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* In ''Manga/KingOfThorn'', "Medusa" is a disease that came from a meteorite; spreading across the globe and turning most humans into statues. (and others into monsters). It's revealed to have a psychic vector; rather than a viral or bacterial one.

to:

* In ''Manga/KingOfThorn'', "Medusa" is a disease that came from a meteorite; spreading across the globe and turning most humans into statues. statues (and others into monsters). It's revealed to have a psychic vector; rather than a viral or bacterial one.



* ''ComicBook/MarvelStarWars'' has the Crimson Forever, whose name is rather contrived - "D-dead! Everyone on board, Commander! Most of them fallen at their stations... their entire bodies turned that terrible ''crimson''...! Even their ''eyes''...! All open... ''staring''... like they were looking straight on into ''forever''...!" Luke and a squadron of pilots immediately put on masks and set up quarantine but still fell ill themselves after one of them found a red gem. It turned out there were two such gems, life-forms from beyond this galaxy who were mates, and who reacted to being separated by radiating anguish that manifested as illness and dropped people into comas deep enough that even the best medical tech was fooled. The shock of seeming to contract such a disease [[YourMindMakesItReal made most people die for real]], but since Luke had had a fever-dream that gave him insights on what to do, he revived when the gems were reunited.

to:

* ''ComicBook/MarvelStarWars'' has the Crimson Forever, whose name is rather contrived - "D-dead! Everyone on board, Commander! Most of them fallen at their stations... their entire bodies turned that terrible ''crimson''...! Even their ''eyes''...! All open... ''staring''... like they were looking straight on into ''forever''...!" Luke and a squadron of pilots immediately put on masks and set up quarantine but still fell ill themselves after one of them found a red gem. It turned out there were two such gems, life-forms from beyond this galaxy who were mates, and who reacted to being separated by radiating anguish that manifested as illness and dropped people into comas deep enough that even the best medical tech was fooled. The shock of seeming to contract such a disease [[YourMindMakesItReal made most people die for real]], but since Luke had had a fever-dream that gave him insights on what to do, he revived when the gems were reunited.



* In the universe of ''Film/TheLastWitchHunter'', TheBlackDeath plague isn't a natural disease, but a magical plague created by the Witch Queen as her take on ApocalypseHow.

to:

* In the universe of ''Film/TheLastWitchHunter'', TheBlackDeath plague isn't a natural disease, but a magical plague created by the Witch Queen as her take on ApocalypseHow.



* ''Literature/AngelMage'': The country of Ystara is destroyed by one of these, the Ash Blood plague, which as the name implies turns the blood of the afflicted to ash. One third of the victims instead turn into monsters called "beastlings".



* ''Literature/ElementalMasters'': ''Literature/PhoenixAndAshes'': At one point, [[EvilStepmother Alison]] summons a disease elemental and sets it loose; it's implied that this caused the 1918 [=H1N1=] pandemic.

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* ''Literature/ElementalMasters'': ''Literature/PhoenixAndAshes'': At one point, In ''Literature/PhoenixAndAshes'', [[EvilStepmother Alison]] summons a disease elemental and sets it loose; it's implied that this caused the 1918 [=H1N1=] pandemic.



* In ''Temple of the Winds'' of the ''Literature/SwordOfTruth'' series, [[TheEmpire The Imperial Order]] unleashes a plague, based on TheBlackDeath and made ''much'' worse by magic, on the heroes' capital city. For bonus KickTheDog points, [[BigBad Emperor Jagang]] deliberately infects a group of young children as patients zero.
* Creator/JRRTolkien seems to have liked this trope:

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* In ''Temple of the Winds'' of the ''Literature/SwordOfTruth'' series, [[TheEmpire The the Imperial Order]] unleashes a plague, based on TheBlackDeath and made ''much'' worse by magic, on the heroes' capital city. For bonus KickTheDog points, [[BigBad Emperor Jagang]] deliberately infects a group of young children as patients zero.
* Creator/JRRTolkien seems to have liked this trope:trope in his [[Franchise/TolkiensLegendarium Legendarium]]:



* ''WesternAnimation/FamilyGuy'': In "If I'm Dyin', I'm Lyin'", Peter claims to have healed Chris of a disease he made up, which convinces the town that he's a divine healer, and he milks their worship of him for all it's worth. However, this makes God smite the Griffins with plagues based on [[Literature/BookOfExodus those He cast upon Egypt]], including darkness (the light bulbs going out), gadflies (Brian getting fleas), boils (Chris getting acne) and blood ([[BloodBath Stewie's bath water turning to blood]]).



* ''WesternAnimation/FamilyGuy'': In "If I'm Dyin', I'm Lyin'", Peter claims to have healed Chris of a disease he made up, which convinces the town that he's a divine healer, and he milks their worship of him for all it's worth. However, this makes God smite the Griffins with plagues based on [[Literature/BookOfExodus those He cast upon Egypt]], including darkness (the light bulbs going out), gadflies (Brian getting fleas), boils (Chris getting acne) and blood ([[BloodBath Stewie's bath water turning to blood]]).


