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1A list of characters who appear in ''VideoGame/TheBindingOfIsaacAntibirth''.\
2Characters introduced in ''Rebirth'' and the orignal Vanilla game go on [[Characters/TheBindingOfIsaac its own page]].
3----
4
5[[foldercontrol]]
6
7
8!Antibirth New Playable Characters
9
10[[folder:Bethany]]
11[[quoteright:162:https://static.tvtropes.org/pmwiki/pub/images/bethany_app_0.png]]
12->Debut: ''Antibirth''
13Named after the village that was home to Lazarus, Bethany is unlocked by having any combination of 12 soul, black, or immortal hearts during a run. She starts with the Book Of Virtues, which summons Wisp familiars that shoot alongside her and block shots, but can be destroyed. Uniquely, she cannot use soul, black, or immortal hearts, instead adding them to a consumable counter when picked up. She can spend these hearts to use her active item if it isn't charged.
14----
15* AerithAndBob: The only playable character with a name taken from a town instead of a character.
16* GirlishPigtails: She sports a pair tied up with blue ribbons.
17* MagikarpPower: Bethany's inability to pick up soul hearts means that one would have less health over all, and needs to avoid taking damage ''period'' to have a good chance at getting an Angel/Devil room for the floor, to say nothing of the fancy dodging required to build up flames with Book of Virtues. However, the soul hearts function to get much more use out of her starting item, and with enough cleared rooms and/or soul hearts picked up, she could have a huge multi-layered tornado of flames that ''each'' fires a spectral shot on its own.
18* MechanicallyUnusualFighter: As stated above, Bethany uses heart pick-ups to increase the counter to recharge space bar items. This lets her use space bar items more often at the cost of being more dependent on health increasing items and pick-ups. Any item that remove all of her hearts will kill her; for example Abaddon remove all of her red hearts and add the Black Hearts to the counter.
19* NonstandardCharacterDesign: Bethany is the only playable character with a pair of eyelashes.
20* SecretArt: Bethany is the only character capable of spawning white and black flames with Book of Virtues, by consuming Immortal and black hearts from her counter. Black flames can inflict fear with their shots, while white flames can regenerate themselves and other flames and their shots can block enemy tears.
21
22[[/folder]]
23
24[[folder:Jacob & Esau]]
25[[quoteright:111:https://static.tvtropes.org/pmwiki/pub/images/jacob_app.png]]
26[[caption-width-right:111:Jacob]]
27[[quoteright:111:https://static.tvtropes.org/pmwiki/pub/images/esau_app.png]]
28[[caption-width-right:111:Esau]]
29->Debut: ''Antibirth''
30A pair of brothers that are unlocked by defeating The Witness for the first time. Both brothers are controlled simultaneously, but they have separate items, trinkets, and health bars with Jacob having more health and Esau having more damage. If Jacob or Esau dies, the run is over. They are named after the twin sons of Isaac.
31----
32* AlwaysIdenticalTwins: Played with. Jacob looks like a normal person while Esau has dark red skin, but both have the same hair style.
33* AntiFrustrationFeatures: Since they automatically use any cards and pills they pick up, picking up a red card would run the risk of that card being [[PressXToDie Suicide King]]. Thankfully, the developers realized this and made it so that Suicide King never spawns in a Jacob & Esau run.
34* AmazingTechnicolorPopulation: Esau is a dark red because the Biblical Esau was described as "red all over" when he was born.
35* BornUnlucky: Esau starts with negative luck.
36* CantLiveWithoutYou: If one of the brothers dies, both die, so neglecting one of them to make the other stronger is out of the question.
37* DamnYouMuscleMemory: The twins automatically use any pick-ups as Esau's "use item" button is "Q", the standard use pick-up item button.
38* TheDividual: Both Jacob and Esau are controlled by the player and if one dies both die.
39* MechanicallyUnusualClass: The player is in control of two characters at once, and needs to manage their health and who gets what items. At first it's essentially like having double firepower, but it starts to get funky once the brothers have different movement speeds, tear effects, or even things like flight. They also have a unique UI to accommodate them, with Esau's health, active item, and trinket all in the bottom corner that normally shows your pill/card/rune.
40* SingleMindedTwins: Literally. Both brothers are controlled by one player, and move and shoot at the same time. You can however control Jacob independently by holding the item swap button, which is useful for positioning them for grabbing items or placing bombs.
41* TearsOfBlood: Esau has these standard.
42
43[[/folder]]
44
45!Monsters
46[[folder:Flies]]
47!Flies
48!!Willo
49* WillOTheWisp: What they're based on, fitting with Downpour's ghost theme.
50* WreathedInFlames: Willos are flies on fire.
51
52!!Fly Bomb
53* ActionBomb: Fly Bombs are literally just bombs with wings.
54* EasterEgg: Using Remote Detonator will instantly detonate all Fly Bombs in the room.
