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* In Myth/PacificMythology, the normally-benevolent [[AnIcePerson Poli'ahu]] inflicted her ex-fiancé Aiwohikupua and his lover [[spoiler:Poli'ahu's [[EveryoneIsRelated sister]], Pele]] with chills and fever because [[YourCheatingHeart they snuck off together]] [[RunawayBride on what would have been Aiwohikupua and Poli'ahu's wedding day]].

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* In Myth/PacificMythology, the normally-benevolent [[AnIcePerson Poli'ahu]] inflicted her ex-fiancé Aiwohikupua and his lover [[spoiler:Poli'ahu's [[EveryoneIsRelated sister]], Pele]] with chills and fever because [[YourCheatingHeart [[LoveForgivesEverythingButLust they snuck off together]] on [[RunawayBride on what would have been Aiwohikupua and Poli'ahu's wedding day]].

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* ''[[Literature/DarkShores Dark Skies]]'': The blight. It is first shown as foul-smelling rivers of black goo flowing through the countryside but then it turns out that any closer contact with it turns living beings into zombie-like creatures, devoid of any rational thought and (according to Grand Master Quindor) any life.


* In ''VideoGame/{{Dishonored}}'', the rat plague initially was a virulent plague that [[spoiler:the Spymaster]] brought from the Pandyssian Continent to wipe out the poor in Dunwall. However, [[HumanoidAbomination the Outsider]]'s interest was piqued and he made the plague more virulent, making all means of quarantine meaningless, and perhaps ensured the infected would become [[TechnicallyLivingZombie Weepers]]. Notably, his primary 'servant', [[spoiler:[[EvilOldFolks Granny Rags]]]] seems to spread the plague by summoning more and more rats to areas. [[spoiler:You can too if you go the High Chaos route]].

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* In ''VideoGame/{{Dishonored}}'', the rat plague initially was a virulent plague that [[spoiler:the Spymaster]] brought from the Pandyssian Continent to wipe out the poor in Dunwall. However, [[HumanoidAbomination the Outsider]]'s interest was piqued and he made the plague more virulent, making all means of quarantine meaningless, and perhaps ensured the infected would become [[TechnicallyLivingZombie Weepers]]. Notably, his primary 'servant', [[spoiler:[[EvilOldFolks Granny Rags]]]] seems to spread the plague by summoning more and more rats to areas. [[spoiler:You can too if you go the High Chaos route]].


* In Myth/OceanianMythology, the normally-benevolent [[AnIcePerson Poli'ahu]] inflicted her ex-fiancé Aiwohikupua and his lover [[spoiler:Poli'ahu's [[EveryoneIsRelated sister]], Pele]] with chills and fever because [[YourCheatingHeart they snuck off together]] [[RunawayBride on what would have been Aiwohikupua and Poli'ahu's wedding day]].

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* In Myth/OceanianMythology, Myth/PacificMythology, the normally-benevolent [[AnIcePerson Poli'ahu]] inflicted her ex-fiancé Aiwohikupua and his lover [[spoiler:Poli'ahu's [[EveryoneIsRelated sister]], Pele]] with chills and fever because [[YourCheatingHeart they snuck off together]] [[RunawayBride on what would have been Aiwohikupua and Poli'ahu's wedding day]].

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* Seen in ''Film/OedipusRex'', being an adaptation of ''Theatre/OedipusTheKing'' (see Theatre below). After Thebes suffers a terrible plague, Oedipus asks a seer why the gods are punishing his people. He gets the unwelcome answer that it's his fault, as punishment for killing his father and marrying his mother.

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* ''Series/TheTwilightZone1985'': In "Many, Many Monkeys", Jean Reed speculates that she and everyone else afflicted with the plague of blindness are being punished because they have [[MonkeyMoralityPose become monkeys who see, hear and speak no evil]]. She thinks that nature has turned a blind eye to humans because of their diminished humanity. Although Nurse Claire Hendricks initially dismisses this idea as preposterous, she later becomes convinced that Jean is correct, [[MaybeMagicMaybeMundane even after the government links the plague to the accidental release of bacteria]].

