Funny / The 40-Year-Old Virgin

  • Trish and Marla's argument. Especially the strangled, disbelieving noise Marla makes when Trish says, "You weren't the mistake, your sister was the mistake!"
    • Not long after that was the boyfriend's response after seeing all the condoms on the bed!
    Boyfriend: Dude... teach me!
  • The waxing scene. Just the entire thing. The best part? It was all improvised.
  • Jay watching Dawn of the Dead on all the TV screens behind Andy and getting caught up in it.
  • Trish gets a call from Andy, thinks he is a telemarketer and responds with a serious Cluster F-Bomb.
  • "Andy, for the last time, I don't want your giant box of pornography!"
  • "Okay, I'll stop flicking your balls, but I'll start punching your nuts!"
  • Andy's argument with Jay's girlfriend. "You should... keep your ho on a leash."
  • "Let's get some fucking French toast!"
  • The entire "You know how I know you're gay?" scene is hilarious in the most juvenile way possible.
  • Jay's whole pep talk to Andy about "slaying 20-30 of them hoodrats".
  • The whole argument between Jay and Mooj over handling a customer.
    • Plus he provides his own entry into "You know how I know you're gay?" Somehow his accent makes it even funnier.
  • When Andy crashed through the billboard.
    Andy: There were two sides to that billboard... And they both hurt equally.
  • Mooj said his sister has a big penis.
  • "Go fuck a goat!"
    • "Why are you always tellin' me to fuck a goat, man?!"
  • After finally getting laid at the end, Andy spontaneously starting to sing "Aquarius/Let the Sunshine In".
  • When Trish thinks Andy is a weird pervert:
    Trish: What is this, your date drug, your roofie?
    Andy: It's a Mentos. They're the freshmaker.
  • Andy's boss hitting on him with al the subtlety of a rhinoceros with a sledgehammer in a china shop during an earthquake.
    Paula: Are you familiar with the term 'fuck buddy'`?
  • The people in the sex support group Andy and Marla go to, including a father asking how to stop his teenaged daughter's menstrual cycle.