55
56!!Ink/Mama Fly
57
58!!Dragonfly/Sick Boom Fly
59* ActionBomb: Just like the other Boom Fly varieties.
60* DeadlyGas: Sick Boom Flies release a cloud of poison gas on death.
61* PlayingWithFire: On death, Dragonflies will release waves of fire in 4 directions. The directions they hit depends on the Dragonfly's appearance: if their eyes are normal, the fire goes in the cardinal directions, and if they have "x" eyes, the fire will be launched diagonally.
62
63[[/folder]]
64
65[[folder:Humanoid]]
66!Humanoid
67!!Blurb/Tidal Gaper/Strifer/Rotten Gaper/Twitchy
68* CompositeCharacter: Twitchy alternates between acting like a Gaper and acting like a Trite.
69* InescapableAmbush: Tidal Gapers start out submerged. They pop out once every other enemy has been cleared, forcing you to kill them before you can leave.
70* ZombiePukeAttack: Blurbs start with a mouth full of water, which they spit at Isaac before becoming effectively a normal Gaper.
71
72!!Wraith
73* InvisibleMonsters: Wraiths are invisible, but (somehow) still leave reflections that can be used to track them.
74* LightningReveal: They're also revealed by the periodic flashes of lightning in the Downpour.
75
76!!Danny/Coal Boy
77* DishingOutDirt: They spit out rocks, which can also be Rock/Coal Spiders.
78
79!!Faceless/Fanatic
80* LosingYourHead: They look like human enough, except they're missing the upper half of their head.
81* UniqueEnemy: Fanatics only appear in the Heretic's boss fight, and nowhere else.
82
83!!Sub Horf
84* CounterAttack: They will spin and fire tears as they take damage.
85
86!!Dumpling/Skinling/Scab
87* {{Gasshole}}: They attack by farting, although the Dumpling's farts only inflict knockback and don't damage you. Skinlings and Scabs upgrade to {{Fartillery}} due to their fart attacks actually being dangerous on their own.
88* PushyMooks: Dumplings can only harm you by tossing you into floor hazards or other enemies.
89* ShoutOut: Taken from Creator/EdmundMcMillen's earlier games.
90* ToiletHumor: They're basically ''floating butts'' that move around by farting.
91
92!!Revenant
93* BreathWeapon: They attack by breathing a stream of purple fire toward Isaac.
94* DemBones: They're EliteMook Bonies.
95
96!!Bubbles/Quakey/Big Bony/Barfy/Vessel
97* ActionBomb: Bubbles bursts into a fountain of tears on death, but it's easy enough to avoid as long as you don't run directly into it.
98* CounterAttack: Bubbles spits tears on taking damage, while Vessel spawns Small Maggots.
99* DeadWeight: Barfy and Vessel, being zombie Fatties.
100* DemBones: Big Bony is a skeletal Fatty. Turns out they're big-boned after all.
101
102!!Prey/Mullighoul/Bouncer/Blaster
103* AchillesHeel: Blasters take massively reduced damage, but are instantly killed by explosives.
104* ActionBomb: Bouncers explode into multiple bullets on death. The salvo is a lot smaller if you manage to kill them before they inflate.
105* BodyHorror: As Mulligan varieties, this is a given for most of them. Of special note is the Bouncer, whose entire head is little more than a ''giant tumor'' that can '''inflate'''.
106* MookMaker: Prey spawns Small Leechers, Mullighouls summon Willos, and Blasters lob Fly Bombs.
107
108!!Mole
109* ByTheLightsOfTheirEyes: They still have visible eyes in Curse of Darkness or the blackout rooms in the Mines.
110* CallASmeerpARabbit: They don't really look like moles, rather they're little humanoids.
111* WhackAMonster: They pop up around the room, fire at you, then duck underground again.
112* {{Wormsign}}: They leave one of these while travelling underground.
113
114!!Cursed Globin/Cohort
115* AsteroidsMonster:
116** Cursed Globins collapse into ''two'' piles of goo when killed, and each is capable of reforming into a new Cursed Globin. Thankfully, they can only duplicate a limited number of times.
117** Cohorts split into several piles of Globin goo on death, which will naturally become Globins if not killed quickly enough.
118* EnemySummoner: One of the Cohort's attacks summons a goo-form Globin.
119
120!!Black Knight/Loose Knight/Empty Knight/Pon
121* AttackItsWeakPoint: As with the other Knight variants, you damage these guys by attacking their exposed brains. The catch with the Empty Knight + Pon is that the brain is now hopping around ''outside'' the Knight.
122* AttackReflector: In addition to being immune to damage, the Black Knight's front end deflects tears.
123* CompositeCharacter: Loose Knight combines the normal Knight enemies and a Mask + Heart.
124* DetachmentCombat: Killing a Loose Knight causes it to split into an Empty Knight and a Pon.
125
126!!Vis Versa/Evis
127* CombatTentacles: Instead of shooting a laser, Evises latch a tentacle on to Isaac. It doesn't deal damage, but slowly drags Isaac towards them.
