- Fan-Preferred Couple: Many fans like the idea of Dave and Penny together, even though Dave is back together with Alex.
- Fridge Brilliance: Why is Dave and his steak truck so popular with customers and Colin Hanks? Because of the turpentine drinks that are making everyone have sex dreams about him. When he stops making them, they stop eating at his truck.
- Why is Jane not only accepting but outright turned on by Brad's various Camp Straight tendencies? Because she dated girls in college and so is completely okay with her partner having a very noticeable feminine side.
- Growing the Beard: Started out as your average generic sitcom, then suddenly grew a personality somewhere around the second season and promptly turned into a regular Fountain of Memes.
- Hollywood Pudgy: The pilot repeatedly has people calling Max a "chubby gay guy", which might not be how the viewer would describe him.
- Ho Yay: Dave's infatuation with his former Hippie Teacher Mr. Fitzgerald goes to this length when he asks Penny what it's like to kiss him. Mr. Fitzgerald also wouldn't mind a threesome with him and Penny.
- Magnificent Bastard: Jane. (Or Guile Hero if she's using her powers for good.)
- Memetic Mutation: Alex weepingly saying "It's so beautiful." is a widespread reaction gif.
- Too Good to Last