These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
One of the final missions, "Light My Pyre". The mission begins with a highly annoying car chase that wouldn't be so bad, except you have to escort Lance, who is riding a motorcycle and seems to enjoy getting in your way (sometimes, even in your line of fire) and getting himself killed, which is a Game Over. Then, you have to fight through a small army of heavily armed, respawning goons to get around the back of a building and through a door. THEN, you have to fight Armando Mendez, who is wielding a flamethrower. If that weren't enough, you're forced to fight him in a disorienting top-down perspective — not to mention, his goons storm in and fight you, as if a man setting you on fire with a flamethrower wasn't enough. (This part is made almost laughably easy if you have a minigun with you, but if you don't...) And if you die? Back to the beginning. And if you do finish it? You find that Louise, the woman you went through all this hell to save, is dead.What fun!
This is subverted to some extent, however, if you took the time to complete the fireman missions, which make the boss' weapon completely useless.
"High Wire". Picking up a few cargo containers of the backs of slow-moving trucks with a sky crane isn't too hard, even with the wonky helicopter controls. However, once you have to fly all the way over to the other island and pick up Diego's small, fast-moving car while he's being chased by armed bikers, those chopper controls will make you want to tear your hair out.
The Scrappy: Armando Mendez manages to be the most hated villain of the entire series. He does not even have interesting features, sympathy or some charisma to do so peculiar. He is hated even more when you have to face him.
The Woobie: Louise. She did not finish high school, her ex-husband abused her verbally (and probably physically), was kidnapped twice (and allegedly raped and tortured) by Jerry Martinez and Armando Mendez, and finally being killed by Armando.
Iron Woobie: Victor Vance. Unlike all the other playable characters of the series (including CJ, who has been considered have more "moral" than most), Victor Vance in the background does not like to be a drug dealer or kill people, he just feels compelled to to. Adding to this, his mother is a drug addict, and his brother an idiot, Jerk Ass, Man Child and a crazy for the money without seeing the consequences.