128* EyesDoNotBelongThere: Vis Versa has an eyeball inside the hole in its stomach (which itself is upgraded to a BellyMouth). It's used to fire a homing Brimstone beam.
129* PunnyName: Both are variants of the Vis enemy, playing off "vice versa" and "evil".
130* VaginaDentata: Are the normal Vis not Freudian enough for you? Vis Versa's hole is filled with teeth.
131
132!!Swapper/Unborn
133* FetusTerrible: Unborn is even smaller than other Baby variants.
134* SwapTeleportation: If a Swapper hits you, you trade positions with it.
135
136!!Bishop
137* MookMedic: They can only protect other enemies, and have no offensive abilities.
138* ShootTheMedicFirst: Unless you focus down the Bishop first, you won't have much luck trying to damage enemies in the room.
139
140!!Necromancer/Exorcist
141* EnemySummoner: Both of them attack by summoning other enemies until killed. Necromancers resummon dead enemies (or Bonies if nothing died yet) while Exorcists summon ghosts.
142* InTheHood: Their heads are pulled back in a way where the loose skin resembles a hood.
143* SkullForAHead: In the most nightmarish way possible. Necromancers have peeled their face back while Exorcists and pulled their entire head skin down, revealing their skulls.
144
145!!Screamer
146* DontWakeTheSleeper: Screamers start out passively wandering around the room. Getting too close to one causes it to wake up, paralyzing you and causing it to run at you.
147* MakeMeWannaShout: They wake up with a scream that inflicts paralysis.
148* ShoutOut: They're based on [[Franchise/TheLegendOfZelda ReDead]].
149
150!!Whipper/Snapper/Lunatic
151* AttackReflector: The Whipper and Lunatic's attacks can deflect tears.
152* TheBerserker: As its name suggests, the Lunatic attacks by charging at you while flailing wildly.
153* CombatTentacles: They attack by lashing out with fleshy whips.
154
155[[/folder]]
156
157[[folder:Worms and Grubs]]
158!Worms and Grubs
159!!Small Leech/Small Maggot
160* AquaticMook: Small Leeches only appear in the Downpour, and because the floor is covered in water, they can swim across gaps.
161* TheGoomba: Small Maggots crawl around very slowly and aimlessly, and pose very little threat. Unusually, these only start appearing in [[spoiler:the Corpse]], the final alternate floor.
162
163!!Adult Leech
164
165!!Fireworm
166
167!!Corpse Eater/Carrion Rider
168* CannibalismSuperpower: Corpse Eaters can eat other enemies that cross their path, gaining a speed boost in the process.
169* MountedCombat: Carrion Rider is a Bony mounted on a Corpse Eater, which can still fling bones at you.
170
171[[/folder]]
172
173[[folder:Spiders]]
174!Spiders
175!!Strider
176* WalkOnWater: Striders are well, water striders. They behave exactly the same as regular spiders, but they can cross over gaps on the Downpour since they're filled with water anyway.
177
178!!Rock Spider/Tinted Rock Spider/Coal Spider
179* KaizoTrap: Coal Spiders leave hot coals where they die, which can still hurt Isaac for a bit.
180* PinataEnemy: Like regular Tinted Rocks, Tinted Rock Spiders drop Soul Hearts on death.
181* ScrappyMechanic: Tinted Rock Spiders spawn when you blow up a tinted rock on the Mines, replacing any Soul Hearts you would've gotten.
182
183!!Soi Creep
184* MoreDakka: They fire a continuous stream of shots, similar to the effect of Soy Milk.
185* WallCrawl: As a Wall Creep variant.
186
187!!Fissure
188[[/folder]]
189
190[[folder:Other]]
191
192!!Hardy
193* RuleOfThree: Hardies can only use their charge attack three times; after the third time, they automatically crumble.
194* TalkingPoo: Well, it doesn't talk, but it's still a living coprolite.
195
196!!Grilled Clotty
197* BalanceBuff: They're one for the Clotty, giving them a powered-up fiery form and by extension making them immune to fire damage.
198* InfernalRetaliation: They're formed when a Clotty catches fire, causing it to move and shoot much faster.
199
200!!Floating Host/Hard Host
201* DishingOutDirt: Hard Hosts attack by releasing rock waves.
202
203!!Cyst
204
205!!Spikeball
206* InvincibleMinorMinion: They're more of an obstacle than an enemy, as they can't be killed and don't become inactive when the room is cleared.
207
208!!Bomb Grimace/Quake Grimace
209* EarthquakeMachine: The Quake Grimace releases rock waves in front of it.
210* HelpfulMook: Bomb Grimaces don't really count as enemies at all, as their only function is to give you bombs that can be picked up and thrown.
211* InvincibleMinorMinion: They can't be damaged, and don't deactivate under any conditions.
212
213!!Pustule
214
215!!Blind Bat/Echo Bat
216* ActuallyFourMooks: Blind Bats are seen hanging from the roof by themselves, but once they're awakened, four of them drop down at once.
