In Spoilsbury Toast Boy, the doctor beetle explains to Liache that "mucus is a living thing" and "it has a certain degree of intelligence." The beetles later drown Liache when her mucus tells them she doesn't deserve to breathe.
In the Global Guardians PBEM Universe, while intelligent apes have been given full civil rights, robots, androids, and other artificial intelligences are still not considered people in the legal sense even though they cannot be harmed with impunity (property laws come into consideration). Demons, the undead, and most other forms of monster are free targets, however.
Deconstructed in this Video Game Confessions which reimagines Samus as a violent torturer and serial killer. She asks "Why is it that when you kill an alien from another world, you're considered a hero?"
Played for laughs in a The Runaway Guys playthrough of Mario Party during the mini game Shy Guy Says when ProtonJon is horrified when the Shy Guy leaves Wario to drown in the ocean, but ignores Yoshi when the same thing happens to him right afterwards.
Chuggaa: And you say I'm racist?
Jon: Ra... How is that racist? It's a dinosaur!
Chuggaa: Dinosaurs are people too.
Jon: No, they're not! They're dinosaurs, that's why we call them dinosaurs!
When Straizo uses the Ripple on Dio's elite zombies during a scene in Vaguely Recalling JoJo, he spares Page because Page had an almost human-like appearance. Also, Page looked like Pesci, who will make an appearance in Vento Aureo.