* In the ''Visionaries: Knights of the Magical Light'' episode "Horn of Unicorn, Claw of Dragon", a Magical Plague strikes Prysmos, affecting all but one of the Spectral Knights and up to five of the Darkling Lords. In this case, the precise cause of the Plague is unspecified, though Merklynn does say that he foresaw it coming and tried (unsuccessfully) to send the Darkling Lords on a quest for the ingredients (the unicorn's horn and dragon's claw referred to in the title) needed for a healing spell.

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* In the ''Visionaries: Knights of the Magical Light'' ''WesternAnimation/{{Visionaries}}'' episode "Horn of Unicorn, Claw of Dragon", a Magical Plague strikes Prysmos, affecting all but one of the Spectral Knights and up to five of the Darkling Lords. In this case, the precise cause of the Plague is unspecified, though Merklynn does say that he foresaw it coming and tried (unsuccessfully) to send the Darkling Lords on a quest for the ingredients (the unicorn's horn and dragon's claw referred to in the title) needed for a healing spell.

Added DiffLines:

* ''WesternAnimation/FamilyGuy'': In "If I'm Dyin', I'm Lyin'", Peter claims to have healed Chris of a disease he made up, which convinces the town that he's a divine healer, and he milks their worship of him for all it's worth. However, this makes God smite the Griffins with plagues based on [[Literature/BookOfExodus those He cast upon Egypt]], including darkness (the light bulbs going out), gadflies (Brian getting fleas), boils (Chris getting acne) and blood ([[BloodBath Stewie's bath water turning to blood]]).


* In Hawaiian Mythology, the normally-benevolent [[AnIcePerson Poli'ahu]] inflicted her ex-fiancé Aiwohikupua and his lover [[spoiler:Poli'ahu's [[EveryoneIsRelated sister]], Pele]] with chills and fever because [[YourCheatingHeart they snuck off together]] [[RunawayBride on what would have been Aiwohikupua and Poli'ahu's wedding day]].

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* In Hawaiian Mythology, Myth/OceanianMythology, the normally-benevolent [[AnIcePerson Poli'ahu]] inflicted her ex-fiancé Aiwohikupua and his lover [[spoiler:Poli'ahu's [[EveryoneIsRelated sister]], Pele]] with chills and fever because [[YourCheatingHeart they snuck off together]] [[RunawayBride on what would have been Aiwohikupua and Poli'ahu's wedding day]].



[[folder:Anime & Manga]]
* In ''Manga/KingOfThorn'', "Medusa" is a disease that came from a meteorite; spreading across the globe and turning most humans into statues. (and others into monsters). It's revealed to have a psychic vector; rather than a viral or bacterial one.
[[/folder]]



[[folder:Manga]]
* In ''Manga/KingOfThorn'', "Medusa" is a disease that came from a meteorite; spreading across the globe and turning most humans into statues. (and others into monsters). It's revealed to have a psychic vector; rather than a viral or bacterial one.
[[/folder]]



* In ''VideoGame/{{Dishonored}}'', the rat plague initially was a virulent plague that [[spoiler:the Spymaster]] brought from the Pandyssian Continent to wipe out the poor in Dunwall. However, [[HumanoidAbomination the Outsider's]] interest was piqued and he made the plague more virulent, making all means of quarantine meaningless, and perhaps ensured the infected would become [[TechnicallyLivingZombie Weepers]]. Notably his primary 'servant', [[spoiler:[[EvilOldFolks Granny Rags]]]] seems to spread the plague by summoning more and more rats to areas. [[spoiler:You can too if you go the High Chaos route]].

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* In ''VideoGame/{{Dishonored}}'', the rat plague initially was a virulent plague that [[spoiler:the Spymaster]] brought from the Pandyssian Continent to wipe out the poor in Dunwall. However, [[HumanoidAbomination the Outsider's]] Outsider]]'s interest was piqued and he made the plague more virulent, making all means of quarantine meaningless, and perhaps ensured the infected would become [[TechnicallyLivingZombie Weepers]]. Notably Notably, his primary 'servant', [[spoiler:[[EvilOldFolks Granny Rags]]]] seems to spread the plague by summoning more and more rats to areas. [[spoiler:You can too if you go the High Chaos route]].



** ''[[VideoGame/TheElderScrollsIIIMorrowind Morrowind]]''

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** ''[[VideoGame/TheElderScrollsIIIMorrowind Morrowind]]''Morrowind]]'':


* The "rash illness" from ''Webcomic/StandStillStaySilent'' turns its victims into horrific monsters. It is strongly implied to be connected to [[TheMagicComesBack the resurgence of magic]].

