- Complete Monster: Juan "Juarez" Mendoza is a ruthless Mexican bandit turned warlord. When the outlaw brothers, Thomas and Ray McCall, arrive in Mexico, Juarez uses them to wipe out his rivals before betraying them to Confederate remnants they escaped from. When he bargains with an Apache tribe trying to fight the army, Juarez simply sells them defective rifles he has lying around, taking the money while letting the natives be slaughtered. Upon learning his mistress Marisa is in love with Thomas, Juarez tries to have the brothers' pacifist younger brother William killed and intends to throw Marisa into slavery in one of his brothels, sneering that she is a "lying, thieving, gold-loving whore." When Ray defeats him, Juarez resurfaces eighteen years later, hunting for a secret treasure he believes Marisa passed on to her son Billy. He kills Thomas and Marisa, lets his men rape his ex, and attempts to hunt down Billy by threatening the life of Billy's love interest Molly. When he fails to sway Billy ( who turns out to be his own son) to his side, he attempts to burn him and Molly alive. At the end, when Juarez is beaten, he still manages to mortally wound Ray himself and attempts to murder Billy to the end before a dying Ray finds the strength to kill him once and for all. Brutal, greedy and treacherous, Juarez prides himself on his ability to come out on top no matter who he has to destroy.
- Contested Sequel: The Cartel.
- Crowning Moment of Awesome: Reverend Ray's showdown with Juarez:
"I bring not peace... BUT THE WRATH OF THE LORD!" [Ray then proceeds to murder an entire army with a Gatling gun].
- And in Bound in Blood, the death of William.
- Hilarious in Hindsight: Head of the RL Juarez Cartel was captured by the police just thirteen days after the release of Call of Juarez: The Cartel. Guess we know who did it...
- Tear Jerker: While the original game already had a touching ending where Billy promises never to run away again at Ray's grave, Bound in Blood outdoes it by far with Ray's solemn So What Do We Do Now? monologue. Even knowing the McCalls' ultimate fate won't stop those Manly Tears.
- They Changed It, Now It Sucks: Turned Up to Eleven, thanks to how most people responded to the announcement of The Cartel as a modern western, saying that the idea is simply ridiculous, apparently never having watched Justifed or Red Hill.