217* InterfaceScrew: The Echo Bat can scramble your movement controls, which can be bad news when you're busy dodging three other enemies.
218
219!!Stillborn
220* InvincibleMinorMinion: Can't be damaged, but will die if all other enemies are killed.
221* KaizoTrap: When they die after clearing the room, they also explode. Fortunately, there's a long enough delay before the explosion that you should be able to get away.
222* TakenForGranite: Stillborns are composed largely of stone. They're inspired by the phenomenon ''lithopedion'', which is where [[BodyHorror a fetus dies in the womb and becomes calcified]].
223
224!!Smoky
225* InvincibleMinorMinion: As a Death's Head variant, they only die when the room is cleared.
226* SupernaturalFearInducer: They're surrounded in a purple aura that inflicts Fear, although it works differently than normal Fear, preventing Isaac from shooting rather than making him run away.
227
228!!Nightwatch
229* EnemySummoner: Nightwatches appear in darkened rooms and hold lanterns; if they catch you in the lantern's beam, they'll lock the doors and disappear while leaving enemies in their place.
230* InvincibleMinorMinion: Nightwatch is invulnerable, but can be ignored as long as you stay out of their line of sight.
231
232!!Polty/Candler
233* ArtificialBrilliance: Polties tend to make a beeline for any explosives in the room to try and get in as much damage on you as possible. And if you're expecting them to crack open a Tinted Rock for you, forget about it; the Polty will throw everything else in the room, [[BanditMook then grab the Tinted Rock and run away with it.]]
234* ImprovisedWeapon: Rocks, TNT, buckets, ''poop''… if it's an obstacle that can be picked up, Polties will use it as a weapon.
235* PlayingWithFire: Candlers periodically create damaging flames in their wake.
236* {{Poltergeist}}: If the name didn't make it obvious, Ploties are ghosts that pick things up and throw them at you.
237
238!!Coil
239* InvincibleMinorMinion: Coils can't be killed normally, and will respawn if destroyed with a Chaos Card. Note that they will cause contact damage even if the room is cleared.
240* ShockAndAwe: They radiate electric beams that attach to enemies in the room. A number of rooms have these in combination with Wall Huggers and Sliders, leading to a lot of dodging with not much else you can do about it.
241
242!!Gyro/Grilled Gyro
243* InfernalRetaliation: Gyros will turn into Grilled Gyros on contact with fire, becoming faster and tougher.
244* OurMonstersAreWeird: Even by the standards of this game, a wheel of meat that rolls around while attached to a bone is pretty out there.
245
246!!Gasbag
247* DeadlyGas: Release a cloud of poison gas around themselves that lingers for a few seconds after they're killed.
248
249[[/folder]]
250
251!Bosses
252
253[[folder:Normal Levels/Shared]]
254
255!Baby Plum
256[[quoteright:111:https://static.tvtropes.org/pmwiki/pub/images/little_jack_horner.png]]
257* BulletHell: Very mild compared to most examples in the game, but it shoots a ''lot'' of projectiles for a boss you can fight on the first floor.
258* KingMook: Of various flies, most notably the Level 2 Flies.
259* MascotMook: Baby Plum is the mascot of the mod. Ironically, it is the only new boss that does not appear on any ''Antibirth'' floor[[note]]Reap Creep can show up in the Mines, and the Pile can show up in the Mausoleum[[/note]].
260
261!Reap Creep
262[[quoteright:232:https://static.tvtropes.org/pmwiki/pub/images/thats_one_big_spider.png]]
263* AllYourPowersCombined: Reap Creep combines the abilities of all three varieties of Wall Creep in the vanilla game and turns them up to eleven.
264* BeamSpam: Its third phase can fire a spray of four sweeping Brimstone beams.
265* GiantSpider: It's a giant Wall Creep around the size of Widow.
266* KingMook: Of the wall creeps.
267* MookMaker: Spawns a lot of creeps to harass the player. It can also shake spiders loose from the ceiling.
268* SequentialBoss: Has three phases, each imitating a different Wall Creep, all with different attacks. Its first phase primarily fires long chains of bullets aimed at the player, its second phase shoots wide spreads, and its third phase attacks with Brimstone lasers.
269
270!The Pile
271[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/boss_the_pile.png]]
272* BackFromTheDead: It's an undead version of Polycephalus and The Stain.
273* BallisticBone: It can launch sprays of bone projectiles.
274* DemBones: A fully skeletal version of Polycephalus.
275* FastTunnelling: One of its attacks is to duck underground then instantly pop up behind you.
276* GetBackHereBoss: Like always, it pops up to attack and pulls away to hide.
277
278[[/folder]]
279
280[[folder:Downpour]]
281
282!Wormwood
283[[quoteright:133:https://static.tvtropes.org/pmwiki/pub/images/no_relation_to_the_teacher.png]]
284* BossArenaUrgency: It can punch holes in the floor with its tail. Given the way pits work in this game, this won't kill you, but it does make it more difficult to dodge Wormwood's attacks and gives it more places to ambush you from.