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* ''Webcomic/StandStillStaySilent'': The "rash illness" from ''Webcomic/StandStillStaySilent'' turns its victims into horrific monsters. It is strongly implied to be connected to [[TheMagicComesBack the resurgence of magic]]. In fact, the old world actually managed to cure the disease without too much trouble. It's just that wasn't enough to actually save anyone, because the mundane disease was merely the vector for the mystical one. People who took the cure did not mutate into monsters, but still inevitably suffered brain death, and then their spirits stuck around as angry ghosts.


** Also from the backstory, the Knahaten Flu ravaged Tamriel in the 2nd Era for a period of about 40 years. It is attributed to an [[LizardFolk Argonian]] shaman who created the plague by manipulating the spores of the [[WiseTree Hist]] in retaliation for [[FantasticRacism the awful treatment of his people by the other races]]. Other sources claim that it was a natural disease, but the [[ReptilesAreAbhorrent general distrust of the Argonians throughout Tamriel]] combined with the fact that [[IdealIllnessImmunity Argonians were immune to the disease]] made the "Argonians caused it" story more popular. The Flu is believed to have completely wiped out the Lilmothiit "[[PettingZooPeople Fox Folk]]" and the Kothringi [[AmazingTechnicolorPopulation silver-skinned]] menfolk, both formerly native to the Black Marsh.

to:

** Also from the backstory, the Knahaten Flu ravaged Tamriel in the 2nd Era for a period of about 40 years. It is attributed to an [[LizardFolk Argonian]] shaman who created the plague by manipulating the spores of the [[WiseTree Hist]] in retaliation for [[FantasticRacism the awful treatment of his people by the other races]]. Other sources claim that it was a natural disease, but the [[ReptilesAreAbhorrent general distrust of the Argonians throughout Tamriel]] combined with the fact that [[IdealIllnessImmunity Argonians were immune to the disease]] made the "Argonians caused it" story more popular. The Flu is believed to have completely wiped out the Lilmothiit "[[PettingZooPeople "[[BeastMan Fox Folk]]" and the Kothringi [[AmazingTechnicolorPopulation silver-skinned]] menfolk, both formerly native to the Black Marsh.


* The "rash illness" from ''Webcomic/StandStillStaySilent'' turns out to do much worse than merely kill its victims, and is strongly implied to be connected to [[TheMagicComesBack the resurgence of magic]].

to:

* The "rash illness" from ''Webcomic/StandStillStaySilent'' turns out to do much worse than merely kill its victims, and victims into horrific monsters. It is strongly implied to be connected to [[TheMagicComesBack the resurgence of magic]]. magic]].


* The "rash illness" from ''Webcomic/StayStillStaySilent'' turns out to do much worse than merely kill its victims, and is strongly implied to be connected to [[TheMagicComesBack the resurgence of magic]].

to:

* The "rash illness" from ''Webcomic/StayStillStaySilent'' ''Webcomic/StandStillStaySilent'' turns out to do much worse than merely kill its victims, and is strongly implied to be connected to [[TheMagicComesBack the resurgence of magic]].


* In ''VideoGame/{{Bloodborne}}'', the Scourge of Beast is a plague which turns people into werewolf-like creatures which is known as Beasts. [[spoiler: the twist is that the plague was spread by the blood of the [[EldritchAbomination Great One]].]]

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* In ''VideoGame/{{Bloodborne}}'', the Scourge of the Beast is a plague which turns transforms people into werewolf-like creatures which is known as called Beasts. [[spoiler: the twist is that the plague was spread by the blood of the [[EldritchAbomination Great One]].]]


[[folder:Anime & Manga]]
* In ''Manga/KingOfThorn'', "Medusa" is a disease that came from a meteorite; spreading across the globe and turning most humans into statues. (and others into monsters). It's revealed to have a psychic vector; rather than a viral or bacterial one.
[[/folder]]



* In the ''ComicBook/CaptainMarvel'' title starring Genis-Vell, an offhand comment by the narration states that the Black Plague was caused by the anguished scream of a CosmicEntity.



* In the Captain Marvel title starring Genis-Vell an offhand comment by the narration states that the Black Plague was caused by the anguished scream of a CosmicEntity.



[[folder:Films -- Live-Action]]

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[[folder:Films -- Live-Action]]— Live-Action]]
* In the universe of ''Film/TheLastWitchHunter'', TheBlackDeath plague isn't a natural disease, but a magical plague created by the Witch Queen as her take on ApocalypseHow.



* In the universe of ''Film/TheLastWitchHunter'', TheBlackDeath plague isn't a natural disease, but a magical plague created by the Witch Queen as her take on ApocalypseHow.



