These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
While shopping for houses, Louie looks out the window of one and sees a crazy hobo muttering to himself on the street. A black car pulls up and two dark-suited men jump out, who stuff the hobo into their car and replace him with a nearly identical, also crazy hobo.
On the way to his aunt's house in Pennsylvania, Louie stops to fill up. As he does so, two Sikh children in suits stare at him in silence.
When Louie is knocking on his date's door in the first episode, the old next door neighbor chides him for making noise as she is naked in her apartment. Eventually, she opens her door fully so the unimpressed Louie can see her standing naked. She calls him a pig multiple times and then slams the door.
At the end of his date in the first episode, the girl jumps off the bench where they're sitting and runs out to climb into a waiting helicopter, which takes off.
Louie and Maria Bamford watch a Big Brother-like show in bed. At one point, one of the contestants psychotically snaps and stabs another in the heart with a knife. Louie and Maria don't react at all.
In the fourth season premiere, Louie is awoken to the sound of garbagemen making a racket outside his apartment. They get progressively louder as they bang cans together and shout at each other, eventually breaking Louie's windows, crawling into his apartment, and trashing his bedroom while Louie is still in bed. Louie treats all this as a routine annoyance and goes on with his day.
Elevator Part 4 and 5 both start with a news broadcast about Hurricane Jasmine Forsythe, which destroyed Cuba and Florida. The newscasters talk about it so casually that the whole thing sounds like something from The Onion. None of this is mentioned afterwards.
Crowning Moment Of Awesome: A meta-example would be Dane Cook, a comedian who has been maligned and accused of stealing Louis CK's jokes, agreeing to come do a bit about his being maligned and accused of joke stealing. Talk about a good sport...
There is also Louie demolishing a heckler at one of his shows in season one. For a good five minutes he insults her for hurting his show with some of the most heinous insults imaginable. Then, when she comes to complain to him backstage, he again rails on her for taking away the small bit of enjoyment comedians get in their crappy lives. This scene probably represents how most comedians feel about people bothering them onstage.
Therapist: Have you ever...heard news about somebody dying...and then you got an erection?
Therapist: (Sex is) very simple: the man takes his penis, into the woman's vagina, he ejaculates, and she dies.
Louie: (beat) ...she dies?
Therapist: Oh no, I was thinking of something else.
Crowning Moment of Heartwarming: In the middle of the night Louie's pregnant sister starts screaming in pain, and not knowing what to do he just freaks out. A gay couple who live a few doors down, whom Louis has never talked to before, hear the screaming, knock on his door and without even knowing Louie's name or what's wrong, offer their help.
"Brother, do not let your sister die from pain or lose her baby because you are awkward with strangers."
Louie kissing the cop on the lips in the fifth episode. He really, truly is grateful that the cop saved his life and is willing to kiss the dude despite having never done it before.
Most of Louie's stand-up bits in "Night Out" are about how wiped out he feels after a day of taking care of his kids and how badly he just wants them to sleep when they're supposed to. It doesn't stop him from taking them for pancakes at 4AM at the end of the episode, though.
The card the girls make for Louie in "Late Show (Part 3)" is adorable.
Louie's confession of love to Pamela is, in her own words, gorgeous. He pours his heart out to her, telling her how much it pains him not being with her, that he feels guilty for wanting her, and that making her be with him would be greedy. It's gut-wrenching.
Louie and Pamela watching a meteor shower together.
Moral Event Horizon: Louie tries to rape Pam, then forces a kiss on her. Pam calls him out on it, saying "You can't even rape well!", and it's mostly played for how pathetic Louie is, but it definitely seems to be the lowest the character's gone so far.
Sean the bully describes a recent fight from the appropriately titled segment Bully.
Sean: So what if I just decided to kick your ass right now? What would you do then? Huh?! D'you want that? I'm serious, I can hurt you really bad — right now. (Pushes his freshly scabbed knuckles into Louie's face) Y'see this, huh?! This was just two days ago, destroyed this guys face, must've hit him like 40 times. Teeth all over the place, just left him there bleeding. Probably sent him to the hospital. Are you ready for that? I'm kinda feeling like doing that to you right now — gonna be honest.
Two somewhat deranged men dressed as zombies accost Louie and his daughters on Halloween. It's a genuinely tense scene as Louie desperately tries to keep the two men from hurting his little girls.
Also the puddle of what looks like blood on the subway seat in "Subway".
Tear Jerker: The second season finale is incredibly heartwrenching. Pamela leaves for Paris to try and patch things up with her son's father, and implores Louie to not pine for her while she's away. She makes this as clear as possible. Then, after she's crossed the turnstile at the airport, she yells at Louie to "wave at me!", only for him to mishear it as "wait for me!". Louie leaves the airport in high spirits.
A lot of the season 3 finale isn't too chipper, either, dealing with the aftermath of Louie failing to get the Late Show gig. Also, Liz's Death, especially seeing as it happens while the rest of the hospital is celebrating the New Year's countdown.
Sort of a meta-example, but during an interview with National Public Radio, listening to audio from "Eddie" of Louie failing to convince his friend not to kill himself actually caused Louis to cry, as he felt that much of the emotion in that scene now applied to the then-recent death of fellow comedian Patrice O'Neal, who Louis' special "Live at the Beacon Theater" is dedicated to.
The Woobie: Louie. Some episodes don't hold back in showing what a tortured, psychological wreck he is.