History RoguesGalleryTransplant / MarvelUniverse

* Other Spidey villains have been known to torment Daredevil from time to time, and vice-versa; the guys practically live next door to each other, so there's a ton of overlap (the Beetle being certainly the most recurring after Kingpin). Inverted with ComicBook/{{Mysterio}} who seems to have not so much transferred to Daredevil's gallery as branched out, via ''ComicBook/GuardianDevil'', a story that saw Mysterio killed off for a time after trying to break Daredevil (copying what happened in ''ComicBook/DaredevilBornAgain'', only this time it got Daredevil's love interest Karen Page killed), becoming an enemy of both of them. Then he ended up [[ComicBook/SpiderMen switching to Spider-Men]]. Electro was prominently considered part of both Spider-Man and Daredevil's galleries at the same time during their early years.[[note]]He actually didn't show up that often at the time, but when he did, he alternated between them.[[/note]] Case in point: The first ''Amazing Spider-Man'' annual had various supervillains Spidey had defeated before gang up, as the Sinister Six, in order to have their revenge on him. When ''Daredevil'' got an annual, too, we saw Electro forming the Emissaries of Evil [[RecycledScript consisting of villains who wanted revenge]] on DD. He later went on to fight a larger variety of heroes before ultimately becoming associated with Spider-Man again, though he is well known for being hired to cause a breakout at the Raft that formed the ComicBook/NewAvengers.

* Nuke first appeared as an enemy of Daredevil in the iconic ''[[ComicBook/DaredevilBornAgain Born Again]]'' storyline, but his ties to Project Rebirth (and, by extension, Weapon X), as well as his general concept of being a crazed SuperSoldier, made him a perfect fit for the likes of Captain America and Wolverine.

* Other Spidey villains have been known to torment Daredevil from time to time, and vice-versa; the guys practically live next door to each other, so there's a ton of overlap (the Beetle being certainly the most recurring after Kingpin). Inverted with ComicBook/{{Mysterio}} who seems to have not so much transferred to Daredevil's gallery as branched out, via a story that saw Mysterio killed off for a time after trying to break Daredevil (copying what happened in ''ComicBook/DaredevilBornAgain'', only this time it got Daredevil's love interest Karen Page killed), becoming an enemy of both of them. Then he ended up [[ComicBook/SpiderMen switching to Spider-Men]]. Electro was prominently considered part of both Spider-Man and Daredevil's galleries at the same time during their early years.[[note]]He actually didn't show up that often at the time, but when he did, he alternated between them.[[/note]] Case in point: The first ''Amazing Spider-Man'' annual had various supervillains Spidey had defeated before gang up, as the Sinister Six, in order to have their revenge on him. When ''Daredevil'' got an annual, too, we saw Electro forming the Emissaries of Evil [[RecycledScript consisting of villains who wanted revenge]] on DD. He later went on to fight a larger variety of heroes before ultimately becoming associated with Spider-Man again, though he is well known for being hired to cause a breakout at the Raft that formed the ComicBook/NewAvengers.

* Current Beetle debuted as a one-time enemy of ComicBook/CaptainAmerica, but is now better known for her role in ''ComicBook/TheSuperiorFoesOfSpiderMan''. Of course, Spider-Man was TheGhost in that series, and writer Nick Spencer wrote her into a DatingCatwoman scenario with Scott Lang during his later run on ComicBook/AntMan, so she probably rates more highly in Scott's Rogues Gallery at this point. She was fully shunted into Spider-Man's gallery come ''ComicBook/TheAmazingSpiderManNickSpencer''.

* Arcade debuted in the pages of ''Marvel Team-Up'', a title that had Spider-Man teaming up with other Marvel heroes, but these days is better known as an ComicBook/XMen villain. He did resurface in TheNewTwenties in ''ComicBook/TheAmazingSpiderManNickSpencer'' as part of the ''ComicBook/{{Hunted}}'' arc before jumping back to the X-Men in ''ComicBook/{{Hellions}}''.