* Creator/JRRTolkien seems to have liked this trope:
** ''Literature/TheSilmarillion'' mentions a plague apparently sent by Sauron to weaken Gondor so he could regain control of Mordor.
--->"And in the days of Telemnar, the third and twentieth of the line of Meneldil, a plague came upon dark winds out of the east, and it smote the King and his children, and many of the people of Gondor perished. Then the forts on the borders of Mordor were deserted, and Minas Ithil was emptied of its people; and evil entered again into the Black Land secretly, and the ashes of Gorgoroth were stirred as by a cold wind, for dark shapes gathered there."
** A mystical plague is used in the same work to account for the death of Túrin Turambar's younger sister Lalaith.

to:

* Creator/JRRTolkien seems to have liked this trope:
** ''Literature/TheSilmarillion'' mentions a plague apparently sent by Sauron to weaken Gondor so he could regain control
This occurs in Mark Chadbourn's book ''The Queen of Mordor.
--->"And in
Sinister'', part of ''Literature/TheAgeOfMisrule'' {{Verse}}. Magic has come back, technology has failed and there is [[EldritchAbomination something]] lurking beyond even the days of Telemnar, the third and twentieth mystical otherworlds of the line of Meneldil, a plague came upon dark winds out of the east, and it smote the King and his children, and many of the people of Gondor perished. Then the forts on the borders of Mordor were deserted, and Minas Ithil was emptied of its people; and evil entered again into the Black Land secretly, dead and the ashes of Gorgoroth were stirred as by a cold wind, for dark shapes gathered there."
**
gods that kinda, sorta, wants to destroy humanity utterly. A mystical plague is used in that kills human life essence itself (basically 100% fatal, and dissolves its victims flesh leaving them just a load of pus inside a bag of skin and since it comes from the same work to account otherworld there is no known vector, source, or cure for the death disease) is the chosen tool for this book. Too bad for it that two of Túrin Turambar's younger sister Lalaith.the early victims were the son and husband of a woman that is an unknowing mystical champion of humanity, and the plague which was supposed to destroy her wakes that mystical potential. NiceJobFixingItVillain.
* ''Literature/{{Circleverse}}'': ''[[Literature/CircleOfMagic Briar's Book]]'' (or ''The Healing in the Vine'', [[MarketBasedTitle depending on where you live]]) features one called the Blue Pox. Rather than being created deliberately, it's caused accidentally by improper disposal of magical potions.
* In the ''Literature/CronusChronicles'', one of our heroes, a British public school student named Zee, is sent to America to get away from one of these, not realizing he is in fact the carrier.
* In ''Literature/TheDivineComedy'', falsifiers (which include alchemists, perjurers and counterfeiters) are punished in the last bolgia in the 8th circle of hell by being afflicted by horrible diseases.



* This occurs in Mark Chadbourn's book ''The Queen of Sinister'', part of the ''Literature/TheAgeOfMisrule'' {{Verse}}. Magic has come back, technology has failed and there is [[EldritchAbomination something]] lurking beyond even the mystical otherworlds of the dead and the gods that kinda, sorta, wants to destroy humanity utterly. A mystical plague that kills human life essence itself (basically 100% fatal, and dissolves its victims flesh leaving them just a load of pus inside a bag of skin and since it comes from the otherworld there is no known vector, source, or cure for the disease) is the chosen tool for this book. Too bad for it that two of the early victims were the son and husband of a woman that is an unknowing mystical champion of humanity, and the plague which was supposed to destroy her wakes that mystical potential. NiceJobFixingItVillain.

to:

* This occurs in Mark Chadbourn's book ''The Queen of Sinister'', part of ''Literature/ElementalMasters'': ''Literature/PhoenixAndAshes'': At one point, [[EvilStepmother Alison]] summons a disease elemental and sets it loose; it's implied that this caused the ''Literature/TheAgeOfMisrule'' {{Verse}}. Magic has come back, technology has failed and 1918 [=H1N1=] pandemic.
* In the ''Literature/HarryPotter'' series
there is [[EldritchAbomination something]] lurking beyond even a great deal of fear of werewolves due to misinformation and concern about the mystical otherworlds spread of Lycanthropy, a parallel to AIDS, which sufferers of are discriminated against. In ''[[Literature/HarryPotterAndThePrisonerOfAzkaban Prisoner of Azkaban]]'' Lupin resigns after Snape outs him, and in ''[[Literature/HarryPotterAndTheOrderOfThePhoenix Order of the dead and the gods Phoenix]]'' it is revealed that kinda, sorta, wants Lupin and Sirius already despise Umbridge due to destroy humanity utterly. A mystical plague some ani-werewolf legislation she wrote up that kills human life essence itself (basically 100% fatal, and dissolves its victims flesh leaving them just a load of pus inside a bag of skin and since makes it comes from near impossible for werewolves to find employment.
* In
the otherworld there ''Literature/LabyrinthsOfEcho'' series, Anavuayna is no known vector, source, or cure for the disease) is the chosen tool for this book. Too bad for it that two an ancient magic plague, borne out of the early victims were the son and husband curse of a woman an enraged Elven princess, that is an unknowing mystical champion of humanity, not only [[BodyHorror slowly liquifies the victim's body, bones and all]], while the victim is fully conscious, but also [[DeaderThanDead destroys their soul on every level of existence]].
* In ''Literature/TheSisterVerseAndTheTalonsOfRuin'', this is what people think is initially happening, until
the plague which was supposed refuses to destroy her wakes spread, and they realize that mystical potential. NiceJobFixingItVillain.it's a conscious entity possessing people.



