One comment on Youtube suggests The Adventures of Lunk skit represents the reaction when you play an RPG for hours on end, Die, then realize your save was hours ago, and have to replay everything.
In the animated short "Last Words", is the son a trans man, does his Mother have alzheimer, or is she just a troll?
Anvilicious: This strip manages to be that and the usual horrible C&H wrongness at the same time. Turns out the real monster is bad parenting.
Big Lipped Alligator Moment: Even though this is a gag-a-day comic, the series of strips starting with here and ending here surely count. They're nonsensical even by the standards of the comic, the art and humor are very out of place, and they are never revisited afterwards.
Broken Base: The Depressing Comic Weeks. Are they a nice change of pace, or do they not belong in an otherwise humorous and goofy webcomic?
Critical Research Failure: In "Rudy It's a Bitch Ass Life", Rudy's gravestone reveals that he was born in 1950, yet he's able to attend a desegregated Kindergarten with no apparent problems at all.