* ComicBook/{{Juggernaut|MarvelComics}} was and still is one of the ComicBook/XMen's most iconic and recurring adversaries, but quite possibly the most famous comic book story he had even been in was ''Nothing Can Stop the Juggernaut!'', where he tangled with ComicBook/SpiderMan. The story was meant to establish Spidey as the ultimate underdog, where the Juggernaut, a character Spidey normally never has to do deal with and far outside his weight class, is causing trouble and Spider-Man is the only one there who can stop him. This battle got a modern sequel in the ''Grim Hunt'' arc.

* ComicBook/{{Mephisto}} works well as a deliberate example: He was originally introduced in the ''ComicBook/SilverSurfer'' series, but has spent stints as an adversary of both ComicBook/TheMightyThor and Ghost Rider. To the modern reader, though, he's best known for his role in ''ComicBook/OneMoreDay'', a Spider-Man story. Mephisto is best understood as a member of the RoguesGallery for the wider Marvel Universe, rather than any one hero, which is fitting as he is basically a stand-in for {{Satan}}. He has tangled with nearly every single major hero and several villains, and is a lot more personal for many. He was notably the BigBad of Creator/JasonAaron's ''[[ComicBook/JasonAaronsAvengers Avengers]]'' run, where it was revealed that there's even a [[AllianceOfAlternates Council of Red]] made up of Mephistos from across the multiverse.

* Nebula was conceived as the nemesis of the second {{ComicBook/Captain Marvel|MarvelComics}}(Monica Rambeau), but remained a general Avengers villain after Captain Marvel mostly disappeared from the book and focused more personally on Starfox. Then she became a frequent opponent of The Silver Surfer before appearing in Loki's stories when he was trying to reform. Then she joined Gamora's team Graces only to betray Gamora and turn the group against her. Then Nebula became a general The Guardians Of The Galaxy enemy.
* The Celestials originated in Creator/JackKirby's ''ComicBook/TheEternals'', but have since crossed paths with [[ComicBook/TheMightyThor Thor]], the ComicBook/FantasticFour, ComicBook/TheAvengers and even the ComicBook/XMen.

* The Multiversal Masters of Evil from Creator/JasonAaron's ''[[ComicBook/JasonAaronsAvengers Avengers]]'' run are an interesting variation on the trope. The group is comprised of [[Characters/MarvelComicsDoctorDoom Doom Supreme]], [[ComicBook/{{Thanos}} Kid Thanos]], Ghost Goblin (ComicBook/NormanOsborn as a Spirit of Vengeance), King Killmonger (ComicBook/ErikKillmonger inside the Asgardian Destroyer armor), and Dark Phoenix ([[Characters/MarvelComicsMystique Mystique]] as a Phoenix Force host), all of whom do traditionally have some connection to the Avengers or at least one of their individual members. However, with the exception of Kid Thanos (who is simply a child version of Earth-616's Thanos), the Masters are all Variants from alternate realities, and thus have no real history with the Avengers of Earth-616.

* While primarily an enemy of Spider-Man, Comicbook/DoctorOctopus has had notable clashes with Comicbook/IronMan, a rival genius. He's also antagonized Comicbook/CaptainAmerica, Comicbook/TheIncredibleHulk and other New York based character like Daredevil and Comicbook/ThePunisher.

** Stilt-Man, appearing in ''Iron Man'' #225, is a straighter example, starting out as a ComicBook/{{Daredevil}} villain (his first appearance in ''Daredevil'' #8), and having fought Franchise/SpiderMan before this.

* In her first appearance, Moondragon was an Iron Man villain named "Madame [=MacEvil=]." Subsequent appearances would see her take on more of an AntiHero role, with her eventually becoming a member of the Avengers, Comicbook/TheDefenders and the Comicbook/GuardiansOfTheGalaxy.