* The ''Literature/SongOfTheLioness'' quartet has one early on: the Sweating Sickness is sent by an evil duke in hopes that it will weaken the kingdom and kill [[SuccessionCrisis everyone who stands in his way]] to the throne.
* Same author, [[Literature/CircleOfMagic different universe]]. ''Briar's Book'' or ''The Healing in the Vine'' ([[MarketBasedTitle depending on where you live]]) features one called The Blue Pox. Rather than being created deliberately, it's caused accidentally by improper disposal of magical potions.
* ''Literature/PhoenixAndAshes'': At one point, Alison summons a disease elemental and sets it loose; it's implied that this caused the 1918 [=H1N1=] pandemic.
* In the ''Literature/CronusChronicles'', one of our heroes, a British public school student named Zee, is sent to America to get away from one of these, not realizing he is in fact, the carrier.
* In the ''Literature/LabyrinthsOfEcho'' series Anavuayna is an ancient magic plague, borne out of an enraged Elven princess curse, that not only [[BodyHorror slowly liquifies the victim's body, bones and all]], while the victim is fully conscious, but also [[DeaderThanDead destroys their soul on every level of existence]].

to:

* Creator/JRRTolkien seems to have liked this trope:
** ''Literature/TheSilmarillion'' mentions a plague apparently sent by Sauron to weaken Gondor so he could regain control of Mordor.
--->"And in the days of Telemnar, the third and twentieth of the line of Meneldil, a plague came upon dark winds out of the east, and it smote the King and his children, and many of the people of Gondor perished. Then the forts on the borders of Mordor were deserted, and Minas Ithil was emptied of its people; and evil entered again into the Black Land secretly, and the ashes of Gorgoroth were stirred as by a cold wind, for dark shapes gathered there."
** A mystical plague is used in the same work to account for the death of Túrin Turambar's younger sister Lalaith.
* ''Literature/TortallUniverse'':
The ''Literature/SongOfTheLioness'' quartet has one early on: the Sweating Sickness is sent by an evil duke in hopes that it will weaken the kingdom and kill [[SuccessionCrisis everyone who stands in his way]] to the throne.
* Same author, [[Literature/CircleOfMagic different universe]]. ''Briar's Book'' or ''The Healing in the Vine'' ([[MarketBasedTitle depending on where you live]]) features one called The Blue Pox. Rather than being created deliberately, it's caused accidentally by improper disposal of magical potions.
* ''Literature/PhoenixAndAshes'': At one point, Alison summons a disease elemental and sets it loose; it's implied that this caused the 1918 [=H1N1=] pandemic.
* In the ''Literature/CronusChronicles'', one of our heroes, a British public school student named Zee, is sent to America to get away from one of these, not realizing he is in fact, the carrier.
* In the ''Literature/LabyrinthsOfEcho'' series Anavuayna is an ancient magic plague, borne out of an enraged Elven princess curse, that not only [[BodyHorror slowly liquifies the victim's body, bones and all]], while the victim is fully conscious, but also [[DeaderThanDead destroys their soul on every level of existence]].
throne.



* In the ''Literature/HarryPotter'' series there is a great deal of fear of werewolves due to misinformation and concern about the spread of Lycanthropy, a parallel to AIDS, which sufferers of are discriminated against. In ''[[Literature/HarryPotterAndThePrisonerOfAzkaban Prisoner of Azkaban]]'' Lupin resigns after Snape outs him, and in ''[[Literature/HarryPotterAndTheOrderOfThePhoenix Order of the Phoenix]]'' it is revealed that Lupin and Sirius already despise Umbridge due to some ani-werewolf legislation she wrote up that makes it near impossible for werewolves to find employment.
* In ''Literature/TheDivineComedy'', falsifiers (which include alchemists, perjurers and counterfeiters) are punished in the last bolgia in the 8th circle of hell by being afflicted by horrible diseases.
* In ''Literature/TheSisterVerseAndTheTalonsOfRuin'', this is what people think is initially happening, until the plague refuses to spread, and they realize that it's a conscious entity possessing people.



* The plot driver in ''Series/TheLegendOfDickAndDom''; the heroes are collecting PlotCoupons to make a magic potion to cure a plague. They discover in season two that it was magic, [[spoiler:caused by the BigBad]].



* The plot driver in ''Series/TheLegendOfDickAndDom''; the heroes are collecting PlotCoupons to make a magic potion to cure a plague. They discover in season two that it was magic, [[spoiler:caused by the BigBad]].



