These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Badass Decay: Leonard's fans believe he's steadily become a victim of this, ever since the A Squad used "plan BC" on him. After which, he all but becomes their slave, since Lori makes him their thrall. The following arc, he seemed return to form, when he briefly helps the PMS during the prom and, later, helps rescue the cheerleaders from Cressida Harrow. But has since gone back to merely being an everydude.
Broken Base: Since the strips merged, the fans have been split into two factions, along the exact lines you'd expect (mostly covered in the Rooting for the Empire entry).
The "Vampire Cheerleaders Must Die!" arc upset fans of the cheerleaders, since the PMS were cast as the heroes and were ultimately the victors. Which caused many of them to drop the comic (see the trivia page), while fans of the PMS crew felt the comics should've remained separate, since they didn't care for the cheerleaders.
The fans took a shine to Leonard and the Bakertown B squad, mostly because they have more likable traits in comparison to the Vampire Cheerleaders.
Suki was chosen to represent the cheerleaders' side for the comic's final volume, because she was the one the fans liked most - between her ditzy personality and because she was the nicest toward Leonard.
Heather did a swan dive over the MEH in the very first chapter, after choosing to become a vampire. The first thing she did with her newfound power was turn on her own parents and reduced them to being her mindless slaves. Up to and including forcing themto make her a baby sister.
Bianca Harrow raped and tortured Lori for days, while Lori was powerless to defend herself after being paralyzed by Bianca's stare. And when her sister, Cressida, found out Lori had killed her, she flew to Miami, where she tortured and killed Bianca's servant in the cruelest way possible.
Rescued from the Scrappy Heap: Vol.4 paints Suki, Zoe, and Lesley in a much better light; showing them to be fairly decent individuals. Including treating Leonard much better than in previous parts of the comic.
The contempt for Heather's character is near universal among the readers; including fans of the vampires. But you know it's bad when Shelfer (the artist for series since vol.3) admitted even he didn't like her and didn't even like drawing her (noted on the Trivia page).
Strawman Has a Point: Many readers sympathize with Marcy's point of capturing and treat cryptids in a more humanitarian way, especially in light of the summary execution Steph delivers early on, even though she doesn't seem to care for the victims of the cryptids, considers any instance were a cryptid was killed as unnecessary, not caring for the circumstances, and just tries to impose her ways over everyone else.