* ComicBook/{{Mephisto}} works well as a deliberate example: He was originally introduced in the ''ComicBook/SilverSurfer'' series, but has spent stints as an adversary of both ComicBook/TheMightyThor and Ghost Rider. To the modern reader, though, he's best known for his role in ''ComicBook/OneMoreDay'', a Spider-Man story. Mephisto is best understood as a member of the RoguesGallery for the wider Marvel Universe, rather than any one hero, which is fitting as he is basically a stand-in for {{Satan}}. He has tangled with nearly every single major hero and several villains, and is a lot more personal for many. He was notably the BigBad of Creator/JasonAaron's ''[[Comicbook/JasonAaronsAvengers Avengers]]'' run, where it was revealed that there's even a [[AllianceOfAlternates Council of Red]] made up of Mephistos from across the multiverse.

* Rhino was introduced as a Franchise/SpiderMan foe but has spent a large chunk of his career battling the Hulk due to him being one of the physically strongest Spider-Man villains. At the very least, it's shared custody.

* The [[PsychoForHire contract killer]] Boomerang, who uses deadly gimmick boomerangs as his weapons, originally started out fighting [[ComicBook/TheIncredibleHulk the Hulk]], before he moved on to become a semi-regular Franchise/SpiderMan villain after writers realized that trick boomerangs versus the most powerful creature on Earth was a bit of a mismatch. Boomerang even appears in the Uncanny X-Men UsefulNotes/{{Nintendo|EntertainmentSystem}} game by LJN even though he's neither a X-Men enemy nor a mutant.
* Mister Hyde, a villain based on ''Literature/TheStrangeCaseOfDrJekyllAndMrHyde'', started out as a [[ComicBook/TheMightyThor Thor]] villain but would later move on to become a ComicBook/{{Daredevil}} regular, although he also took the time to mess with Franchise/SpiderMan, ComicBook/CaptainAmerica, ComicBook/GhostRider, and [[ComicBook/TheIncredibleHulk the Hulk]], finally settling in to become a regular foe of Cap, DD and the Big Green Machine. These days he seems to have moved to fighting teen heroes, considering his appearances in both ''ComicBook/YoungAvengers'' and ''ComicBook/AllNewGhostRider''. He was later revealed as the father of ComicBook/DaisyJohnson, and has been a foe of her as well.

* In the very early days of the Silver Age Franchise/MarvelUniverse, the ComicBook/FantasticFour's ComicBook/HumanTorch had his own rogues gallery as a solo hero. Two of his mainstays, the Wizard and the Trapster, would later become enemies of the Fantastic Four, with the Wizard becoming an EvilCounterpart to [[ComicBook/MisterFantastic Reed Richards]] and even forming his own EvilCounterpart team in the Frightful Four, of which the Trapster was a charter member. The Trapster and the Beetle, another long-standing enemy of the Torch, would also become recurring enemies of Franchise/SpiderMan. It's so pronounced that in both the ''Ultimate Spider-Man'' [[ComicBook/UltimateSpiderMan comic]] and [[WesternAnimation/UltimateSpiderMan2012 TV show]], the Beetle is more or less treated as a straight-up Spidey villain (being a founding member of the Sinister Six there). Though during the days he wore his first costume, he fought Daredevil more often, only to completely abandon him with his upgrade, choosing Iron Man as a secondary nemesis. The Eel also originally debuted as a foe of the Human Torch before becoming a semi-regular ComicBook/{{Daredevil}} villain.

