Actor Allusion: Benjamin's father asks about "the house on paper street", a reference to Fight Club - which was also directed by David Fincher and starred Brad Pitt.
Development Hell: At various points during production, Steven Spielberg, Ron Howard, and Spike Jonze were going to direct, and Tom Cruise, John Travolta, or even Jack Nicholson was going to star. It had been bouncing around as potential film for decades. Like David Fincher said, nobody wanted to make a $150 million film with the idea of death at its center. It took a while for someone to A) turn the bizarre, lifetime-spanning plot into a workable film narrative, and B) find a way to age a main character but keep it clearly the same character.
Executive Meddling: The studio had the film set in New Orleans - as opposed to the short story's Baltimore setting - in order to take advantage of Louisiana's filming discounts.
Fake American: Benjamin's father is played by the British Jason Flemyng. Amusingly his daughter Caroline is also played by a Brit, Julia Ormond. Australian Cate Blanchett also plays the Louisiana native Daisy.
Real Life Writes the Plot: The reason Brad Pitt doesn't portray the teenaged Benjamin is quite simply because the special effects budget had been depleted.
Shown Their Work: Daisy talks about Agnes de Mille on her date with Benjamin. When he goes to see her performing, the show she's dancing in is Carousel. The sequence is the dream ballet, which was indeed choreographed by Agnes de Mille.
Throw It In: Director Tarsem Singh was hired to shoot the shots of Benjamin in Cambodia and India, after David Fincher heard that he and Brad Pitt would both be in Southeast Asia at the same time.
What Could Have Been: Rachel Weisz was the first choice for Daisy but she had to turn it down due to a scheduling conflict.