[[folder:Manga]]
* In ''Manga/KingOfThorn'', "Medusa" is a disease that came from a meteorite; spreading across the globe and turning most humans into statues. (and others into monsters). It's revealed to have a psychic vector; rather than a viral or bacterial one.
[[/folder]]



* Miasma (as referenced in the ''Theatre/OedipusTheKing'' example below) was a part of the ancient Greek's cosmological view: If a people or their ruler acted in a way that defied the natural order (as they saw it), this was a logical consequence of said actions.

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* Myth/ClassicalMythology: Miasma (as referenced in the ''Theatre/OedipusTheKing'' example below) was a part of the ancient Greek's cosmological view: If a people or their ruler acted in a way that defied the natural order (as they saw it), this was a logical consequence of said actions.



* In Hawaiian Mythology, the normally-benevolent [[AnIcePerson Poli'ahu]] inflicted her ex-fiancé Aiwohikupua and his lover [[spoiler: Poli'ahu's [[EveryoneIsRelated sister]], Pele]] with chills and fever because [[YourCheatingHeart they snuck off together]] [[RunawayBride on what would have been Aiwohikupua and Poli'ahu's wedding day]].

to:

* In Hawaiian Mythology, the normally-benevolent [[AnIcePerson Poli'ahu]] inflicted her ex-fiancé Aiwohikupua and his lover [[spoiler: Poli'ahu's [[spoiler:Poli'ahu's [[EveryoneIsRelated sister]], Pele]] with chills and fever because [[YourCheatingHeart they snuck off together]] [[RunawayBride on what would have been Aiwohikupua and Poli'ahu's wedding day]].



* One rise scenario from zombie game ''All Flesh Must Be Eaten'' has the PHADE virus, which is the zombie plague... as an STD. The whole thing started when a guy was so bereaved about the loss of his girlfriend, he used necromancy to bring her back for [[ILoveTheDead one last fling]]. And then he decided he wasn't that into her, and slept with someone else, and it just spread from there.
* ''TabletopGame/ArsMagica''. The spell "Curse of the Unportended Plague" starts a plague in a city over a period of 6-12 months. It will kill 10% of the city's population over a period of a few months.



* ''TabletopGame/{{Exalted}}'' features, among many others, the Great Contagion. Dug out of a [[EldritchLocation dimensional nexus that instills insanity in all those who view it without proper protection]] by one of the Deathlords, it killed about 90% of Creation on the first go. The only thing that stopped it from finishing the job was one of the other Deathlords inviting TheFairFolk in to finish the job; the chaotic energies of the Wyld that came with the invasion actually ''bolstered'' the immunities of the survivors.
** To clarify; not 90% of Creation's people. 90% of ''everything''. Plants, animals, spirits, gods... anything that could basically constitute "alive" in Creation was fair game. On top of that, the disease was so infectious that ''mystically observing it'' was capable of contracting it.



* ''TabletopGame/{{Exalted}}'' features, among many others, the Great Contagion. Dug out of a [[EldritchLocation dimensional nexus that instills insanity in all those who view it without proper protection]] by one of the Deathlords, it killed about 90% of Creation on the first go. The only thing that stopped it from finishing the job was one of the other Deathlords inviting TheFairFolk in to finish the job; the chaotic energies of the Wyld that came with the invasion actually ''bolstered'' the immunities of the survivors.
** To clarify; not 90% of Creation's people. 90% of ''everything''. Plants, animals, spirits, gods... anything that could basically constitute "alive" in Creation was fair game. On top of that, the disease was so infectious that ''mystically observing it'' was capable of contracting it.
* One rise scenario from zombie game ''All Flesh Must Be Eaten'' has the PHADE virus, which is the zombie plague... as an STD. The whole thing started when a guy was so bereaved about the loss of his girlfriend, he used necromancy to bring her back for [[ILoveTheDead one last fling]]. And then he decided he wasn't that into her, and slept with someone else, and it just spread from there.
* ''TabletopGame/ArsMagica''. The spell "Curse of the Unportended Plague" starts a plague in a city over a period of 6-12 months. It will kill 10% of the city's population over a period of a few months.



[[folder:Theater]]

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[[folder:Theater]][[folder:Theatre]]



* ''VideoGame/{{Warcraft}} 3'': The plague of undeath that turns people into zombies, preparing the way for a demonic invasion.

to:

* ''VideoGame/{{Warcraft}} 3'': The In ''VideoGame/{{Dishonored}}'', the rat plague of undeath initially was a virulent plague that turns people into zombies, preparing [[spoiler:the Spymaster]] brought from the way for a demonic invasion.Pandyssian Continent to wipe out the poor in Dunwall. However, [[HumanoidAbomination the Outsider's]] interest was piqued and he made the plague more virulent, making all means of quarantine meaningless, and perhaps ensured the infected would become [[TechnicallyLivingZombie Weepers]]. Notably his primary 'servant', [[spoiler:[[EvilOldFolks Granny Rags]]]] seems to spread the plague by summoning more and more rats to areas. [[spoiler:You can too if you go the High Chaos route]].



