One comment on Youtube suggests The Adventures of Lunk skit represents the reaction when you play an RPG for hours on end, Die, then realize your save was hours ago, and have to replay everything.
In the animated short "Last Words", is the son a trans man, does his Mother have alzheimer, or is she just a troll?
Anvilicious: This strip manages to be that and the usual horrible C&H wrongness at the same time. Turns out the real monster is bad parenting.
Big Lipped Alligator Moment: Even though this is a gag-a-day comic, the series of strips starting with here and ending here surely count. They're nonsensical even by the standards of the comic, the art and humor are very out of place, and they are never revisited afterwards.
The Depressing Comic Weeks. Are they a nice change of pace, or do they not belong in an otherwise humorous and goofy webcomic?
Season Too requiring a paid subscription to Seeso hasn't sat well with some fans, while others see it as Explosm deserving to make money off the series.
Joking Hazard, Explosm's attempt at making a card game. Some thought it was great. Others thought it was a cheap knockoff of Cards Against Humanity and that the requested Kickstarter amount was ludicrous for such a game.
Growing the Beard: The Depressing Comic Week strips started out as rather weak, mostly ruined by Wangst or the simplistic artstyle. Around week 3 was where the characters started to show a wider variety of facial expressions and the writers improved with timing.