These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Tear Jerker: Even the online comics snark community found the tribute to Thel Keane to be rather touching.
Values Dissonance: A lot of the humour in parodies like Dysfunctional Family Circus comes from the fact that the original strips can often be read as promoting traditionalist values to the point of being retrograde. For example, this◊ strip's meaning is (Hopefully) that the two statements are one and the same.
We're Still Relevant, Dammit: The occasional attempts at referencing current events and pop culture. In general the comic's done a good job keeping on top of kiddie trends, using it as background detail most of the time, but elsewhere you get such oddities as Dolly dressing up as Sarah Palin for Halloween 2008 — and that one wasn't even presented as a joke.
That same Halloween Billy was dressed as Iron Man, but for some reason colored as if he was Spider-Man.
Oddly inverted in the Halloween 2012 comic, where Billy declares he wants to go out as "Tactical Sergeant Tarkus from the Blood Ravens 4th Company in Warhammer 40,000." Even for 40k fans that's a ridiculously obscure reference, and you would expect it to be completely unknown to an 8 year old or the target audience.
In the mid-'80s when the Chrysler minivans first came out, the family traded their generic station wagon in for one. For the rest of The Eighties, Keane drew it with authentic 1984-86 Plymouth Voyager styling cues; since then it's slowly morphed back into a generic wagon.