* The Multiversal Masters of Evil from Creator/JasonAaron's ''[[Comicbook/JasonAaronsAvengers Avengers]]'' run are an interesting variation on the trope. The group is comprised of [[Characters/MarvelComicsDoctorDoom Doom Supreme]], [[Comicbook/{{Thanos}} Kid Thanos]], Ghost Goblin (Comicbook/NormanOsborn as a Spirit of Vengeance), King Killmonger (Comicbook/ErikKillmonger inside the Asgardian Destroyer armor), and Dark Phoenix ([[Characters/MarvelComicsMystique Mystique]] as a Phoenix Force host), all of whom do traditionally have some connection to the Avengers or at least one of their individual members. However, with the exception of Kid Thanos (who is simply a child version of Earth-616's Thanos), the Masters are all Variants from alternate realities, and thus have no real history with the Avengers of Earth-616.

* The first Moonstone was a ComicBook/CaptainAmerica villain, and the woman who would eventually steal his powers as the second Moonstone was initially an EvilMinion who was of little concern to Captain America. When she became a full fledge super villain she started off as a foe of [[ComicBook/TheIncredibleHulk the Hulk]], but became more of a general Avengers villain after joining the Masters of Evil, forming a direct rivalry with the second ComicBook/{{Captain Marvel|MarvelComics}}(Monica Rambeau). Then she became a rival to Baron Zemo and the third Captain Marvel/second Photon, Genis-Vell, during ''ComicBook/{{Thunderbolts}}''. Then during ''Comicbook/DarkReign'', she was positioned as ComicBook/MsMarvel's EvilCounterpart in Norman Osborn's ComicBook/DarkAvengers. She continues to oppose ComicBook/CarolDanvers as she becomes Captain Marvel #6, though not always willingly.

* Minor-league ComicBook/IronMan villains [[AnIcePerson Blizzard]] and [[PlayingWithFire Firebrand]] started out fighting Shellhead, but eventually transitioned to fighting street-level heroes like Franchise/SpiderMan after Tony Stark's equipment began to completely outclass theirs. And Shellhead's greatest foe, The Mandarin, took time out - primarily in the 60s and 70s - to deal with other characters. The very first ''Avengers'' annual had Enchantress and Executioner, Living Laser, the original Power Man and the Swordsman working for him to distract the Avengers from his plan of broadcasting worldwide hate-rays. The late 60s had him clash with [[ComicBook/TheIncredibleHulk the Hulk]] a few times (one time getting Nick Fury involved, another involving the Sandman, normally a Spider-Man foe), another time he kidnapped a peacemaker who was rescued by Captain America, and still another time saw him encounter the Inhumans in an attempt to gain a Makluan artifact. Since then though, he's been sticking with Iron Man.

* [[EldritchAbomination Shuma-Gorath]] was actually first mentioned in a Creator/RobertEHoward short story, but has been better known for his classic fights against ComicBook/DoctorStrange. He more or less lost his association with the good doctor when he [[UnexpectedCharacter unexpectedly appeared in]] ''VideoGame/MarvelSuperHeroes'', [[AdaptedOut where Strange was absent]]. Due to the Howard connection, Shuma also menaced ComicBook/ConanTheBarbarian in his Marvel series, as well as the ''Comicbook/SavageAvengers'' when Conan was part of that group. ''ComicBook/TheThanosImperative'' and a few other appearances helped him get upgraded to universal threat, like Mephisto or Thanos, and he later served as a StarterVillain for Comicbook/LukeCage's incarnation of the ''Comicbook/MightyAvengers2013''. Similarly, Nightmare started as a ComicBook/DoctorStrange foe, but has since then fought with pretty much everybody.
* ComicBook/{{Juggernaut|MarvelComics}} was and still is one of the ComicBook/XMen's most iconic and recurring adversaries, but quite possibly the most famous comic book story he had even been in was ''Nothing Can Stop the Juggernaut!'', where he tangled with Franchise/SpiderMan. The story was meant to establish Spidey as the ultimate underdog, where the Juggernaut, a character Spidey normally never has to do deal with and far outside his weight class, is causing trouble and Spider-Man is the only one there who can stop him. This battle got a modern sequel in the ''Grim Hunt'' arc.

