In "All the Mayor's Men," Mike quotes Johnny B. Goode - his signature song from Back to the Future - as a Bible passage.
In "The Great Debate," the Mayor goads a political opponent with clucking. When Mike is asked what the Mayor is up to, he responds knowingly that he's "doing the chicken." Marty McFly could be goaded into anything if he was called a chicken.
The Other Darrin: Carter's pet Rags suddenly turns into a way more shaggy breed in a later season episode.
What Could Have Been: According to an interview with Jon Cryer, at an ABC upfront presentation, he was asked if Charlie Sheen would be a good match to replace Michael J. Fox (this was right after Sheen's first period of sobering up). Cryer later learned that he himself was on the list of potential Fox replacements and had essentially talked himself out of a job. Of course, Cryer and Sheen would later collaborate on a success of their own.