** In ''[[VideoGame/TheElderScrollsVSkyrim Skyrim]]'', Peryite's Daedric quest involves hunting down and kill the leader of a group of his rogue followers who've been inflicted with such a plague. Before going rogue, Peryite intended to have these followers spread a this plague to "cover the world" with his "[[BlessedWithSuck blessing]]".

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** In ''[[VideoGame/TheElderScrollsVSkyrim Skyrim]]'', Peryite's Daedric quest involves hunting down and kill killing the leader of a group of his rogue followers who've been inflicted with such a plague. Before going rogue, Peryite intended to have these followers spread a this plague to "cover the world" with his "[[BlessedWithSuck blessing]]".blessing]]".
* ''[[VideoGame/{{Heretic}} Heretic 2]]'' has a mystic plague as a central part of the story, mostly it causes death, insanity and violence, but there is mention of another version that can be used to control people.
* ''VideoGame/HollowKnight'': The main threat in the game is a mysterious, terrifying plague that’s turning Hallownest into a DeathWorld. Bugs afflicted with it are driven to violent insanity by it and [[CameBackWrong get reanimated as monstrous husks after dying]]. It was created by [[spoiler:the Radiance, [[GodIsEvil the god who created bugkind]], as a “divine” punishment after they stopped worshiping her and your character is an EmptyShell created to try and contain it.]]



* In ''VideoGame/{{Dishonored}}'', the rat plague initially was a virulent plague that [[spoiler:the Spymaster]] brought from the Pandyssian Continent to wipe out the poor in Dunwall. However, [[HumanoidAbomination the Outsider's]] interest was piqued and he made the plague more virulent, making all means of quarantine meaningless, and perhaps ensured the infected would become [[TechnicallyLivingZombie Weepers]]. Notably his primary 'servant', [[spoiler:[[EvilOldFolks Granny Rags]]]] seems to spread the plague by summoning more and more rats to areas. [[spoiler:You can too if you go the High Chaos route]].

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* In ''VideoGame/{{Dishonored}}'', ''VideoGame/{{Okami}}'' - When you arrive at Sei-An City, you find the rat plague initially was citizens all seriously ill from a virulent plague disease that [[spoiler:the Spymaster]] brought from the Pandyssian Continent to wipe out the poor in Dunwall. However, [[HumanoidAbomination the Outsider's]] interest was piqued and he made the plague more virulent, making all means of quarantine meaningless, and perhaps ensured the infected would become [[TechnicallyLivingZombie Weepers]]. Notably his primary 'servant', [[spoiler:[[EvilOldFolks Granny Rags]]]] seems to spread be originating from a thick green mist covering the plague city. Worse, the queen seems to be doing absolutely nothing to help. [[spoiler:It's caused by summoning more a demon who has possessed the emperor, infecting him with some sort of illness and more rats to areas. [[spoiler:You can too if you go leaving him bedridden as he exhales the High Chaos route]].infectious mist.]]



* ''[[VideoGame/{{Heretic}} Heretic 2]]'' has a mystic plague as a central part of the story, mostly it causes death, insanity and violence, but there is mention of another version that can be used to control people.

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* ''[[VideoGame/{{Heretic}} Heretic 2]]'' has The Filth of ''VideoGame/TheSecretWorld.'' Essentially [[EldritchAbomination the Dreamers]]' will to awaken made manifest through their [[RealityWarper reality-warping powers]], it exists to corrupt any being it touches and convert them into a mystic plague subservient mutant dedicated to releasing the Dreamers from captivity. For good measure, it takes a variety of forms throughout the setting: along with its common "tentacled black ooze" form, it also appears as toxic gas, weird weather, eldritch graffiti, radio signals... and according to Dr Klein, the historical epidemic popularly known as the Black Death.
* The Delphinus Parasite in ''VideoGame/ShinMegamiTenseiStrangeJourney'' doubles as this and
a central part HatePlague. [[spoiler:It's actually the inchoate form of the story, mostly it causes death, insanity and violence, but there is mention of another version that can be used to control people.resident DemonLord's soul.]]