* Cobalt Man was originally a very minor Silver Age Comicbook/XMen villain, but soon drifted away from that corner of the Marvel Universe and instead fought characters like [[ComicBook/TheIncredibleHulk the Hulk]] and Comicbook/TheDefenders.

* Speaking of Spider-Woman, Morgan Le Fay used to be her arch-nemesis, but now she's a general Marvel Universe villain, mainly tangling with the Avengers. This included an encounter with the ComicBook/DarkAvengers, due to her targeting Doctor Doom for revenge. In the [[ComicBook/SpiderWoman2014 2014 volume]], Spider-Woman mainly fought C-list/D-List villains such as Tiger Shark (a traditional ComicBook/SubMariner villain), the Sandman (a Franchise/SpiderMan villain), and the Blizzard (traditionally an ComicBook/IronMan villain).

* Many of Marvel's 2019 annuals were themed under the banner ''Acts of Evil'', with no actual story throughline, but a theme of heroes fighting villains they would normally have nothing to do with, such as [[ComicBook/MsMarvel2014 Ms. Marvel]] versus the Super-Skrull, the Punisher versus the Brood, Comicbook/MoonKnight versus Kang the Conqueror and ComicBook/SheHulk versus ComicBook/{{Bullseye|Marvel Comics}}.

* ''Comicbook/HeroesReborn2021'' has multiple instances of this, as it revolves around a world where the Comicbook/SquadronSupreme have supplanted the Avengers as Earth's premier superhero team.

** Comicbook/{{Batman}} expy Nighthawk gains most of Spider-Man's traditional RoguesGallery, with Comicbook/NormanOsborn serving as his Comicbook/TheJoker-like arch nemesis.
** Comicbook/{{Superman}} expy Hyperion gains Characters/DoctorDoom, the Hulk, the Beyonder, Annihilus and Comicbook/{{Ultron}}, with most of them positioned as pastiches of traditional Superman rogues (the Hulk as Comicbook/{{Bizarro}}, Mr. Beyonder as Mr. Mxyzptlk, General Annihilus as General Zod and Ultron as Metallo).
** Comicbook/WonderWoman expy Power Princess gains traditional Thor baddies Mangog, Gorr the God Butcher, Ulik and Hela, as well as traditional Avengers [[Comicbook/TheWasp Janet Van Dyne]], Tigra and [[Comicbook/TheIncredibleHercules Hercules]] (serving as pastiches of Wonder Woman's foes Giganta, Comicbook/{{Cheetah}} and Hercules, respectively), traditional X-Men members [[Comicbook/JeanGrey Phoenix]] and Comicbook/IllyanaRasputin, and the Venom villain Knull.
** Comicbook/TheFlash expy the Blur gains the Silver Witch (a version of Characters/ScarletWitch who absorbed the speed of her brother Comicbook/{{Quicksilver}}) as his nemesis, and also fights Ursa Major (here a stand-in for Gorilla Grodd).
** Comicbook/GreenLantern expy Doctor Spectrum gains a bunch of cosmic villains like Thanos, Ego the Living Planet, the Super-Skrull, Ronan the Accuser, and despite not being cosmic-themed, M.O.D.O.K. and the Circus of Crime. Uatu the Watcher also serves as another of his adversaries despite mostly being a good guy in the mainline universe.

** Comicbook/TeenTitans[=/=]Comicbook/YoungJustice expies the Young Squadron battle Deadpool and the Wrecking Crew.

** Bolivar Trask is most associated with the ComicBook/XMen in mainstream Marvel continuity, but in the [[ComicBook/UltimateMarvel Ultimate Universe]] he became integrated into ComicBook/UltimateSpiderMan's mythos, eventually becoming the BigBad of [[VideoGame/UltimateSpiderMan the video game adaptation]].