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* Implied in ''[[Videogame/TraumaCenter Trauma Team]]'', despite the developers otherwise trying to up the realism compared to previous games. [[spoiler:The Rosalia Virus causes insanity via tumors in the brain, but oddly two people infected know the name ''Rosalia'', the name of the original carrier, (who [[AsymptomaticDiseaseCarrier suffered none of the symptoms]]) before the disease was named or Rosalia's connection was even known. Also, Rosalia herself appears as a ghost to her childhood friend, and her last words imply she knew her death would lead to the pandemic in the last part of the game.]]


** In the series backstory, the Thrassian Plague ravaged Tamriel in the 1st Era. Created by the "slug-men" Sload of Thras, the "coral kingdom" to the southwest of Tamriel, who are known to excel as [[{{Necromancy}} necromancers]] and [[EvilSorcerer Evil Sorcerers]]. The Thrassian Plague killed more than half of Tamriel's population. In response, the nations of Tamriel formed [[TheAlliance the All-Flags Navy]], which ravaged Thras, killed all of the Sload it could find, and finally sunk Thras beneath the sea. (The Sload survived, however, and would raise Thras to the surface once again.) Unsurprisingly, Peryite, the [[OurGodsAreDifferent Daedric Prince]] of [[{{Plaguemaster}} Pestilence]] and Tasks, is rumored to have been associated with the creation of the plague.

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** In the series backstory, the Thrassian Plague ravaged Tamriel in the 1st Era. Created by the "slug-men" Sload of Thras, the "coral kingdom" to the southwest of Tamriel, who are known to excel as [[{{Necromancy}} necromancers]] and [[EvilSorcerer Evil Sorcerers]]. The Thrassian Plague killed more than half of Tamriel's population. In response, the nations of Tamriel formed [[TheAlliance the All-Flags Navy]], which ravaged Thras, killed all of the Sload it could find, and finally sunk Thras beneath the sea. (The Sload survived, however, and would raise Thras to the surface once again.) again, but never again tried something as ambitious as the Thrassian Plague) Unsurprisingly, Peryite, the [[OurGodsAreDifferent Daedric Prince]] of [[{{Plaguemaster}} Pestilence]] and Tasks, is rumored to have been associated with the creation of the plague.


* ''VideoGame/HollowKnight'': The main threat in the game is a mysterious, terrifying plague that’s turning Hallownest into a DeathWorld. Bugs afflicted with it are driven to violent insanity by it and [[CameBackWrong get reanimated as monstrous husks after dying]]. It was created by [[spoiler:the Radiance, [[GodIsEvil the god who created bugkind]], as a “divine” punishment after they stopped worshiping her and your character is an EmptyShell created to try and contain it.]]

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* ''VideoGame/HollowKnight'': The main threat in the game is a mysterious, terrifying plague that’s turning Hallownest into a DeathWorld. Bugs afflicted with it are driven to violent insanity by it and [[CameBackWrong get reanimated as monstrous husks after dying]]. It was created by [[spoiler:the Radiance, [[GodIsEvil the god who created bugkind]], as a “divine” "divine" punishment after they stopped worshiping her and your character is an EmptyShell created to try and contain it.]]


* In the ''ComicBook/CaptainMarvel'' title starring Genis-Vell, an offhand comment by the narration states that the Black Plague was caused by the anguished scream of a CosmicEntity.

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* In the ''ComicBook/CaptainMarvel'' ''[[ComicBook/CaptainMarVell Captain Marvel]]'' title starring Genis-Vell, an offhand comment by the narration states that the Black Plague was caused by the anguished scream of a CosmicEntity.


* ''[[VideoGame/{{Heretic}} Heretic 2]]'' has a mystic plague as a central part of the story, mostly it causes death, insanity and violence, but there is mention of another version that can be used to control people.

