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* In ''Film/WeAreTheNight'' it is forbidden to turn men into vampires. The last male vampires were [[{{Gendercide}} killed by the female vampires]] a few centuries ago. But in the course of the plot, Lena falls in love with the policeman Tom. However, the vampire Louise injures him so badly that he is unlikely to survive the injuries. The last scene shows that Lena actually wants to transform him so that he can survive these injuries as a vampire, but hesitates at the last moment. Tom's fate is thus unknown. In the book, however, it is clearer. She turns him so that he survives and the wounds heal instantly, making Tom the first male vampire in centuries.

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* In ''Film/WeAreTheNight'' it is forbidden to turn men into vampires. The last male vampires were [[{{Gendercide}} killed by the female vampires]] a few centuries ago. But in the course of the plot, Lena falls in love with the policeman Tom. However, the vampire Louise injures him so badly that he is unlikely to survive the injuries. The last scene shows that Lena [[spoiler:Lena actually wants to transform him so that he can survive these injuries as a vampire, but hesitates at the last moment. Tom's fate is thus unknown. In the book, however, it is clearer. She turns him so that he survives and the wounds heal instantly, making Tom the first male vampire in centuries.]]
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* ''TabletopGame/BeastThePrimordial'': If a Beast dies while at max Satiety, his Horror may attempt the Retreat, separating itself from its human host to live on as a spirit of horror. While this can be the result of the Beast deliberately suiciding, it can also very easily happen by "accident" as a maxed-Satiety Beast does something stupid and gets killed.
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[[folder:Real Life]]
* A horrific RealLife example is David Reimer. Shortly after his birth, his penis was destroyed in a botched circumcision. His parents consulted with Dr. John Money, a sexologist who believed that gender was entirely socialized, who suggested that they have David undergo a sex change operation (as an infant!) and raise him as a girl. Since David had an identical twin brother, Money saw it as the perfect opportunity to prove his hypothesis. It...didn't work, as David struggled with his gender identity throughout his life, eventually deciding to live as male, and later [[DownerEnding committing suicide]].
[[/folder]]
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* In [[https://www.deviantart.com/slifofinadragon SilfofinaDragon]]'s ''VideoGame/SengokuBasara'' fanfics, Date Masamune and Katakura Kojuro change into a horse and a panther respectively from potions brewed by [[HotWitch Kyogoku Maria]], as means to protect Masamune and Sanada Yukimura's children. Both of them change back [[ShapeshiftingExcludesClothing minus any clothing]] after getting [[TrueLovesKiss smooched]] by Yukimura and Masamune & Yukimura's son Masa respectively (and here's an illustration of [[https://www.deviantart.com/misakiyu/art/Changed-Back-2-786035017 Masamune changing back after Yukimura kisses him]].

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* In [[https://www.deviantart.com/slifofinadragon SilfofinaDragon]]'s ''VideoGame/SengokuBasara'' fanfics, Date Masamune and Katakura Kojuro change into a horse and a panther [[OurWerewolvesAreDifferent wolf]] respectively from potions brewed by [[HotWitch Kyogoku Maria]], as means to protect Masamune and Sanada Yukimura's children. Both of them change back [[ShapeshiftingExcludesClothing minus any clothing]] after getting [[TrueLovesKiss smooched]] by Yukimura and Masamune & Yukimura's son Masa respectively (and here's an illustration of [[https://www.deviantart.com/misakiyu/art/Changed-Back-2-786035017 Masamune changing back after Yukimura kisses him]].
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* ''Podcast/TheChroniclesOfOz'''s adaptation of ''Literature/TheLifeAndAdventuresOfSantaClaus'' has Santa being fatally wounded by King Awgwa in a confrontation in the Emerald City palace during his first Christmas toy run, with the Mantle of Immortality being used to save his life.
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* ''[[https://archiveofourown.org/works/51699247/chapters/131765455#workskin Little by Little, Step by Step]]'': The Corvid Token is an artifact that lets the wearer transform into a Dire Raven while retaining their mind and faculties. According to legend, a girl suffering from illness used the token to 'cure' her sickness by living as a raven. [[VideoGame/BaldursGateIII Astarion the vampire spawn]] is the current owner, and he regularly transforms to go about in sunlight.
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-->'''Taurus Bulba:''' So, you ''[[SarcasmMode allow]]'' [[SarcasmMode me to be part of your]] ''[[SarcasmMode great]]'' [[SarcasmMode experiment]], without bothering me with petty nuisances such as... ''getting '''my permission'''.\\
MassOhCrap from every member of [[NebulousEvilOrganisation F.O.W.L.]] present, including '''Steelbeak'''''.

