- Actor Allusion: The concept of the virtuadolls is a thinly-veiled reference to the Vocaloid phenomenon, with µ being an Expy of flagship character Hatsune Miku. So it stands to reason that Asami Shimoda, whose most famous role is that of Miku's successor Vocaloids Kagamine Rin and Len, would voice µ's counterpart virtuadoll Aria.
- Contractual Purity: In a similar vein to the infamous case from Kannagi: Crazy Shrine Maidens, this reaction occurred in the Japanese fandom with Kotono and The Reveal that she's a single mother.
- The Other Darrin: Owing to Yuichiro Umehara being hospitalized due to acute disseminated encephalomyelitis, Tomoaki Maeno voices Izuru from Episode 9 onwards in the anime.
- Real-Life Relative: The male and female protagonists are voiced by siblings Chiharu Sawashiro and Miyuki Sawashiro, respectively.
- What Could Have Been:
- In the game, Mifue (and by extension, Mirei) was originally going to have a whip as her weapon, but it was too difficult to animate on the Vita's hardware, so they went with a hammer instead. In Overdose, Eiji and Stork ended up using whips.
- The anime went through a few concepts for Ritsu before settling on what they did, including him being a sentient virus made to counteract μ and an elderly man on his deathbed.
- A stage play adaptation of Overdose was announced in June of 2020, but was ultimately cancelled.
- The Wiki Rule: Caligula Wiki.
Trivia / The Caligula Effect