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* In the main series, the Red Blood Cells are coed, but rather than simply {{gender flip}}ping them in ''Manga/CellsAtWorkBlack'', the squad is all men. There's a good chance that the main series host body actually has AB type blood, with As and Bs treated as separate genders. Of course, this becomes a bit problematic when one remembers about the lack of A or B antigens making a person have O-type blood (and even the extremely rare Bombay Phenotype if they don't have H antigens either!), and doesn't help with determining more with how RH factors for Erythrocytes can be a thing, depending on whether your blood is positive or negative. This gets further elaborated on in the Fridge Logic section.

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* In the main series, the Red Blood Cells are coed, but rather than simply {{gender flip}}ping them in ''Manga/CellsAtWorkBlack'', ''Manga/CellsAtWorkCodeBlack'', the squad is all men. There's a good chance that the main series host body actually has AB type blood, with As and Bs treated as separate genders. Of course, this becomes a bit problematic when one remembers about the lack of A or B antigens making a person have O-type blood (and even the extremely rare Bombay Phenotype if they don't have H antigens either!), and doesn't help with determining more with how RH factors for Erythrocytes can be a thing, depending on whether your blood is positive or negative. This gets further elaborated on in the Fridge Logic section.



** Excluding traumatic death by bacteria, scrape wound, or sickness, or just being in ''Manga/CellsAtWorkBlack'', cells which reach the end of their normal biological lifespans return to the bone marrow to have their clothes and equipment changed. The cells have also been shown to have days off, or other jobs, such as the Platelets sweeping up the leaves from the Dendritic cells' offices.
** In ''Black,'' it's depicted as having their corpses eaten by the liver cells.

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** Excluding traumatic death by bacteria, scrape wound, or sickness, or just being in ''Manga/CellsAtWorkBlack'', ''Manga/CellsAtWorkCodeBlack'', cells which reach the end of their normal biological lifespans return to the bone marrow to have their clothes and equipment changed. The cells have also been shown to have days off, or other jobs, such as the Platelets sweeping up the leaves from the Dendritic cells' offices.
** In ''Black,'' ''Code Black,'' it's depicted as having their corpses eaten by the liver cells.



** ''Manga/CellsAtWorkBlack'' chapter 5, anyone?

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** ''Manga/CellsAtWorkBlack'' ''Manga/CellsAtWorkCodeBlack'' chapter 5, anyone?



** In ''Manga/CellsAtWorkBlack'', one red blood cell even mentions how their "organelles were removed to carry hemoglobin." Did they literally have their equivalents of hearts ripped out and the cavity filled with even more "blood"?

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** In ''Manga/CellsAtWorkBlack'', ''Manga/CellsAtWorkCodeBlack'', one red blood cell even mentions how their "organelles were removed to carry hemoglobin." Did they literally have their equivalents of hearts ripped out and the cavity filled with even more "blood"?
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Please put all Fride relating to ''Manga/CellsAtWorkBlack'' on it's own page.

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Please put all Fride Fridge relating to ''Manga/CellsAtWorkBlack'' ''Manga/CellsAtWorkCodeBlack'' on it's own page.
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* While cancer usually causes problems by sitting there quite literally eating all the pies (and therefore doesn't trigger much of an immune response), the carcinoma elicits a huge response from the immune system because he's actively trying to destroy the whole Body-he's an aggressive cancer!

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* While cancer usually causes problems by sitting there quite literally sitting there eating all the pies (and therefore doesn't trigger much of an immune response), the carcinoma elicits a huge response from the immune system because he's actively trying to destroy the whole Body-he's an aggressive cancer!
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* The carcinoma elicits a huge response from the immune system because he's actively trying to destroy the whole body-he's an aggressive cancer!

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* The While cancer usually causes problems by sitting there quite literally eating all the pies (and therefore doesn't trigger much of an immune response), the carcinoma elicits a huge response from the immune system because he's actively trying to destroy the whole body-he's Body-he's an aggressive cancer!
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* The carcinoma elicits a huge response from the immune system because he's actively trying to destroy the whole body-he's an aggressive cancer!
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* One kind of Opportunistic Bacteria is represented as a Kitsune. Kitsunes are trickster fairies who could help you one day and harm you the next, which is largely how opportunistic bacteria act.

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** Actually yes. Biologists explicitly compare it to the internet, so it's like that one 3rd cousin on another you only talk to on Facebook Messenger but know everything about.