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* ''[[VideoGame/{{Heretic}} Heretic 2]]'' has a mystic plague as a central part of the story, mostly which was unleashed as D'Sparil's DyingCurse from the end of the first game. Mostly it causes death, insanity and violence, but there is mention of another version that can be used to control people.








* In ''Manga/KingOfThorn'', "Medusa" is a disease that came from a meteorite; spreading across the globe and turning most humans into statues. (and others into monsters). It's revealed to have a psychic vector; rather than a viral or bacterial one.

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* In ''Manga/KingOfThorn'', "Medusa" is a disease that came from a meteorite; spreading across the globe and turning most humans into statues. statues (and others into monsters). It's revealed to have a psychic vector; rather than a viral or bacterial one.



* ''ComicBook/MarvelStarWars'' has the Crimson Forever, whose name is rather contrived - "D-dead! Everyone on board, Commander! Most of them fallen at their stations... their entire bodies turned that terrible ''crimson''...! Even their ''eyes''...! All open... ''staring''... like they were looking straight on into ''forever''...!" Luke and a squadron of pilots immediately put on masks and set up quarantine but still fell ill themselves after one of them found a red gem. It turned out there were two such gems, life-forms from beyond this galaxy who were mates, and who reacted to being separated by radiating anguish that manifested as illness and dropped people into comas deep enough that even the best medical tech was fooled. The shock of seeming to contract such a disease [[YourMindMakesItReal made most people die for real]], but since Luke had had a fever-dream that gave him insights on what to do, he revived when the gems were reunited.

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* ''ComicBook/MarvelStarWars'' has the Crimson Forever, whose name is rather contrived - "D-dead! Everyone on board, Commander! Most of them fallen at their stations... their entire bodies turned that terrible ''crimson''...! Even their ''eyes''...! All open... ''staring''... like they were looking straight on into ''forever''...!" Luke and a squadron of pilots immediately put on masks and set up quarantine but still fell ill themselves after one of them found a red gem. It turned out there were two such gems, life-forms from beyond this galaxy who were mates, and who reacted to being separated by radiating anguish that manifested as illness and dropped people into comas deep enough that even the best medical tech was fooled. The shock of seeming to contract such a disease [[YourMindMakesItReal made most people die for real]], but since Luke had had a fever-dream that gave him insights on what to do, he revived when the gems were reunited.



* In the universe of ''Film/TheLastWitchHunter'', TheBlackDeath plague isn't a natural disease, but a magical plague created by the Witch Queen as her take on ApocalypseHow.

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* In the universe of ''Film/TheLastWitchHunter'', TheBlackDeath plague isn't a natural disease, but a magical plague created by the Witch Queen as her take on ApocalypseHow.



* ''Literature/AngelMage'': The country of Ystara is destroyed by one of these, the Ash Blood plague, which as the name implies turns the blood of the afflicted to ash. One third of the victims instead turn into monsters called "beastlings".



* ''Literature/ElementalMasters'': ''Literature/PhoenixAndAshes'': At one point, [[EvilStepmother Alison]] summons a disease elemental and sets it loose; it's implied that this caused the 1918 [=H1N1=] pandemic.

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* ''Literature/ElementalMasters'': ''Literature/PhoenixAndAshes'': At one point, In ''Literature/PhoenixAndAshes'', [[EvilStepmother Alison]] summons a disease elemental and sets it loose; it's implied that this caused the 1918 [=H1N1=] pandemic.