285* DeadlyLunge: Gains a ''very'' fast one when it's at low health.
286* KingMook: To the leech enemies found throughout the game, but especially the Small Leeches in the Downpour.
287* MakingASplash: Its projectiles appear to be water, as opposed to the standard blood projectiles.
288* MeaningfulName: Named after the biblical [[https://en.wikipedia.org/wiki/Wormwood_(Bible) Wormwood]], a star which will fall and turn a third of Earth's waters bitter and deadly.
289* TurnsRed: It becomes much more aggressive and will start making holes in the ground at low health.
290
291!Beelzeblub
292[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/boss_beelzeblub.png]]
293* FlunkyBoss: Just like the original Duke of Flies, but with small leeches instead of flies.
294* PunnyName: "Beelzebub" + "blub", an onomatopoeia for bubbling water.
295* UndergroundMonkey: A drowned, but still animate, version of the Duke of Flies.
296
297!The Rainmaker
298[[quoteright:89:https://static.tvtropes.org/pmwiki/pub/images/let_it_rain.png]]
299* BattleInTheRain: The battle against him is accompanied by a constant downpour that stops when he's defeated.
300* DanceBattler: His movements in battle borrow heavily from the flamenco.
301* MakingASplash: Rainmaker's attacks all have him levitating balls of water to hurl at the player.
302* OurGhostsAreDifferent: This ghost has [[MakingASplash water-based powers]] and [[TheDeadCanDance dances the flamenco]].
303* SomethingAboutARose: He carries a rose in his mouth in the VersusCharacterSplash. In the fight itself, it's mostly absent except when he pulls it out after one of his attacks.
304
305!!The Haunt
306[[quoteright:150:https://static.tvtropes.org/pmwiki/pub/images/spooky_scary_son_of_a.png]]
307-> Debut: ''Rebirth''
308* BedsheetGhost: What's underneath its sheet is quite a bit scarier, however.
309* EnergyWeapon: In his second phase, he'll fire Brimstone downwards as he strafes along the top of the screen.
310* FlyingFace: That rips itself open to reveal a [[SkullForAHead skull]] when its minions are dealt with.
311* FlunkyBoss: He is surrounded by three Lil Haunts which attack before he does. First one attacks, then the other two do. He's invulnerable until they're dead and he moves to the top of the room. His black Champion version spawns spiders instead of shooting Brimstone.
312* HeelFaceTurn: The Lil' Haunt item gives you a friendly Lil' Haunt who chases your enemies.
313* {{Intangibility}}: Until his minions are dead.
314* KingMook: To the Lil' Haunts.
315* NoFairCheating: He normally paces from side to side along the top edge of the screen, shooting downwards. If you try to move to the top where he can't shoot you, he'll immediately charge at you to cause damage. Which ''hurts like '''crazy.''''' Of course, if you're fast enough you can dodge it and still hurt the boss before it loops back.
316* OurGhostsAreDifferent: This one has a skeleton. Which he'll gladly show to you.
317* ThePawnsGoFirst: Sends his Lil' Haunt minions to attack you while he himself remains intangible. When they go down, then he fights you.
318
319[[/folder]]
320
321[[folder:Mines]]
322
323!Tuff Twins
324[[quoteright:203:https://static.tvtropes.org/pmwiki/pub/images/boss_tuff_twins.png]]
325* BossArenaIdiocy: The Tuff Twins start out covered in a rock shell that makes them impervious to attack and must be broken with explosions. Their boss room always happens to contain a number of Bomb Grimaces that provide free bombs to chuck at them, and occasionally a couple of TNT barrels as well.
326* FlunkyBoss: They spawn Inks (which release four bullets in the diagonal directions on death along with a puddle of slowing creep) to harass the player throughout the fight. If their head is exposed, they switch to Suckers instead.
327* ShedArmorGainSpeed: They become faster as you blow up their stone armor.
328
329!Great Gideon
330[[quoteright:126:https://static.tvtropes.org/pmwiki/pub/images/a_scott_pilgrim_reference.png]]
331* AddedAlliterativeAppeal: '''G'''reat '''G'''ideon. [[spoiler:As a bonus EasterEgg, in the codes, the crawlspace under him is called: "Gideon's Grave". A nod to the Scott Pilgrim comic book series.]]
332* AllYourPowersCombined: Combines the abilities of all Grimace varieties in ''Rebirth'' and the new Quake Grimace in ''Antibirth''.
333* EasterEgg: Throwing a Chaos Card at him will instantly kill him, as well as [[spoiler:open a hidden crawl space that holds several items and chests]].
334* FireBreathingWeapon: One of Gideon's attacks has it spewing fiery bullets down the middle of the room, which will leave lingering fires on the ground. It also exploits this by summoning a number of enemies that [[InfernalRetaliation become more powerful when lit on fire]].