* The Multiversal Masters of Evil from Creator/JasonAaron's ''[[Comicbook/JasonAaronsAvengers Avengers]]'' run are an interesting variation on the trope. The group is comprised of [[Characters/MarvelComicsDoctorDoom Doom Supreme]], [[Comicbook/{{Thanos}} Kid Thanos]], Ghost Goblin (Comicbook/NormanOsborn as a Spirit of Vengeance), King Killmonger (Comicbook/ErikKillmonger inside the Asgardian Destroyer armor), and Dark Phoenix (Characters/{{Mystique}} as a Phoenix Force host), all of whom do traditionally have some connection to the Avengers or at least one of their individual members. However, with the exception of Kid Thanos (who is simply a child version of Earth-616's Thanos), the Masters are all Variants from alternate realities, and thus have no real history with the Avengers of Earth-616.

* ComicBook/{{Mystique}} first appeared in ''[[ComicBook/CarolDanvers Ms. Marvel]]'' and was originally slated to be her ArchEnemy. She's pretty much entirely an X-Villain nowadays, and her history with Ms. Marvel (such as killing her boyfriend) has been all but forgotten. She did return to torment Ms. Marvel in Carol's later series.
** As far as invidual X-Men, She tends to have the most conflict with Rogue (her adopted daughter), Nightcrawler (her biological son), and Wolverine (her former lover).

* Nebula was conceived as the nemesis of the second {{ComicBook/Captain Marvel|MarvelComics}}, but remained a general Avengers villain after Captain Marvel mostly disappeared from the book and focused more personally on Starfox. Then she became a frequent opponent of The Silver Surfer before appearing in Loki's stories when he was trying to reform. Then she joined Gamora's team Graces only to betray Gamora and turn the group against her. Then Nebula became a general The Guardians Of The Galaxy enemy.

* The first Moonstone was a ComicBook/CaptainAmerica villain, and the woman who would eventually steal his powers as the second Moonstone was initially an EvilMinion who was of little concern to Captain America. When she became a full fledge super villain she started off as a foe of [[ComicBook/TheIncredibleHulk the Hulk]], but became more of a general Avengers villain after joining the Masters of Evil, forming a direct rivalry with the second ComicBook/{{Captain Marvel|MarvelComics}}. Then she became a rival to Baron Zemo and the third Captain Marvel/second Photon, Genis-Vell during ''ComicBook/{{Thunderbolts}}''. Then during ''Comicbook/DarkReign'', she was positioned as ComicBook/MsMarvel's EvilCounterpart in Norman Osborn's ComicBook/DarkAvengers. She continues to oppose ComicBook/CarolDanvers as she becomes Captain Marvel #6, though not always willingly.

* Blackout was originally an obscure ComicBook/{{Nova}} villain, but is probably best remembered for his role in Creator/RogerStern's ''ComicBook/TheAvengers'' run, where he battled the team as part of the [[LegionOfDoom Masters of Evil]]. On a more specific level, his powers were used to counteract those of [[ComicBook/MonicaRambeau Captain Marvel]].

* Kingpin is the primary villain of ''WesternAnimation/SpiderManIntoTheSpiderVerse''. But while he's always been a major enemy of Peter Parker, he's rarely come into contact with Miles Morales, the central protagonist of the film. The Ultimate Kingpin was also killed off long before Miles was introduced.

* The ''ComicBook/ExtremeCarnage'' event puts the Friends of Humanity, usually an anti-mutant extremist organization, into the symbiotes' rogues gallery. In-universe, Iron Man notes how strange it is for an old mutant hate group to suddenly go after aliens. One can only surmise, assume, or speculate is that the F.O.H. are unable to go after Krakoa with starting an international incident nor they can afford the luxury or privledge of joining Orchis. So, they cooul only go after the next best thing: aliens.

* The ''ComicBook/ExtremeCarnage'' event puts the Friends of Humanity, usually an anti-mutant extremist organization, into the symbiotes' rogues gallery. In-universe, Iron Man notes how strange it is for an old mutant hate group to suddenly go after aliens. One can only surmise, assume, or speculate is that unable to go after Krakoa with starting an international incident nor they can afford the luxury or privledge of joining Orchis so they can only go after the next best thing: aliens.