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** Actually yes. Biologists explicitly compare it to the internet, so it's like that one 3rd cousin on another you only talk to on Facebook Messenger but know everything about.


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* According to ''An Actual Doctor Reacts to Cells at Work,'' the reason the Body keeps getting sick may be because it has cancer, which leaves less goodies for the other bodily systems.
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Please put all Fride relating to ''Manga/CellsAtWorkBlack'' on it's own page.
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* In ''Black,'' Streptococcus-B cells look more like [[TabletopGame/Warhammer40000 Hormigaunts]] than the humanized bacteria of the regular series. Streptococcus-B is [[MakeThemRot flesh-eating disease]]. Tyranids eat whole planets and streppe plans to eat the whole body.



* Issuess of ''Black,'' start with a looming, winged shadow overlooking the run-down cityscape as Guy!Red toils on. While this is obviously the Angel of Death, the carcinoma in ''C@W!'' manifested angel wings as a directed mutation. All the preservatives and toxins present in or resultant from the various vices the Body indulges in may cause a breakdown in the tissue cells' cloning machinery, leading to cancer.



* In ''Black,'' liver cells manifest as sexy waitresses and dancers at a nightclub. Since cells reproduce by way of cloning themselves or by being produced by a literal baby factory, why would they be excited by tiddy dancers?

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* In ''Black,'' Streptococcus-B cells look more like Hormigaunts than the humanized bacteria of the regular series. Streptococcus-B is [[MakeThemRot flesh-eating disease]]. Tyranids eat whole planets and streppe plans to eat the whole body.

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* In ''Black,'' Streptococcus-B cells look more like Hormigaunts [[TabletopGame/Warhammer40000 Hormigaunts]] than the humanized bacteria of the regular series. Streptococcus-B is [[MakeThemRot flesh-eating disease]]. Tyranids eat whole planets and streppe plans to eat the whole body.body.
* The carcinoma is referred to as "buggy" by a T-cell. Another word for a computer error is a bug. Cancer forms from an error in a cell's coding.


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** Going from this, Red is probably a Reticulocyte herself, since she's still being mentored until about halfway through the series.


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** Actually yes. Biologists explicitly compare it to the internet, so it's like that one 3rd cousin on another you only talk to on Facebook Messenger but know everything about.
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* In ''Black,'' liver cells manifest as sexy waitresses and dancers at a nightclub. Since cells reproduce by way of GatticaBabies, why would they be excited by tiddy dancers?

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* In ''Black,'' liver cells manifest as sexy waitresses and dancers at a nightclub. Since cells reproduce by way of GatticaBabies, cloning themselves or by being produced by a literal baby factory, why would would they be excited by tiddy dancers?
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* In ''Black,'' liver cells manifest as sexy waitresses and dancers at a nightclub. Since cells reproduce by budding, why would they be excited by tiddy dancers?

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* In ''Black,'' liver cells manifest as sexy waitresses and dancers at a nightclub. Since cells reproduce by budding, way of GatticaBabies, why would would they be excited by tiddy dancers?

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* Everyone throwing a tantrum whenever the poor Mast cell does her job isn't just a gag. This is how pain works. Your cells send out a DistressCall, which the brain interprets as discomfort. Being rapidly rearranged by hystamines is no fun, so they get mad, and that's why your sinuses feel like complete ass when you're sick.

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* Everyone throwing a tantrum whenever the poor Mast cell does her job isn't just a gag. This is how pain works. Your cells send out a DistressCall, which the brain interprets as discomfort. Being rapidly (and forcibly) rearranged by hystamines is no fun, so they get mad, and that's why your sinuses feel like complete ass when you're sick.sick.
* In ''Black,'' Streptococcus-B cells look more like Hormigaunts than the humanized bacteria of the regular series. Streptococcus-B is [[MakeThemRot flesh-eating disease]]. Tyranids eat whole planets and streppe plans to eat the whole body.


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* Issuess of ''Black,'' start with a looming, winged shadow overlooking the run-down cityscape as Guy!Red toils on. While this is obviously the Angel of Death, the carcinoma in ''C@W!'' manifested angel wings as a directed mutation. All the preservatives and toxins present in or resultant from the various vices the Body indulges in may cause a breakdown in the tissue cells' cloning machinery, leading to cancer.


