Big-Lipped Alligator Moment: The end sequence, a performance of the Hair number "Age of Aquarius/Let the Sunshine In" featuring the entire cast. This happens immediately after Andy and Trish's consummation of their marriage.
Hollywood Homely: Cal. Granted few people would consider Seth Rogen their dream man but he is average-looking at worst and certainly not "ugly as fuck" by traditional standards.
One-Scene Wonder: Jonah Hill as the guy who wants to buy the goldfish platform boots so he can wear them. He reappears again during the ending sequence above.
Some Anvils Need to Be Dropped: There's nothing really wrong with being a virgin. Sex doesn't have to be integral to a healthy and meaningful relationship at any given point, nor be an indicator of a person's maturity.
The Woobie: Andy. David is arguable as well because of his love/hate relationship with his ex-girlfriend.