* The ''ComicBook/ExtremeCarnage'' event puts the Friends of Humanity, usually an anti-mutant extremist organization, into the symbiotes' rogues gallery. In-universe, Iron Man notes how strange it is for an old mutant hate group to suddenly go after aliens.

** The episode "Today, I Am a Woman" sees Lunella clash with Odessa Drake, a rival and ex-lover of Comicbook/BlackCat.

* ''ComicBook/AnnihilationConquest'' does a similar thing - Avengers villain (created by ComicBook/AntMan) ComicBook/{{Ultron}} takes control over the Phalanx, a race mostly known for their fights with the X-Men, as well as a few lesser-known villains like the Avengers' enemy Ultra-Adaptoid or the Fantastic Four's foe Blastaar, and then goes against cosmic heroes. Ultron later returned to fighting the Avengers, though.

* Baron von Strucker was introduced as ComicBook/NickFury's ArchEnemy, but, as the leader of ComicBook/{{HYDRA}}, he's also clashed with the likes of ComicBook/{{Daredevil}}, Captain America, the Avengers, ComicBook/{{Wolverine}}, Black Panther and the ComicBook/{{Thunderbolts}}. A memorable issue from Creator/ChrisClaremont’s ''X-Men'' run also revealed that Strucker played a key role in the shared backstory of ComicBook/ProfessorX and ComicBook/{{Magneto}}, having fought against both mutants back when they were young men in the years after World War 2.

* ''WesternAnimation/MoonGirlAndDevilDinosaur2023'': Allison Dillon / Aftershock serves as the main villain Lunella and Devil face in the pilot episode. The character was originally created as a villain for ComicBook/SpiderGirl. The Beyonder, a universe-wide threat primarily known for his association with heroes like Spider-Man and the Avengers, serves as a major antagonist throughout the season despite having no real connection to Lunella in the comics.

* The various Green Goblins were notable for being solely Spider-Man villains, never antagonizing other New York-based heroes as ComicBook/DoctorOctopus or Electro would. Since ''ComicBook/SecretInvasion'', however, ComicBook/NormanOsborn has been transformed into an over-riding BigBad of the Franchise/MarvelUniverse, specifically clashing with the ComicBook/NewAvengers. After trying to take the Avengers again with another team of ComicBook/DarkAvengers and a H.A.M.M.E.R. made up of ComicBook/{{HYDRA}} and A.I.M. personnel, he has gone back to being a Spidey villain. [[spoiler:Firmly reestablished at the GrandFinale of ''ComicBook/SuperiorSpiderMan''.]] The run of Captain America by Ta-Nehisi Coates would then include him in the Power Elite that opposed Captain America.

* The Multiversal Masters of Evil from Creator/JasonAaron's ''[[Comicbook/JasonAaronsAvengers Avengers]]'' run are an interesting variation on the trope. The group is comprised of [[Characters/MarvelComicsDoctorDoom Doom Supreme]], [[Comicbook/{{Thanos}} Kid Thanos]], Ghost Goblin (Comicbook/NormanOsborn as a Spirit of Vengeance), King Killmonger (Comicbook/ErikKillmonger inside the Asgardian Destroyer armor), and Dark Phoenix (Comicbook/{{Mystique}} as a Phoenix Force host), all of whom do traditionally have some connection to the Avengers or at least one of their individual members. However, with the exception of Kid Thanos (who is simply a child version of Earth-616's Thanos), the Masters are all Variants from alternate realities and have no real history with the Avengers of the mainline universe.

