- Accidentally Correct Writing: This episode featured the term "embiggen" as a nonsensical word, but the writers later learned that the word "embiggen" had been used by writer C.A. Ward in 1884.
- Inspiration for the Work: The story was inspired by the real events surrounding the exhumation of President Zachary Taylor. In the late 1980s, college professor and author Clara Rising theorized that Taylor was murdered by poison and was able to convince Taylor's closest living relative and the Coroner of Jefferson County, Kentucky, to order an exhumation. On June 17, 1991, Taylor's remains were exhumed and transported to the Office of the Kentucky Chief Medical Examiner, who found that the level of arsenic was much smaller than would be expected if Taylor had been thus poisoned. The remains were then returned to the cemetery and received appropriate honors at reinterment. Then-show runner Bill Oakley said "Lisa the Iconoclast" is "essentially the same" story but with Lisa in the role as Rising.
- Throw It In!: Donald Sutherland ad-libbed the line "you had arthritis?" in response to Lisa's joke that she was getting over her "Chester A. Arthuritis". The producers liked it so much that they kept it.
Trivia / The Simpsons S 7 E 16 Lisa The Iconoclast