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1* The ExcusePlot of ''VideoGame/AdventureIsland III'' is set in motion when aliens in a FlyingSaucer kidnap Master Higgins' [[DamselInDistress girlfriend Tina]] and he promptly chases them down to rescure her. For the third time.
2* In ''VideoGame/BaldursGateIII'', the mind flayer that captures you in the intro has CombatTentacles on its nautiloid that teleport people they strike into tanks on the ship for later infestation with an illithid tadpole.
3* In ''VideoGame/{{Bully}}'', after Jimmy Hopkins collects all the radio transistors for The Hobo, the latter is beamed up into the sky, implying that he was voluntarily picked up by a UFO.
4* ''VideoGame/CavemanWarriors'': The story mode starts with an alien spaceship grabbing a couple cave kids with robot arms.
5* One mission in ''VideoGame/DestroyAllHumans'' involves abducting a beauty pageant winner. Several side missions also require you to throw a number of people or [[AliensStealCattle cows]] into the Mothership's [[TractorBeam Abduct-O-Beam]].
6%%* In ''{{VideoGame/Disgaea 4|APromiseUnforgotten}}'' all of the generic classes have introductory cutscenes which play when you create a new one to add to your team. The [[InfinityPlusOneSword cyborg]] class's cutscene shows a female fighter being abducted in this manner, before being StrappedToAnOperatingTable and undergoing UnwillingRoboticisation. %%Missing context: The manner in which the fighter is abducted.
7* ''Videogame/EarthBoundBeginnings'':
8** Nearly every adult resident of Youngtown was abducted by aliens at some point before the protagonists arrive there, leaving it to become a NeverLand populated almost entirely by children.
9** In the game's BackStory, [[spoiler:the protagonist's great-grandmother and great-grandfather, Maria and George, were abducted and held for an unspecified amount of time by a SufficientlyAdvancedAlien race. Maria became the [[ParentalSubstitute surrogate mother]] of the then-infant BigBad Giegue and raised him to adulthood, while George studied and presumably gained the ability to use [[PsychicPowers PSI]], well against the alien race in question's wishes. George eventually made it back to Earth, but Maria wasn't so lucky.]]
10* ''VideoGame/EchoesOperationStranglehold'': The Hybrid Pantheon have managed to capture almost the entire human race, save for about half a million people.
11* The ''VideoGame/Fallout3'' add-on ''Mothership Zeta'' has the player and various wastelanders being abducted and studied aboard an alien ship. The evidence on the ship indicates that they have been doing this for centuries. In fact, one of the abductees is a Japanese samurai in full armor who proceeds to slice up his abductors with his {{katana|sAreJustBetter}}. Naturally, you can't understand each other. Another is a Wild West cowboy, whose Colt comes in handy.
12* There is a funny [[https://www.youtube.com/watch?v=5NBEtbXJR5Q cheat mode]] in ''[[VideoGame/FIFASoccer FIFA Soccer 2000]]'', which enables a spaceship hovering above the pitch during a match and beaming up players who accidentally happen to stand right under the ship's tractor beam.
13%%* In the ''VideoGame/Interstate76 Nitro Pack'' expansion, this was a NonstandardGameOver EasterEgg you could get on some missions that required you to go into a specific area well away from the normal mission zone. %%Missing context: What this Easter egg is.
14* In ''VideoGame/TheLegendOfZeldaMajorasMask'', one of the side quests involves some aliens attacking Romani Ranch on the Night of the First Day. They mostly seem interested in [[AliensStealCattle the cows]], but if Link fails to stop them, they'll abduct poor Romani as well (she was in the barn, trying to save the cows). [[spoiler:If she's taken, she'll be dropped back around the afternoon of the Second Day, dazed and having obviously had her mind wiped.]]
15* ''VideoGame/MassEffect2'':
16** The plot revolves around mysterious aliens called "Collectors" abducting entire human colonies at once. [[spoiler:They're using said colonists to build a [[EldritchAbomination Reaper]].]]