335* FlunkyBoss: Summons six waves of enemies to attack you in addition to shooting at you himself. Defeating all of the minions ends the fight.
336* KingMook: To the Grimaces.
337* NighInvulnerable: Like the [[InvincibleMinorMinion enemies]] he's based on, Great Gideon is immune to everything that's not a Chaos Card, and you defeat him (without actually killing him) by killing all of the other monsters in the room.
338* VacuumMouth: One of his attacks, taken from the Gaping Maw enemy. Only he'll also suck in rocks from the walls which you have to dodge.
339
340!Hornfel
341[[quoteright:74:https://static.tvtropes.org/pmwiki/pub/images/i_wanna_take_you_for_a_minecart_ride.png]]
342* MadBomber: His main modus operandi is to ride around on his minecart, chucking various bombs at you.
343* MinecartMadness: Inverted. He's the one on the minecart, but you're still the one doing the dodging.
344* ScoobyDoobyDoors: His boss room is lined with them, and Hornfel can emerge from any one at any time. Of course, the player can't use them.
345* ScrewThisImOuttaHere: Depleting Hornfel's health destroys his minecart, at which point Hornfel will run for the nearest door. This makes Hornfel the only boss that can be defeated non-lethally, but you do get a few bomb pickups or even a bomb-based item if you can kill him before he escapes.
346* ShoutOut: The Brimstone bombs he uses are visually based on the grenades launched by the Iron Bomber, an unlockable weapon in ''VideoGame/TeamFortress2'' which was originally designed and submitted to the Steam Workshop by Kilburn (one of the mod's creators).
347* SuperSpit: His main non-bomb attack has him continually speeding up on his minecart, only to end up going so fast that he gets sick and [[VomitIndiscretionShot projectile vomits in your general direction]]. The puke, of course, explodes.
348* TrickBomb: Hornfel's bombs use several different modifiers: he can throw Hot Bombs which leave damaging fire behind, Rock Bombs which send rock waves in the cardinal directions, and a unique Brimstone bomb that explodes into a four-way Brimstone laser.
349
350[[/folder]]
351
352[[folder:Mausoleum]]
353
354!The Heretic
355[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/boss_the_heretic.png]]
356----
357* InTheHood: He traded his ectoplasm skin for a black cloak.
358* KaizoTrap: After it dies, the fire in its eye falls to the ground and erupts into a four-way burst, possibly damaging you if you're not paying attention.
359* NonHumanUndead: It's an undead ghost. Try to wrap your head around that.
360* OurGhostsAreDifferent: And apparently more undead.
361* ThePawnsGoFirst: Just like the Haunt, the Heretic will send its minions after you first and only start fighting once they're all dead.
362* ReflectingLaser: His boss room always comes with a number of extinguished fireplaces. One of his attacks lights them up, then fires a Brimstone beam that chains between them.
363* UngratefulBastard: It gets revived by cultists, and it thanks them by turning them into {{Mooks}} to send after you.
364
365!The Visage
366[[quoteright:181:https://static.tvtropes.org/pmwiki/pub/images/how_does_a_mask_die_anyway.png]]
367* AttackItsWeakPoint: Initially, it's the chain holding the two together; afterwards, the heart itself becomes the weak point, and the mask can be incapacitated by attacking it from behind.
368* CatAndMouseBoss: As with Mask of Infamy, the heart flees while the mask tries to run you down. The difference is that the heart is fully capable of fighting back, and the mask doesn't like to stay dead.
369* DualBoss: As opposed to the original Mask of Infamy which is taken down one part at a time, both parts of The Visage attack simultaneously, and even come with a number of {{Combination Attack}}s.
370* GrapplingHookPistol: The Visage's heart can use chains to pull itself to nearby surfaces. Note that this includes the mask and ''Isaac''.
371* TurnsRed: Twice. Once when the chain is destroyed and gives the two parts of the Visage free movement, and a second time when the heart's health drops low and it changes its attack patterns.
372* VariableLengthChain: The chain binding the heart and mask together in the initial phase, particularly noticeable when the mask charges and stretches the chain to around twice its usual length. During the second phase, the heart uses one in a number of its attacks.
373
374!The Siren
375[[quoteright:192:https://static.tvtropes.org/pmwiki/pub/images/boss_the_siren.png]]
376----
377* BeatTheCurseOutOfHim: If she steals one of your familiars, you can get it back by shooting it.
378* BulletHell: Like a number of other bosses, The Siren can unleash a dense array of bullets in all directions. Her shots actually curve in the air, making them harder to dodge.
379* CharmPerson: Can steal your familiars with her voice and turn them against you.
380* {{Expy}}: Of, oddly enough, the Gorgun from VideoGame/EnterTheGungeon, having several similar attacks and a similar appearance.
381* MagicMusic: Her singing can lure your familiars over to her side.
