Actor Allusion: Benjamin's father asks about "the house on paper street", a reference to Fight Club - which was also directed by David Fincher and starred Brad Pitt.
Development Hell: At various points during production, Steven Spielberg, Ron Howard, and Spike Jonze were going to direct, and Tom Cruise, John Travolta, or even Jack Nicholson was going to star. It had been bouncing around as potential film for decades. Like David Fincher said, nobody wanted to make a $150 million film with the idea of death at its center. It took a while for someone to A) turn the bizarre, lifetime-spanning plot into a workable film narrative, and B) find a way to age a main character but keep it clearly the same character.
Executive Meddling: The studio had the film set in New Orleans - as opposed to the short story's Baltimore setting - in order to take advantage of Louisiana's filming discounts.
Fake American: Benjamin's father is played by the British Jason Flemyng. Amusingly his daughter Caroline is also played by a Brit, Julia Ormond. Australian Cate Blanchett also plays the Louisiana native Daisy.