused, even after her boyfriend's death, choosing to live the rest of her life on land instead.
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* ''WesternAnimation/TheBarbieDiaries'': Barbie and Raquelle used to be best friends, until Raquelle became an AlphaBitch.

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* ''WesternAnimation/MonstersUniversity'' reveals that Randall and Mike, who are enemies in the [[WesternAnimation/MonstersInc original film]] were roommates in college and were good friends until Mike got kicked out of the scaring program and Randall attached himself to the “cool kids”.



* ''WesternAnimation/MonstersUniversity'' reveals that Randall and Mike, who are enemies in the [[WesternAnimation/MonstersInc original film]] were roommates in college and were good friends until Mike got kicked out of the scaring program and Randall attached himself to the “cool kids”.

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* ''WesternAnimation/BarbieAsRapunzel'': Gothel and [[spoiler: King Wilhelm]] were friends when they were young. However, Gothel developed romantic feelings for him that were unrequited. [[WomanScorned Enraged that he married another woman]], Gothel [[spoiler: kidnaps his daughter Rapunzel and cuts ties with him altogether]].



* In ''WesternAnimation/ThePrinceOfEgypt'', Rameses and Moses were raised as brothers. They became enemies when Rameses was Pharaoh and Moses returned from hiding to free the Hebrews from bondage.
-->"You who I called brother, how could you have come to hate me so?"



* ''WesternAnimation/MonstersUniversity'' reveals that Randall and Mike, who are enemies in the [[WesternAnimation/MonstersInc original film]] were roommates in college and were good friends until Mike got kicked out of the scaring program and Randall attached himself to the “cool kids”.
* In ''WesternAnimation/MyLittlePonyEquestriaGirls1'', the five human girls were friends at one point in the past, but they had drifted apart when [[AlphaBitch Sunset Shimmer]] sabotaged their friendship. However, Twilight manages to clear up the misunderstanding and get them all back on friendly terms.


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* In ''WesternAnimation/MyLittlePonyEquestriaGirls1'', the five human girls were friends at one point in the past, but they had drifted apart when [[AlphaBitch Sunset Shimmer]] sabotaged their friendship. However, Twilight manages to clear up the misunderstanding and get them all back on friendly terms.
* In ''WesternAnimation/ThePrinceOfEgypt'', Rameses and Moses were raised as brothers. They became enemies when Rameses was Pharaoh and Moses returned from hiding to free the Hebrews from bondage.
-->"You who I called brother, how could you have come to hate me so?"
* ''WesternAnimation/MonstersUniversity'' reveals that Randall and Mike, who are enemies in the [[WesternAnimation/MonstersInc original film]] were roommates in college and were good friends until Mike got kicked out of the scaring program and Randall attached himself to the “cool kids”.
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* ''Literature/TheDresdenFiles'': As a result of Harry suspcious actions of the past few years and refusal to trust him Ramirez has had enough of Harry putting his secrecy above their friendship and comes to a head at the end of Literature/BattleGround2020 with Ramirez fed up with being lied to or rebuff when he just trying to help.

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* ''Literature/TheDresdenFiles'': As a result of Harry suspcious suspicious actions of the past few years and refusal to trust him him, Ramirez has had enough of Harry putting his secrecy above their friendship and friendship. It comes to a head at the end of Literature/BattleGround2020 with Ramirez fed up with being lied to or rebuff when he just trying to help.help and he ends their friendship for seems like for good.
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* ''Film/{{M3gan}}'': [=M3GAN=] expresses this sentiment toward Gemma, feeling they had a real relationship during her development, only to be sold off as a toy.
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* The entire plot of ''Film/TheBansheesOfInisherin'' revolves around Colm suddenly deciding one day that he no longer wants to be friends with his longtime drinking buddy Pádraic and the effect it has on them both. [[spoiler:The feud escalates to the point where Pádraic burns down Colm's house in a fit of rage, which is enough for Colm to want to call it quits, but Pádraic makes it clear that it'll only be over once one of them is dead.]]
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* ''Literature/IveGotYouUnderMySkin'':
** The four graduates, Alison, Claire, Regina and Nina, used to be best friends and Nina, Claire and Regina were Alison's bridemaids just months after Betsy's murder, but over the past twenty years they've drifted apart, all moving away and losing touch. Even when they're reunited things are a bit awkward and stilted between them. Besides all their lives going in different directions, the near-constant shadow of suspicion that has hung over them for two decades made staying in contact difficult, especially as many people believed that some or all of them plotted Betsy's murder together. [[spoiler:Once Betsy's real killer is revealed and things settle down, the women find it much easier to relax around each other and properly rekindle their friendship]].
** Jane Novak and Betsy Bonner were good friends when they both worked together at a theatre, Betsy as an actress or - more often - an usher when she couldn't get roles and Jane as a cleaner. When Betsy married Robert Powell, she offered Jane a permanent position as a live-in housekeeper. Jane was thrilled with this opportunity, but her friendship with Betsy soon turned sour, as Betsy almost immediately began acting as though she was superior to Jane and treated her merely as 'the help' rather than her old friend, starting with her insistence Jane call her "Mrs Powell" at all times. Jane was also aware that [[spoiler:Betsy was cheating on Robert with numerous men]] and came to resent Betsy, especially as Jane herself fell in love with Robert.
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* ''Film/DarbyAndTheDead'': Darby and Capri had been friends as girls years before the events of the film. However, after Darby's mom died they drifted apart, to the point that Capri bullies her after she's grown into the [[AlphaBitch most popular girl]] at their school.
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* Music/GoodKid: "Slingshot" was partly inspired by "the exaggerated tales of friends turned bitter rivals found in fantasy and anime." The lyrics describe two friends who split up along the way, and now are engaged in an intense argument. The singer repeatedly wishes ill will on his enemy and insists that they don't need each other anymore.
-->''Well, I remember when you said that you hate everything I do\\
You didn't have a reason then, wish I'd given one to you''

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* ''Series/GameOfThrones'':
** Robb executing Lord Rickard greatly fractures House Karstark's ties with House Stark. Catelyn freeing the murderer of Lord Rickard's children probably did not help.
** Jon allowing the Wildlings to go South of the Wall pisses off House Umber's new Lord so much that he allied with the Boltons despite hating them.

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* ''[[Franchise/ASongOfIceAndFire Game of Thrones]]'' universe:
**
''Series/GameOfThrones'':
** *** Robb executing Lord Rickard greatly fractures House Karstark's ties with House Stark. Catelyn freeing the murderer of Lord Rickard's children probably did not help.
** *** Jon allowing the Wildlings to go South of the Wall pisses off House Umber's new Lord so much that he allied with the Boltons despite hating them.



** Oberyn told Cersei that he last saw Myrcella playing with his daughters at the Water Gardens. It isn't clear if he means his younger daughters or the Sand Snakes of Season 5, but either case they aren't friends after Oberyn's death. This is a major change from the books where absolutely none of his daughters and no one in Dorne, aside from a nutcase knight, wanted to hurt Myrcella.

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** *** Oberyn Martell told Cersei that he last saw Myrcella playing with his daughters at the Water Gardens. It isn't clear if he means his younger daughters or the Sand Snakes of Season 5, Snakes, but either case they aren't friends after Oberyn's death. This is a major change from the books where absolutely none of his daughters and no one in Dorne, aside from a nutcase knight, wanted to hurt Myrcella.Myrcella.
** ''Series/HouseOfTheDragon'': Rhaenyra Targaryen and Alicent Hightower were the best of childhood friends. Then their life and opposite viewpoints led to a clash, a SuccessionCrisis and a CivilWar.

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