382* NotQuiteDead: If she steals an extra life familiar like Dead Cat or 1up, she'll use it to bring herself back with 10% health and [[BanditMook eat the extra life in the process]]. You'll want to make sure you get those familiars back before killing her.
383* PowerParasite: Effectively copies the abilities of your familiars by charming them. Things can get very messy if she steals something like Dry Baby or Dead Cat.
384* StrippedToTheBone: The Siren is rapidly reduced to an inert skeleton upon death. [[spoiler:Destroying her skull unlocks a trinket.]]
385
386!Mausoleum Mom
387[[quoteright:141:https://static.tvtropes.org/pmwiki/pub/images/boss_mom.png]]
388----
389* AttackOfTheFiftyFootWhatever: Her boss fight.
390* AxCrazy: Her goal is to kill her own son, and she doesn't sound too upset about it during the fight, what with the laughing and all.
391* BattleThemeMusic: ''Matricide'', as with normal Mom.
392* BodyHorror: The way Mom's body parts move throughout the fight (such as both eyes appearing on opposite sides of the room while she tries to stomp on you) suggest an ability to contort herself in rather… impossible ways.
393* BossBanter: ''ISAAAAAC!''
394* DeathByIrony: [[spoiler:Crushed by her own Bible!]]
395* DiscOneFinalBoss: Demoted to this on your second playthrough and beyond. She's still a Disc One boss in the alternate path, but in terms of floor number, she's faced much closer to the path's final boss than the main path's end.
396* EvilIsVisceral: Likely the reason her body parts are detailed and somewhat deformed.
397* EvilLaugh: She lets out one every time she successfully damages Isaac.
398* EyeBeams: Mausoleum Mom gains the ability to fire Brimstone beams from her eye.
399* TheFaceless: Her entire face is never shown at any point in the main game (the intro and epilogue don't count, as they're Isaac's cartoon drawings). This is [[SubvertedTrope subverted]] after you beat the Chest in ''WOTL'' or ''Rebirth'', but only briefly. In photographs, to be precise.
400* FanDisservice: When Isaac uses the Mom's Bra item, a picture of his mother's shirtless torso flashes on the screen. A ''very'' unflattering picture of his mother's less-than-fit shirtless torso.
401* FatBastard: As shown by her giant leg and the picture that shows up when using Mom's Bra.
402* FinalBoss: In your first playthrough. She's nowhere near the TrueFinalBoss, though.
403* FlunkyBoss: She'll summon groups of random enemies to battle Isaac.
404* GameplayAndStoryIntegration: Using [[spoiler:the Bible]] instantly defeats her in her boss fight.
405* GiantFootOfStomping: Her main method of direct attack.
406* {{Gonk}}: Same deal as normal Mom.
407* GrossUpCloseUp: One of her leg in the boss portrait, and one of her body in the picture that appears when using Mom's Bra.
408* HumanoidAbomination: Most of what she does in-game and in a few cutscenes blatantly disregards normal body movements if not physics. She can step on her own eye, generally alter size, and [[spoiler:her arm can fit in a chest inside her heart inside her womb]].
409* MookMaker: And these mooks are a lot harder than last time!
410* MotherOfAThousandYoung: If you go by the theory that the majority of the enemies are her former children.
411* SayMyName: ISAAC!
412* SkippableBoss: Provided you have [[spoiler:the Bible]] on you by the time you reach her, and it's fully charged.
413* TacticalSuicideBoss: It's not actually mandatory, but making her stomp herself is possible, and deals lots of damage.
414* TrickBoss: [[spoiler:Defeating her while holding the Knife Pieces throws you into a fight against Mom's Heart immediately afterwards.]]
415* YourSizeMayVary: Just how big is she? In the cutscenes, she's a normal-sized human being, but her underwear is the right size to be worn by a child visibly smaller than her, in the boss fight her leg is the length of the screen, and then [[spoiler:her womb is big enough to have two entire levels in it, with her heart being larger than Isaac]].
416
417!Mausoleum Mom's Heart
418[[quoteright:147:https://static.tvtropes.org/pmwiki/pub/images/momsheart.png]]
419* BattleThemeMusic: The mod gives Mom's Heart the new battle theme ''Gloria Filio'', a slower but no less triumphant and dramatic rock theme with [[HeartbeatSoundtrack an audible heartbeat]] keeping time. "Gloria filio" roughly translates from Latin as "glory to the son", representing Isaac overcoming his abusive mother [[spoiler:and killing her, as seen in the Corpse ending]].
420* BossRush: Can be fought right after Mausoleum Mom [[spoiler:if you enter the Mom fight with all three Knife Pieces]].
421* BulletHell: Just like regular Mom's Heart, only its bullet patterns are ''much'' flashier and more complex, travelling in zig-zagging paths or spiraling through the air. They also follow the rhythm of the heart's beating, meaning they will zigzag ''faster'' as the heart loses health.
422* ClimaxBoss: Mausoleum Mom's Heart is an alternate path run's point of no return, and the point where the mod's atmosphere really takes a turn for the worse. Once it's defeated, you're locked into the Corpse.
