| 1 | * ActorAllusion: The concept of the virtuadolls is a thinly-veiled reference to the Music/{{Vocaloid}} phenomenon, with µ being an {{Expy}} of flagship character Hatsune Miku. So it stands to reason that [[Creator/AsamiShimoda Asami Shimoda]], whose most famous role is that of Miku's successor Vocaloids Kagamine Rin and Len, would voice µ's counterpart virtuadoll Aria. |
| 2 | * ContractualPurity: In a similar vein to the infamous case from ''Manga/KannagiCrazyShrineMaidens'', this reaction occurred in the Japanese fandom with Kotono and TheReveal that [[spoiler:she's a single mother]]. |
| 3 | * TheForeignSubtitle: The game, the remake, and the sequel is called ''Caligula'' in Japan but ''The Caligula Effect'' outside Japan. |
| 4 | * TheOtherDarrin: Owing to Creator/YuichiroUmehara being hospitalized due to acute disseminated encephalomyelitis, Creator/TomoakiMaeno voices Izuru from Episode 9 onwards in the anime. |
| 5 | * PlayingAgainstType: ''Creator/YukaOotsubo'' voicing the cold Thorn. |
| 6 | * RealLifeRelative: The male and female protagonists are voiced by siblings Chiharu Sawashiro and Creator/MiyukiSawashiro, respectively. |
| 7 | * WhatCouldHaveBeen: |
| 8 | ** In the game, Mifue (and by extension, Mirei) was originally going to have a whip as her weapon, but it was too difficult to animate on the Vita's hardware, so they went with a hammer instead. In ''Overdose'', Eiji and Stork ended up using whips. |
| 9 | ** The anime went through a few concepts for Ritsu before settling on what they did, including him being a sentient virus made to counteract μ and an elderly man on his deathbed. |
| 10 | ** A stage play adaptation of ''Overdose'' was announced in June of 2020, but was ultimately cancelled. |
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