17** TheProfessor Mordin's loyalty mission shows that [[LizardFolk krogan]] mercenaries had been abducting humans and experimenting on them in an effort to cure their SterilityPlague. Mordin explains that because [[HumansAreSpecial humans have more variance and flexibility in their genomes]] they make for useful test subjects, although for obvious ethical reasons no respectable researcher would do so.
18* ''VideoGame/MetalGear'':
19** In the fourth game, ''VideoGame/MetalGearSolid2SonsOfLiberty'', the Colonel, shortly after Raiden manages to escape Arsenal Gear's torture room, suddenly starts telling what seems to be a typical UFO story where it is implied that he was abducted while trying to get home from work, giving the early implication that the Colonel is not who, or rather, [[AIIsACrapshoot what]], he claims to be.
20** The third game, ''VideoGame/MetalGearSolid3SnakeEater'', has Sigint remarking that Zero claimed that he was abducted by Aliens once as a reason for him to suspend disbelief in regards to Snake procuring the Spirit Camo.
21** In the novel within a video game, ''The Shocking Conspiracy on Shadow Moses'', the main character once thought he was abducted by aliens.
22** ''VideoGame/MetalGearSolidPeaceWalker'' implies that most of the UFO encounters, Alien abductions, and Cattle Mutilations were actually caused by the CIA, more specifically their rogue unit: the Peace Sentinels, and their AI weapons.
23* ''VideoGame/OnEscapee'' is about a man who survives his abductors' shipwreck, leaving him stranded on a distant planet.
24* The plot of ''VideoGame/OttoMatic'' goes that [[MyBrainIsBig Brain Aliens]] from Planet X are abducting humans to turn them into more of themselves, and it's up to the eponymous SpacePolice robot to stop them. In each level there are civilians which -- once you're close -- you must rush to teleport them to safety before a FlyingSaucer arrives to [[TractorBeam scoop them up]].
25* In ''VideoGame/PhantasyStarOnline2'', undertaking specific quests on Very Hard difficulty or above has a small chance of the players' campship getting abducted and thrown into the Darker Den.
26%%* ''VideoGame/Prey2006'':
27%%** This happens to the protagonist, his [[DamselInDistress girlfriend]], his grandfather, and apparently half of Texas. %%Missing context: The thing that happens to the protagonist, his girlfriend, his grandfather, and apparently half of Texas.
28%%** Also if you listen to the radio they have also done this to Garland, Texas, and if you look around they are planing on doing this to New York City. [[spoiler:They already got a school bus filled with kids, you watch them take an airplane, and they have abducted other human-like people from different planets. Plus with a ship that size who knows what else could be up there?]] %%Missing context: The thing that has been done to Garland, Texas; and the culprit.
29%%** The protagonist of [[{{Vaporware}} the sequel]] is one of the passengers on that airliner. He has a few missing years in his memory (starting with the abduction) and is looking for the truth, while working as a bounty hunter on an alien world.
30* In the Taiwanese video game ''[[VideoGame/{{Richman}} Richman 4]]'', a game similar to ''TabletopGame/{{Monopoly}}'', one of the events from the "Chance" spot involved the player being abudct by aliens, which sent the player off the board via a [=UFO=] for three rounds, being unable to collect any rents during that preiod.
31* ''VideoGame/{{Seedship}}'': A random event can have your colonists get stolen by aliens.
32* In ''VideoGame/ShinSuperRobotWars'', [[Characters/SuperRobotWarsAlpha Professor Eri Anzai]] is kidnapped by the [[Characters/SuperRobotWarsAlpha Ze Balmary Empire]] because of her vast knowledge on ancient history.
33* ''VideoGame/TheSimpsonsGame'' Kang and Codos's {{mook}}s raid the Springfield mall and abduct people. After [[HalfWittedHillbilly Cletus]] complains that he spend all day cutting out coupons for a new flat screen TV they get impressed by his tiny pieces of paper and decide that they must [[AnalProbe study]] him.
