History Funny / TheBindingOfIsaac

** And then it plays the {{Sting}} from ''SuperMeatBoy''.

* In ''Wrath of the Lamb'', getting the Speed Ball item (a syringe with white fluid in it) gives Isaac [[OpenTheIris very large, dilated eyes]] and [[http://images2.wikia.nocookie.net/__cb20120529091325/bindingofisaac/images/6/63/Speedfront.png a little smile]]. It looks incredibly goofy (though less so once you see [[http://images4.wikia.nocookie.net/__cb20120529091414/bindingofisaac/images/7/77/Speedback.png the bloody syringe]] sticking out the back of his head).

* Some of the boss enemies make some pretty funny expressions, such as Chub's [[MemeticMutation poker face]] or War's OhCrap face when he runs out of stamina.

* Any of the secret messages from the Fortune Telling machine. Some of these include cryptic nonsense like "LOOK TO LA LUNA", "DON'T LEAVE THE HOUSE TODAY", or "BRING HIM THE PHOTO". Then there are some that seem to be talking to the player, such as "GO OUTSIDE" or "YOU ARE THROWING YOUR LIFE AWAY". The way the game is just totally fucking with you in this moment is priceless. Oh, the best of all these? [[spoiler: YOU ARE WORSHIPPING A SUN GOD.]]

* [[ToiletHumor Number]] [[UrineTrouble One]]. The look on Isaac's face as he chooses to [[http://images2.wikia.nocookie.net/__cb20111111185827/bindingofisaac/images/4/45/Number_one%21.jpg pee on everything]] is just priceless.

* One of the random effects of pills is "I Found Some Pills" with the description "...and ate them."

* In ''Wrath of the Lamb'', getting the Speed Ball item (a syringe with white fluid in it) gives Isaac [[OpenTheIris very large, dilated eyes]] and [[http://images2.wikia.nocookie.net/__cb20120529091325/bindingofisaac/images/6/63/Speedfront.png a little smile]], kinda like this: 0u0. It looks incredibly goofy (though less so once you see the bloody syringe sticking out the back of his head).

* In ''Wrath of the Lamb'', getting the Speed Ball item (a syringe with white fluid in it) gives Isaac [[OpenTheIris very large, dilated eyes]] and a little smile, kinda like this: 0u0. It looks incredibly goofy (though less so once you see the bloody syringe sticking out the back of his head).

* Any of the secret messages from the Fortune Telling machine. Some of these include cryptic nonsense like "LOOK TO LA LUNA", "DON'T LEAVE THE HOUSE TODAY", or "BRING HIM THE PHOTO". Then there are some that seem to be talking to the player, such as "GO OUTSIDE" or "YOU ARE THROWING YOUR LIFE AWAY". The way the game is just totally fucking with you in this moment is priceless.

* One of the random effects of pills is "I Found Some Pills" with the description "...and ate them."

* [[ToiletHumor Number]] [[UrineTrouble One]]. The look on Isaac's face as he chooses to [[http://www.comics.chickennation.com/archive/personality-quiz/ pee on everything]] is just priceless.

* In ''Wrath of the Lamb'', getting the Speed Ball item (a syringe with white fluid in it) gives Isaac [[OpenTheIris very large, dilated eyes]] and a little smile, kinda like this: 0u0}. It looks incredibly goofy (though less so once you see the bloody syringe sticking out the back of his head).

* In ''Wrath of the Lamb'', getting the Speed Ball item (a syringe with white fluid in it) gives Isaac [[OpenTheIris very large, dilated eyes]] and a little smile, kinda like this: OuO. It looks incredibly goofy (though less so once you see the bloody syringe sticking out the back of his head).

* In ''Wrath of the Lamb'', getting the Speed Ball item (a syringe with white fluid in it) gives Isaac [[OpenTheIris very large, dilated eyes]] and a little smile, kinda like this: 0u0. It looks incredibly goofy (though less so once you see the bloody syringe sticking out the back of his head).

* The glitches in this game can sometimes cause [[http://www.youtube.com/watch?v=DY_aTu0mUWQ&t=11m40s hilarious reactions]] from players. Especially since, given the tone of the game and previous games by Edmund Mcmillen, it's difficult to tell if some of them are actually glitches.

* [[ToiletHumor Number One]]. The look on Isaac's face as he chooses to [[http://www.comics.chickennation.com/archive/personality-quiz/ pee on everything]] is just priceless.

* The glitches in this game can sometimes cause [[http://www.youtube.com/watch?v=DY_aTu0mUWQ&t=11m40s hilarious reactions]] from players.

* In ''Wrath of the Lamb'', getting the Speed Ball item (a syringe with white fluid in it) gives Isaac [[OpenTheIris very large, dilated eyes]] and a little smile, kinda like this: 0u0. It looks incredibly goofy (though less so once you see the bloody syringe sticking out the back of his head).

* In ''Wrath of the Lamb'', getting the Speed Ball item (a syringe with white fluid in it) gives Isaac [[OpenTheIris very large, dilated eyes]] and a little smile, kinda like this: 0U0. It looks incredibly goofy (though less so once you see the bloody syringe sticking out the back of his head).

* The beggar that runs the shell game in the arcade is a jerk. Giving you a giant grin as he takes all your money without giving you the items you want? Seeing the slot machine throw a troll bomb at him is just too hilarious a karma to be true.

* When you meet Greed in a hidden room, you can immediately leave through the hole you made without having to defeat him. Hi, Greed. Bye, Greed. If you have X-ray glasses, you can even use his room as a shortcut, running past him without ever engaging him.

* Isaac can wear his mother's brassiere or her menstrual pad as items. Doing so causes the enemies to freeze or back away, respectively. Presumably, they're {{Squick}}ed out by the sight of it!

* [[ToiletHumor Number One]]. The look on Isaac's face as he chooses to [[http://www.comics.chickennation.com/archive/personality-quiz/ pee on everything]] is just priceless.

* Unlocking a treasure chest, only to find another treasure chest inside it. It appears Edmund likes to toy with expectations.

* This, of all games, has one where in one of the endings, Isaac picks up a fetus in a jar...and is shown wearing a Dr Fetus Costume.