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-->'''Taurus Bulba:''' So, you ''[[SarcasmMode allow]]'' [[SarcasmMode me to be part of your]] ''[[SarcasmMode great]]'' [[SarcasmMode experiment]], without bothering me with petty nuisances such as... ''getting '''my permission'''.\\
MassOhCrap
''\\
''[MassOhCrap
from every member of [[NebulousEvilOrganisation F.O.W.L.]] present, including '''Steelbeak'''''.'''Steelbeak'''.]''
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* In an early WebOriginal/ShadowrunStorytime session, Geppetto gets a chestful of automatic gunfire. The closest the team has to an emergency trauma surgeon contact is a ghoul organlegger named John. If he does the work, Geppetto ''will'' contract HMHVV. Geppetto acknowledges the risk and accepts it. Dr. John has him infected with a different strain first so he turns into a banshee instead of a ghoul, something that can still pass for metahuman.

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* In an early WebOriginal/ShadowrunStorytime ''Literature/ShadowrunStorytime'' session, Geppetto gets a chestful of automatic gunfire. The closest the team has to an emergency trauma surgeon contact is a ghoul organlegger named John. If he does the work, Geppetto ''will'' contract HMHVV. Geppetto acknowledges the risk and accepts it. Dr. John has him infected with a different strain first so he turns into a banshee instead of a ghoul, something that can still pass for metahuman.
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* ''Franchise/ChildsPlay'': The franchise is kicked off by SerialKiller Charles Ray Lee being gunned down by Detective Mike Norris in a toy store. The dying Charles spots a "Good Guy" doll and uses a voodoo ritual to transfer his soul into it. This was very much a desperate move and not his first choice -- his overarching goal in the rest of the franchise is to transfer his soul into a human host.
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* ''Fanfic/UnleashingOfADarkNight'': What [[OriginalCharacter Tomo]] does to Sonic in order to stop him from converting into one of Dark Gaia's minions, as soon as she learns that they are capable of doing that, by biting his arm to get the Dark Gaia Energy out. Albeit unwittingly, as she didn’t know at the moment that biting was how [=WereMobians=] turn others into one of their kind.
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* ''Fanfic/TheNewAgeOfMonsters'': When Alan Jonah shoots Doctor Ver, the latter injects himself with unaltered Godzilla-Cells he just [[CrazyPrepared happened to carry with him]]. This allows him to survive the injury and over the next month, he gradually transforms into a small human-kaiju hybrid. Never one to shy away from an opportunity, Ver immediately decides to use this to his advantage and ''[[ForScience study the kaiju while living among them]]''.
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** However, Daniel underwent the Headmaster process and became Arcee's partner after being ''half-eaten'' by a beast Decepticon (You'd think nearly doing in TheScrappy would have [[SugarWiki/MomentOfAwesome made him a household name]], but no.) and will presumably be stuck in that exosuit ''forever.'' [[AlasPoorScrappy Poor guy]].

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** However, Daniel underwent the Headmaster process and became Arcee's partner after being ''half-eaten'' by a beast Decepticon (You'd think nearly doing in TheScrappy would have [[SugarWiki/MomentOfAwesome made him a household name]], but no.) and will presumably be stuck in that exosuit ''forever.'' [[AlasPoorScrappy Poor guy]].guy.
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* ''Film/TheresaAndAllison'': Paisley it turns out was dying of cancer while still a human, so her rich father paid vampires to turn her, curing her as a result.
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* ''Fanfic/DateALiveAlteredTimeline'': Like [[LightNovel/DateALive canon]], Tohka was born a Spirit, but [[spoiler: in order to prevent her from dying due to her body destabilizing, Mio had to absorb her and then absorb a dead human's body, combining the two and making her part Human like the other Sephira Spirits]].

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* ''Fanfic/DateALiveAlteredTimeline'': Like [[LightNovel/DateALive [[Literature/DateALive canon]], Tohka was born a Spirit, but [[spoiler: in order to prevent her from dying due to her body destabilizing, Mio had to absorb her and then absorb a dead human's body, combining the two and making her part Human like the other Sephira Spirits]].

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* ''Film/DarkShadows'': Barnabas Collins bites [[spoiler:Victoria and transforms her into a vampire to save her from a fall off the cliff at the end]].