* ComicBook/{{Mephisto}} works well as a deliberate example: He was originally introduced in the ''ComicBook/SilverSurfer'' series, but has spent stints as an adversary of both ComicBook/TheMightyThor and Ghost Rider. To the modern reader, though, he's best known for his role in ''ComicBook/OneMoreDay'', a Spider-Man story. Mephisto is best understood as a member of the RoguesGallery for the wider Marvel Universe, rather than any one hero, which is fitting as he is basically a stand-in for {{Satan}}. He has tangled with nearly every single major hero and several villains, and is a lot more personal for many.

* ''WesternAnimation/MoonGirlAndDevilDinosaur2023'': Allison Dillon / Aftershock serves as the main villain Lunella and Devil face in the pilot episode. The character was originally created as a villain for ComicBook/SpiderGirl. The Beyonder, a universe-wide villain primarily known for his association with heroes like Spider-Man and the Avengers, serves as a major villain despite having no real connection to Lunella in the comics.

* ''WesternAnimation/MoonGirlAndDevilDinosaur2023'': Allison Dillon / Aftershock serves as the main villain Lunella and Devil face in the pilot episode. The character was originally created as a villain for ComicBook/SpiderGirl.

* During Kaine's tenure as the ComicBook/ScarletSpider, he seems to have inherited the Jackal, the Lobo siblings, Shathra, Kraven and Ana Kravinoff from his 'brother', Spidey (though the Jackal is his creator and therefore a long standing part of his story), the Hand from Daredevil, Belladonna Boudreaux and the Assassins Guild from ComicBook/{{Gambit}}, [[Characters/MarvelComicsCarnage Carnage]] from Spider-Man/Venom and evil MegaCorp Roxxon from Iron Man - though currently it seems to be a case of shared custody with Thor. Now, he's (reluctantly) one of the ComicBook/NewWarriors and as a result seems to have acquired the High Evolutionary and the Evolutionaries from the ComicBook/XMen.
* Speaking of, the High Evolutionary originated in the pages of ''ComicBook/TheMightyThor'', but has since gone on to encounter the Avengers, the Fantastic Four, [[ComicBook/Warlock1967 Adam Warlock]], the Silver Surfer, the X-Men, the ComicBook/GuardiansOfTheGalaxy, the ComicBook/HeroesForHire, the ComicBook/UncannyAvengers and even the ComicBook/NewWarriors. What makes him somewhat unique is that he is [[HeelFaceRevolvingDoor often an ally rather than an enemy]], depending on who is writing at the time. He notably appeared as the main antagonist of the ''Evolutionary War'' CrisisCrossover during the 80s, where his machinations threatened pretty much the entire Marvel Universe. He also played a role in the origins of ComicBook/ScarletWitch, ComicBook/{{Quicksilver}} and ComicBook/SpiderWoman.

* Wilson Fisk, ComicBook/TheKingpin, was introduced as a Franchise/SpiderMan villain, and although very much still a part of Spidey's RoguesGallery, you'd be hard-pressed to say that the character is not best known for being a nemesis of ComicBook/{{Daredevil}}, taking the place of the Owl (who is a lot harder to take seriously) among his enemies. Since he is more of a BigBad for street-level superheroes in general, Kingpin unlike most examples on this list never completely lost his connection with Spider-Man, and across all media still opposes him on a semi-regular basis, but it's just that his beef with Daredevil is far more [[ItsPersonal personal.]] This transition is so well accepted that Creator/StanLee himself confessed that in retrospect, the Kingpin is much better suited as a Daredevil villain and that was the case legally when the film license rights to ''Daredevil'' were out of Marvel's hands with Kingpin officially part of that property.

* The demon Blackheart debuted in ''Daredevil'', though now spends most of his time messing with ComicBook/GhostRider, even appearing as the villain in [[Film/GhostRider the movie adaptation]]. He also shows up in ComicBook/XMen from time to time (amongst others), even at one point serving as the Black King of the Hellfire Club. He’s also had run-ins with ComicBook/MilesMorales and ComicBook/TheFalcon.