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* In ''Black,'' liver cells manifest as sexy waitresses and dancers at a nightclub. Since cells reproduce by budding, why would they be excited by tiddy dancers?
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* Megakaryocyte is the cell that produces platelets, here she is depicted as a mother who gives birth to lots of children so they can do heavy manual labor...
** Slightly better than in reality, because actual megakaryocytes desintergrate into platelettes instead of birth them in litters.

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* Megakaryocyte is the cell that produces platelets, here she is depicted as [[BabyFactory a mother who gives birth to lots of children so they can do heavy manual labor...
labor...]]
** Slightly better than in reality, because actual megakaryocytes [[AsteroidsMonster desintergrate into platelettes hordes of platelettes]] instead of birth them in litters.
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** Slightly better than in reality, because actual megakaryocytes desintergrate into platelettes instead of birth them in litters.
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* Everyone throwing a tantrum whenever the poor Mast cell does her job isn't just a gag. This is how pain works. Your cells send out a DistressCall, which the brain interprets as discomfort. Being rapidly rearranged by hystamines is no fun, so they get mad, and that's why your sinuses feel like complete ass when you're sick.


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** In ''Black,'' it's depicted as having their corpses eaten by the liver cells.
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** Most likely, it would be similar to what would happen if you suddenly found yourself in outer space - the low pressure would result in your body beginning to loose internal pressure, taking bodily fluids and gasses with it. Which adds it's own level of fridge horror - what sort of panic must something like a bloody nose cause?

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[[AC:Fridge Brilliance]]

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[[AC:Fridge Horror]]

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[[AC:Fridge [[folder:Fridge Horror]]



[[AC: Fridge Logic]]

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[[AC: [[folder: Fridge Logic]]


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** Plot Armor?
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* One of the Killer T cells' secondary jobs within the body is to stimulate exhausted immune cells, essentially forcing them them not to give up and keep going. With that in mind, Killer T's personification as a DrillSargeantNasty becomes even more fitting.

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* One of the Killer T cells' secondary jobs within the body is to stimulate exhausted immune cells, essentially forcing them motivating them not to give up and keep going. With that in mind, Killer T's personification as a DrillSargeantNasty DrillSergeantNasty becomes even more fitting.fitting. To drive the point home, we actually see him doing just this during the hemorrhagic shock arc, albeit to a normal cell instead.




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* During the hemorrhagic shock arc, one germ we see being fought off is the ''Pseudomonas aeruginosa'', returning from the bone marrow episode. While it may just be one of many BackForTheFinale cameos, it could also be a reference to the fact that ''P. aeruginosa'' infections are extremely common in hospitals, which the body must have been taken to at some point given the way the episode ends.
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** It's been shown that the regular cells are aware of the immune cells' harsh sense of justice, and are deeply uncomfortable with it.

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* During the battle against Cancer, Eosinophil showed up to join the fight. While it may seem strange for her to be there, given her introduction had her fighting a parasitic worm, it makes sense. An increase in blood eosinophil levels can be triggered by the presence of parasites, but also allergic reactions, autoimmune diseases, and, yes, cancer.


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** Also, Eosinophil is shown to battle things other than parasites. She's capable of phagocytosis and tries to fight a bacteria, she's just not as strong as other white blood cells. And, as noted in the Fridge Brilliance entry above, eosinophil levels are elevated in the body with the occurrence of certain types of cancer.
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** Again, trivial accidents that can turn deadly can happen all the time. While the event itself and how it almost led to death were scary, the cause of the accident may not have been. Getting into a fight where you got hit in the head, or even tripping and knocking your head on a rock or counter edge can happen to anyone.
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** Reticulocytes are a natural part of the red blood cells' life cycle, a time period just after red blood cell is enucleated but before they're fully mature. In universe it's more likely to be some form of internship or maybe a part time job. They get enucleated, are taught the basics of navigating a couple times, then get declared fully matured and go off on their own.
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** It has been pointed out that there exists an autoimmune disease that causes the the immune system to attack platelets. '''[[https://i.kym-cdn.com/photos/images/original/001/401/289/694.png Imagine this in a setting where platelets are portrayed as adorable children.]]'''