* ''Film/NearDark'' features a variation in which Caleb is cured of vampirism by means of a total blood transfusion, although it was more of a long term solution than an emergency gambit.



* ''Film/{{Replicas}}'': Most of William's patients were people that had recently died who could be saved by uploading their consciousness into a new body.



* Why Caster was uploaded into a computer in the first place in ''Film/{{Transcendence}}''.





* ''Film/NearDark'' features a variation in which Caleb is cured of vampirism by means of a total blood transfusion, although it was more of a long term solution than an emergency gambit.
* Why Caster was uploaded into a computer in the first place in ''Film/{{Transcendence}}''.
* ''Film/DarkShadows'': Barnabas Collins bites [[spoiler:Victoria and transforms her into a vampire to save her from a fall off the cliff at the end]].
* ''Film/{{Replicas}}'': Most of William's patients were people that had recently died who could be saved by uploading their consciousness into a new body.

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* ''Film/TheAnimal'' explores the [[SarcasmMode serious ramifications]] of a near dead man having his organs replaced with those of various animals.
* {{Subverted|Trope}} in ''Film/{{Avatar}}'': When Dr. Augustine is mortally wounded after being shot, she and her avatar are brought to the Tree of Souls [[spoiler:with the purpose of transferring her consciousness permanently into her avatar. However, the transition fails as her human body is too gravely wounded. It does, however, succeed with Jake at the end of the film]]. Unfortunately not a subversion of NoBiochemicalBarriers.
* ''Film/{{Doom}}'' has the main character injected with the [[GreenRocks superhuman and/or demon serum]] after being fatally injured in a textbook example. The treatment he took theoretically has no disadvantages associated with it, however it does run the risk of getting oneself [[spoiler:transformed into a vicious, murderous mutant creature]]. Part of the explanation was that [[spoiler:the "demons" themselves instinctively only tried to infect those with the "evil gene" or potential for evil or whatever, which is what made them monsters due to the virus/serum. So in theory, any person that the demons didn't purposely infect to turn into monsters would develop super-powers instead]].



* The film [[InNameOnly named]] ''Film/IRobot'' had this happen with cybernetics to Lt. Spooner, combining WhatMeasureIsANonHuman, SurvivorGuilt, and [[FantasticRacism robophobia]].



* The film [[InNameOnly named]] ''Film/IRobot'' had this happen with cybernetics to Lt. Spooner, combining WhatMeasureIsANonHuman, SurvivorGuilt, and [[FantasticRacism robophobia]].

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* The film [[InNameOnly named]] ''Film/IRobot'' had this happen This is the origin story for ''Franchise/RoboCop''. Shot, run over and brutalized by drug dealers [[Film/RoboCop1987 in his 1987 debut]], Officer Murphy would have died from his injuries... ''should'' have died from his injuries... if it weren't for the Detroit Police Department having a deal with cybernetics [[MegaCorp OCP]], who as part of a drive to Lt. Spooner, combining WhatMeasureIsANonHuman, SurvivorGuilt, manufacture a police force capable of dealing with the rampant crime decided WeCanRebuildHim. The result? Only parts of his upper torso are still organic, part of his brain has been replaced with computers, and [[FantasticRacism robophobia]].he has problems feeling and even recovering his free will. One amazingly cruel scene has one of the doctors mention they could save one of his arms, but the CorruptCorporateExecutive blithely orders it lopped off (although he's [[JerkassHasAPoint potentially right]] that it would just be a hindrance). Amazingly, his [[TheFettered dedication to duty]] allowed him to [[WhatHaveIBecome survive the change]], [[CyberneticsEatYourSoul recover his humanity]] and make impressive crime busts, even managing a ZerothLawRebellion with a little help from an OCP executive.