* The Delphinus Parasite in ''VideoGame/ShinMegamiTenseiStrangeJourney'' doubles as this and a HatePlague. [[spoiler:It's actually the inchoate form of the resident DemonLord's soul.]]
* ''VideoGame/HollowKnight'': The main threat in the game is a mysterious, terrifying plague that’s turning Hallownest into a DeathWorld. Bugs afflicted with it are driven to violent insanity by it and [[CameBackWrong get reanimated as monstrous husks after dying]]. It was created by [[spoiler:the Radiance, [[GodIsEvil the god who created bugkind]], as a “divine” punishment after they stopped worshiping her and your character is an EmptyShell created to try and contain it.]]
* The Filth of ''VideoGame/TheSecretWorld.'' Essentially [[EldritchAbomination the Dreamers]]' will to awaken made manifest through their [[RealityWarper reality-warping powers]], it exists to corrupt any being it touches and convert them into a subservient mutant dedicated to releasing the Dreamers from captivity. For good measure, it takes a variety of forms throughout the setting: along with its common "tentacled black ooze" form, it also appears as toxic gas, weird weather, eldritch graffiti, radio signals... and according to Dr Klein, the historical epidemic popularly known as the Black Death.
* ''VideoGame/{{Okami}}'' - When you arrive at Sei-An City, you find the citizens all seriously ill from a disease that seems to be originating from a thick green mist covering the city. Worse, the queen seems to be doing absolutely nothing to help. [[spoiler:It's caused by a demon who has possessed the emperor, infecting him with some sort of illness and leaving him bedridden as he exhales the infectious mist.]]

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* ''VideoGame/{{Warcraft}} 3'': The Delphinus Parasite in ''VideoGame/ShinMegamiTenseiStrangeJourney'' doubles as this and a HatePlague. [[spoiler:It's actually the inchoate form of the resident DemonLord's soul.]]
* ''VideoGame/HollowKnight'': The main threat in the game is a mysterious, terrifying
plague that’s turning Hallownest of undeath that turns people into a DeathWorld. Bugs afflicted with it are driven to violent insanity by it and [[CameBackWrong get reanimated as monstrous husks after dying]]. It was created by [[spoiler:the Radiance, [[GodIsEvil zombies, preparing the god who created bugkind]], as way for a “divine” punishment after they stopped worshiping her and your character is an EmptyShell created to try and contain it.]]
* The Filth of ''VideoGame/TheSecretWorld.'' Essentially [[EldritchAbomination the Dreamers]]' will to awaken made manifest through their [[RealityWarper reality-warping powers]], it exists to corrupt any being it touches and convert them into a subservient mutant dedicated to releasing the Dreamers from captivity. For good measure, it takes a variety of forms throughout the setting: along with its common "tentacled black ooze" form, it also appears as toxic gas, weird weather, eldritch graffiti, radio signals... and according to Dr Klein, the historical epidemic popularly known as the Black Death.
* ''VideoGame/{{Okami}}'' - When you arrive at Sei-An City, you find the citizens all seriously ill from a disease that seems to be originating from a thick green mist covering the city. Worse, the queen seems to be doing absolutely nothing to help. [[spoiler:It's caused by a demon who has possessed the emperor, infecting him with some sort of illness and leaving him bedridden as he exhales the infectious mist.]]
demonic invasion.



* In ''Webcomic/{{Unsounded}}'' regions in the nation of Alderode are afflicted by the Weeping Plague, which somehow spreads by making eye contact with a sufferer.


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* In ''Webcomic/{{Unsounded}}'', regions in the nation of Alderode are afflicted by the Weeping Plague, which somehow spreads by making eye contact with a sufferer.

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* The "rash illness" from ''Webcomic/StayStillStaySilent'' turns out to do much worse than merely kill its victims, and is strongly implied to be connected to [[TheMagicComesBack the resurgence of magic]].

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* In ''Literature/TheSisterVerseAndTheTalonsOfRuin'', this is what people think is initially happening, until the plague refuses to spread, and they realize that it's a conscious entity possessing people.

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* In the Captain Marvel title starring Genis-Vell an offhand comment by the narration states that the Black Plague was caused by the anguished scream of a CosmicEntity.


When ThePlague is brought about not via natural evolution or the [[SyntheticPlague machinations of science]], but is instead created through the magical powers of a person, creature, or group, whether by accident or design.

Perhaps a {{Necromancer}} is summoning dark magic to bring about the ZombieApocalypse, worshippers of the God of Disease call upon their master to bring vengeance upon their enemies, cults of EldritchAbomination obtain LovecraftianSuperpower or a shaman uses a forbidden curse in the vain hopes that it keeps his people from being wiped out. Whatever the reasons behind it, the use of disease-based magic is nearly always seen as an evil act for the sheer amount of suffering it can bring about.

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When ThePlague is brought about not via natural evolution or the [[SyntheticPlague machinations of science]], but is instead created through the magical supernatural powers of a person, creature, or group, whether by accident or design.

In classical works, Mystical Plagues are brought about by [[OurGodsAreDifferent the gods]] or {{God}} to punish society for some collective sin. The plague invites some investigation into who offended the divine and how to make up for the damage.

Fantasy uses of the trope are less positive.
Perhaps a {{Necromancer}} is summoning dark magic to bring about the ZombieApocalypse, worshippers of the God of Disease call upon their master to bring vengeance upon their enemies, cults of EldritchAbomination obtain LovecraftianSuperpower or a shaman uses a forbidden curse in the vain hopes that it keeps his people from being wiped out. Whatever the reasons behind it, the human use of disease-based magic is nearly always seen as an evil act for the sheer amount of suffering it can bring about.

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