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** It has been pointed out that there exists an autoimmune disease that causes the the immune system to attack platelets. '''[[https://i.kym-cdn.com/photos/images/original/001/401/289/694.png Imagine this in a setting where platelets are portrayed as adorable children.]]'''
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* The way Killer T Cell reacted when U-1146 spoke fondly about [=AE3803=] and his hopes that immune and non-immune cells could eventually get along becomes way more understandable when you consider the fact that T cells are specially designed for the purpose of killing the body's own cells - in this world, it's literally their day job to kill cells just as friendly as [=AE3803=] without hesitation if they become cancerous or infected, lest they pose a threat to the body. From his perspective, [[GoodIsNotNice he's protecting U-1146 from potential heartbreak at best, and a path that would compromise his duty as an immune cell at worst.]] Crosses over into FridgeHorror when one imagines just what kind of horrible things this guy has had to see and do in his time, and what kind of psychological damage it would do if he weren't raised to be so desensitized to it. No wonder the T Cell training is so brutal...



* The way Killer T Cell reacted when U-1146 spoke fondly about AE3803 and his hopes that immune and non-immune cells could eventually get along becomes way more understandable when you consider the fact that T cells are specially designed for the purpose of killing the body's own cells - in this world, it's literally their day job to kill cells just as friendly as AE3803 without hesitation if they become cancerous or infected, lest they pose a threat to the body. From his perspective, [[GoodIsNotNice he's protecting U-1146 from potential heartbreak at best, and a path that would compromise his duty as an immune cell at worst.]]


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* The way Natural Killer T Cell reacted when U-1146 spoke fondly angrily [[SuspiciouslySpecificDenial denies]] being "envious" of Neutrophil after he opens up about AE3803 how much he admires and his hopes cares about [=AE3803=], wording which implies that immune and non-immune cells could eventually get along becomes way more understandable when you consider the fact that T cells are specially designed for the purpose he couldn't have a friendship like those two have even if he wanted to. Now compare their two lines of killing work: Neutrophil spends his days fighting against CardCarryingVillain invading bacteria, while Natural Killer Cell is specifically trained to kill the body's own cells - in this world, it's literally their day job to kill cells just as friendly as AE3803 without hesitation ''own cells'' if they become cancerous or get infected, lest they pose a threat to the body. From who are depicted in this universe as his perspective, [[GoodIsNotNice he's protecting U-1146 from potential heartbreak at best, friendly allies and a path neighbors. It's in his own best interest that would compromise he not even consider making friends outside of his duty as an immune immediate kin, a fact that makes his jerkass behavior [[JerkassWoobie a pretty obvious coping mechanism.]] How many times has this guy gone home after killing yet another innocent cell that was just in the wrong place at worst.]]

the wrong time, wishing he had been selected to be something else?



** It may have been part of the replication error.[[FridgeBrilliance It would explain]] why they were wearing adult sized clothes in the flashback.

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** It may have been part of the replication error. [[FridgeBrilliance It would explain]] why they were wearing adult sized clothes in the flashback.
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* One of the Killer T cells' secondary jobs within the body is to stimulate exhausted immune cells, essentially forcing them them not to give up and keep going. With that in mind, Killer T's personification as a DrillSargeantNasty becomes even more fitting.





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\n* The way Killer T Cell reacted when U-1146 spoke fondly about AE3803 and his hopes that immune and non-immune cells could eventually get along becomes way more understandable when you consider the fact that T cells are specially designed for the purpose of killing the body's own cells - in this world, it's literally their day job to kill cells just as friendly as AE3803 without hesitation if they become cancerous or infected, lest they pose a threat to the body. From his perspective, [[GoodIsNotNice he's protecting U-1146 from potential heartbreak at best, and a path that would compromise his duty as an immune cell at worst.]]

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\n* [=HeLa=] in this setting would be horrifying. Usually, even in the best conditions cells eventually stop dividing and die, even most cancer cells. There ''are'' significantly mutated cell lines, mostly cancers, which are [[TheAgeless immortal]]; [=HeLa=] is the oldest of the human ones, and about fifty tons of it have been grown from one tumor in the past sixty-odd years. These cells proliferate fast even for cancer, and survive outside of a body or a controlled setting well enough to contaminate and replace other cell cultures kept in the same lab. A Cells At Work [=HeLa=] would be some kind of EldritchAbomination, huge and composed of cells not even as recognizable as Cancer Cell.

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* How did White Blood Cell survive his fall in episode 11? There was nothing to break it, and the water would have flowed in far too late to sweep him up before he hit the ground.

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