* ''Film/{{Doom}}'' has the main character injected with the [[GreenRocks superhuman and/or demon serum]] after being fatally injured in a textbook example. The treatment he took theoretically has no disadvantages associated with it, however it does run the risk of getting oneself [[spoiler:transformed into a vicious, murderous mutant creature]]. Part of the explanation was that [[spoiler:the "demons" themselves instinctively only tried to infect those with the "evil gene" or potential for evil or whatever, which is what made them monsters due to the virus/serum. So in theory, any person that the demons didn't purposely infect to turn into monsters would develop super-powers instead]].
* This is the origin story for ''Franchise/RoboCop''. Shot, run over and brutalized by drug dealers [[Film/RoboCop1987 in his 1987 debut]], Officer Murphy would have died from his injuries... ''should'' have died from his injuries... if it weren't for the Detroit Police Department having a deal with [[MegaCorp OCP]], who as part of a drive to manufacture a police force capable of dealing with the rampant crime decided WeCanRebuildHim. The result? Only parts of his upper torso are still organic, part of his brain has been replaced with computers, and he has problems feeling and even recovering his free will. One amazingly cruel scene has one of the doctors mention they could save one of his arms, but the CorruptCorporateExecutive blithely orders it lopped off (although he's [[JerkassHasAPoint potentially right]] that it would just be a hindrance). Amazingly, his [[TheFettered dedication to duty]] allowed him to [[WhatHaveIBecome survive the change]], [[CyberneticsEatYourSoul recover his humanity]] and make impressive crime busts, even managing a ZerothLawRebellion with a little help from an OCP executive.

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* ''Film/{{Doom}}'' has the main character injected with the [[GreenRocks superhuman and/or demon serum]] after being fatally injured in In ''Film/Thirst2009'', accidental vampire Sang-hyeon makes a textbook example. The treatment he took theoretically has no disadvantages associated with it, however it does run the risk of getting oneself [[spoiler:transformed into a vicious, murderous mutant creature]]. Part of the explanation was that [[spoiler:the "demons" themselves instinctively only tried last-minute decision to infect those with the "evil gene" or potential for evil or whatever, which is what made them monsters due to the virus/serum. So in theory, any person that the demons didn't purposely infect to turn into monsters would develop super-powers instead]].
* This is the origin story for ''Franchise/RoboCop''. Shot, run over and brutalized by drug dealers [[Film/RoboCop1987 in his 1987 debut]], Officer Murphy would have died from his injuries... ''should'' have died from his injuries... if it weren't for the Detroit Police Department having a deal with [[MegaCorp OCP]], who as part of a drive to manufacture a police force capable of dealing with the rampant crime decided WeCanRebuildHim. The result? Only parts of his upper torso are still organic, part of his brain has been replaced with computers, and he has problems feeling and even recovering his free will. One amazingly cruel scene has one of the doctors mention they could
save one of his arms, but the CorruptCorporateExecutive blithely orders it lopped off (although he's [[JerkassHasAPoint potentially right]] that it would just be a hindrance). Amazingly, his [[TheFettered dedication to duty]] allowed him to [[WhatHaveIBecome survive the change]], [[CyberneticsEatYourSoul recover his humanity]] and make impressive crime busts, even managing a ZerothLawRebellion with a little help from an OCP executive.human lover Tae-ju by this means. [[AlwaysNeedWhatYouGaveUp At first]], this seems [[ILoveYouVampireSon pretty positive]]. [[IHateYouVampireDad At first]]...



* {{Subverted|Trope}} in ''Film/{{Avatar}}'': When Dr. Augustine is mortally wounded after being shot, she and her avatar are brought to the Tree of Souls [[spoiler:with the purpose of transferring her consciousness permanently into her avatar. However, the transition fails as her human body is too gravely wounded. It does, however, succeed with Jake at the end of the film]]. Unfortunately not a subversion of NoBiochemicalBarriers.
* In ''Film/Thirst2009'', accidental vampire Sang-hyeon makes a last-minute decision to save his human lover Tae-ju by this means. [[AlwaysNeedWhatYouGaveUp At first]], this seems [[ILoveYouVampireSon pretty positive]]. [[IHateYouVampireDad At first]]...

to:

* {{Subverted|Trope}} in ''Film/{{Avatar}}'': When Dr. Augustine is mortally wounded after being shot, she and her avatar are brought to the Tree of Souls [[spoiler:with the purpose of transferring her consciousness permanently into her avatar. However, the transition fails as her human body is too gravely wounded. It does, however, succeed with Jake at the end of the film]]. Unfortunately not a subversion of NoBiochemicalBarriers.
* In ''Film/Thirst2009'', accidental vampire Sang-hyeon makes a last-minute decision to save his human lover Tae-ju by this means. [[AlwaysNeedWhatYouGaveUp At first]], this seems [[ILoveYouVampireSon pretty positive]]. [[IHateYouVampireDad At first]]...




* ''Film/TheAnimal'' explores the [[SarcasmMode serious ramifications]] of a near dead man having his organs replaced with those of various animals.

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