History Fridge / ResidentEvil4Remake

* During Separate Ways, Ada puts a tracking device on Leon with a microphone on the island and then activates it later only to hear Ashley struggling to say "No, No! Stop! No!", then Saddler saying "Sweet child, do not resist!". Ada doesn't have much knowledge of Saddler's mind control of the plaga so it can lead to some unfortunate implications to what Ada is thinking of what Saddler is doing to Ashley at this moment in front of Leon.

* During Separate Ways, Ada puts a tracking device on Leon with a microphone on the island and then activates it later only to hear Ashley struggling to say "No, No! Stop! No!", then Saddler saying "Sweet child, do not resist!". Ada doesn't have much knowledge of Saddler's mind control of the plaga so what do you think, Ada is thinking of what Saddler is doing to Ashley at this moment in front of Leon?

* Osmund Saddler might have already been dead by the time the game begins. His advanced mutation compared to the original, his lack of care about his henchmen (the original game made a note of how Salazar and Mendez's losses hurt him) and hideously mutated body imply the Plagas infection destroyed the man. What's walking around now is a parasite wearing his skin like a suit. Alternately, Osmund and the Plaga inside him might have been working in concert up until Leon forces the OneWingedAngel transformation in the climax. Saddler makes many of the same chants in the climax that the ordinary Ganados do. Perhaps his powerful parasite also required a sacrifice of his higher brain functions?

* A lot of fans have taken shots at Regeneradors having flabby skin, noting that it looks silly in an otherwise horrifying redesign. The thing is that the flabby skin is a realistic sign of what the regeneration is doing to the monster's body. If high speed regeneration was real, it would significantly increase the chances of cancer because the influx of new cells doesn't necessarily mean each new cell was replicated properly. If the Regeneradors have been regenerating on a constant basis since they were created, then there is a high chance those flabs of skin are tumors... tumors that can't kill them because they constantly regenerate. The alternative idea, is that the flabby skin is caused by high blood pressure. To regenerate at such rabid speeds, the Regenerador would need hyper fast blood pressure that is able to carry the nutrients through the blood stream as fast as possible. In real life, a side effect of high blood pressure is flabby skin, meaning that the Regeneradors with a [[ShownTheirWork blood pressure that is dozens of times faster than a normal human would have immensely flabby skin.]] It's easy to mock them as "thicc" or "fat" but what you're seeing is the realistic consequences of high speed regeneraton.

** Luis being a former cop in the original RE4, it kind of makes sense that original RE4 Leon was not wary against Luis then. But considering that RE2 REmake's Leon met RE2 REmake Ada who introduced herself as an "FBI Agent", it still makes sense for RE4 REmake Leon to be wary of Luis even if Luis is still introduced as a former cop.

* Leon is notably cold towards Luis for a long time, only really accepting his earnestness just before he dies. It seems strange, but considering the last person Leon trusted during a crisis situation was [[FemmeFatale Ada Wong]]? It makes sense Leon would consider outside parties offering "help" untrustworthy.

* Fridge Humor: It's shown that the black-robed Verdugo, Pesanta, is a mutation of Salazar's female housekeeper in lore documents in the main game. From that, it suddenly makes sense why she was [[WhatHappenedToTheMouse absent for most of the remake]] and became TheHeavy to Ada Wong - her gender makes her pursuit of Ada a DesignatedGirlFight, fully aping [[AffectionateParody the more schlocky B-movies]] Resident Evil invokes, made horrifying by Pesanta's completely inhuman appearance.

-->"8th Gen. Count Ramon"
-->"His illness should have taken him."

** Salazar's castle contains a number of notes that cover the history of the Salazar family and Ramon himself. For generations, the Salazars had managed to both seal away Las Plagas and expand their household, but all of their efforts eventually unraveled by the modern day. Ramon's mother, Catalina, had "invited the devil" into their home and Ramon himself descended into complete violent insanity as he pledged to released the Plagas by Saddler's orders.

** The island covers the research that went on behind the scenes of the game's events. Saddler had kidnapped scientists and forced them to create new, evolved stages of the Plagas. If they refused, they were injected with the initial strain of Plagas that would eventually become too simple-minded for any complex task. If they followed orders, they would be injected with the superior species as part of Saddler's end goal.

* The Plaga suppressant Luis gives Leon is now an injector pen rather than a pill bottle. This makes a lot more sense; injectable medicine is delivered much faster into the bloodstream whereas pills have to be metabolized in the stomach which takes more time and their potency can be diminished.

* In the remake Ashley is slower to trust Leon during their first meeting, running away from him even after he tells her that her father sent him to rescue her. This makes sense when you find the document in Krauser's camp outlining the kidnapping plan, as it reveals that Krauser and his accomplices had infiltrated her security detail. Ashley has already been betrayed by her father's people once, so of course she's going to be jumpy even around her supposed rescuer.

* The ED theme "The Bullet or The Blade" has several lyrics that foreshadow Leon's careers before and after he joined DSO and worked with the others to combat biohazard threats. The mention of "how do you fight when the enemy's within" refers to suppose allies who turn against their countries to align with the bad guy.

** The island covers the research that went on behind the scenes of the game's events. Saddler had kidnapped scientists and forced them to create new, evolved stages of the Plagas. If they refused, they were injected with the initial strain of Plagas that would eventually become too simple-minded for any complex task. If they followed orders, they would be injected with the superior species as part of Saddler's end goal.

* Leon congratulates Ashley at one point by believing she already has experience in running away from creeps. He meant well, but it was obviously a very awkward thing to say. Assuming he's right in his assessment, however, implies some uncomfortable details about Ashley's life prior to having been kidnapped...

* Leon congratulates Ashley at one point by believing she already has experience in running away from creeps. He meant well, but it was very awkward. Assuming he's right in his assessment, however, implies some uncomfortable details about Ashley's life prior to have been kidnapped...