423* DegradedBoss: Mom's Heart normally appears at the end of the Womb, but shows up two chapters early here as its regular place is taken by [[spoiler:the Witness]].
424* MookMaker: Like regular Mom's Heart, it will spawn enemies in between BulletHell salvos, except its spawns are all ''Antibirth'' monsters like Gyros and Loose Knights.
425* PaletteSwap: It can summon Blurbs colored in a more natural skin tone, whose water bullet spray is also reskinned into blood.
426
427[[/folder]]
428
429[[folder:Corpse]]
430
431!The Scourge
432[[quoteright:158:https://static.tvtropes.org/pmwiki/pub/images/not_an_evil_green_hedgehog.png]]
433* BulletHell: Particularly notable is that one of its attacks has it sucking in bullets from the walls of the room.
434* CombatTentacles: Has two of these tipped with sharp blades that it uses to lash out at you or confine you to a certain part of the room.
435* FacelessEye: Its "head" consists of a single eye and nothing else.
436* KingMook: To the Whipper enemies encountered in Mausoleum.
437
438!Rotgut
439[[quoteright:163:https://static.tvtropes.org/pmwiki/pub/images/worm_in_a_worm.png]]
440* AllThereInTheManual: The maggot fought in the second phase is named "Gus" according to the ''Antibirth'' devs.
441* BodyHorror: It's some sort of gaping mouth with a giant maggot and rotten heart inside. Not something that should be inside ''anyone's'' body.
442* NestedMouths: A smaller brown-yellow mouth inside the original, which pops up to spew out shots.
443* SequentialBoss: Has three separate phases. First it's a fight with its maw. Once that's defeated, it eats you and you kill a maggot in its gut. Then you kill it by destroying its heart.
444* StationaryBoss: In all three phases.
445* SwallowedWhole: After defeating the first phase, it sucks you in with its VacuumMouth and you have to kill a giant maggot and Rotgut's heart.
446* UnexpectedGameplayChange: The second and third phases use Crawl Space physics and controls, turning the game into a 2-D platforming shooter.
447
448!Chimera
449[[quoteright:126:https://static.tvtropes.org/pmwiki/pub/images/could_lucas_beat_it.png]]
450* ConfusionFu: Chimera has perhaps the widest range of attacks of any non-final boss in the game, which changes up in its second phase; as such, it can be a very unpredictable opponent.
451* DualBoss: In the second phase.
452* FastballSpecial: In its first phase, it can throw Sick Boom Flies at the player. In the second phase, it throws its own head.
453* LosingYourHead: Chimera's head detaches when it takes enough damage, turning it into a DualBoss.
454* MixAndMatchCritters: It's The Cage with Gurdy Jr. for a head.
455* SequentialBoss: Once Chimera is at about 50%, it splits into both the head and body and gains totally different attacks.
456
457!The Witness
458[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/400px_boss_the_witness.png]]
459----
460* AttackOfTheFiftyFootWhatever: ''The'' biggest boss in the game (barring perhaps Mega Satan, or Mom counting the unseen rest of her body), taking up the entire top wall of a 2x2 room.
461* BackFromTheDead: It's the rotting corpse of Mama Gurdy, grey from time.
462* BattleThemeMusic: ''Memento Mori'', a chilling and oppressive rock theme with heavy synthesizer, bass, and a droning [[OminousPipeOrgan organ accompaniment]]. "Memento mori" means, of course, "remember that you will die", as if the Witness is already lording its inevitable victory over you.
463* {{BFS}}: One of its attacks has it pulling out and throwing a gigantic knife.
464* BodyHorror: ''Oh yes''. Not only is it a decayed version of a boss that's already pretty far in BodyHorror territory, but when its head detaches, it exposes two more skulls where its shoulders would be.
465* BulletHell: As expected of a ''Binding of Isaac'' endboss, but The Witness takes this to a whole new level that would only be rivaled by Hush.
466* EvilOverlooker: Its boss portrait has the Witness looming over Isaac in this fashion, instead of the "facing Isaac from the side" view of every single other boss.
467* FemaleMonsterSurprise: ''Repentance'' reveals her to not only be female, but a grotesque, undead form of Mom. Of course, the ''Antibirth'' version was already female, given that it's based on Mama Gurdy.
468* FinalBoss: Of the ''Antibirth'' content.
469* InterfaceScrew: A minor example. The Witness's fight takes place in a quadruple-size room that is zoomed out so that the entire room is visible.
470* MarathonBoss: Downplayed. While the fight against it is still longer than a normal fight, it lacks the scaling damage resistance that the canon final bosses have, meaning that it's a relative GlassCannon.
471* TakenForGranite: After you finally kill it, it hardens over into stone.
472* TurnsRed: After you deplete its health bar once, its arms explode, and its head bursts out out of its body to keep attacking.
473* TwoFaced: Half of its face has rotted down to the skull.
474

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