34* ''VideoGame/TheSims'' games allow your Sims to get abducted by aliens if they spend too long stargazing. (It's a very small chance without hacks or cheats.) In ''VideoGame/TheSims2'', they can also come back pregnant with an alien baby... [[MisterSeahorse if they're male.]] Now ''that's'' extreme AnalProbing. Even if they're not pregnant, there's a possibility of [[http://cloudlessnights.livejournal.com/26890.html them starving to death]] after their return if they aren't fed immediately; the aliens don't have human food, it seems. This was also introduced in ''VideoGame/TheSims3: Seasons'' expansion pack and ''VideoGame/TheSims4: Get to Work'' expansion pack.
35%%* ''VideoGame/{{Spore}}'': While players themselves can't be subjected to this, during the Creature and Tribal stages their allied creatures most certainly can, hence why it's a good idea to run away whenever a spacecraft appears if you value your teammates. Once you reach the Space stage you can also freely do this any creatures you encounter, including sentient beings and [[WhatTheHellHero even members of your own race]]. Some missions you can accept even require you to do this and deliver the abductee to another planet. Your ability to experiment on whatever you abduct is limited to altering them physically, but once you've abducted them you can also [[VideoGameCrueltyPotential drop them from your ship and send them falling to their doom, jettison them from your cargo hold while in space, or beam them down onto an unlivable planet to suffocate/burn/freeze to death]]. %%Missing context.
36* In ''VideoGame/{{Stellaris}}'', empires that engage in "Active Observation" of a pre-FTL species will abduct specimens for study. Fanatic Xenophile empires won't tolerate the practice and it has a chance of making the natives more Xenophobic.
37* ''Franchise/SuperMarioBros'':
38** In ''VideoGame/SuperMarioLand'', Mario has to save Princess Daisy (who makes her debut here) from an evil alien [[spoiler:who kidnapped her just so he can distract Mario while the game's ''real'' villain, Wario can succeed in his evil plans as revealed in the sequel.]]
39** ''VideoGame/SuperMarioGalaxy'': Rosalina, according to her backstory was actually abducted by the Lumas because one of them thought that she was its mother. When Rosalina realizes that her real family is now long dead since her departure, she eventually becomes their leader, and even helps Mario save both Peach and the entire Mushroom Galaxy from {{B|igBad}}owser, who at the same time did this to Peach.
40* ''VideoGame/{{Warframe}}'': In the "Sands of Inaros" quest, we find out that that the primitive human inhabitants of Mars were preyed upon by "golden spacemen," while Inaros did his best to defend them. Eventually Inaros disappeared, and the people were wiped out. [[spoiler:The golden spacemen were most likely the Orokin, a human empire of immortals who, among other horrible things, [[GrandTheftMe stole the bodies of children]]]].
41* In the shooting minigames of both ''VideoGame/WiiPlay'' and ''VideoGame/WiiPlayMotion'', there is one level in which some UFO will try to abduct Miis with {{Tractor Beam}}s.
42* ''VideoGame/XCom'':
43** The {{Backstory}} of ''VideoGame/XCOMUFODefense'' includes humanity being terrorised by mass abductions, and the aliens continue mounting missions to abduct humans through the game... while [[WhoYouGonnaCall it's up to you to stop them]].
44** In ''VideoGame/XCOMEnemyUnknown'', the most common mission type are alien abductions occurring in major cities across the world. It's also the most straightforward mission type: Kill all aliens on the ground. However, the aliens will ''always'' attack three cities on three different continents at the same time, forcing the player to make a choice, as each mission provides a different reward (all of them useful for different reasons), and panic increases in the continents you don't save, putting them at risk to stop funding you. Fortunately, every country with a satellite over them at the start of the month will no longer suffer abductions, so they can be minimized and eventually shut out entirely.
45** In ''VideoGame/XCOMChimeraSquad'', one of the investigations involves a string of aliens being abducted, but the abductors are also aliens.

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