These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
YMMV: Pearls Before Swine
Angst? What Angst?: Pastis loves to play this up for dark humor. The deaths of characters rarely elicit any sort of grief (and Pastis has killed many). Various crocodiles, the roommate Leonard, and even Pastis himself have fallen victim to this.
Base Breaker: Pig has resided in this position. For some, he's an endearing character whose innocence adds humor and heartwarming goodness to an otherwise dark and cynical strip. But for others, he's just an idiot whose stupidity becomes unbearable. It doesn't help that Pig can be frustratingly stupid and unclear at times.
Many people are torn by the questionable voice acting in the animated shorts, particularly Goat's British accent and Guard Duck's deep, gravelly voice.
To be sure, Rat is..."liked", and to note, Pastis has stated that Rat is his evil alter-ego and he often lets Rat say things he wishes he could. So, a possibly Justified version.
Crosses the Line Twice: The character of Alphonse the Porcupine revolves around pretending to attempt suicide to get attention.
Ensemble Darkhorse: Da Crocs. Also, Orca. Ironically, Pastis decided to kill him off when he thought he was unpopular. By the time he realized Orca was popular, it was too late. Nonetheless, the character has sporadically made a couple appearances here and there, with the usual explanation that he "un-died".
Pastis has commented that he gets letters if Danny Donkey goes to long without appearing.
One of his Danny Donkey books has a group of Environmental Activists ask him to cut down on drinking beer, recycle, and he can help save the world. Danny replies, "Why? When the world is so full of lies and greed, why save it?". The Activists are awed by his speech and change the Save the World rally to a Destroy the World rally.
Fan Hater: Pastis claimed in an interview that he deliberately gets a rise out of these people. In response to angry letters, he sends them form letters of the "Thank You for Writing" variety, which only causes the complainants to send in more angry letters... in return for which he sends out more form letters...
"Funny Aneurysm" Moment: One strip featured a croc disappointed that Steve Irwin's head has never been bitten off, published just a few months before Irwin's real death from a stingray attack. Also, a fat joke about Ted Kennedy became much less funny after his death.
In a strip from an arc where Pig had Newt Gingrich as a pet, Rat said that Newt can never be president and John McCain is a lock for 2008. He was proven right about the former, considering Newt's dropout of the 2012 election, but wrong about the latter, considering the other nominee won that election.
Ever since the conception of Google+, let's just say that plenty of people on the Internet screamed Kill da Google! in unison.
Anytime Calvin & Hobbes was mentioned is now this (such as Rat saying he misses Bill Watterson) since Watterson guest-drew three strips in June 2014.
Moral Event Horizon: Rat has crossed this once, when he killed a random guy, just to stop him from reproducing.
Rooting for the Empire: Based on the comments posted on the Go Comics website, many readers want the Crocs to catch and kill Zebra.
Tear Jerker: Surprisingly common, however, the infamous "Israel bus" strip around Christmas one year is soul-crushing, as is Pastis' commentary on it.
What Do You Mean, It's Not for Kids?: The main characters are all Funny Animals who make Incredibly Lame Puns on a regular basis. Perfect for kids, right? Then they start talking about current events and issues kids probably don't know about. And then there are the deaths. And the (albeit censored) swearing. And a bunch of other family-unfriendly activity. Yeah, this is one of those few comics meant just for older readers than all ages.
Ellie the Elephant (one of the Rat's characters) who really, really wants a grand romance with her apathetic boyfriend and goes overboard trying to impress him or to make a lasting impact on the world, but ultimately resigns herself to romance novels.
Andy, a dog who's left outside on a chain day and night and never gives up hope of seeing the world.
Jerkass Woobie: Rat, who's sometimes even proud to be a jerk, has had his heart broken by his love, Farina, and fails at doing anything that would benefit others. There are even times that he worries that he is a worse person than he thinks.