* In ''Temple of the Winds'' of the ''Literature/SwordOfTruth'' series, [[TheEmpire The Imperial Order]] unleashes a plague, based on TheBlackDeath and made ''much'' worse by magic, on the heroes' capital city. For bonus KickTheDog points, [[BigBad Emperor Jagang]] deliberately infects a group of young children as patients zero.
* Creator/JRRTolkien seems to have liked this trope:

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* In ''Temple of the Winds'' of the ''Literature/SwordOfTruth'' series, [[TheEmpire The the Imperial Order]] unleashes a plague, based on TheBlackDeath and made ''much'' worse by magic, on the heroes' capital city. For bonus KickTheDog points, [[BigBad Emperor Jagang]] deliberately infects a group of young children as patients zero.
* Creator/JRRTolkien seems to have liked this trope:trope in his [[Franchise/TolkiensLegendarium Legendarium]]:



* ''WesternAnimation/FamilyGuy'': In "If I'm Dyin', I'm Lyin'", Peter claims to have healed Chris of a disease he made up, which convinces the town that he's a divine healer, and he milks their worship of him for all it's worth. However, this makes God smite the Griffins with plagues based on [[Literature/BookOfExodus those He cast upon Egypt]], including darkness (the light bulbs going out), gadflies (Brian getting fleas), boils (Chris getting acne) and blood ([[BloodBath Stewie's bath water turning to blood]]).



* ''WesternAnimation/FamilyGuy'': In "If I'm Dyin', I'm Lyin'", Peter claims to have healed Chris of a disease he made up, which convinces the town that he's a divine healer, and he milks their worship of him for all it's worth. However, this makes God smite the Griffins with plagues based on [[Literature/BookOfExodus those He cast upon Egypt]], including darkness (the light bulbs going out), gadflies (Brian getting fleas), boils (Chris getting acne) and blood ([[BloodBath Stewie's bath water turning to blood]]).


* In the ''Visionaries: Knights of the Magical Light'' episode "Horn of Unicorn, Claw of Dragon", a Magical Plague strikes Prysmos, affecting all but one of the Spectral Knights and up to five of the Darkling Lords. In this case, the precise cause of the Plague is unspecified, though Merklynn does say that he foresaw it coming and tried (unsuccessfully) to send the Darkling Lords on a quest for the ingredients (the unicorn's horn and dragon's claw referred to in the title) needed for a healing spell.

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* In the ''Visionaries: Knights of the Magical Light'' ''WesternAnimation/{{Visionaries}}'' episode "Horn of Unicorn, Claw of Dragon", a Magical Plague strikes Prysmos, affecting all but one of the Spectral Knights and up to five of the Darkling Lords. In this case, the precise cause of the Plague is unspecified, though Merklynn does say that he foresaw it coming and tried (unsuccessfully) to send the Darkling Lords on a quest for the ingredients (the unicorn's horn and dragon's claw referred to in the title) needed for a healing spell.

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* ''WesternAnimation/FamilyGuy'': In "If I'm Dyin', I'm Lyin'", Peter claims to have healed Chris of a disease he made up, which convinces the town that he's a divine healer, and he milks their worship of him for all it's worth. However, this makes God smite the Griffins with plagues based on [[Literature/BookOfExodus those He cast upon Egypt]], including darkness (the light bulbs going out), gadflies (Brian getting fleas), boils (Chris getting acne) and blood ([[BloodBath Stewie's bath water turning to blood]]).


* In Hawaiian Mythology, the normally-benevolent [[AnIcePerson Poli'ahu]] inflicted her ex-fiancé Aiwohikupua and his lover [[spoiler:Poli'ahu's [[EveryoneIsRelated sister]], Pele]] with chills and fever because [[YourCheatingHeart they snuck off together]] [[RunawayBride on what would have been Aiwohikupua and Poli'ahu's wedding day]].

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* In Hawaiian Mythology, Myth/OceanianMythology, the normally-benevolent [[AnIcePerson Poli'ahu]] inflicted her ex-fiancé Aiwohikupua and his lover [[spoiler:Poli'ahu's [[EveryoneIsRelated sister]], Pele]] with chills and fever because [[YourCheatingHeart they snuck off together]] [[RunawayBride on what would have been Aiwohikupua and Poli'ahu's wedding day]].

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